CA3081653A1 - Process for preparing large size isoxazoline particles - Google Patents
Process for preparing large size isoxazoline particles Download PDFInfo
- Publication number
- CA3081653A1 CA3081653A1 CA3081653A CA3081653A CA3081653A1 CA 3081653 A1 CA3081653 A1 CA 3081653A1 CA 3081653 A CA3081653 A CA 3081653A CA 3081653 A CA3081653 A CA 3081653A CA 3081653 A1 CA3081653 A1 CA 3081653A1
- Authority
- CA
- Canada
- Prior art keywords
- isoxazoline compound
- particles
- isoxazoline
- particle size
- crystallizer vessel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Wood Science & Technology (AREA)
- Agronomy & Crop Science (AREA)
- Dentistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Dispersion Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Insects & Arthropods (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762582381P | 2017-11-07 | 2017-11-07 | |
| US62/582,381 | 2017-11-07 | ||
| US201762608904P | 2017-12-21 | 2017-12-21 | |
| US62/608,904 | 2017-12-21 | ||
| PCT/EP2018/080230 WO2019091940A1 (en) | 2017-11-07 | 2018-11-06 | Process for preparing large size isoxazoline particles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3081653A1 true CA3081653A1 (en) | 2019-05-16 |
Family
ID=64172503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3081653A Pending CA3081653A1 (en) | 2017-11-07 | 2018-11-06 | Process for preparing large size isoxazoline particles |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US11858904B2 (enExample) |
| EP (1) | EP3707129A1 (enExample) |
| JP (3) | JP7446222B2 (enExample) |
| KR (2) | KR102819993B1 (enExample) |
| CN (1) | CN111295375B (enExample) |
| AU (2) | AU2018363686B2 (enExample) |
| BR (1) | BR112020008848A2 (enExample) |
| CA (1) | CA3081653A1 (enExample) |
| CL (1) | CL2020001172A1 (enExample) |
| CO (1) | CO2020006258A2 (enExample) |
| IL (1) | IL274075A (enExample) |
| MX (3) | MX2020004693A (enExample) |
| PE (1) | PE20210170A1 (enExample) |
| PH (1) | PH12020500586A1 (enExample) |
| UA (1) | UA127892C2 (enExample) |
| WO (1) | WO2019091940A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3081646C (en) | 2017-11-07 | 2024-03-19 | Intervet International B.V. | Injectable isoxazoline pharmaceutical compositions and uses thereof |
| MX2022007455A (es) | 2019-12-18 | 2022-08-15 | Elanco Tiergesundheit Ag | Derivados de isoxazolina como plaguicidas. |
| AU2021277491B2 (en) | 2020-05-20 | 2024-05-16 | Intervet International B.V. | Injectable pharmaceutical compositions and uses thereof |
| KR20230043904A (ko) | 2020-07-24 | 2023-03-31 | 엘랑코 유에스 인코포레이티드 | 이속사졸린 화합물 및 이의 중간체의 제조 공정 |
| CN112724095A (zh) * | 2020-09-25 | 2021-04-30 | 安徽省公众检验研究院有限公司 | 氟雷拉钠晶型及其制备方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4883296B2 (ja) | 2004-03-05 | 2012-02-22 | 日産化学工業株式会社 | イソキサゾリン置換ベンズアミド化合物及び有害生物防除剤 |
| TWI412322B (zh) | 2005-12-30 | 2013-10-21 | Du Pont | 控制無脊椎害蟲之異唑啉 |
