CA3064064A1 - Methods of inhibiting aging and treating aging-related disorders - Google Patents

Methods of inhibiting aging and treating aging-related disorders Download PDF

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Publication number
CA3064064A1
CA3064064A1 CA3064064A CA3064064A CA3064064A1 CA 3064064 A1 CA3064064 A1 CA 3064064A1 CA 3064064 A CA3064064 A CA 3064064A CA 3064064 A CA3064064 A CA 3064064A CA 3064064 A1 CA3064064 A1 CA 3064064A1
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CA
Canada
Prior art keywords
mir
msc
aging
mscs
muscle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA3064064A
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English (en)
French (fr)
Inventor
Chaya Brodie
Aharon Brodie
Original Assignee
Exostem Biotec Ltd
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Publication date
Application filed by Exostem Biotec Ltd filed Critical Exostem Biotec Ltd
Publication of CA3064064A1 publication Critical patent/CA3064064A1/en
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA3064064A 2017-05-16 2018-05-16 Methods of inhibiting aging and treating aging-related disorders Abandoned CA3064064A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762506661P 2017-05-16 2017-05-16
US62/506,661 2017-05-16
PCT/IL2018/050538 WO2018211510A1 (en) 2017-05-16 2018-05-16 Methods of inhibiting aging and treating aging-related disorders

Publications (1)

Publication Number Publication Date
CA3064064A1 true CA3064064A1 (en) 2018-11-22

Family

ID=64273428

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3064064A Abandoned CA3064064A1 (en) 2017-05-16 2018-05-16 Methods of inhibiting aging and treating aging-related disorders

Country Status (6)

Country Link
US (2) US20200188440A1 (https=)
EP (1) EP3624817A4 (https=)
JP (1) JP2020519668A (https=)
AU (1) AU2018270408A1 (https=)
CA (1) CA3064064A1 (https=)
WO (1) WO2018211510A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116926072A (zh) * 2023-05-04 2023-10-24 广州准优生物科技有限公司 一种抑制神经干细胞诱导分化方法及其应用
EP4245308A4 (en) * 2020-11-16 2024-11-20 Human Life Cord Japan Inc. CELLULAR PREPARATION FOR USE IN PREVENTING MUSCLE MASS REDUCTION

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EP3801028A4 (en) 2018-05-30 2022-04-13 Direct Biologics LLC A growth factor and extracellular vesicle frozen or powdered additive comprising a mesenchymal stem cell (msc) preparation and methods of use
CN108753779B (zh) * 2018-06-07 2021-12-14 天津农学院 牛lncRNA-133a及在牛骨骼肌卫星细胞增殖分化调控中的应用和验证方法
US20220177921A1 (en) * 2018-08-27 2022-06-09 BioViva USA, Inc. Gene therapy using genetically modified viral vectors
WO2020106997A1 (en) * 2018-11-21 2020-05-28 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods and materials for reducing age-related striated muscle and cognitive decline
US12569517B2 (en) * 2019-02-07 2026-03-10 Direct Biologics, Llc Method for treating osteoarthritis with mesenchymal stem cell exosomes
TWI722400B (zh) * 2019-03-18 2021-03-21 佛教慈濟醫療財團法人 間質幹細胞之胞外泌體及其用途
CN111218451B (zh) * 2020-02-05 2021-08-10 华中农业大学 一种提高猪肌肉量的方法
KR20230004709A (ko) 2020-04-22 2023-01-06 다이렉트 바이오로직스 엘엘씨 감염성 질환과 연관된 염증성 병태를 치료하기 위한 방법 및 조성물
KR102317052B1 (ko) * 2020-05-04 2021-10-25 주식회사 티에스셀바이오 태반 유래의 세포외 소포의 항염증 항바이러스 효과 조성물
CN111593114B (zh) * 2020-05-29 2022-12-20 广东医科大学附属医院 miR-122及其抑制剂在预防/治疗放射性脑损伤中的应用
JP6967308B1 (ja) * 2020-06-30 2021-11-17 国立大学法人高知大学 胎児付属物由来組織細胞培養上清を含む脳神経障害治療剤
CN112280742A (zh) * 2020-11-05 2021-01-29 北京欣颂生物科技有限公司 干细胞制备的抗衰老的药物组合物或者保健品
CN112089733B (zh) * 2020-11-05 2021-03-12 广东赛尔生物科技有限公司 一种改造的脐带干细胞在制备抗衰老的药物组合物或者保健品中的用途
WO2022170056A1 (en) * 2021-02-05 2022-08-11 BioViva USA, Inc. Systems and methods for gene therapy via administration of genetically modified viral vectors
KR102523933B1 (ko) * 2021-05-03 2023-04-20 고려대학교 산학협력단 융모막 추출물로부터 분리된 엑소좀을 유효성분으로 포함하는 골형성 촉진용 약학적 조성물
CN113981074A (zh) * 2021-12-10 2022-01-28 石河子大学 一种与2型糖尿病相关的microRNA及其应用
JP2023167026A (ja) * 2022-05-11 2023-11-24 克昭 團 膵機能活性化剤、抗老化剤、２型糖尿病の治療薬または予防薬、医薬品、化粧品および食品または飲料
CN115044543A (zh) * 2022-08-17 2022-09-13 山东卓东生物科技有限公司 一种提高衰老人体来源肌肉干细胞活性的方法
US12502407B2 (en) 2024-04-25 2025-12-23 Direct Biologics, Llc Treatment of fistula with bone marrow mesenchymal stem cell derived extracellular vesicles

