AU2019255603B2 - Nerve block by electrical pulses at sub-threshold intensity - Google Patents

Nerve block by electrical pulses at sub-threshold intensity Download PDF

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Publication number
AU2019255603B2
AU2019255603B2 AU2019255603A AU2019255603A AU2019255603B2 AU 2019255603 B2 AU2019255603 B2 AU 2019255603B2 AU 2019255603 A AU2019255603 A AU 2019255603A AU 2019255603 A AU2019255603 A AU 2019255603A AU 2019255603 B2 AU2019255603 B2 AU 2019255603B2
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Australia
Prior art keywords
nerve
neuron
intensity
electrical stimulation
increased
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AU2019255603A
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AU2019255603A1 (en
Inventor
Changfeng Tai
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University of Pittsburgh
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University of Pittsburgh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36062—Spinal stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36071—Pain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/3615—Intensity
    • A61N1/36153—Voltage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/3615—Intensity
    • A61N1/36157—Current
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/3615—Intensity
    • A61N1/36164—Sub-threshold or non-excitatory signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/36167—Timing, e.g. stimulation onset
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/36167—Timing, e.g. stimulation onset
    • A61N1/36171—Frequency

Landscapes

  • Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Electrotherapy Devices (AREA)
  • Magnetic Treatment Devices (AREA)
AU2019255603A 2018-04-16 2019-04-15 Nerve block by electrical pulses at sub-threshold intensity Active AU2019255603B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862658147P 2018-04-16 2018-04-16
US62/658,147 2018-04-16
PCT/US2019/027471 WO2019204198A1 (en) 2018-04-16 2019-04-15 Nerve block by electrical pulses at sub-threshold intensity

Publications (2)

Publication Number Publication Date
AU2019255603A1 AU2019255603A1 (en) 2020-11-12
AU2019255603B2 true AU2019255603B2 (en) 2024-09-05

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2019255603A Active AU2019255603B2 (en) 2018-04-16 2019-04-15 Nerve block by electrical pulses at sub-threshold intensity

Country Status (8)

Country Link
US (3) US11865346B2 (https=)
EP (1) EP3781252B1 (https=)
JP (2) JP2021520942A (https=)
KR (1) KR102873485B1 (https=)
CN (1) CN112368047A (https=)
AU (1) AU2019255603B2 (https=)
CA (1) CA3097142A1 (https=)
WO (1) WO2019204198A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11413458B2 (en) 2011-05-19 2022-08-16 Neuros Medical, Inc. Nerve cuff electrode for neuromodulation in large human nerve trunks
KR102648346B1 (ko) 2017-12-13 2024-03-15 뉴로스 메디컬 인코포레이티드 신경 커프 배치 장치
CN112188915A (zh) 2018-04-09 2021-01-05 纽若斯医疗公司 用于设置电剂量的装置和方法
JP2021520942A (ja) * 2018-04-16 2021-08-26 ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 閾値下強度における電気パルスによる神経ブロック
US12370079B2 (en) 2018-06-19 2025-07-29 Thermaquil, Inc. Apparatus and method for thermal blockade of nerves
EP4103267B1 (en) 2020-02-11 2025-06-04 Neuros Medical, Inc. System for quantifying qualitative patient-reported data sets
CN115040230B (zh) * 2022-07-12 2024-04-23 上海宏桐实业有限公司 一种脉冲电场消融系统及电子设备
KR102682382B1 (ko) * 2023-11-28 2024-07-08 (주)리솔 통증 완화 장치 및 그 제어방법
CN118105624B (zh) * 2024-01-30 2024-09-13 上海诺诚电气股份有限公司 神经电刺激监测方法和系统

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040127953A1 (en) * 2001-02-20 2004-07-01 Kilgore Kevin L. Systems and methods for reversibly blocking nerve activity
US20100036454A1 (en) * 1998-06-03 2010-02-11 Ndi Medical, Llc. Systems and methods to place one or more leads in muscle for providing electrical stimulation to treat pain
US20130238049A1 (en) * 2009-03-20 2013-09-12 ElectroCore, LLC Non-invasive vagal nerve stimulation to treat disorders
US20150032181A1 (en) * 2013-07-26 2015-01-29 Boston Scientific Neuromodulation Corporation Systems and methods of providing modulation therapy without patient-perception of stimulation
US20170348540A1 (en) * 2016-06-02 2017-12-07 Boston Scientific Neuromodulation Corporation Priming-assisted neuromodulation therapy

