CA3104507A1 - Protein tyrosine phosphatase inhibitors and methods of use thereof - Google Patents

Protein tyrosine phosphatase inhibitors and methods of use thereof Download PDF

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Publication number
CA3104507A1
CA3104507A1 CA3104507A CA3104507A CA3104507A1 CA 3104507 A1 CA3104507 A1 CA 3104507A1 CA 3104507 A CA3104507 A CA 3104507A CA 3104507 A CA3104507 A CA 3104507A CA 3104507 A1 CA3104507 A1 CA 3104507A1
Authority
CA
Canada
Prior art keywords
fluoro
trione
thiadiazolidine
lambda
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3104507A
Other languages
English (en)
French (fr)
Inventor
Elliot FARNEY
Roohollah Kazem SHIROODI
Zhaoming Xiong
Qingwei Zhang
Matthew O'connor
Geoff HALVORSEN
Hongyu Zhao
Christina BAUMGARTNER
Jennifer M. Frost
Phil KYM
Jason R. ABBOTT
Andrew Bogdan
Christos ECONOMOU
Xueqing Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AbbVie Inc
Calico Life Sciences LLC
Original Assignee
AbbVie Inc
Calico Life Sciences LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AbbVie Inc, Calico Life Sciences LLC filed Critical AbbVie Inc
Publication of CA3104507A1 publication Critical patent/CA3104507A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/13—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
CA3104507A 2018-06-21 2019-06-21 Protein tyrosine phosphatase inhibitors and methods of use thereof Pending CA3104507A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862688226P 2018-06-21 2018-06-21
US62/688,226 2018-06-21
PCT/US2019/038459 WO2019246513A1 (en) 2018-06-21 2019-06-21 Protein tyrosine phosphatase inhibitors and methods of use thereof

Publications (1)

Publication Number Publication Date
CA3104507A1 true CA3104507A1 (en) 2019-12-26

Family

ID=67254011

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3104507A Pending CA3104507A1 (en) 2018-06-21 2019-06-21 Protein tyrosine phosphatase inhibitors and methods of use thereof

Country Status (23)

Country Link
US (1) US10954202B2 (enExample)
EP (1) EP3810580A1 (enExample)
JP (3) JP7217762B2 (enExample)
KR (3) KR102850637B1 (enExample)
CN (1) CN112955438A (enExample)
AR (1) AR125425A1 (enExample)
AU (3) AU2019290197B2 (enExample)
BR (1) BR112020026086A2 (enExample)
CA (1) CA3104507A1 (enExample)
CL (1) CL2020003316A1 (enExample)
CO (1) CO2021000447A2 (enExample)
CR (1) CR20210017A (enExample)
DO (1) DOP2020000252A (enExample)
EC (1) ECSP21003520A (enExample)
IL (1) IL279587A (enExample)
MA (1) MA52963A (enExample)
MX (2) MX2020014223A (enExample)
PE (2) PE20260750A1 (enExample)
PH (1) PH12020552228A1 (enExample)
SG (1) SG11202012820PA (enExample)
TW (2) TWI888352B (enExample)
UY (2) UY41151A (enExample)
WO (1) WO2019246513A1 (enExample)

