CN111479917A - 经基因修饰以消除T细胞受体和β2-微球蛋白表达的永生化CAR-T细胞 - Google Patents

经基因修饰以消除T细胞受体和β2-微球蛋白表达的永生化CAR-T细胞 Download PDF

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CN111479917A
CN111479917A CN201880080452.1A CN201880080452A CN111479917A CN 111479917 A CN111479917 A CN 111479917A CN 201880080452 A CN201880080452 A CN 201880080452A CN 111479917 A CN111479917 A CN 111479917A
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cells
car
domain
cell
immortalized
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J.李
J.莫尼
M.纳松
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Janssen Biotech Inc
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Janssen Biotech Inc
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CN201880080452.1A 2017-12-13 2018-12-11 经基因修饰以消除T细胞受体和β2-微球蛋白表达的永生化CAR-T细胞 Pending CN111479917A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762598032P 2017-12-13 2017-12-13
US62/598032 2017-12-13
PCT/US2018/064971 WO2019118475A1 (en) 2017-12-13 2018-12-11 Immortalized car-t cells genetically modified to eliminate t-cell receptor and beta 2-microglobulin expression

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CN111479917A true CN111479917A (zh) 2020-07-31

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US (2) US20190175651A1 (https=)
EP (1) EP3724321A4 (https=)
JP (1) JP2021506243A (https=)
KR (1) KR20200088383A (https=)
CN (1) CN111479917A (https=)
AU (1) AU2018386010A1 (https=)
CA (1) CA3082204A1 (https=)
SG (1) SG11202003864XA (https=)
WO (1) WO2019118475A1 (https=)

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CN111093696A (zh) * 2017-07-17 2020-05-01 詹森生物科技公司 抗iii型纤连蛋白结构域的抗原结合区及其使用方法
WO2023072131A1 (zh) * 2021-10-27 2023-05-04 深圳市菲鹏生物治疗股份有限公司 一种制备通用型car-t细胞的方法及其应用

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CN110225770B (zh) 2016-12-14 2022-04-26 杨森生物科技公司 结合cd8a的纤连蛋白iii型结构域
EP3554535A4 (en) 2016-12-14 2020-10-21 Janssen Biotech, Inc. PD-L1 BINDING FIBRONECTIN TYPE III DOMAINS
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US10676516B2 (en) 2017-05-24 2020-06-09 Pandion Therapeutics, Inc. Targeted immunotolerance
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US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
US10174092B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
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