CA3104778A1 - Pd1-4-1bbl variant fusion protein and methods of use thereof - Google Patents

Pd1-4-1bbl variant fusion protein and methods of use thereof Download PDF

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Publication number
CA3104778A1
CA3104778A1 CA3104778A CA3104778A CA3104778A1 CA 3104778 A1 CA3104778 A1 CA 3104778A1 CA 3104778 A CA3104778 A CA 3104778A CA 3104778 A CA3104778 A CA 3104778A CA 3104778 A1 CA3104778 A1 CA 3104778A1
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Canada
Prior art keywords
amino acid
acid sequence
seq
1bbl
specific embodiments
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Pending
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CA3104778A
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English (en)
French (fr)
Inventor
Iris Pecker
Itai BLOCH
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Kahr Medical Ltd
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Kahr Medical Ltd
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Publication of CA3104778A1 publication Critical patent/CA3104778A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA3104778A 2018-07-11 2019-07-11 Pd1-4-1bbl variant fusion protein and methods of use thereof Pending CA3104778A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862696365P 2018-07-11 2018-07-11
US62/696,365 2018-07-11
US201862786599P 2018-12-31 2018-12-31
US62/786,599 2018-12-31
PCT/IL2019/050782 WO2020012485A1 (en) 2018-07-11 2019-07-11 Pd1-4-1bbl variant fusion protein and methods of use thereof

Publications (1)

Publication Number Publication Date
CA3104778A1 true CA3104778A1 (en) 2020-01-16

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA3104778A Pending CA3104778A1 (en) 2018-07-11 2019-07-11 Pd1-4-1bbl variant fusion protein and methods of use thereof

Country Status (12)

Country Link
US (1) US12286466B2 (enExample)
EP (1) EP3820887A4 (enExample)
JP (1) JP2021531265A (enExample)
KR (1) KR20210044221A (enExample)
CN (1) CN112543767B (enExample)
AU (1) AU2019301315A1 (enExample)
BR (1) BR112021000347A2 (enExample)
CA (1) CA3104778A1 (enExample)
IL (1) IL280102B1 (enExample)
MX (1) MX2021000047A (enExample)
SG (1) SG11202013170RA (enExample)
WO (1) WO2020012485A1 (enExample)

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Publication number Publication date
US12286466B2 (en) 2025-04-29
BR112021000347A2 (pt) 2021-04-13
EP3820887A1 (en) 2021-05-19
EP3820887A4 (en) 2022-04-20
MX2021000047A (es) 2021-05-12
CN112543767B (zh) 2024-05-31
SG11202013170RA (en) 2021-01-28
KR20210044221A (ko) 2021-04-22
JP2021531265A (ja) 2021-11-18
WO2020012485A1 (en) 2020-01-16
IL280102A (en) 2021-03-01
AU2019301315A1 (en) 2021-02-11
WO2020012485A9 (en) 2020-04-30
IL280102B1 (en) 2026-07-01
US20210284711A1 (en) 2021-09-16
CN112543767A (zh) 2021-03-23

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