CA3055791A1 - Treatment methods - Google Patents

Treatment methods Download PDF

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Publication number
CA3055791A1
CA3055791A1 CA3055791A CA3055791A CA3055791A1 CA 3055791 A1 CA3055791 A1 CA 3055791A1 CA 3055791 A CA3055791 A CA 3055791A CA 3055791 A CA3055791 A CA 3055791A CA 3055791 A1 CA3055791 A1 CA 3055791A1
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Canada
Prior art keywords
treatment methods
identifying
methods
compositions
cancer therapy
Prior art date
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Pending
Application number
CA3055791A
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English (en)
French (fr)
Inventor
Jessica Baker Flechtner
Marie LOSSKY-ELIAS
Pamela M. Carroll
Hubert LAM
Lisa K. MCNEIL
Wendy Jane BROOM
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Genocea Biosciences Inc
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Genocea Biosciences Inc
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Publication of CA3055791A1 publication Critical patent/CA3055791A1/en
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Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112019019407A2 (pt) 2017-03-20 2020-05-26 Genocea Biosciences Inc. Métodos de tratamento
EP3873614A4 (en) 2018-10-29 2022-09-07 Genocea Biosciences, Inc. TREATMENT PROCEDURES
CN109957549A (zh) * 2018-12-03 2019-07-02 胜武（北京）生物科技有限公司 一种双功能溶瘤病毒及其应用
US20200179500A1 (en) 2018-12-05 2020-06-11 Wayne State University Methods and immunogenic compositions relating to her2 with selective sequence modifications
CN110016082B (zh) * 2018-12-25 2021-03-23 海南医学院第一附属医院 MIP3α-FGFR1-PD1/Fc融合蛋白及其核酸分子和应用
WO2020232408A1 (en) * 2019-05-15 2020-11-19 Genocea Biosciences, Inc. Treatment methods
US20230031980A1 (en) * 2019-12-13 2023-02-02 Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine Methods and compositions for treating and diagnosing a sage1-related condition
WO2021203022A1 (en) * 2020-04-02 2021-10-07 Genocea Biosciences, Inc. Treatment methods
WO2021231436A1 (en) * 2020-05-11 2021-11-18 The Board Of Trustees Of The Leland Stanford Junior University Therapeutic methods for treating covid-19 infections
WO2021232200A1 (en) * 2020-05-18 2021-11-25 Guangdong Tcrcure Biopharma Technology Co., Ltd. Il-12 armored immune cell therapy and uses thereof
US20230243849A1 (en) * 2020-05-26 2023-08-03 University Of Kentucky Research Foundation Identifying Risk of Cerebra Edema
CN115836122A (zh) * 2020-08-07 2023-03-21 基因泰克公司 用于预测多肽免疫原性的基于t细胞的方法
WO2022056491A1 (en) * 2020-09-14 2022-03-17 Genocea Biosciences, Inc. Treatment methods
AU2022233285A1 (en) 2021-03-09 2023-10-19 Cdr-Life Ag Mage-a4 peptide-mhc antigen binding proteins
US12435444B2 (en) 2021-03-09 2025-10-07 Cdr-Life Ag Rabbit-derived antigen binding protein nucleic acid libraries and methods of making the same
AU2022270155B2 (en) * 2021-05-07 2025-09-11 University Of North Texas Health Science Center At Fort Worth Blood test to screen out parkinson's disease
WO2023086969A2 (en) 2021-11-12 2023-05-19 Ichor Medical Systems Inc. Treatment methods
AU2023305322A1 (en) * 2022-07-14 2025-02-27 Adelaide university Methods and products for determining responsiveness to anti-pd1 immune checkpoint inhibitor immunotherapy
CN120202015A (zh) 2022-09-14 2025-06-24 Cdr-生物科技股份有限公司 Mage-a4肽双重t细胞衔接子
CN118955735A (zh) * 2024-08-02 2024-11-15 中国药科大学 一种融合蛋白及基于其的mRNA递送系统和应用

