CA3074732A1 - Methods of using dantrolene to treat nerve agent exposure - Google Patents
Methods of using dantrolene to treat nerve agent exposure Download PDFInfo
- Publication number
- CA3074732A1 CA3074732A1 CA3074732A CA3074732A CA3074732A1 CA 3074732 A1 CA3074732 A1 CA 3074732A1 CA 3074732 A CA3074732 A CA 3074732A CA 3074732 A CA3074732 A CA 3074732A CA 3074732 A1 CA3074732 A1 CA 3074732A1
- Authority
- CA
- Canada
- Prior art keywords
- dantrolene
- subject
- pharmaceutical composition
- nerve agent
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762554049P | 2017-09-05 | 2017-09-05 | |
| US62/554,049 | 2017-09-05 | ||
| US201862674406P | 2018-05-21 | 2018-05-21 | |
| US62/674,406 | 2018-05-21 | ||
| PCT/US2018/049515 WO2019050923A1 (en) | 2017-09-05 | 2018-09-05 | METHODS OF USING DANTROLENE TO TREAT EXPOSURE TO A NEUROTOXIC AGENT |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3074732A1 true CA3074732A1 (en) | 2019-03-14 |
Family
ID=63708449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3074732A Pending CA3074732A1 (en) | 2017-09-05 | 2018-09-05 | Methods of using dantrolene to treat nerve agent exposure |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20200383954A1 (https=) |
| EP (1) | EP3678659B1 (https=) |
| JP (2) | JP2020532555A (https=) |
| KR (1) | KR20200047655A (https=) |
| CN (1) | CN111093652A (https=) |
| AU (1) | AU2018328131B2 (https=) |
| BR (1) | BR112020004429A2 (https=) |
| CA (1) | CA3074732A1 (https=) |
| IL (1) | IL272847B1 (https=) |
| MA (1) | MA50080A (https=) |
| MX (2) | MX2020002485A (https=) |
| SG (1) | SG11202001749SA (https=) |
| UA (1) | UA126688C2 (https=) |
| WO (1) | WO2019050923A1 (https=) |
| ZA (1) | ZA202001258B (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022538608A (ja) * | 2019-06-28 | 2022-09-05 | ザ トラスティーズ オヴ ザ ユニヴァーシティー オヴ ペンシルバニア | アルツハイマー病の治療のための鼻腔内ダントロレン投与 |
| WO2023081873A1 (en) * | 2021-11-05 | 2023-05-11 | Quorum Innovations, Llc | Materials and methods for preventing or reducing toxicity to organophosphates and other toxic materials |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7758890B2 (en) * | 2001-06-23 | 2010-07-20 | Lyotropic Therapeutics, Inc. | Treatment using dantrolene |
| EP1603513B1 (en) * | 2003-03-04 | 2020-12-30 | Lyotropic Therapeutics, Inc. | Dantrolene compositions |
| WO2013040501A1 (en) * | 2011-09-16 | 2013-03-21 | Pharmathene, Inc. | Compositions and combinations of organophosphorus bioscavengers and hyaluronan-degrading enzymes, and uses thereof |
| DK2925327T3 (da) * | 2012-11-30 | 2024-03-25 | Univ California | Allopregnanolon til behandling, reduktion eller lindring af symptomer på fødselsdepression |
-
2018
- 2018-09-05 UA UAA202002205A patent/UA126688C2/uk unknown
- 2018-09-05 BR BR112020004429-6A patent/BR112020004429A2/pt unknown
- 2018-09-05 JP JP2020512813A patent/JP2020532555A/ja active Pending
- 2018-09-05 MX MX2020002485A patent/MX2020002485A/es unknown
- 2018-09-05 US US16/644,281 patent/US20200383954A1/en not_active Abandoned
- 2018-09-05 WO PCT/US2018/049515 patent/WO2019050923A1/en not_active Ceased
- 2018-09-05 MA MA050080A patent/MA50080A/fr unknown
- 2018-09-05 KR KR1020207009450A patent/KR20200047655A/ko not_active Ceased
- 2018-09-05 EP EP18779490.4A patent/EP3678659B1/en active Active
- 2018-09-05 CA CA3074732A patent/CA3074732A1/en active Pending
- 2018-09-05 CN CN201880057290.XA patent/CN111093652A/zh active Pending
- 2018-09-05 AU AU2018328131A patent/AU2018328131B2/en active Active
- 2018-09-05 SG SG11202001749SA patent/SG11202001749SA/en unknown
-
2020
- 2020-02-23 IL IL272847A patent/IL272847B1/en unknown
- 2020-02-27 ZA ZA2020/01258A patent/ZA202001258B/en unknown
- 2020-03-04 MX MX2023012415A patent/MX2023012415A/es unknown
-
2021
- 2021-12-02 US US17/540,878 patent/US20220087980A1/en active Pending
-
2023
- 2023-01-27 JP JP2023010846A patent/JP2023055802A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2023055802A (ja) | 2023-04-18 |
| EP3678659C0 (en) | 2025-12-17 |
| MX2020002485A (es) | 2020-07-20 |
| SG11202001749SA (en) | 2020-03-30 |
| BR112020004429A2 (pt) | 2020-10-20 |
| RU2020112318A (ru) | 2021-10-06 |
| NZ762056A (en) | 2025-10-31 |
| JP2020532555A (ja) | 2020-11-12 |
| AU2018328131B2 (en) | 2024-04-18 |
| US20200383954A1 (en) | 2020-12-10 |
| EP3678659A1 (en) | 2020-07-15 |
| UA126688C2 (uk) | 2023-01-11 |
| MA50080A (fr) | 2020-07-15 |
| IL272847B1 (en) | 2026-03-01 |
| MX2023012415A (es) | 2023-11-01 |
| US20220087980A1 (en) | 2022-03-24 |