| TWI430995B (zh) | 2007-06-26 | 2014-03-21 | Du Pont | 萘異唑啉無脊椎有害動物控制劑 |
| MX2009013748A (es) | 2007-06-27 | 2010-01-26 | Du Pont | Metodo de control de plagas en animales. |
| TWI556741B (zh) | 2007-08-17 | 2016-11-11 | 英特威特國際股份有限公司 | 異唑啉組成物及其作為抗寄生蟲藥上的應用 |
| WO2009063910A1 (ja) | 2007-11-12 | 2009-05-22 | Nissan Chemical Industries, Ltd. | 光学活性イソキサゾリン化合物の触媒的不斉合成方法 |
| TWI411395B (zh) | 2007-12-24 | 2013-10-11 | Syngenta Participations Ag | 殺蟲化合物 |
| CA2973871C (en) * | 2008-07-09 | 2019-09-10 | Nissan Chemical Industries, Ltd. | Production method of isoxazoline-substituted benzoic acid amide compound |
| ES2442342T3 (es) | 2008-12-18 | 2014-02-11 | Novartis Ag | Derivados de las isoxazolinas y su uso como pesticida |
| BRPI0923009B1 (pt) | 2008-12-19 | 2018-07-17 | Elanco Tiergesundheit Ag | compostos de isoxazolina, composição para o controle de parasitas e uso de compostos de isoxazolina para o preparo de composição para o controle de parasitas |
| CA2766291C (en) * | 2009-06-24 | 2016-06-21 | Msd Oss B.V. | Injectable formulations containing asenapine and method of treatment using same |
| JP5679102B2 (ja) | 2009-08-03 | 2015-03-04 | 日産化学工業株式会社 | ジヒドロイソキサゾール置換安息香酸化合物の光学活性体とジアステレオマー塩及びその製造方法 |
| TWI487486B (zh) | 2009-12-01 | 2015-06-11 | Syngenta Participations Ag | 以異唑啉衍生物為主之殺蟲化合物 |
| DE102010003711B4 (de) | 2010-04-08 | 2015-04-09 | Jesalis Pharma Gmbh | Verfahren zur Herstellung kristalliner Wirkstoffpartikel |
| PH12012502333A1 (en) | 2010-05-27 | 2015-02-04 | Corteva Agriscience Llc | Crystalline form of 4- [5 - [3 -chloro-5 - (trifluoromethyl) phenyl] -4, 5 - dihydro - 5 - (trifluoromethyl) -3 - isoxazolyl] -n- [2-0x0-2- [ ( 2, 2, 2 - trifluoroethyl) amino] ethyl] -1- naphthalenecarboxamide |
| AU2013245478A1 (en) | 2012-11-01 | 2014-05-15 | Sumitomo Chemical Company, Limited | Method for administering agent for controlling ectoparasite to dog |
| WO2014126208A1 (ja) | 2013-02-14 | 2014-08-21 | 日産化学工業株式会社 | イソキサゾリン置換ベンズアミド化合物の結晶性多形体及びその製造方法 |
| JP2015028006A (ja) | 2013-06-27 | 2015-02-12 | 日産化学工業株式会社 | イソキサゾリン化合物の結晶性多形体およびその製造方法 |
| LT3052080T (lt) | 2013-09-30 | 2025-08-25 | Zoetis Services Llc | Ilgo veikimo spiro-izoksazolino vaistinės formos |
| PL3082867T3 (pl) * | 2013-12-20 | 2024-05-13 | Intervet International B.V. | Kompozycje izoksazoliny i ich zastosowanie w zapobieganiu lub leczeniu inwazji pasożytów u zwierząt |
| UY36570A (es) | 2015-02-26 | 2016-10-31 | Merial Inc | Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas |
| US20170020848A1 (en) | 2015-04-08 | 2017-01-26 | Merial Inc. | Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereof |
| UY37137A (es) | 2016-02-24 | 2017-09-29 | Merial Inc | Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos |
| CA3081646C (en) | 2017-11-07 | 2024-03-19 | Intervet International B.V. | Injectable isoxazoline pharmaceutical compositions and uses thereof |
-
2018
- 2018-11-06 CN CN201880071993.8A patent/CN111295375B/zh active Active
