CA3089161A1 - Compounds for the treatment of acute brain injury - Google Patents
Compounds for the treatment of acute brain injury Download PDFInfo
- Publication number
- CA3089161A1 CA3089161A1 CA3089161A CA3089161A CA3089161A1 CA 3089161 A1 CA3089161 A1 CA 3089161A1 CA 3089161 A CA3089161 A CA 3089161A CA 3089161 A CA3089161 A CA 3089161A CA 3089161 A1 CA3089161 A1 CA 3089161A1
- Authority
- CA
- Canada
- Prior art keywords
- formula
- compound
- aryl
- branched
- ipr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/54—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings and other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/32—All rings being cycloaliphatic the ring system containing at least eleven carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201870067 | 2018-02-02 | ||
| DKPA201870067 | 2018-02-02 | ||
| PCT/DK2019/050041 WO2019149329A1 (en) | 2018-02-02 | 2019-02-01 | Compounds for the treatment of acute brain injury |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3089161A1 true CA3089161A1 (en) | 2019-08-08 |
Family
ID=65363024
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3089161A Pending CA3089161A1 (en) | 2018-02-02 | 2019-02-01 | Compounds for the treatment of acute brain injury |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US12077495B2 (https=) |
| EP (1) | EP3746064B1 (https=) |
| JP (1) | JP7488521B2 (https=) |
| CN (1) | CN111989094A (https=) |
| AU (1) | AU2019214252B2 (https=) |
| CA (1) | CA3089161A1 (https=) |
| ES (1) | ES3035679T3 (https=) |
| WO (1) | WO2019149329A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7709202B2 (ja) * | 2019-06-28 | 2025-07-16 | ユニバーシティ オブ コペンハーゲン | 睡眠障害を伴うｃｎｓ障害の治療 |
| WO2023170024A1 (en) | 2022-03-11 | 2023-09-14 | University Of Copenhagen | Camk2 modulators and their use in medicine |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5466715A (en) * | 1991-12-31 | 1995-11-14 | Sterling Winthrop Inc. | 3,4-disubstituted phenols-immunomodulating agents |
| IT1312362B1 (it) * | 1999-06-29 | 2002-04-15 | Neuroscienze S C A R L | Derivati dell'acido (5,7,8,9-tetraidro-5-idrossi-6h-benzociclo-ept-6-iliden) acetico |
| US20090247770A1 (en) * | 2006-08-09 | 2009-10-01 | Campos Kevin R | Process for making lactam tachykinin receptor antagonists |
| JP6084207B2 (ja) * | 2011-05-13 | 2017-02-22 | ケベンハウンス ウニヴェルジテート（ユニバーシティ オブ コペンハーゲン）Ｋｏｅｂｅｎｈａｖｎｓ Ｕｎｉｖｅｒｓｉｔｅｔ（Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｏｐｅｎｈａｇｅｎ） | 虚血性脳損傷及び疼痛治療用の効率的な神経保護剤としてのｐｓｄ−９５の高親和性二量体阻害剤 |
| WO2013024028A1 (en) | 2011-08-12 | 2013-02-21 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Compounds and compositions for treating proteinopathies |
-
2019
- 2019-02-01 ES ES19704185T patent/ES3035679T3/es active Active
- 2019-02-01 CA CA3089161A patent/CA3089161A1/en active Pending
- 2019-02-01 EP EP19704185.8A patent/EP3746064B1/en active Active
- 2019-02-01 AU AU2019214252A patent/AU2019214252B2/en active Active
- 2019-02-01 WO PCT/DK2019/050041 patent/WO2019149329A1/en not_active Ceased
- 2019-02-01 US US16/965,343 patent/US12077495B2/en active Active
- 2019-02-01 CN CN201980011451.6A patent/CN111989094A/zh active Pending
- 2019-02-01 JP JP2020542088A patent/JP7488521B2/ja active Active
-
2024
- 2024-07-22 US US18/779,719 patent/US20240391865A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2021513522A (ja) | 2021-05-27 |
| AU2019214252B2 (en) | 2024-04-04 |
| EP3746064B1 (en) | 2025-04-16 |
| WO2019149329A1 (en) | 2019-08-08 |
| ES3035679T3 (en) | 2025-09-08 |
| US20240391865A1 (en) | 2024-11-28 |
| US20210122700A1 (en) | 2021-04-29 |
| AU2019214252A1 (en) | 2020-08-13 |
| US12077495B2 (en) | 2024-09-03 |
| CN111989094A (zh) | 2020-11-24 |
| JP7488521B2 (ja) | 2024-05-22 |
| EP3746064A1 (en) | 2020-12-09 |
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| EEER | Examination request |
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