| AU2018328131A1 (en) | 2020-03-12 |
| ZA202001258B (en) | 2023-10-25 |
| RU2020112318A3 (https=) | 2021-10-26 |
| EP3678659B1 (en) | 2025-12-17 |
| CN111093652A (zh) | 2020-05-01 |
| IL272847A (en) | 2020-04-30 |
| WO2019050923A1 (en) | 2019-03-14 |
| KR20200047655A (ko) | 2020-05-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Shih et al. | Anticonvulsants for nerve agent-induced seizures: the influence of the therapeutic dose of atropine | |
| Aardema et al. | Organophosphorus pesticide poisoning: cases and developments | |
| WO2000003713A1 (en) | Treatment for schizophrenia and other dopamine system dysfunctions | |
| Schultz et al. | The anticholinergic and antiglutamatergic drug caramiphen reduces seizure duration in soman-exposed rats: synergism with the benzodiazepine diazepam | |
| US20220087980A1 (en) | Methods of using dantrolene to treat nerve agent exposure | |
| MX2012001814A (es) | Uso de 4-aminopiridina para mejorar la discapacidad neuro - cognoscitiva y/o neuro - psiquiatrica en pacientes con condiciones desmielizantes y otras condiciones del sistema nervioso. | |
| Lumley et al. | Combination of antiseizure medications phenobarbital, ketamine, and midazolam reduces soman‐induced epileptogenesis and brain pathology in rats | |
| US20110144093A1 (en) | Method of treating organophosphorous poisoning | |
| KR20150067168A (ko) | 기억력 증진용 향정신성 조성물 | |
| EP0414568A2 (en) | Use of anticholinergic compounds for protecting the central nervous system against cholinergic neurotoxins | |
| US20220175753A1 (en) | Treating of side-effects resulting from chemodenervation | |
| RU2817851C2 (ru) | Способы применения дантролена для лечения воздействия нервно-паралитического вещества | |
| Myhrer et al. | Prophylactic and Therapeutic Measures in Nerve Agents Poisoning | |
| Sinha et al. | Organophosphate poisoning: A review | |
| Nekoukar et al. | Management of organophosphorus poisoning and the role of magnesium sulfate: A scoping review of literature. | |
| Scott | Pretreatment for nerve agent poisoning | |
| Winkler et al. | Anticonvulsant efficacy of antihistamine cyproheptadine in rats exposed to the chemical warfare nerve agent soman | |
| Ivosevic et al. | Mechanism and clinical importance of respiratory failure induced by anticholinesterases | |
| Thunga et al. | Pharmacokinetic Studies on Oximes in Organophosphate Poisoning: A Mini Review | |
| Dawson | Recent Advances in the Treatment of Nerve Agent Poisoning1 | |
| Nekoukar et al. | The key role of magnesium sulfate in the management of organophosphorus pesticide poisoning: a scoping literature | |
| Ido Layish et al. | Pharmacologic Prophylaxis against Nerve Agent Poisoning |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20220912 |
|
| MFA | Maintenance fee for application paid |
Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 6TH ANNIV.) - STANDARD Year of fee payment: 6 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20240830 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT Effective date: 20240830 Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20240830 |
|
| D15 | Examination report completed |
Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D15-D126 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: EXAMINER'S REPORT Effective date: 20241107 |
|
| P11 | Amendment of application requested |
Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-P100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT RECEIVED - RESPONSE TO EXAMINER'S REQUISITION Effective date: 20250303 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT Effective date: 20250305 |
|
| P11 | Amendment of application requested |
Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-P102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT DETERMINED COMPLIANT Effective date: 20250710 |
|
| P13 | Application amended |
Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P13-X000 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: APPLICATION AMENDED Effective date: 20250710 |
|
| MFA | Maintenance fee for application paid |
Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 7TH ANNIV.) - STANDARD Year of fee payment: 7 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20250829 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20250829 |
|
| D15 | Examination report completed |
Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D15-D126 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: EXAMINER'S REPORT Effective date: 20251007 |