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925661A (en) 1984-04-19 1990-05-15 Leaf Huang Target-specific cytotoxic liposomes
US4921757A (en) 1985-04-26 1990-05-01 Massachusetts Institute Of Technology System for delayed and pulsed release of biologically active substances
US4863874A (en) 1986-07-11 1989-09-05 The United States Of America As Represented By The Secretary Of The Army Method for detecting phosphatidylinositol through binding to Concanavalin A
US5225212A (en) 1989-10-20 1993-07-06 Liposome Technology, Inc. Microreservoir liposome composition and method
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
US5199942A (en) 1991-06-07 1993-04-06 Immunex Corporation Method for improving autologous transplantation
US5989565A (en) 1993-01-29 1999-11-23 University Of Pittsburgh Elution and identification of T cell epitopes from viable cells
US5643599A (en) 1995-06-07 1997-07-01 President And Fellows Of Harvard College Intracellular delivery of macromolecules
US6872518B2 (en) 1997-09-22 2005-03-29 University Of Rochester Methods for selecting polynucleotides encoding T cell epitopes
US6541011B2 (en) 1998-02-11 2003-04-01 Maxygen, Inc. Antigen library immunization
EP1089751A4 (en) 1998-06-23 2001-07-25 Univ Leland Stanford Junior Adjuvant therapy
US6004815A (en) 1998-08-13 1999-12-21 The Regents Of The University Of California Bacteria expressing nonsecreted cytolysin as intracellular microbial delivery vehicles to eukaryotic cells
US6407063B1 (en) 1998-10-02 2002-06-18 Ludwig Institute For Cancer Research Tumor antigens and CTL clones isolated by a novel procedure
WO2000067761A1 (en) 1999-05-06 2000-11-16 Wake Forest University Compositions and methods for identifying antigens which elicit an immune response
US20030077263A1 (en) 1999-10-29 2003-04-24 Immunex Corporation Method of activating dendritic cells
US20040002068A1 (en) 2000-03-01 2004-01-01 Corixa Corporation Compositions and methods for the detection, diagnosis and therapy of hematological malignancies
US20030003485A1 (en) 2001-05-15 2003-01-02 Ludwig Institute For Cancer Research Methods for identifying antigens
US7262269B2 (en) 2001-10-26 2007-08-28 The Regents Of University Of California Method for screening combinational bead library; ligands for cancer cells
DE10164819A1 (de) 2001-11-20 2005-05-19 Deml, Ludwig, Dr. Verfahren zur Identifizierung von Zielepitopen der T-Zell-vermittelten Immunantwort und zum Nachweis Epitop-spezifischer T-Zellen
US7413868B2 (en) 2003-11-05 2008-08-19 Trellis Bioscience, Inc. Use of particulate labels in bioanalyte detection methods
EP1715346A1 (en) 2005-04-22 2006-10-25 GSF-Forschungszentrum für Umwelt und Gesundheit GmbH Method of identifying CD4+ T cell antigens
US20100080792A1 (en) 2005-06-16 2010-04-01 Dorothee Herlyn Method for Identifying a MHC Class II-Dependent Tumor-Associated T Helper Cell Antigen
WO2007098255A2 (en) 2006-02-21 2007-08-30 President And Fellows Of Harvard College Compositions for and methods of identifying antigens
WO2009020553A2 (en) 2007-08-03 2009-02-12 President And Fellows Of Harvard College Chlamydia antigens
AU2009266924B2 (en) 2008-07-01 2015-12-10 Genocea Biosciences, Inc. Antigen screening system
KR102095670B1 (ko) 2010-05-14 2020-03-31 더 제너럴 하스피톨 코포레이션 종양 특이적 신생항원을 확인하는 조성물 및 방법
EP2992000B1 (en) 2013-05-03 2020-07-08 The Regents of The University of California Cyclic di-nucleotide induction of type i interferon
ME03586B (me) 2013-05-18 2020-07-20 Univ California Sastavi i metode za aktiviranje signaliziranja koje je zavisno od .,stimulatora gena za interferon"
MA40737A (fr) * 2014-11-21 2017-07-04 Memorial Sloan Kettering Cancer Center Déterminants de la réponse d'un cancer à une immunothérapie par blocage de pd-1
ES2764178T3 (es) 2014-12-16 2020-06-02 Kayla Therapeutics Dinucleótidos cíclicos fluorados para inducción de citocinas
BR112019019407A2 (pt) 2017-03-20 2020-05-26 Genocea Biosciences Inc. Métodos de tratamento

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