CA3055109A1 - Pharmaceutical formulations comprising 5-chloro-n4-[2-(dimethylphosphoryl)phenyl]-n2-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diamine - Google Patents
Pharmaceutical formulations comprising 5-chloro-n4-[2-(dimethylphosphoryl)phenyl]-n2-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diamine Download PDFInfo
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- CA3055109A1 CA3055109A1 CA3055109A CA3055109A CA3055109A1 CA 3055109 A1 CA3055109 A1 CA 3055109A1 CA 3055109 A CA3055109 A CA 3055109A CA 3055109 A CA3055109 A CA 3055109A CA 3055109 A1 CA3055109 A1 CA 3055109A1
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- Prior art keywords
- brigatinib
- pharmaceutical composition
- composition according
- phenyl
- tablet
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Classifications
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- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762468696P | 2017-03-08 | 2017-03-08 | |
| US62/468,696 | 2017-03-08 | ||
| US201762491179P | 2017-04-27 | 2017-04-27 | |
| US62/491,179 | 2017-04-27 | ||
| US201762569954P | 2017-10-09 | 2017-10-09 | |
| US62/569,954 | 2017-10-09 | ||
| PCT/US2018/021128 WO2018165145A1 (en) | 2017-03-08 | 2018-03-06 | Pharmaceutical formulations comprising 5-chloro-n4-[2-(dimethylphosphoryl) phenyl]-n2-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl} pyrimidine-2,4-diamine |
Publications (1)
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| CA3055109A1 true CA3055109A1 (en) | 2018-09-13 |
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| CA (1) | CA3055109A1 (enExample) |
| TW (1) | TWI794214B (enExample) |
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| WO2019182936A1 (en) * | 2018-03-19 | 2019-09-26 | Ariad Pharmaceuticals, Inc. | Methods of treating cancer in pediatric patients |
| TW202207940A (zh) * | 2020-04-14 | 2022-03-01 | 美商健生生物科技公司 | 包含胺基嘧啶衍生物或其醫藥上可接受之鹽、水合物、或溶劑化物之用於經口投予之醫藥組成物 |
| AU2022306151B2 (en) * | 2021-07-05 | 2024-11-14 | Qilu Pharmaceutical Co., Ltd. | Pharmaceutical composition, and preparation method therefor and application thereof |
| CN116407512A (zh) * | 2021-12-31 | 2023-07-11 | 南京艾德凯腾生物医药有限责任公司 | 一种布格替尼冻干口崩片及其制备方法 |
| CN115154473A (zh) * | 2022-08-04 | 2022-10-11 | 中国人民解放军陆军特色医学中心 | 布格替尼作为axl、c-met、st3gal4抑制剂的新应用 |
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| US20120208824A1 (en) * | 2006-01-20 | 2012-08-16 | Cell Signaling Technology, Inc. | ROS Kinase in Lung Cancer |
| CN102105150B (zh) | 2008-05-21 | 2014-03-12 | 阿里亚德医药股份有限公司 | 用作激酶抑制剂的磷衍生物 |
| RU2011137516A (ru) * | 2009-02-13 | 2013-03-20 | Ипсен Фарма С.А.С. | ТВЕРДАЯ ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ 6-ОКСО-6,7,8,9,10,11-ГЕКСАГИДРОЦИКЛОГЕПТА[c]ХРОМЕН-3-ИЛСУЛЬФАМАТ И ЕГО ПОЛИФОРМЫ |
| US8691281B2 (en) * | 2009-02-13 | 2014-04-08 | Ipsen Pharma S.A.S. | Solid pharmaceutical composition containing 6-oxo-6,7,8,9,10,11-hexahydrocyclohepta (C)chromen-3-yl sulfamate and polymorphs thereof |
| EP2627179A4 (en) * | 2010-10-14 | 2014-04-02 | Ariad Pharma Inc | METHODS OF INHIBITING CELL PROLIFERATION IN EGFR-INDUCED CANCERS |
