JP7488521B2 - 急性脳損傷の治療のための化合物 - Google Patents

急性脳損傷の治療のための化合物 Download PDF

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JP7488521B2
JP7488521B2 JP2020542088A JP2020542088A JP7488521B2 JP 7488521 B2 JP7488521 B2 JP 7488521B2 JP 2020542088 A JP2020542088 A JP 2020542088A JP 2020542088 A JP2020542088 A JP 2020542088A JP 7488521 B2 JP7488521 B2 JP 7488521B2
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JP2021513522A (ja
JP2021513522A5 (https=
JPWO2019149329A5 (https=
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ブエ クライン，アンダース
ネイル クラークソン，アンドリュー
マクドナルド ホールトン，ジョシュア
レウルス，ウルリケ
プレトリウス クラウセン，ラスマス
フロルンド，ベンテ
ウェレンドルフ，ペトリン
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コペンハーゲン大学
オタゴ イノベーション リミテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/54—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/32—All rings being cycloaliphatic the ring system containing at least eleven carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
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  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2020542088A 2018-02-02 2019-02-01 急性脳損傷の治療のための化合物 Active JP7488521B2 (ja)

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DKPA201870067 2018-02-02
DKPA201870067 2018-02-02
PCT/DK2019/050041 WO2019149329A1 (en) 2018-02-02 2019-02-01 Compounds for the treatment of acute brain injury

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JP2021513522A JP2021513522A (ja) 2021-05-27
JP2021513522A5 JP2021513522A5 (https=) 2022-02-09
JPWO2019149329A5 JPWO2019149329A5 (https=) 2022-02-09
JP7488521B2 true JP7488521B2 (ja) 2024-05-22

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US (2) US12077495B2 (https=)
EP (1) EP3746064B1 (https=)
JP (1) JP7488521B2 (https=)
CN (1) CN111989094A (https=)
AU (1) AU2019214252B2 (https=)
CA (1) CA3089161A1 (https=)
ES (1) ES3035679T3 (https=)
WO (1) WO2019149329A1 (https=)

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JP7709202B2 (ja) * 2019-06-28 2025-07-16 ユニバーシティ オブ コペンハーゲン 睡眠障害を伴うｃｎｓ障害の治療
WO2023170024A1 (en) 2022-03-11 2023-09-14 University Of Copenhagen Camk2 modulators and their use in medicine

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010500351A (ja) 2006-08-09 2010-01-07 メルク エンド カムパニー インコーポレーテッド ラクタムタキキニン受容体拮抗薬の製造法
WO2013024028A1 (en) 2011-08-12 2013-02-21 Institut National De La Sante Et De La Recherche Medicale (Inserm) Compounds and compositions for treating proteinopathies

Family Cites Families (3)

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US5466715A (en) * 1991-12-31 1995-11-14 Sterling Winthrop Inc. 3,4-disubstituted phenols-immunomodulating agents
IT1312362B1 (it) * 1999-06-29 2002-04-15 Neuroscienze S C A R L Derivati dell'acido (5,7,8,9-tetraidro-5-idrossi-6h-benzociclo-ept-6-iliden) acetico
JP6084207B2 (ja) * 2011-05-13 2017-02-22 ケベンハウンス ウニヴェルジテート（ユニバーシティ オブ コペンハーゲン）Ｋｏｅｂｅｎｈａｖｎｓ Ｕｎｉｖｅｒｓｉｔｅｔ（Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｏｐｅｎｈａｇｅｎ） 虚血性脳損傷及び疼痛治療用の効率的な神経保護剤としてのｐｓｄ−９５の高親和性二量体阻害剤

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010500351A (ja) 2006-08-09 2010-01-07 メルク エンド カムパニー インコーポレーテッド ラクタムタキキニン受容体拮抗薬の製造法
WO2013024028A1 (en) 2011-08-12 2013-02-21 Institut National De La Sante Et De La Recherche Medicale (Inserm) Compounds and compositions for treating proteinopathies

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BAY TINA; ET AL，GHB RECEPTOR TARGETS IN THE CNS: FOCUS ON HIGH-AFFINITY BINDING SITES，BIOCHEMICAL PHARMACOLOGY，米国，ELSEVIER，2013年11月20日，VOL:87, NR:2，PAGE(S):220 - 228，http://dx.doi.org/10.1016/j.bcp.2013.10.028
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FONTENEAU L; ET AL，CHEMOENZYMATIC SYNTHESIS OF ENANTIOPURE ISOPROPYL (3R)-AND (3S)-3-HYDROXYCYCLOHEX-以下備考，TETRAHEDRON:ASYMMETRY，英国，2002年04月19日，VOL:13, NR:6，PAGE(S):579 - 585，http://dx.doi.org/10.1016/S0957-4166(02)00152-0，1-ENE-1-CARBOXYLATES AND THEIR REDUCTION TO ISOMERS OF ISOPROPYL 3-HYDROXY-以下省略
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PHIL HO LEE; ET AL，FREE RADICAL-MEDIATED RING EXPANSION REACTIONS: ENDOCYCLIC CLEAVAGE OF CYCLOPROPYLCARBINYL RADICALS，BULL. KOREAN CHEM. SOC，2000年，VOL:21, NR:6，PAGE(S):595 - 603，https://www.koreascience.or.kr/article/JAKO200013464476906.page1ff8
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JP2021513522A (ja) 2021-05-27
AU2019214252B2 (en) 2024-04-04
EP3746064B1 (en) 2025-04-16
WO2019149329A1 (en) 2019-08-08
ES3035679T3 (en) 2025-09-08
US20240391865A1 (en) 2024-11-28
US20210122700A1 (en) 2021-04-29
AU2019214252A1 (en) 2020-08-13
US12077495B2 (en) 2024-09-03
CA3089161A1 (en) 2019-08-08
CN111989094A (zh) 2020-11-24
EP3746064A1 (en) 2020-12-09

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