CA3097142A1 - Nerve block by electrical pulses at sub-threshold intensity - Google Patents

Nerve block by electrical pulses at sub-threshold intensity Download PDF

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Publication number
CA3097142A1
CA3097142A1 CA3097142A CA3097142A CA3097142A1 CA 3097142 A1 CA3097142 A1 CA 3097142A1 CA 3097142 A CA3097142 A CA 3097142A CA 3097142 A CA3097142 A CA 3097142A CA 3097142 A1 CA3097142 A1 CA 3097142A1
Authority
CA
Canada
Prior art keywords
nerve
neuron
intensity
electrical stimulation
increased
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3097142A
Other languages
English (en)
French (fr)
Inventor
Changfeng Tai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pittsburgh
Original Assignee
University of Pittsburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pittsburgh filed Critical University of Pittsburgh
Publication of CA3097142A1 publication Critical patent/CA3097142A1/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/3615—Intensity
    • A61N1/36164—Sub-threshold or non-excitatory signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36062—Spinal stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36071—Pain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/3615—Intensity
    • A61N1/36153—Voltage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/3615—Intensity
    • A61N1/36157—Current
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/36167—Timing, e.g. stimulation onset
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/36167—Timing, e.g. stimulation onset
    • A61N1/36171—Frequency

Landscapes

  • Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Electrotherapy Devices (AREA)
  • Magnetic Treatment Devices (AREA)
CA3097142A 2018-04-16 2019-04-15 Nerve block by electrical pulses at sub-threshold intensity Pending CA3097142A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862658147P 2018-04-16 2018-04-16
US62/658,147 2018-04-16
PCT/US2019/027471 WO2019204198A1 (en) 2018-04-16 2019-04-15 Nerve block by electrical pulses at sub-threshold intensity

Publications (1)

Publication Number Publication Date
CA3097142A1 true CA3097142A1 (en) 2019-10-24

Family

ID=68239950

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3097142A Pending CA3097142A1 (en) 2018-04-16 2019-04-15 Nerve block by electrical pulses at sub-threshold intensity

Country Status (8)

Country Link
US (3) US11865346B2 (https=)
EP (1) EP3781252B1 (https=)
JP (2) JP2021520942A (https=)
KR (1) KR102873485B1 (https=)
CN (1) CN112368047A (https=)
AU (1) AU2019255603B2 (https=)
CA (1) CA3097142A1 (https=)
WO (1) WO2019204198A1 (https=)

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US11413458B2 (en) 2011-05-19 2022-08-16 Neuros Medical, Inc. Nerve cuff electrode for neuromodulation in large human nerve trunks
KR102648346B1 (ko) 2017-12-13 2024-03-15 뉴로스 메디컬 인코포레이티드 신경 커프 배치 장치
CN112188915A (zh) 2018-04-09 2021-01-05 纽若斯医疗公司 用于设置电剂量的装置和方法
JP2021520942A (ja) * 2018-04-16 2021-08-26 ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 閾値下強度における電気パルスによる神経ブロック
US12370079B2 (en) 2018-06-19 2025-07-29 Thermaquil, Inc. Apparatus and method for thermal blockade of nerves
EP4103267B1 (en) 2020-02-11 2025-06-04 Neuros Medical, Inc. System for quantifying qualitative patient-reported data sets
CN115040230B (zh) * 2022-07-12 2024-04-23 上海宏桐实业有限公司 一种脉冲电场消融系统及电子设备
KR102682382B1 (ko) * 2023-11-28 2024-07-08 (주)리솔 통증 완화 장치 및 그 제어방법
CN118105624B (zh) * 2024-01-30 2024-09-13 上海诺诚电气股份有限公司 神经电刺激监测方法和系统

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US6421566B1 (en) * 1998-04-30 2002-07-16 Medtronic, Inc. Selective dorsal column stimulation in SCS, using conditioning pulses
US8626302B2 (en) * 1998-06-03 2014-01-07 Spr Therapeutics, Llc Systems and methods to place one or more leads in muscle for providing electrical stimulation to treat pain
US6697670B2 (en) * 2001-08-17 2004-02-24 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation with improved comfort of patients
US7389145B2 (en) * 2001-02-20 2008-06-17 Case Western Reserve University Systems and methods for reversibly blocking nerve activity
US7904176B2 (en) * 2006-09-07 2011-03-08 Bio Control Medical (B.C.M.) Ltd. Techniques for reducing pain associated with nerve stimulation
US7689277B2 (en) * 2002-03-22 2010-03-30 Leptos Biomedical, Inc. Neural stimulation for treatment of metabolic syndrome and type 2 diabetes
US20070025608A1 (en) * 2005-07-29 2007-02-01 Cyberonics, Inc. Enhancing intrinsic neural activity using a medical device to treat a patient
US20070173908A1 (en) * 2006-01-20 2007-07-26 Cyberonics, Inc. Transcutaneous trigeminal nerve stimulation to treat motion sickness
US9020597B2 (en) * 2008-11-12 2015-04-28 Endostim, Inc. Device and implantation system for electrical stimulation of biological systems
US8805510B2 (en) 2007-08-02 2014-08-12 University of Pittsburgh—of the Commonwealth System of Higher Education Methods and systems for achieving a physiological response by pudendal nerve stimulation and blockade
US20090105786A1 (en) * 2007-10-22 2009-04-23 University Of Washington Method and device for strengthening synaptic connections
US20090204173A1 (en) 2007-11-05 2009-08-13 Zi-Ping Fang Multi-Frequency Neural Treatments and Associated Systems and Methods
US8918178B2 (en) * 2009-03-20 2014-12-23 ElectroCore, LLC Non-invasive vagal nerve stimulation to treat disorders
WO2011041526A2 (en) 2009-10-01 2011-04-07 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Non-invasive method to treat urological and gastrointestinal disorders
US10279163B2 (en) * 2011-03-10 2019-05-07 Electrocore, Inc. Electrical and magnetic stimulators used to treat migraine/sinus headache, rhinitis, sinusitis, rhinosinusitis, and comorbid disorders
CN107376115A (zh) * 2011-11-15 2017-11-24 神经系统检测公司 用于使用经皮电神经刺激减轻疼痛的设备和方法
US20140243943A1 (en) * 2013-02-25 2014-08-28 Boston Scientific Neuromodulation Corporation System and method for stimulating intraosseous nerve fibers
JP6181307B2 (ja) * 2013-07-26 2017-08-16 ボストン サイエンティフィック ニューロモデュレイション コーポレイション 知覚なしに変調治療を与えるシステム
US10335596B2 (en) 2014-03-14 2019-07-02 Nalu Medical, Inc. Method and apparatus for neuromodulation treatments of pain and other conditions
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Also Published As

Publication number Publication date
JP2021520942A (ja) 2021-08-26
US20210283401A1 (en) 2021-09-16
AU2019255603A1 (en) 2020-11-12
JP2025013960A (ja) 2025-01-28
US20240042211A1 (en) 2024-02-08
US11865346B2 (en) 2024-01-09
AU2019255603B2 (en) 2024-09-05
CN112368047A (zh) 2021-02-12
WO2019204198A1 (en) 2019-10-24
US11826572B2 (en) 2023-11-28
KR20210002535A (ko) 2021-01-08
KR102873485B1 (ko) 2025-10-20
US20210106831A1 (en) 2021-04-15
EP3781252A4 (en) 2021-12-15
EP3781252A1 (en) 2021-02-24
EP3781252B1 (en) 2024-11-20

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