CA3068363A1 - Identification and elimination of damaged and/or senescent cells - Google Patents

Identification and elimination of damaged and/or senescent cells Download PDF

Info

Publication number
CA3068363A1
CA3068363A1 CA3068363A CA3068363A CA3068363A1 CA 3068363 A1 CA3068363 A1 CA 3068363A1 CA 3068363 A CA3068363 A CA 3068363A CA 3068363 A CA3068363 A CA 3068363A CA 3068363 A1 CA3068363 A1 CA 3068363A1
Authority
CA
Canada
Prior art keywords
damaged
cells
antagonist
senescent cells
interaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3068363A
Other languages
English (en)
French (fr)
Inventor
Manuel Serrano Marugan
Susana LLANOS GIRON
Andy Selim CHAIB
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fundacion del Sector Publico Estatal Centro Nacional de Investigaciones Oncologicas Carlos III FSP CNIO
Original Assignee
Fundacion del Sector Publico Estatal Centro Nacional de Investigaciones Oncologicas Carlos III FSP CNIO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fundacion del Sector Publico Estatal Centro Nacional de Investigaciones Oncologicas Carlos III FSP CNIO filed Critical Fundacion del Sector Publico Estatal Centro Nacional de Investigaciones Oncologicas Carlos III FSP CNIO
Publication of CA3068363A1 publication Critical patent/CA3068363A1/en
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306Solid-phase reaction mechanisms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Cosmetics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA3068363A 2017-06-29 2018-06-29 Identification and elimination of damaged and/or senescent cells Pending CA3068363A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17382417.8 2017-06-29
EP17382417.8A EP3421607A1 (en) 2017-06-29 2017-06-29 Identification and elimination of damaged and/or senescent cells
PCT/EP2018/067655 WO2019002581A1 (en) 2017-06-29 2018-06-29 IDENTIFICATION AND ELIMINATION OF DAMAGED AND / OR SENESCENT CELLS

Publications (1)

Publication Number Publication Date
CA3068363A1 true CA3068363A1 (en) 2019-01-03

Family

ID=59315550

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3068363A Pending CA3068363A1 (en) 2017-06-29 2018-06-29 Identification and elimination of damaged and/or senescent cells

Country Status (5)

Country Link
US (2) US20200123607A1 (enExample)
EP (2) EP3421607A1 (enExample)
JP (2) JP2020525021A (enExample)
CA (1) CA3068363A1 (enExample)
WO (1) WO2019002581A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7407822B2 (ja) 2018-08-30 2024-01-04 エイチシーダブリュー バイオロジックス インコーポレイテッド 単鎖キメラポリペプチドおよびその使用
CA3108949A1 (en) 2018-08-30 2020-03-05 HCW Biologics, Inc. Multi-chain chimeric polypeptides and uses thereof
WO2020257639A1 (en) 2019-06-21 2020-12-24 HCW Biologics, Inc. Multi-chain chimeric polypeptides and uses thereof
US12187763B2 (en) 2020-02-11 2025-01-07 Immunitybio, Inc. Chromatography resin and uses thereof
CA3169243A1 (en) 2020-02-11 2021-08-19 HCW Biologics, Inc. Methods of activating regulatory t cells
WO2021163369A2 (en) 2020-02-11 2021-08-19 HCW Biologics, Inc. Methods of treating age-related and inflammatory diseases
JP7734693B2 (ja) 2020-04-29 2025-09-05 イミュニティーバイオ インコーポレイテッド 抗cd26タンパク質及びそれらの使用法
US12024545B2 (en) * 2020-06-01 2024-07-02 HCW Biologics, Inc. Methods of treating aging-related disorders
EP4431102A4 (en) * 2021-11-10 2025-10-29 Lifeceutix Co Ltd Senescent Cell Elimination Compositions and Their Uses
CN114836508A (zh) * 2021-12-08 2022-08-02 上海锐翌医学检验实验室有限公司 慢性阻塞性肺病标志微生物及其应用
KR20240155337A (ko) 2022-03-04 2024-10-28 리주베론 세네센스 테라퓨틱스 아게 항-pd-l2 항체
JPWO2023238845A1 (enExample) * 2022-06-07 2023-12-14
CN115154611B (zh) * 2022-06-23 2023-11-17 中山大学孙逸仙纪念医院 免疫检查点抑制剂与抗衰老药物联合在制备肿瘤治疗产品中的用途
WO2024063109A1 (ja) * 2022-09-20 2024-03-28 国立大学法人東京大学 老化細胞除去剤
WO2024228599A1 (ko) * 2023-05-04 2024-11-07 주식회사 라이프신약 노화세포 제거 또는 억제용 조성물 및 이의 용도
WO2024249938A1 (en) * 2023-05-31 2024-12-05 Mayo Foundation For Medical Education And Research Methods and materials for identifying and treating senescence/age-related diseases
WO2025051889A1 (en) * 2023-09-06 2025-03-13 Rejuveron Senescence Therapeutics Ag Anti pd-l2 antibodies for use in treating fibrotic diseases

