CA3057741A1 - Novel crystal forms of a pol1 inhibitor - Google Patents

Novel crystal forms of a pol1 inhibitor Download PDF

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Publication number
CA3057741A1
CA3057741A1 CA3057741A CA3057741A CA3057741A1 CA 3057741 A1 CA3057741 A1 CA 3057741A1 CA 3057741 A CA3057741 A CA 3057741A CA 3057741 A CA3057741 A CA 3057741A CA 3057741 A1 CA3057741 A1 CA 3057741A1
Authority
CA
Canada
Prior art keywords
crystalline form
crystalline
degree
compound
depicts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3057741A
Other languages
English (en)
French (fr)
Inventor
Mustapha Haddach
Original Assignee
Pimera Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pimera Inc filed Critical Pimera Inc
Publication of CA3057741A1 publication Critical patent/CA3057741A1/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA3057741A 2017-03-28 2018-03-28 Novel crystal forms of a pol1 inhibitor Pending CA3057741A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762477746P 2017-03-28 2017-03-28
US62/477,746 2017-03-28
US201762491635P 2017-04-28 2017-04-28
US62/491,635 2017-04-28
PCT/US2018/024898 WO2018183540A1 (en) 2017-03-28 2018-03-28 Novel crystal forms of a pol1 inhibitor

Publications (1)

Publication Number Publication Date
CA3057741A1 true CA3057741A1 (en) 2018-10-04

Family

ID=63676829

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3057741A Pending CA3057741A1 (en) 2017-03-28 2018-03-28 Novel crystal forms of a pol1 inhibitor

Country Status (7)

Country Link
US (2) US11912706B2 (https=)
EP (1) EP3601286A4 (https=)
JP (3) JP2020512975A (https=)
CN (2) CN115583948A (https=)
BR (1) BR112019020058A2 (https=)
CA (1) CA3057741A1 (https=)
WO (1) WO2018183540A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9758518B2 (en) 2015-03-04 2017-09-12 Pimera, Inc. Compositions, uses and methods for making them
CA3057741A1 (en) 2017-03-28 2018-10-04 Pimera, Inc. Novel crystal forms of a pol1 inhibitor

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* Cited by examiner, † Cited by third party
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DE2929414A1 (de) 1979-07-20 1981-02-05 Hoechst Ag Pyrimido- eckige klammer auf 5',4' zu 5,6 eckige klammer zu -pyrido- eckige klammer auf 1,2-a eckige klammer zu -benzimidazole, verfahren zu ihrer herstellung und deren verwendung
DE3502689A1 (de) 1985-01-26 1986-07-31 Hoechst Ag, 6230 Frankfurt Elektrophotographisches aufzeichnungsmaterial
DE19509043A1 (de) 1995-03-03 1996-09-05 Bayer Ag Cyanierung von Doppelbindungssystemen
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EP1610759A4 (en) 2003-04-07 2007-04-25 Cylene Pharmaceuticals Inc SUBSTITUTED CHINOBENZOXAZINE ANALOGUE
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PL3092901T3 (pl) 2007-10-05 2020-10-19 Senhwa Biosciences, Inc. Analogi chinolonu i sposoby z nimi związane
ES2378513T3 (es) 2008-08-06 2012-04-13 Pfizer Inc. Compuestos 2-heterociclilamino piracinas sustituidas en posición 6 como inhibidores de CHK-1
JP5801193B2 (ja) 2008-11-03 2015-10-28 エルジー・ケム・リミテッド 新しい含窒素複素環化合物およびそれを用いた有機電子素子
US8124770B2 (en) 2009-04-01 2012-02-28 Beatriz Zayas Fluorescent cellular markers
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PL3140305T3 (pl) * 2014-05-09 2018-10-31 Pimera, Inc. Nowe kompozycje, ich zastosowania i sposoby wytwarzania
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CA3057741A1 (en) 2017-03-28 2018-10-04 Pimera, Inc. Novel crystal forms of a pol1 inhibitor

Also Published As

Publication number Publication date
US11912706B2 (en) 2024-02-27
WO2018183540A1 (en) 2018-10-04
JP2020512975A (ja) 2020-04-30
US20230192694A1 (en) 2023-06-22
CN115583948A (zh) 2023-01-10
JP2025060702A (ja) 2025-04-10
EP3601286A1 (en) 2020-02-05
JP2023126708A (ja) 2023-09-08
US20250243200A1 (en) 2025-07-31
BR112019020058A2 (pt) 2020-07-14
EP3601286A4 (en) 2020-09-23
CN110709400A (zh) 2020-01-17

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