Family Cites Families (11)

* Cited by examiner, † Cited by third party
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US8192988B2 (en) * 2004-10-22 2012-06-05 University Of Central Florida Research Foundation, Inc. Methods for increasing potency of adult mesenchymal stem cells
KR20120096793A (ko) * 2011-02-23 2012-08-31 (주)차바이오앤디오스텍 태반 유래 줄기세포를 포함한 면역반응억제용 조성물
WO2013124817A2 (en) * 2012-02-22 2013-08-29 Brainstem Biotec Ltd. MicroRNAS FOR THE GENERATION OF ASTROCYTES
KR101555981B1 (ko) * 2013-05-01 2015-09-30 차의과학대학교 산학협력단 태반 유래 중간엽 줄기 세포, 또는 태반 유래 줄기세포로부터 유도된 신경 전구세포, 이를 포함하는 약학적 조성물, 질환 치료용 키트, 및 이를 이용하는 질환 치료방법
EP3004328A4 (en) * 2013-05-30 2016-12-07 Cells For Cells MESENCHYMAL STEM CELLS OF CHORIONIC ORIGIN, CONDITIONED MEDIUM AS AN ANGIOGENESIS INDUCER AND USE THEREOF FOR TREATMENT OF CARDIAC DEGENERATION
EP3140417B1 (en) * 2014-05-09 2021-04-21 Reelabs Private Limited Foetal polymix of mesenchymal stem cells under hypoxic conditions for the treatment of clinical disorders
WO2016057755A1 (en) * 2014-10-09 2016-04-14 Anthrogenesis Corporation Placenta-derived adherent cell exosomes and uses thereof
CN104560869B (zh) * 2014-12-18 2018-02-23 江苏省北科生物科技有限公司 一种制备绒毛膜间充质干细胞的方法
US20160324898A1 (en) * 2015-05-04 2016-11-10 Stemedica International, Sa Compositions and methods for the treatment of alzheimer's disease
JP2019514416A (ja) * 2016-05-16 2019-06-06 エグゾステム バイオテック リミテッド 間葉系幹細胞と筋損傷及び筋肉関連疾患の治療のための間葉系幹細胞の使用
KR20190109389A (ko) * 2016-11-03 2019-09-25 엑소스템 바이오텍 리미티드 간엽 줄기 세포 집단, 이들의 산물 및 이들의 용도

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4245308A4 (en) * 2020-11-16 2024-11-20 Human Life Cord Japan Inc. CELLULAR PREPARATION FOR USE IN PREVENTING MUSCLE MASS REDUCTION
CN116926072A (zh) * 2023-05-04 2023-10-24 广州准优生物科技有限公司 一种抑制神经干细胞诱导分化方法及其应用
CN116926072B (zh) * 2023-05-04 2024-03-08 广州飞来爱生命科技有限公司 一种抑制神经干细胞诱导分化方法及其应用

Also Published As

Publication number Publication date
JP2020519668A (ja) 2020-07-02
EP3624817A4 (en) 2021-05-19
US20240173354A1 (en) 2024-05-30
EP3624817A1 (en) 2020-03-25
US20200188440A1 (en) 2020-06-18
WO2018211510A1 (en) 2018-11-22
AU2018270408A1 (en) 2019-12-12

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Effective date: 20231116