- 2018-11-06 AU AU2018363686A patent/AU2018363686B2/en active Active
- 2018-11-06 US US16/761,695 patent/US11858904B2/en active Active
- 2018-11-06 WO PCT/EP2018/080230 patent/WO2019091940A1/en not_active Ceased
- 2018-11-06 JP JP2020524272A patent/JP7446222B2/ja active Active
- 2018-11-06 CA CA3081653A patent/CA3081653A1/en active Pending
- 2018-11-06 BR BR112020008848-0A patent/BR112020008848A2/pt active Search and Examination
- 2018-11-06 KR KR1020247026604A patent/KR102819993B1/ko active Active
- 2018-11-06 PE PE2020000564A patent/PE20210170A1/es unknown
- 2018-11-06 UA UAA202003421A patent/UA127892C2/uk unknown
- 2018-11-06 EP EP18799512.1A patent/EP3707129A1/en active Pending
- 2018-11-06 KR KR1020207015894A patent/KR102694519B1/ko active Active
- 2018-11-06 MX MX2020004693A patent/MX2020004693A/es unknown
-
2020
- 2020-04-20 IL IL274075A patent/IL274075A/en unknown
- 2020-05-04 CL CL2020001172A patent/CL2020001172A1/es unknown
- 2020-05-22 CO CONC2020/0006258A patent/CO2020006258A2/es unknown
- 2020-06-01 PH PH12020500586A patent/PH12020500586A1/en unknown
- 2020-07-13 MX MX2025006001A patent/MX2025006001A/es unknown
- 2020-07-13 MX MX2023014279A patent/MX2023014279A/es unknown
-
2023
- 2023-04-24 JP JP2023070584A patent/JP7578752B2/ja active Active
- 2023-10-20 JP JP2023180745A patent/JP2024010042A/ja active Pending
- 2023-11-16 US US18/510,718 patent/US20240246921A1/en active Pending
-
2024
- 2024-02-22 AU AU2024201160A patent/AU2024201160A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20200085295A (ko) | 2020-07-14 |
| JP2021501755A (ja) | 2021-01-21 |
| US20240246921A1 (en) | 2024-07-25 |
| AU2024201160A1 (en) | 2024-03-14 |
| CN111295375B (zh) | 2025-06-24 |
| AU2018363686A1 (en) | 2020-05-07 |
| KR20240125076A (ko) | 2024-08-19 |
| JP2023099059A (ja) | 2023-07-11 |
| MX2025006001A (es) | 2025-07-01 |
| NZ765172A (en) | 2024-05-31 |
| JP2024010042A (ja) | 2024-01-23 |
| RU2020117583A3 (enExample) | 2021-12-24 |
| KR102819993B1 (ko) | 2025-06-11 |
| BR112020008848A2 (pt) | 2020-10-20 |
| EP3707129A1 (en) | 2020-09-16 |
| CO2020006258A2 (es) | 2020-05-29 |
| AU2018363686B2 (en) | 2023-11-23 |
| CL2020001172A1 (es) | 2020-10-23 |
| JP7446222B2 (ja) | 2024-03-08 |
| US20200331867A1 (en) | 2020-10-22 |
| IL274075A (en) | 2020-06-30 |
| PH12020500586A1 (en) | 2021-06-21 |
| CN111295375A (zh) | 2020-06-16 |
| JP7578752B2 (ja) | 2024-11-06 |
| PE20210170A1 (es) | 2021-01-29 |
| RU2020117583A (ru) | 2021-12-08 |
| MX2023014279A (es) | 2024-07-10 |
| US11858904B2 (en) | 2024-01-02 |
| MX2020004693A (es) | 2020-08-20 |
| WO2019091940A1 (en) | 2019-05-16 |
| KR102694519B1 (ko) | 2024-08-13 |
| UA127892C2 (uk) | 2024-02-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20220928 |
|
| EEER | Examination request |
Effective date: 20220928 |
|
| EEER | Examination request |
Effective date: 20220928 |
|
| EEER | Examination request |
Effective date: 20220928 |