CA3045475A1 - Treatment of a disease of the gastrointestinal tract with an il-12/il-23 inhibitor released using an ingestible device - Google Patents

Treatment of a disease of the gastrointestinal tract with an il-12/il-23 inhibitor released using an ingestible device Download PDF

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Publication number
CA3045475A1
CA3045475A1 CA3045475A CA3045475A CA3045475A1 CA 3045475 A1 CA3045475 A1 CA 3045475A1 CA 3045475 A CA3045475 A CA 3045475A CA 3045475 A CA3045475 A CA 3045475A CA 3045475 A1 CA3045475 A1 CA 3045475A1
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CA
Canada
Prior art keywords
inhibitor
subject
ingestible device
disease
location
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3045475A
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English (en)
French (fr)
Inventor
Mitchell Lawrence Jones
Sharat Singh
Christopher Loren WAHL
Harry Stylli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biora Therapeutics Inc
Original Assignee
Progenity Inc
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Filing date
Publication date
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Publication of CA3045475A1 publication Critical patent/CA3045475A1/en
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
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    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • A61B10/0045—Devices for taking samples of body liquids
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Biotechnology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Endocrinology (AREA)
CA3045475A 2016-12-14 2017-12-14 Treatment of a disease of the gastrointestinal tract with an il-12/il-23 inhibitor released using an ingestible device Pending CA3045475A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201662434348P 2016-12-14 2016-12-14
US62/434,348 2016-12-14
US201762478744P 2017-03-30 2017-03-30
US62/478,744 2017-03-30
US201762545188P 2017-08-14 2017-08-14
US62/545,188 2017-08-14
US201762583797P 2017-11-09 2017-11-09
US62/583,797 2017-11-09
PCT/US2017/066474 WO2018112232A1 (en) 2016-12-14 2017-12-14 Treatment of a disease of the gastrointestinal tract with an il-12/il-23 inhibitor released using an ingestible device

Publications (1)

Publication Number Publication Date
CA3045475A1 true CA3045475A1 (en) 2018-06-21

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA3045475A Pending CA3045475A1 (en) 2016-12-14 2017-12-14 Treatment of a disease of the gastrointestinal tract with an il-12/il-23 inhibitor released using an ingestible device

Country Status (10)

Country Link
US (2) US11597762B2 (enExample)
EP (1) EP3554540B1 (enExample)
JP (2) JP7237834B2 (enExample)
KR (1) KR20190095931A (enExample)
CN (2) CN117045784A (enExample)
AU (1) AU2017376807B2 (enExample)
BR (1) BR112019011702A2 (enExample)
CA (1) CA3045475A1 (enExample)
MX (1) MX2019006823A (enExample)
WO (1) WO2018112232A1 (enExample)

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CA3085330A1 (en) * 2017-12-14 2019-06-20 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with a s1p modulator
JP6611833B2 (ja) * 2018-01-16 2019-11-27 キヤノン株式会社 放射線撮影システム、並びに、カメラ制御装置及びその制御方法
EP3810268A1 (en) * 2018-06-20 2021-04-28 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an il-12/il-23 inhibitor
FI13575Y1 (fi) * 2018-09-24 2024-03-26 Janssen Biotech Inc IL12/IL23-vasta-aine käytettäväksi turvallisessa ja tehokaassa menetelmässä haavaisen paksusuolitulehduksen hoitamiseksi
JP7657714B2 (ja) * 2018-11-15 2025-04-07 ヤンセン バイオテツク，インコーポレーテツド 炎症性腸疾患の治療に対する応答を予測するための方法及び組成物
CN109350599A (zh) * 2018-12-12 2019-02-19 辽宁新高制药有限公司 一种用于皮肤念球菌病治疗的喷雾剂
CA3138241A1 (en) 2019-05-23 2020-11-26 Janssen Biotech, Inc. Method of treating inflammatory bowel disease with a combination therapy of antibodies to il-23 and tnf alpha
CN114555120A (zh) * 2019-10-18 2022-05-27 詹森生物科技公司 用抗il12/il23抗体治疗溃疡性结肠炎的安全且有效的方法
JP7444991B2 (ja) * 2019-12-16 2024-03-06 イーライ リリー アンド カンパニー 消化器サンプリングのためのカプセル
KR102391865B1 (ko) * 2020-04-03 2022-04-27 재단법인대구경북과학기술원 약물 전달 디바이스
EP4596046A3 (en) 2020-05-21 2025-10-22 Janssen Biotech, Inc. Method of treating inflammatory bowel disease with a combination therapy of antibodies to il-23 and tnf alpha
CN112731954B (zh) * 2020-12-25 2024-06-21 深圳市优必选科技股份有限公司 机器人的运动控制方法、装置、机器人及存储介质
US20240316324A1 (en) * 2021-01-29 2024-09-26 Biograil ApS Drug delivery device with releasable attachment part
IL303862A (en) * 2021-01-29 2023-08-01 Biograil ApS Single attachment part drug delivery device
DK180991B1 (en) * 2021-01-29 2022-09-06 Biograil ApS Drug delivery device with carrier and insert
CN118176034A (zh) * 2021-10-28 2024-06-11 柏欧格瑞有限责任公司 高剂量药物输送装置
EP4197437A1 (en) * 2021-12-17 2023-06-21 Stichting IMEC Nederland Methods and devices for in vivo assessment of analytes in the gastrointestinal tract
CA3270918A1 (en) * 2022-10-17 2024-04-25 Rani Therapeutics Llc Dosage Forms and Methods of Ustekinumab
CN116027048A (zh) * 2023-02-06 2023-04-28 山东中鸿特检生物科技有限公司 一种细胞因子风暴综合征诊断试剂盒及其应用
WO2025235985A1 (en) * 2024-05-10 2025-11-13 University Of Southern California Ingestible sensor or treatment system and method with localization from magnetic-field generating wearable device

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