CA3095186A1 - Stable anti-cd79b immunoconjugate formulations - Google Patents

Stable anti-cd79b immunoconjugate formulations Download PDF

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Publication number
CA3095186A1
CA3095186A1 CA3095186A CA3095186A CA3095186A1 CA 3095186 A1 CA3095186 A1 CA 3095186A1 CA 3095186 A CA3095186 A CA 3095186A CA 3095186 A CA3095186 A CA 3095186A CA 3095186 A1 CA3095186 A1 CA 3095186A1
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Canada
Prior art keywords
pharmaceutical composition
composition
cd79b
seq
concentration
Prior art date
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Pending
Application number
CA3095186A
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English (en)
French (fr)
Inventor
Ankit R. Patel
Jun Liu
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Genentech Inc
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Genentech Inc
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Publication of CA3095186A1 publication Critical patent/CA3095186A1/en
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    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/6889Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • CCHEMISTRY; METALLURGY
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    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07KPEPTIDES
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    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL

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  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Hematology (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
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  • Microbiology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA3095186A 2018-04-13 2019-04-12 Stable anti-cd79b immunoconjugate formulations Pending CA3095186A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862657185P 2018-04-13 2018-04-13
US62/657,185 2018-04-13
PCT/US2019/027329 WO2019200322A1 (en) 2018-04-13 2019-04-12 Stable anti-cd79b immunoconjugate formulations

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