ES3035679T3 - Compounds for use in the treatment of acute brain injury - Google Patents

Compounds for use in the treatment of acute brain injury

Info

Publication number
ES3035679T3
ES3035679T3 ES19704185T ES19704185T ES3035679T3 ES 3035679 T3 ES3035679 T3 ES 3035679T3 ES 19704185 T ES19704185 T ES 19704185T ES 19704185 T ES19704185 T ES 19704185T ES 3035679 T3 ES3035679 T3 ES 3035679T3
Authority
ES
Spain
Prior art keywords
compound
mmol
tetrahydro
mice
benzo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES19704185T
Other languages
English (en)
Spanish (es)
Inventor
Anders Bue Klein
Andrew Neil Clarkson
Joshua Macdonald Houlton
Ulrike Leurs
Rasmus Prætorius Clausen
Bente Frølund
Petrine Wellendorph
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Københavns Universitet
Otago Innovation Ltd
Original Assignee
Københavns Universitet
Otago Innovation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Københavns Universitet, Otago Innovation Ltd filed Critical Københavns Universitet
Application granted granted Critical
Publication of ES3035679T3 publication Critical patent/ES3035679T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/192Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/40Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/42Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/54Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings and other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/42Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/757Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/06Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14All rings being cycloaliphatic
    • C07C2602/32All rings being cycloaliphatic the ring system containing at least eleven carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ES19704185T 2018-02-02 2019-02-01 Compounds for use in the treatment of acute brain injury Active ES3035679T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201870067 2018-02-02
PCT/DK2019/050041 WO2019149329A1 (en) 2018-02-02 2019-02-01 Compounds for the treatment of acute brain injury

Publications (1)

Publication Number Publication Date
ES3035679T3 true ES3035679T3 (en) 2025-09-08

Family

ID=65363024

Family Applications (1)

Application Number Title Priority Date Filing Date
ES19704185T Active ES3035679T3 (en) 2018-02-02 2019-02-01 Compounds for use in the treatment of acute brain injury

Country Status (8)

Country Link
US (2) US12077495B2 (https=)
EP (1) EP3746064B1 (https=)
JP (1) JP7488521B2 (https=)
CN (1) CN111989094A (https=)
AU (1) AU2019214252B2 (https=)
CA (1) CA3089161A1 (https=)
ES (1) ES3035679T3 (https=)
WO (1) WO2019149329A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7709202B2 (ja) * 2019-06-28 2025-07-16 ユニバーシティ オブ コペンハーゲン 睡眠障害を伴うcns障害の治療
WO2023170024A1 (en) 2022-03-11 2023-09-14 University Of Copenhagen Camk2 modulators and their use in medicine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5466715A (en) * 1991-12-31 1995-11-14 Sterling Winthrop Inc. 3,4-disubstituted phenols-immunomodulating agents
IT1312362B1 (it) * 1999-06-29 2002-04-15 Neuroscienze S C A R L Derivati dell'acido (5,7,8,9-tetraidro-5-idrossi-6h-benzociclo-ept-6-iliden) acetico
US20090247770A1 (en) * 2006-08-09 2009-10-01 Campos Kevin R Process for making lactam tachykinin receptor antagonists
JP6084207B2 (ja) * 2011-05-13 2017-02-22 ケベンハウンス ウニヴェルジテート(ユニバーシティ オブ コペンハーゲン)Koebenhavns Universitet(University Of Copenhagen) 虚血性脳損傷及び疼痛治療用の効率的な神経保護剤としてのpsd−95の高親和性二量体阻害剤
WO2013024028A1 (en) 2011-08-12 2013-02-21 Institut National De La Sante Et De La Recherche Medicale (Inserm) Compounds and compositions for treating proteinopathies

Also Published As

Publication number Publication date
JP2021513522A (ja) 2021-05-27
AU2019214252B2 (en) 2024-04-04
EP3746064B1 (en) 2025-04-16
WO2019149329A1 (en) 2019-08-08
US20240391865A1 (en) 2024-11-28
US20210122700A1 (en) 2021-04-29
AU2019214252A1 (en) 2020-08-13
US12077495B2 (en) 2024-09-03
CA3089161A1 (en) 2019-08-08
CN111989094A (zh) 2020-11-24
JP7488521B2 (ja) 2024-05-22
EP3746064A1 (en) 2020-12-09

Similar Documents

Publication Publication Date Title
ES2250463T3 (es) Pirrolocarbazoles condensados antiinflamatorios.
ES2969383T3 (es) Derivados de N-(fenil)-indol-3-sulfonamida y compuestos relacionados como moduladores de GPR17 para el tratamiento de trastornos del SNC tales como la esclerosis múltiple
TWI776886B (zh) Sestrin-gator2交互作用之調節劑及其用途
KR102464274B1 (ko) 진단 및 치료를 위한 바이사이클릭 화합물
US20240391865A1 (en) Compounds for the treatment of acute brain injury
ES2360632T3 (es) Moduladores alostéricos del receptor a3 de adenosina.
ES2968807T3 (es) Derivados de 1-((2-(2,2,2-trifluoroetoxi)piridin-4-il)metil)urea como potenciadores de KCNQ
KR102388621B1 (ko) 피라졸로[1,5-a]피리미딘 화합물
US9334291B2 (en) Antiviral compounds highly effective as HCV-NS5A inhibitor
ES2587856T3 (es) Derivado de tetrahidrocarbolina
ES2915200T3 (es) Derivados de 7,8-dihidro-[2H]-imidazo-[1,2-a]pirazolo[4,3-e]pirimidin-4(5H)-ona como inhibidores de fosfodiesterasa 1 (PDE1) para tratar enfermedades, trastornos o lesiones del sistema nervioso central (SNC)
CN107922340B (zh) 1,2,3,4-四氢异喹啉衍生物、其制备方法和应用
ES2608356T3 (es) Novedosos derivados tricíclicos de 3,4-dihidro-2H-pirido[1,2-a]pirazin-1,6-diona como moduladores de la secretasa gamma
WO2020024977A1 (zh) 用于治疗神经系统疾病的化合物及其应用
ES2985674T3 (es) Retinoides sintéticos para su uso en la activación de RAR
JP2019523245A (ja) オーファン核内受容体Nur77のリガンド及びその使用
KR20240138079A (ko) 프리드라이히 운동실조를 치료하기 위한 화합물 및 방법
ES2849153T3 (es) 2H-Selenofeno[3,2-h]cromenos antimetastásicos, síntesis de los mismos, y métodos de uso de tales agentes
WO2018102262A1 (en) Inhibitors of protein arginine deiminases (pads) and methods of preparation and use thereof
ES2804304T3 (es) Moduladores del receptor X hepático (LXR)
RU2671194C2 (ru) Ингибирующие hcv химические соединения, их фармацевтические композиции и применения
CN104557897B (zh) 法舒地尔‑硫辛酸二联体的合成及其应用
He et al. Design, synthesis, and potent antiepileptic activity with latent nerve rehabilitation of novel γ-aminobutyric acid derivatives
ES2909707T3 (es) Mofezolaco y dos derivados para su uso en el tratamiento de la neuroinflamación
ES3040106T3 (en) A class of small-molecule compounds and their prodrugs for intervention with camk2a, and their use in acute brain injuries and central hypersomnias