| WO2013008253A2 (en) * | 2011-07-11 | 2013-01-17 | Dr. Reddys Laboratories Limited | Imatinib formulations |
| TWI589576B (zh) * | 2011-07-15 | 2017-07-01 | 諾華公司 | 氮雜－雙環二芳基醚之鹽類及製造彼等或其前驅物之方法 |
| EP2753312B1 (en) * | 2011-09-08 | 2016-12-14 | Mereo BioPharma 2 Limited | Use of an aromatase inhibitor for the treatment of hypogonadism and related diseases |
| HK1202377A1 (en) * | 2011-11-14 | 2015-10-02 | Tesaro Inc. | Modulating certain tyrosine kinases |
| JP2015501645A (ja) * | 2011-12-10 | 2015-01-19 | オハイオ・ステイト・イノベーション・ファウンデーション | 肺がんの腫瘍発生および化学療法耐性を低減するために有用なｍｉＲＮＡならびに関連する組成物および方法 |
| CN102600146B (zh) * | 2012-04-11 | 2014-10-08 | 兆科药业（合肥）有限公司 | 一种盐酸乐卡地平和氯沙坦钾复方制剂及其制备方法 |
| BR112015023020A2 (pt) * | 2013-03-14 | 2017-07-18 | Pfizer | combinação de inibidor de egfr t790m e inibidor de egfr para o tratamento de câncer pulmonar de células não-pequenas |
| US9474761B2 (en) * | 2014-06-10 | 2016-10-25 | The George Washington University | Use of NK-1 receptor antagonists for treating hypomagnesemia, neurogenic inflammation, and cardiac dysfunction associated with EGFR-blocking drugs |
| HRP20201343T1 (hr) * | 2014-10-21 | 2020-11-27 | Ariad Pharmaceuticals, Inc. | Kristalni oblici 5-kloro-n4-[-2-(dimetilfosforil)fenil]-n2-{2-metoksi-4-[4-(4-metilpiperazin-1-il)piperidin-1-il]pirimidin-2,4-diamina |
| CN105061506B (zh) * | 2015-07-27 | 2017-08-29 | 苏州明锐医药科技有限公司 | 抗肿瘤药物ap26113的制备方法 |
| US10813935B2 (en) * | 2017-02-23 | 2020-10-27 | Transgenex Nanobiotech, Inc. | Methods and compositions for treating drug resistance in cancer |
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2018
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- 2018-03-06 JP JP2019548708A patent/JP2020510027A/ja active Pending
- 2018-03-06 CN CN201880021866.7A patent/CN110520110A/zh active Pending
- 2018-03-06 CA CA3055109A patent/CA3055109A1/en active Pending
- 2018-03-06 EP EP18712759.2A patent/EP3592338A1/en not_active Withdrawn
- 2018-03-07 US US15/914,899 patent/US20180256610A1/en not_active Abandoned
- 2018-03-08 TW TW107107838A patent/TWI794214B/zh active
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2021
- 2021-03-05 US US17/193,502 patent/US20210186994A1/en not_active Abandoned
- 2021-09-14 US US17/474,246 patent/US20210401860A1/en not_active Abandoned
-
2022
- 2022-04-22 US US17/726,736 patent/US20220249524A1/en not_active Abandoned
- 2022-12-19 JP JP2022201704A patent/JP2023027312A/ja active Pending
-
2023
- 2023-11-14 US US18/508,499 patent/US20240082275A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| TWI794214B (zh) | 2023-03-01 |
| US20210401860A1 (en) | 2021-12-30 |
| US20180256610A1 (en) | 2018-09-13 |
| JP2020510027A (ja) | 2020-04-02 |
| US20240082275A1 (en) | 2024-03-14 |
| TW201840320A (zh) | 2018-11-16 |
| EP3592338A1 (en) | 2020-01-15 |
| WO2018165145A1 (en) | 2018-09-13 |
| CN110520110A (zh) | 2019-11-29 |
| US20210186994A1 (en) | 2021-06-24 |
| US20220249524A1 (en) | 2022-08-11 |
| JP2023027312A (ja) | 2023-03-01 |
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