CA3091950A1 - Nouveaux composes sulfonimidoylpurinone substitues en position 7 et derives pour le traitement et la prophylaxie du cancer du foie - Google Patents
Nouveaux composes sulfonimidoylpurinone substitues en position 7 et derives pour le traitement et la prophylaxie du cancer du foie Download PDFInfo
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- CA3091950A1 CA3091950A1 CA3091950A CA3091950A CA3091950A1 CA 3091950 A1 CA3091950 A1 CA 3091950A1 CA 3091950 A CA3091950 A CA 3091950A CA 3091950 A CA3091950 A CA 3091950A CA 3091950 A1 CA3091950 A1 CA 3091950A1
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- Prior art keywords
- amino
- methyl
- oxo
- purine
- compound
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- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/24—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one nitrogen and one sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention concerne des composés de formule (I), dans laquelle les R1, R2 et R3 sont tels que décrits dans la description, et leurs promédicaments ou sel, énantiomère ou diastéréoisomère pharmaceutiquement acceptables, (destinés à être utilisés) pour le traitement et/ou la prophylaxie du cancer du foie.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2018077501 | 2018-02-28 | ||
CNPCT/CN2018/077501 | 2018-02-28 | ||
PCT/EP2019/054729 WO2019166432A1 (fr) | 2018-02-28 | 2019-02-26 | Nouveaux composés sulfonimidoylpurinone substitués en position 7 et dérivés pour le traitement et la prophylaxie du cancer du foie |
Publications (1)
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CA3091950A1 true CA3091950A1 (fr) | 2019-09-06 |
Family
ID=65685310
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CA3091950A Pending CA3091950A1 (fr) | 2018-02-28 | 2019-02-26 | Nouveaux composes sulfonimidoylpurinone substitues en position 7 et derives pour le traitement et la prophylaxie du cancer du foie |
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EP (1) | EP3758707A1 (fr) |
JP (1) | JP7089596B2 (fr) |
KR (1) | KR20200128414A (fr) |
CN (1) | CN111801100B (fr) |
AR (1) | AR114419A1 (fr) |
AU (1) | AU2019228654A1 (fr) |
BR (1) | BR112020016509A2 (fr) |
CA (1) | CA3091950A1 (fr) |
CL (1) | CL2020002139A1 (fr) |
CO (1) | CO2020010306A2 (fr) |
IL (1) | IL276817A (fr) |
MA (1) | MA52412A (fr) |
MX (1) | MX2020008746A (fr) |
PE (1) | PE20211456A1 (fr) |
PH (1) | PH12020551343A1 (fr) |
RU (1) | RU2020131012A (fr) |
SG (1) | SG11202008291XA (fr) |
TW (1) | TW202003518A (fr) |
WO (1) | WO2019166432A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112420196A (zh) * | 2020-11-20 | 2021-02-26 | 长沙市弘源心血管健康研究院 | 急性心肌梗死患者5年内生存率的预测方法和系统 |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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JOP20170169A1 (ar) | 2016-08-29 | 2019-01-30 | Novartis Ag | مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو |
KR102409595B1 (ko) | 2020-06-29 | 2022-06-17 | 한국과학기술연구원 | 단백질 카이네이즈 csf-1r 억제제로서의 신규 퓨리논 유도체 |
WO2024013205A1 (fr) * | 2022-07-14 | 2024-01-18 | F. Hoffmann-La Roche Ag | Composés de phosphorylpurinone pour le traitement du cancer |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
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JP4189048B2 (ja) | 1997-12-26 | 2008-12-03 | 大日本住友製薬株式会社 | 複素環化合物 |
WO2010077613A1 (fr) | 2008-12-09 | 2010-07-08 | Gilead Sciences, Inc. | Modulateurs de récepteurs de type toll (tlr) |
EA201101650A1 (ru) * | 2009-05-21 | 2012-07-30 | Астразенека Аб | Новые производные пиримидина и их применение в лечении злокачественных новообразований и последующих заболеваний |
