SG11202003864XA - Immortalized car-t cells genetically modified to eliminate t-cell receptor and beta 2-microglobulin expression - Google Patents

Immortalized car-t cells genetically modified to eliminate t-cell receptor and beta 2-microglobulin expression

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Publication number
SG11202003864XA
SG11202003864XA SG11202003864XA SG11202003864XA SG11202003864XA SG 11202003864X A SG11202003864X A SG 11202003864XA SG 11202003864X A SG11202003864X A SG 11202003864XA SG 11202003864X A SG11202003864X A SG 11202003864XA SG 11202003864X A SG11202003864X A SG 11202003864XA
Authority
SG
Singapore
Prior art keywords
immortalized
beta
car
eliminate
genetically modified
Prior art date
Application number
SG11202003864XA
Other languages
English (en)
Inventor
John Lee
Jill Mooney
Michael Naso
Original Assignee
Janssen Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of SG11202003864XA publication Critical patent/SG11202003864XA/en

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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SG11202003864XA 2017-12-13 2018-12-11 Immortalized car-t cells genetically modified to eliminate t-cell receptor and beta 2-microglobulin expression SG11202003864XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762598032P 2017-12-13 2017-12-13
PCT/US2018/064971 WO2019118475A1 (en) 2017-12-13 2018-12-11 Immortalized car-t cells genetically modified to eliminate t-cell receptor and beta 2-microglobulin expression

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SG11202003864XA true SG11202003864XA (en) 2020-07-29

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US (2) US20190175651A1 (https=)
EP (1) EP3724321A4 (https=)
JP (1) JP2021506243A (https=)
KR (1) KR20200088383A (https=)
CN (1) CN111479917A (https=)
AU (1) AU2018386010A1 (https=)
CA (1) CA3082204A1 (https=)
SG (1) SG11202003864XA (https=)
WO (1) WO2019118475A1 (https=)

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