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TWI888352B (zh) * 2018-06-21 2025-07-01 美商嘉來克生命科學有限責任公司 蛋白質酪胺酸磷酸酯酶抑制劑及其使用方法
KR102983496B1 (ko) * 2019-03-14 2026-06-29 칼리코 라이프 사이언시스 엘엘씨 단백질 티로신 포스파타제 억제제 및 이의 사용 방법
AU2020395612A1 (en) * 2019-12-04 2022-06-09 Monash University Methods of activating cytotoxic leukocytes using PTP1B and PTPN2 inhibitors
AU2020401376A1 (en) 2019-12-12 2022-06-30 Kumquat Biosciences Inc. Compositions and methods for potentiating immune activity
MX2022007441A (es) * 2019-12-18 2022-09-02 Calico Life Sciences Llc Inhibidores de proteína tirosina fosfatasa y sus métodos de uso.
EP4211122A1 (en) * 2020-09-11 2023-07-19 Calico Life Sciences LLC Protein tyrosine phosphatase inhibitors and methods of use thereof
EP4351558A4 (en) * 2021-06-10 2025-05-07 Ness Therapeutics, Inc. Compounds containing 5-(2-fluoro-6-hydroxyphenyl)-1,2,5-thiazolidin-3-one 1,1-dioxide as inhibitors of protein kinase phosphatase enzymes
WO2022271727A1 (en) * 2021-06-21 2022-12-29 Calico Life Sciences Llc Degrader compounds and uses thereof
CN118556055A (zh) * 2021-11-11 2024-08-27 卡里科生命科学有限责任公司 蛋白酪氨酸磷酸酶抑制剂及其使用方法
MX2024005658A (es) * 2021-11-11 2024-08-06 Calico Life Sciences Llc Inhibidores de proteina tirosina fosfatasa y metodos de uso de estos.
IL314650A (en) * 2022-02-02 2024-09-01 Nerio Therapeutics Inc Protein tyrosine phosphatase inhibitors and uses thereof
KR20250011138A (ko) * 2022-05-13 2025-01-21 네스 테라퓨틱스 인코포레이티드 Ptpn2 저해제
CN116675653B (zh) * 2022-07-22 2024-10-01 中国药科大学 氨基烷基取代的1,2,4-噻二唑烷-3,5-二酮化合物及其制备方法和应用
JP2025530135A (ja) * 2022-09-13 2025-09-11 カムクワット バイオサイエンシーズ インコーポレイテッド ベンゾ縮合n-複素環及びその使用
EP4615840A1 (en) * 2022-11-09 2025-09-17 Bristol-Myers Squibb Company Indazol substituted 1,2,5-thiadiazolidin derivatives as inhibitors of protein tyrosine phosphatase (ptpn2) for the treatment of cancer diseases
WO2024243441A1 (en) 2023-05-24 2024-11-28 Kumquat Biosciences Inc. Heterocyclic compounds and uses thereof
CN117343052B (zh) * 2023-12-04 2024-02-06 英矽智能科技(上海)有限公司 蛋白酪氨酸磷酸酶抑制剂及其应用
WO2026112350A1 (en) * 2024-11-22 2026-05-28 Kumquat Biosciences Inc. Heterocyclic compounds and uses thereof

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Publication number Publication date
CO2021000447A2 (es) 2021-07-19
PH12020552228A1 (en) 2021-08-16
MA52963A (fr) 2021-04-28
TW202016082A (zh) 2020-05-01
JP7704787B2 (ja) 2025-07-08
ECSP21003520A (es) 2021-02-26
PE20260750A1 (es) 2026-03-31
JP2021530443A (ja) 2021-11-11
AU2019290197A1 (en) 2021-01-21
JP7217762B2 (ja) 2023-02-03
SG11202012820PA (en) 2021-01-28
IL279587A (en) 2021-03-01
PE20210372A1 (es) 2021-02-26
TWI888352B (zh) 2025-07-01
UY38272A (es) 2019-12-31
MX2020014223A (es) 2021-06-23
WO2019246513A1 (en) 2019-12-26
CR20210017A (es) 2021-11-03
US10954202B2 (en) 2021-03-23
AU2023263567A1 (en) 2023-11-30
BR112020026086A2 (pt) 2021-03-23
CN112955438A (zh) 2021-06-11
AU2023263567B2 (en) 2026-02-19
KR20230074286A (ko) 2023-05-26
KR102533477B1 (ko) 2023-05-18
US20210009542A1 (en) 2021-01-14
JP2025143330A (ja) 2025-10-01
KR20250133466A (ko) 2025-09-05
AR125425A1 (es) 2023-07-19
JP2023055771A (ja) 2023-04-18
DOP2020000252A (es) 2021-07-15
CL2020003316A1 (es) 2021-06-11
JP7881804B2 (ja) 2026-06-29
UY41151A (es) 2025-09-30
TW202600546A (zh) 2026-01-01
KR102850637B1 (ko) 2025-08-27
EP3810580A1 (en) 2021-04-28
AU2026203759A1 (en) 2026-06-04
AU2019290197B2 (en) 2023-08-24
MX2024004318A (es) 2024-04-23
KR20210034589A (ko) 2021-03-30

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