CA3053069A1 - Therapeutic dendrimers - Google Patents
Therapeutic dendrimers Download PDFInfo
- Publication number
- CA3053069A1 CA3053069A1 CA3053069A CA3053069A CA3053069A1 CA 3053069 A1 CA3053069 A1 CA 3053069A1 CA 3053069 A CA3053069 A CA 3053069A CA 3053069 A CA3053069 A CA 3053069A CA 3053069 A1 CA3053069 A1 CA 3053069A1
- Authority
- CA
- Canada
- Prior art keywords
- dendrimer
- formula
- pharmaceutically acceptable
- acceptable salt
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
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Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Prostheses (AREA)
- Pyridine Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (7)
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| PCT/EP2018/054420 WO2018154004A1 (en) | 2017-02-22 | 2018-02-22 | Therapeutic dendrimers |
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| US20180326081A1 (en) * | 2011-06-06 | 2018-11-15 | Starpharma Pty Ltd | Macromolecules |
| JOP20190191A1 (ar) * | 2017-02-22 | 2019-08-08 | Astrazeneca Ab | وحدات شجرية علاجية |
| TWI856967B (zh) * | 2018-08-17 | 2024-10-01 | 瑞典商阿斯特捷利康公司 | 樹枝狀體配製物 |
| TWI831817B (zh) * | 2018-08-17 | 2024-02-11 | 瑞典商阿斯特捷利康公司 | 治療癌症之方法 |
| MX2021005756A (es) * | 2018-11-20 | 2021-09-21 | Starpharma Pty Ltd | Dendrimero terapeutico. |
| WO2020225307A1 (en) | 2019-05-07 | 2020-11-12 | Syddansk Universitet | Mechanism for dispensing biological material |
| KR20220072851A (ko) * | 2019-09-26 | 2022-06-02 | 스타파마 피티와이 리미티드 | 치료용 덴드리머 |
| EP4069307A2 (en) * | 2019-12-04 | 2022-10-12 | Ashvattha Therapeutics, Inc. | Dendrimer compositions and methods for drug delivery |
| CA3181171A1 (en) | 2020-04-24 | 2021-10-28 | Ashvattha Therapeutics, Inc. | Dendrimer compositions and methods for treatment of severe acute respiratory distress syndrome |
| TW202206106A (zh) * | 2020-04-24 | 2022-02-16 | 大陸商上海森輝醫藥有限公司 | 一類載藥的大分子及其製備方法 |
| WO2022007940A1 (zh) * | 2020-07-10 | 2022-01-13 | 江苏恒瑞医药股份有限公司 | 磺酰苯甲酰胺类衍生物及其偶联物、其制备方法及其应用 |
| JP2023538695A (ja) * | 2020-08-25 | 2023-09-08 | 上海森輝医薬有限公司 | 薬剤を担持する高分子及びその調製方法 |
| EP4203968A4 (en) * | 2020-08-31 | 2025-07-30 | Starpharma Pty Ltd | DENDRIMER-DRUG CONJUGATE |
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| US4289872A (en) * | 1979-04-06 | 1981-09-15 | Allied Corporation | Macromolecular highly branched homogeneous compound based on lysine units |
| US4410688A (en) * | 1981-04-29 | 1983-10-18 | Allied Corporation | Macromolecular highly branched homogeneous compound |
| US6720338B2 (en) | 2000-09-20 | 2004-04-13 | Abbott Laboratories | N-acylsulfonamide apoptosis promoters |
| UY26942A1 (es) | 2000-09-20 | 2002-04-26 | Abbott Lab | N-acilsulfonamidas promotoras de la apoptosis |
| WO2005049593A2 (en) | 2003-11-13 | 2005-06-02 | Abbott Laboratories | N-acylsulfonamide apoptosis promoters |
| PL1888550T3 (pl) | 2005-05-12 | 2014-12-31 | Abbvie Bahamas Ltd | Promotory apoptozy |
| ES2625109T3 (es) * | 2005-10-25 | 2017-07-18 | Starpharma Pty Limited | Compuestos macromoleculares que tienen estequiometría controlada |
| CN101420962A (zh) * | 2006-01-20 | 2009-04-29 | 星药股份有限公司 | 经修饰的大分子 |
| US9127130B2 (en) * | 2006-08-11 | 2015-09-08 | Starpharma Pty Ltd. | Polylysine dendrimer contrast agent |
| EP2052011B1 (en) * | 2006-08-11 | 2020-11-04 | Starpharma Pty Limited | Targeted polylysine dendrimer therapeutic agent |
| WO2008061208A2 (en) | 2006-11-15 | 2008-05-22 | Genentech, Inc. | Arylsulfonamide compounds |
| US9283302B2 (en) | 2011-12-16 | 2016-03-15 | Cormatrix Cardiovascular, Inc. | Extracellular matrix encasement structures and methods |
| WO2009036035A1 (en) | 2007-09-10 | 2009-03-19 | Curis, Inc. | Bcl-2 inhibitors |
| JP6084770B2 (ja) | 2008-06-26 | 2017-02-22 | プロリンクス エルエルシー | 制御された薬剤放出速度を有するプロドラッグ及び薬剤−高分子のコンジュゲート |