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6421566B1 (en) * 1998-04-30 2002-07-16 Medtronic, Inc. Selective dorsal column stimulation in SCS, using conditioning pulses
US6697670B2 (en) * 2001-08-17 2004-02-24 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation with improved comfort of patients
US7904176B2 (en) * 2006-09-07 2011-03-08 Bio Control Medical (B.C.M.) Ltd. Techniques for reducing pain associated with nerve stimulation
US7689277B2 (en) * 2002-03-22 2010-03-30 Leptos Biomedical, Inc. Neural stimulation for treatment of metabolic syndrome and type 2 diabetes
US20070025608A1 (en) * 2005-07-29 2007-02-01 Cyberonics, Inc. Enhancing intrinsic neural activity using a medical device to treat a patient
US20070173908A1 (en) * 2006-01-20 2007-07-26 Cyberonics, Inc. Transcutaneous trigeminal nerve stimulation to treat motion sickness
US9020597B2 (en) * 2008-11-12 2015-04-28 Endostim, Inc. Device and implantation system for electrical stimulation of biological systems
US8805510B2 (en) 2007-08-02 2014-08-12 University of Pittsburgh—of the Commonwealth System of Higher Education Methods and systems for achieving a physiological response by pudendal nerve stimulation and blockade
US20090105786A1 (en) * 2007-10-22 2009-04-23 University Of Washington Method and device for strengthening synaptic connections
US20090204173A1 (en) 2007-11-05 2009-08-13 Zi-Ping Fang Multi-Frequency Neural Treatments and Associated Systems and Methods
WO2011041526A2 (en) 2009-10-01 2011-04-07 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Non-invasive method to treat urological and gastrointestinal disorders
US10279163B2 (en) * 2011-03-10 2019-05-07 Electrocore, Inc. Electrical and magnetic stimulators used to treat migraine/sinus headache, rhinitis, sinusitis, rhinosinusitis, and comorbid disorders
CN107376115A (zh) * 2011-11-15 2017-11-24 神经系统检测公司 用于使用经皮电神经刺激减轻疼痛的设备和方法
US20140243943A1 (en) * 2013-02-25 2014-08-28 Boston Scientific Neuromodulation Corporation System and method for stimulating intraosseous nerve fibers
US10335596B2 (en) 2014-03-14 2019-07-02 Nalu Medical, Inc. Method and apparatus for neuromodulation treatments of pain and other conditions
US20160158551A1 (en) * 2014-12-05 2016-06-09 Pacesstter, Inc. System and method for dorsal root block during spinal cord stimulation
US20170361091A1 (en) 2014-12-23 2017-12-21 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Devices, Systems and Methods for Treating Urological and Gastrointestinal Disorders by Electrical Stimulation of the Foot
US9962547B2 (en) * 2015-02-05 2018-05-08 Stimgenics, Llc Method and apparatus for multimodal electrical modulation of pain
US10765863B2 (en) * 2015-02-24 2020-09-08 Elira, Inc. Systems and methods for using a transcutaneous electrical stimulation device to deliver titrated therapy
US9872985B2 (en) * 2015-03-03 2018-01-23 Georgia Tech Research Corporation Glucose regulation via electrical stimulation of nerves innervating the liver
CA3014317C (en) * 2016-02-19 2024-07-02 Nalu Medical, Inc. DEVICE FEATURING ENHANCED STIMULATION WAVEFORMS
US11285318B2 (en) 2017-05-04 2022-03-29 University of Pittsburgh—of the Commonwealth System of Higher Education Peripheral neuromodulation to treat bladder and bowel dysfunction
JP2021520942A (ja) * 2018-04-16 2021-08-26 ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 閾値下強度における電気パルスによる神経ブロック

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100036454A1 (en) * 1998-06-03 2010-02-11 Ndi Medical, Llc. Systems and methods to place one or more leads in muscle for providing electrical stimulation to treat pain
US20040127953A1 (en) * 2001-02-20 2004-07-01 Kilgore Kevin L. Systems and methods for reversibly blocking nerve activity
US20130238049A1 (en) * 2009-03-20 2013-09-12 ElectroCore, LLC Non-invasive vagal nerve stimulation to treat disorders
US20150032181A1 (en) * 2013-07-26 2015-01-29 Boston Scientific Neuromodulation Corporation Systems and methods of providing modulation therapy without patient-perception of stimulation
US20170348540A1 (en) * 2016-06-02 2017-12-07 Boston Scientific Neuromodulation Corporation Priming-assisted neuromodulation therapy

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Peng, et. al, "Influence of stimulus waveforms of high-frequency electrical current on nerve conduction block," 2009 4th International IEEE/EMBS Conference on Neural Engineering, 2009, pp. 72-75, doi: 10.1109/NER.2009.5109237 (Year: 2009) *

Also Published As

Publication number Publication date
JP2021520942A (ja) 2021-08-26
US20210283401A1 (en) 2021-09-16
AU2019255603A1 (en) 2020-11-12
JP2025013960A (ja) 2025-01-28
US20240042211A1 (en) 2024-02-08
US11865346B2 (en) 2024-01-09
CN112368047A (zh) 2021-02-12
CA3097142A1 (en) 2019-10-24
WO2019204198A1 (en) 2019-10-24
US11826572B2 (en) 2023-11-28
KR20210002535A (ko) 2021-01-08
KR102873485B1 (ko) 2025-10-20
US20210106831A1 (en) 2021-04-15
EP3781252A4 (en) 2021-12-15
EP3781252A1 (en) 2021-02-24
EP3781252B1 (en) 2024-11-20

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