CA3082204A1 - Immortalized car-t cells genetically modified to eliminate t-cell receptor and beta 2-microglobulin expression - Google Patents

Immortalized car-t cells genetically modified to eliminate t-cell receptor and beta 2-microglobulin expression Download PDF

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Publication number
CA3082204A1
CA3082204A1 CA3082204A CA3082204A CA3082204A1 CA 3082204 A1 CA3082204 A1 CA 3082204A1 CA 3082204 A CA3082204 A CA 3082204A CA 3082204 A CA3082204 A CA 3082204A CA 3082204 A1 CA3082204 A1 CA 3082204A1
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cells
cell
domain
immortalized
car
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CA3082204A
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French (fr)
Inventor
John Lee
Jill MOONEY
Michael Naso
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Janssen Biotech Inc
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Janssen Biotech Inc
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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CA3082204A 2017-12-13 2018-12-11 Immortalized car-t cells genetically modified to eliminate t-cell receptor and beta 2-microglobulin expression Pending CA3082204A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762598032P 2017-12-13 2017-12-13
US62/598,032 2017-12-13
PCT/US2018/064971 WO2019118475A1 (en) 2017-12-13 2018-12-11 Immortalized car-t cells genetically modified to eliminate t-cell receptor and beta 2-microglobulin expression

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CA3082204A1 true CA3082204A1 (en) 2019-06-20

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CA3082204A Pending CA3082204A1 (en) 2017-12-13 2018-12-11 Immortalized car-t cells genetically modified to eliminate t-cell receptor and beta 2-microglobulin expression

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US (2) US20190175651A1 (https=)
EP (1) EP3724321A4 (https=)
JP (1) JP2021506243A (https=)
KR (1) KR20200088383A (https=)
CN (1) CN111479917A (https=)
AU (1) AU2018386010A1 (https=)
CA (1) CA3082204A1 (https=)
SG (1) SG11202003864XA (https=)
WO (1) WO2019118475A1 (https=)

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