ES2644286T3 (es) * | 2009-10-22 | 2017-11-28 | Gilead Sciences, Inc. | Derivados de purina o deazapurina útiles para el tratamiento de (entre otros) infecciones víricas |
US20110150836A1 (en) * | 2009-12-22 | 2011-06-23 | Gilead Sciences, Inc. | Methods of treating hbv and hcv infection |
NZ604423A (en) * | 2010-06-24 | 2015-01-30 | Alkermes Pharma Ireland Ltd | Prodrugs of nh-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives |
CA2807585A1 (fr) * | 2010-08-13 | 2012-02-16 | Baylor Research Institute | Nouveaux adjuvants pour vaccins bases sur le ciblage d'adjuvants pour anticorps directement sur les cellules presentant des antigenes |
RU2745269C2 (ru) * | 2015-05-08 | 2021-03-22 | Ф. Хоффманн-Ля Рош Аг | Новые соединения и производные сульфонимидоилпуринона для лечения и профилактики вирусной инфекции |
MA44334A (fr) | 2015-10-29 | 2018-09-05 | Novartis Ag | Conjugués d'anticorps comprenant un agoniste du récepteur de type toll |
MA46038B1 (fr) * | 2016-08-29 | 2021-05-31 | Hoffmann La Roche | Composés de sulfonimidoylpurinone substitués dans la position 7 pour le traitement et la prophylaxie d'infection virale |
ES2894605T3 (es) * | 2016-09-13 | 2022-02-15 | Hoffmann La Roche | Tratamiento combinado con un agonista de TLR7 y un inhibidor del ensamblaje de la cápside del VHB |
-
2019
- 2019-02-26 EP EP19708981.6A patent/EP3758707A1/fr active Pending
- 2019-02-26 AU AU2019228654A patent/AU2019228654A1/en not_active Abandoned
- 2019-02-26 PE PE2020001228A patent/PE20211456A1/es unknown
- 2019-02-26 RU RU2020131012A patent/RU2020131012A/ru unknown
- 2019-02-26 MX MX2020008746A patent/MX2020008746A/es unknown
- 2019-02-26 WO PCT/EP2019/054729 patent/WO2019166432A1/fr unknown
- 2019-02-26 JP JP2020544794A patent/JP7089596B2/ja active Active
- 2019-02-26 CA CA3091950A patent/CA3091950A1/fr active Pending
- 2019-02-26 BR BR112020016509-3A patent/BR112020016509A2/pt not_active Application Discontinuation
- 2019-02-26 KR KR1020207027935A patent/KR20200128414A/ko unknown
- 2019-02-26 MA MA052412A patent/MA52412A/fr unknown
- 2019-02-26 CN CN201980015912.7A patent/CN111801100B/zh active Active
- 2019-02-26 SG SG11202008291XA patent/SG11202008291XA/en unknown
- 2019-02-27 TW TW108106752A patent/TW202003518A/zh unknown
- 2019-02-28 AR ARP190100505A patent/AR114419A1/es unknown
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2020
- 2020-08-19 CL CL2020002139A patent/CL2020002139A1/es unknown
- 2020-08-19 IL IL276817A patent/IL276817A/en unknown
- 2020-08-21 CO CONC2020/0010306A patent/CO2020010306A2/es unknown
- 2020-08-27 PH PH12020551343A patent/PH12020551343A1/en unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112420196A (zh) * | 2020-11-20 | 2021-02-26 | 长沙市弘源心血管健康研究院 | 急性心肌梗死患者5年内生存率的预测方法和系统 |
Also Published As
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CO2020010306A2 (es) | 2020-08-31 |
JP2021514972A (ja) | 2021-06-17 |
WO2019166432A1 (fr) | 2019-09-06 |
IL276817A (en) | 2020-10-29 |
CN111801100A (zh) | 2020-10-20 |
MX2020008746A (es) | 2020-09-28 |
CN111801100B (zh) | 2023-10-24 |
AU2019228654A1 (en) | 2020-09-03 |
MA52412A (fr) | 2021-06-02 |
SG11202008291XA (en) | 2020-09-29 |
BR112020016509A2 (pt) | 2020-12-15 |
RU2020131012A (ru) | 2022-03-28 |
PE20211456A1 (es) | 2021-08-05 |
KR20200128414A (ko) | 2020-11-12 |
CL2020002139A1 (es) | 2021-01-04 |
AR114419A1 (es) | 2020-09-02 |
JP7089596B2 (ja) | 2022-06-22 |
TW202003518A (zh) | 2020-01-16 |
PH12020551343A1 (en) | 2021-06-21 |
EP3758707A1 (fr) | 2021-01-06 |
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