CA3056816A1 - Constructions d'inducteur de presentation d'antigene tumoral et leurs utilisations - Google Patents

Constructions d'inducteur de presentation d'antigene tumoral et leurs utilisations Download PDF

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Publication number
CA3056816A1
CA3056816A1 CA3056816A CA3056816A CA3056816A1 CA 3056816 A1 CA3056816 A1 CA 3056816A1 CA 3056816 A CA3056816 A CA 3056816A CA 3056816 A CA3056816 A CA 3056816A CA 3056816 A1 CA3056816 A1 CA 3056816A1
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Prior art keywords
taa
presentation inducer
construct
isr
cells
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CA3056816A
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David M. Mills
Eric Escobar-Cabrera
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ZYMEWORKS Inc
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ZYMEWORKS Inc
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Publication of CA3056816A1 publication Critical patent/CA3056816A1/fr
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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Abstract

L'invention concerne des constructions d'inducteur de présentation d'antigène associé à une tumeur (TAA) comprenant au moins une construction de liaison de récepteur de stimulation inné (ISR) qui se lie à un ISR exprimé sur une cellule présentatrice d'antigène (APC), et au moins une construction de liaison à un TAA qui se lie directement à un premier TAA qui est physiquement associé à un matériel dérivé de cellules tumorales (TCDM) comprenant un ou plusieurs autres TAA. La construction de liaison à l'ISR et la construction de liaison au TAA sont liées l'une à l'autre, et la construction d'inducteur de présentation de TAA induit une réponse des lymphocytes T polyclonaux au premier TAA et à l'autre ou aux autres TAA. L'invention concerne également des procédés d'utilisation des constructions d'inducteur de présentation de TAA, par exemple, dans le traitement du cancer.
CA3056816A 2017-03-31 2018-03-29 Constructions d'inducteur de presentation d'antigene tumoral et leurs utilisations Abandoned CA3056816A1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762479854P 2017-03-31 2017-03-31
US62/479,854 2017-03-31
US201762489427P 2017-04-24 2017-04-24
US62/489,427 2017-04-24
US201762555347P 2017-09-07 2017-09-07
US62/555,347 2017-09-07
PCT/CA2018/050401 WO2018176159A1 (fr) 2017-03-31 2018-03-29 Constructions d'inducteur de présentation d'antigène tumoral et leurs utilisations

Publications (1)

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CA3056816A1 true CA3056816A1 (fr) 2018-10-04

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CA3056816A Abandoned CA3056816A1 (fr) 2017-03-31 2018-03-29 Constructions d'inducteur de presentation d'antigene tumoral et leurs utilisations

Country Status (11)

Country Link
US (1) US20200048371A1 (fr)
EP (1) EP3601368A4 (fr)
JP (1) JP2020511997A (fr)
KR (1) KR20190135007A (fr)
CN (1) CN110831979A (fr)
AU (1) AU2018241535A1 (fr)
BR (1) BR112019020456A2 (fr)
CA (1) CA3056816A1 (fr)
MX (1) MX2019011504A (fr)
RU (1) RU2019134273A (fr)
WO (1) WO2018176159A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018009916A1 (fr) 2016-07-07 2018-01-11 The Board Of Trustees Of The Leland Stanford Junior University Conjugués d'adjuvant d'anticorps
EP3812399A4 (fr) * 2018-06-20 2022-03-23 Chugai Seiyaku Kabushiki Kaisha Procédé d'activation de la réponse immunitaire d'une cellule cible et composition associée
JP2022525594A (ja) 2019-03-15 2022-05-18 ボルト バイオセラピューティクス、インコーポレーテッド Ｈｅｒ２を標的とする免疫結合体
WO2020206354A1 (fr) * 2019-04-05 2020-10-08 Dren Bio, Inc. Procédés d'appauvrissement d'agents provoquant une maladie par phagocytose ciblée d'anticorps
MX2022007688A (es) * 2019-12-20 2022-07-19 Amgen Inc Constructos de anticuerpo multiespecificos agonistas de cd40 dirigidos a mesotelina para el tratamiento de tumores solidos.
CN111467472B (zh) * 2020-04-21 2020-12-25 南京中医药大学 一种靶向肿瘤相关巨噬细胞的免疫调节微球制剂及其制备方法与应用
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AU2018241535A1 (en) 2019-11-07
WO2018176159A1 (fr) 2018-10-04
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