| US8216549B2 (en) * | 2008-07-25 | 2012-07-10 | National Health Research Institutes | Method for making a ligand-quantum dot conjugate |
| TWI600642B (zh) | 2008-12-05 | 2017-10-01 | 艾伯維有限公司 | 用於治療癌症及免疫疾病之ｂｃｌ-２-選擇性細胞凋亡誘發劑 |
| AR076705A1 (es) | 2009-05-26 | 2011-06-29 | Abbott Lab | Agentes inductores de la apoptosis para el tratamiento del cancer y enfermedades inmunes y autoinmunes |
| US8546399B2 (en) | 2009-05-26 | 2013-10-01 | Abbvie Inc. | Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases |
| TWI471321B (zh) | 2009-06-08 | 2015-02-01 | 亞培公司 | Ｂｃｌ－２族群抑制劑之口服醫藥劑型 |
| WO2011046842A1 (en) * | 2009-10-12 | 2011-04-21 | The Regents Of The University Of California | Targeted nanoclusters and methods of their use |
| CN103025164B (zh) | 2010-05-05 | 2017-03-08 | 普罗林科斯有限责任公司 | 从固体支撑物中药物的控制释放 |
| US8754190B2 (en) | 2010-05-05 | 2014-06-17 | Prolynx Llc | Controlled release from macromolecular conjugates |
| WO2011140376A1 (en) | 2010-05-05 | 2011-11-10 | Prolynx Llc | Controlled drug release from dendrimers |
| TWI535712B (zh) | 2010-08-06 | 2016-06-01 | 阿斯特捷利康公司 | 化合物 |
| DK2729179T3 (da) * | 2011-06-06 | 2020-12-21 | Starpharma Pty Ltd | Makromolekyler |
| US20160220689A1 (en) * | 2013-09-10 | 2016-08-04 | Starpharma Pty Ltd. | Macromolecules of dendrimer-platinum conjugates |
| US10730999B2 (en) * | 2014-06-06 | 2020-08-04 | Starpharma Pty Ltd | Dendrimer-drug conjugates |
| JOP20190191A1 (ar) * | 2017-02-22 | 2019-08-08 | Astrazeneca Ab | وحدات شجرية علاجية |
| TWI831817B (zh) * | 2018-08-17 | 2024-02-11 | 瑞典商阿斯特捷利康公司 | 治療癌症之方法 |
| TWI856967B (zh) * | 2018-08-17 | 2024-10-01 | 瑞典商阿斯特捷利康公司 | 樹枝狀體配製物 |
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2017
- 2017-06-16 JO JOP/2019/0191A patent/JOP20190191A1/ar unknown
-
2018
- 2018-02-12 TW TW107105033A patent/TWI773730B/zh active
- 2018-02-20 US US15/899,892 patent/US10314920B2/en active Active
- 2018-02-22 CA CA3053069A patent/CA3053069A1/en active Pending
- 2018-02-22 CN CN202311534590.1A patent/CN117582521A/zh active Pending
- 2018-02-22 EP EP18707681.5A patent/EP3585441A1/en active Pending
- 2018-02-22 CR CR20190361A patent/CR20190361A/es unknown
- 2018-02-22 KR KR1020197027415A patent/KR102544033B1/ko active Active
- 2018-02-22 PE PE2019001564A patent/PE20191660A1/es unknown
- 2018-02-22 JP JP2019543376A patent/JP7074761B2/ja active Active
- 2018-02-22 CN CN201880012429.9A patent/CN110312531A/zh active Pending
- 2018-02-22 MX MX2019009442A patent/MX2019009442A/es unknown
- 2018-02-22 SG SG11201907334QA patent/SG11201907334QA/en unknown
- 2018-02-22 WO PCT/EP2018/054420 patent/WO2018154004A1/en not_active Ceased
- 2018-02-22 AU AU2018223149A patent/AU2018223149B2/en not_active Ceased
- 2018-02-22 KR KR1020237019533A patent/KR20230093346A/ko not_active Abandoned
- 2018-02-22 UA UAA201909735A patent/UA125655C2/uk unknown
- 2018-02-22 BR BR112019016409A patent/BR112019016409A2/pt active Search and Examination
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2019
- 2019-04-05 US US16/376,419 patent/US10888624B2/en active Active
- 2019-08-06 EC ECSENADI201956271A patent/ECSP19056271A/es unknown
- 2019-08-08 DO DO2019000204A patent/DOP2019000204A/es unknown
- 2019-08-08 CL CL2019002240A patent/CL2019002240A1/es unknown
- 2019-08-12 IL IL268648A patent/IL268648B/en unknown
- 2019-08-15 PH PH12019501896A patent/PH12019501896A1/en unknown
- 2019-08-20 NI NI201900088A patent/NI201900088A/es unknown
- 2019-09-09 CO CONC2019/0009722A patent/CO2019009722A2/es unknown
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2020
- 2020-11-11 US US17/095,043 patent/US11717574B2/en active Active
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2023
- 2023-06-14 US US18/334,672 patent/US20240115716A1/en not_active Abandoned
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