CA3105681A1 - Pyridazinone derivative - Google Patents

Pyridazinone derivative Download PDF

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Publication number
CA3105681A1
CA3105681A1 CA3105681A CA3105681A CA3105681A1 CA 3105681 A1 CA3105681 A1 CA 3105681A1 CA 3105681 A CA3105681 A CA 3105681A CA 3105681 A CA3105681 A CA 3105681A CA 3105681 A1 CA3105681 A1 CA 3105681A1
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CA
Canada
Prior art keywords
optionally substituted
group
same
substituents selected
alkoxy
Prior art date
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Pending
Application number
CA3105681A
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English (en)
French (fr)
Inventor
Tomoaki Nishida
Hiro UEMACHI
Masato Iwata
Hajime Shibata
Takuya NISHIMAKI
Saori KIYOSHIGE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharma Co Ltd
Original Assignee
Sumitomo Dainippon Pharma Co Ltd
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Application filed by Sumitomo Dainippon Pharma Co Ltd filed Critical Sumitomo Dainippon Pharma Co Ltd
Publication of CA3105681A1 publication Critical patent/CA3105681A1/en
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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CA3105681A 2018-07-19 2019-07-18 Pyridazinone derivative Pending CA3105681A1 (en)

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US12240831B2 (en) 2018-11-06 2025-03-04 Edgewise Therapeutics, Inc. Pyridazinone compounds and uses thereof
US12240833B2 (en) 2018-11-06 2025-03-04 Edgewise Therapeutics, Inc. Pyridazinone compounds and uses thereof
US12415794B2 (en) 2018-11-06 2025-09-16 Edgewise Therapeutics, Inc. Pyridazinone compounds and uses thereof

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WO2021149767A1 (ja) * 2020-01-22 2021-07-29 大日本住友製薬株式会社 ヘテロ環誘導体
JP2023523418A (ja) * 2020-04-23 2023-06-05 ヤンセン ファーマシューティカ エヌ．ベー． Ｎｌｒｐ３の阻害剤としての三環式化合物
KR20230035049A (ko) * 2020-07-02 2023-03-10 데날리 테라퓨틱스 인크. 화합물, 조성물 및 방법
CN116964052A (zh) * 2021-03-04 2023-10-27 詹森药业有限公司 调节nlrp3的4-氨基-6-氧代-哒嗪衍生物
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US12054486B2 (en) 2021-09-24 2024-08-06 Xenon Pharmaceuticals Inc. Pyridine derivatives and their use as sodium channel activators
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12240831B2 (en) 2018-11-06 2025-03-04 Edgewise Therapeutics, Inc. Pyridazinone compounds and uses thereof
US12240833B2 (en) 2018-11-06 2025-03-04 Edgewise Therapeutics, Inc. Pyridazinone compounds and uses thereof
US12415794B2 (en) 2018-11-06 2025-09-16 Edgewise Therapeutics, Inc. Pyridazinone compounds and uses thereof

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JP7476100B2 (ja) 2024-04-30
JPWO2020017587A1 (ja) 2021-08-05
WO2020017587A1 (ja) 2020-01-23

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