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
AU2005248958A1 (en) * 2000-06-28 2006-02-02 Brigham And Women's Hospital PD-L2 molecules: novel PD-1 ligands and uses therefor
US20020164600A1 (en) * 2000-06-28 2002-11-07 Gordon Freeman PD-L2 molecules: novel PD-1 ligands and uses therefor
JP2017508785A (ja) * 2014-02-04 2017-03-30 インサイト・コーポレイションIncyte Corporation 癌を治療するためのpd−1アンタゴニストおよびido1阻害剤の組み合わせ
WO2016134416A1 (en) * 2015-02-23 2016-09-01 The University Of Queensland A method for assessing prognosis of lymphoma
WO2016176504A1 (en) * 2015-04-28 2016-11-03 Bristol-Myers Squibb Company Treatment of pd-l1-positive melanoma using an anti-pd-1 antibody
CN107847598B (zh) * 2015-06-24 2022-01-25 英摩杜伦治疗学公司 用于癌症治疗的检查点抑制剂和全细胞分枝杆菌
JP6949009B2 (ja) * 2015-09-21 2021-10-13 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. ヒトプログラム死リガンド2(pd−l2)に結合する抗体およびその用途

Also Published As

Publication number Publication date
US20200123607A1 (en) 2020-04-23
EP3645746A1 (en) 2020-05-06
WO2019002581A1 (en) 2019-01-03
EP3421607A1 (en) 2019-01-02
JP2020525021A (ja) 2020-08-27
US20240344128A1 (en) 2024-10-17
JP2023098947A (ja) 2023-07-11

Similar Documents

Publication Publication Date Title
US20240344128A1 (en) Identification and elimination of damaged and/or senescent cells
US12235270B2 (en) Depleting tumor-specific tregs
EP4129336B1 (en) Anti-cd47 agent-based treatment of cd20-positive cancer
JP6564408B2 (ja) S100a4抗体およびその治療上の使用
US20200155675A1 (en) Methods and compositions for cancer treatment and treatment selection
JP2020517640A (ja) 併用療法
KR102644408B1 (ko) 암의 치료를 위한 항-pd-l1 항체 및 dna-pk 억제제의 병용
HK1252272A1 (zh) 使用抗ox40抗体治疗癌症的方法
HK1251474A1 (zh) 使用抗ox40抗体和pd-1轴结合拮抗剂治疗癌症的方法
KR20140024914A (ko) 예측인자로 세레브론을 사용하는 암 및 염증성 질환의 치료를 위한 방법
JP7402691B2 (ja) 抗cd25抗体薬物複合体による併用療法
US12173042B2 (en) Methods of treating cancers with CT45 targeted therapies
JP6316498B2 (ja) Ckap4を標的分子とした抗腫瘍剤
AU2013222185A1 (en) Prediction of responsiveness to treatment with immunomodulatory therapeutics and method of monitoring abscopal effects during such treatment
JP2020517629A5 (enExample)
WO2020071554A1 (ja) がん幹細胞特異的抗体
WO2008046529A1 (en) Treatment of chemotherapy- or radiotherapy-resistant tumors using an l1 interfering molecule
WO2018203875A1 (en) Antitumor effect of cryptotanshinone
EP4215211A1 (en) Tumor immune microenvironment regulator, and preventive, diagnostic or therapeutic use thereof
WO2008046459A1 (en) Treatment of chemotherapy- or radiotherapy-resistant tumors using an l1 interfering molecule
WO2025068426A1 (en) Treatment of cancers associated with beta-catenin
TW202528342A (zh) Hla/癌症抗原pvt1衍生胜肽複合體特異性抗體
NZ750663A (en) Compositions and methods for cancer immunotherapy
HK40043124A (en) Anti-cancer regimen using anti-cd47 and anti-cd20 antibodies
EA041126B1 (ru) Антитела и полипептиды, направленные против cd127

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20220308

EEER Examination request

Effective date: 20220308

EEER Examination request

Effective date: 20220308

EEER Examination request

Effective date: 20220308

EEER Examination request

Effective date: 20220308

EEER Examination request

Effective date: 20220308

EEER Examination request

Effective date: 20220308