CA3082204A1 - Immortalized car-t cells genetically modified to eliminate t-cell receptor and beta 2-microglobulin expression - Google Patents

Immortalized car-t cells genetically modified to eliminate t-cell receptor and beta 2-microglobulin expression Download PDF

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Publication number
CA3082204A1
CA3082204A1 CA3082204A CA3082204A CA3082204A1 CA 3082204 A1 CA3082204 A1 CA 3082204A1 CA 3082204 A CA3082204 A CA 3082204A CA 3082204 A CA3082204 A CA 3082204A CA 3082204 A1 CA3082204 A1 CA 3082204A1
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cells
cell
domain
immortalized
car
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CA3082204A
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English (en)
French (fr)
Inventor
John Lee
Jill MOONEY
Michael Naso
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Janssen Biotech Inc
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Janssen Biotech Inc
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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CA3082204A 2017-12-13 2018-12-11 Immortalized car-t cells genetically modified to eliminate t-cell receptor and beta 2-microglobulin expression Pending CA3082204A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762598032P 2017-12-13 2017-12-13
US62/598,032 2017-12-13
PCT/US2018/064971 WO2019118475A1 (en) 2017-12-13 2018-12-11 Immortalized car-t cells genetically modified to eliminate t-cell receptor and beta 2-microglobulin expression

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CA3082204A1 true CA3082204A1 (en) 2019-06-20

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CA3082204A Pending CA3082204A1 (en) 2017-12-13 2018-12-11 Immortalized car-t cells genetically modified to eliminate t-cell receptor and beta 2-microglobulin expression

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US (2) US20200332255A1 (enExample)
EP (1) EP3724321A4 (enExample)
JP (1) JP2021506243A (enExample)
KR (1) KR20200088383A (enExample)
CN (1) CN111479917A (enExample)
AU (1) AU2018386010A1 (enExample)
CA (1) CA3082204A1 (enExample)
SG (1) SG11202003864XA (enExample)
WO (1) WO2019118475A1 (enExample)

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KR20220040474A (ko) * 2019-07-26 2022-03-30 얀센 바이오테크 인코포레이티드 항-hK2 키메라 항원 수용체(CAR)
CN114729325A (zh) 2019-09-06 2022-07-08 克里斯珀医疗股份公司 在培养物中具有改善的持久性的基因工程化t细胞
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