MX2019006823A - Tratamiento de una enfermedad del tracto gastrointestinal con inhibidor de interleucina-12/interleucina-23 (il-12/il-23) liberado usando un dispositivo ingerible. - Google Patents

Tratamiento de una enfermedad del tracto gastrointestinal con inhibidor de interleucina-12/interleucina-23 (il-12/il-23) liberado usando un dispositivo ingerible.

Info

Publication number
MX2019006823A
MX2019006823A MX2019006823A MX2019006823A MX2019006823A MX 2019006823 A MX2019006823 A MX 2019006823A MX 2019006823 A MX2019006823 A MX 2019006823A MX 2019006823 A MX2019006823 A MX 2019006823A MX 2019006823 A MX2019006823 A MX 2019006823A
Authority
MX
Mexico
Prior art keywords
disease
gastrointestinal tract
treatment
ingestible device
inhibitor released
Prior art date
Application number
MX2019006823A
Other languages
English (en)
Inventor
Singh Sharat
Lawrence Jones Mitchell
Loren Wahl Christopher
Stylli Harry
Original Assignee
Progenity Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Progenity Inc filed Critical Progenity Inc
Publication of MX2019006823A publication Critical patent/MX2019006823A/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/713Double-stranded nucleic acids or oligonucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13Cyclosporins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241Tumor Necrosis Factors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045Devices for taking samples of body liquids
    • A61B2010/0061Alimentary tract secretions, e.g. biliary, gastric, intestinal, pancreatic secretions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/07Endoradiosondes
    • A61B5/073Intestinal transmitters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0097Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/11Antisense
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52Assays involving cytokines
    • G01N2333/525Tumor necrosis factor [TNF]
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52Assays involving cytokines
    • G01N2333/54Interleukins [IL]
    • G01N2333/5412IL-6
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52Assays involving cytokines
    • G01N2333/54Interleukins [IL]
    • G01N2333/545IL-1
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52Assays involving cytokines
    • G01N2333/54Interleukins [IL]
    • G01N2333/55IL-2
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52Assays involving cytokines
    • G01N2333/555Interferons [IFN]
    • G01N2333/57IFN-gamma

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Pain & Pain Management (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)

Abstract

Esta descripción presenta métodos y composiciones para tratar enfermedades del tracto gastrointestinal con un inhibidor de IL-12/IL-23. En particular, los medicamentos son administrados en la proximidad de sitios de la enfermedad usando dispositivos ingeribles que pueden liberar el fármaco en una manera controlada.
MX2019006823A 2016-12-14 2017-12-14 Tratamiento de una enfermedad del tracto gastrointestinal con inhibidor de interleucina-12/interleucina-23 (il-12/il-23) liberado usando un dispositivo ingerible. MX2019006823A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662434348P 2016-12-14 2016-12-14
US201762478744P 2017-03-30 2017-03-30
US201762545188P 2017-08-14 2017-08-14
US201762583797P 2017-11-09 2017-11-09
PCT/US2017/066474 WO2018112232A1 (en) 2016-12-14 2017-12-14 Treatment of a disease of the gastrointestinal tract with an il-12/il-23 inhibitor released using an ingestible device

Publications (1)

Publication Number Publication Date
MX2019006823A true MX2019006823A (es) 2019-10-21

Family

ID=60953956

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019006823A MX2019006823A (es) 2016-12-14 2017-12-14 Tratamiento de una enfermedad del tracto gastrointestinal con inhibidor de interleucina-12/interleucina-23 (il-12/il-23) liberado usando un dispositivo ingerible.

Country Status (9)

Country Link
US (1) US11597762B2 (es)
EP (1) EP3554540B1 (es)
JP (2) JP7237834B2 (es)
KR (1) KR20190095931A (es)
CN (2) CN117045784A (es)
BR (1) BR112019011702A2 (es)
CA (1) CA3045475A1 (es)
MX (1) MX2019006823A (es)
WO (1) WO2018112232A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019118778A1 (en) * 2017-12-14 2019-06-20 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with a s1p modulator
JP6611833B2 (ja) * 2018-01-16 2019-11-27 キヤノン株式会社 放射線撮影システム、並びに、カメラ制御装置及びその制御方法
EP3810268A1 (en) * 2018-06-20 2021-04-28 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an il-12/il-23 inhibitor
LT3883606T (lt) * 2018-09-24 2023-09-11 Janssen Biotech, Inc. Saugus ir veiksmingas opinio kolito gydymo būdas anti-il12/il23 antikūnu
EP3880836A4 (en) * 2018-11-15 2022-11-16 Janssen Biotech, Inc. METHODS AND COMPOSITIONS FOR PREDICTING RESPONSE TO INFLAMMATORY BOWEL DISEASE THERAPY
CN109350599A (zh) * 2018-12-12 2019-02-19 辽宁新高制药有限公司 一种用于皮肤念球菌病治疗的喷雾剂
WO2020234834A1 (en) 2019-05-23 2020-11-26 Janssen Biotech, Inc. Method of treating inflammatory bowel disease with a combination therapy of antibodies to il-23 and tnf alpha
AU2020365589A1 (en) * 2019-10-18 2022-05-19 Janssen Biotech, Inc. Safe and effective method of treating ulcerative colitis with anti-IL12/IL23 antibody
KR102391865B1 (ko) * 2020-04-03 2022-04-27 재단법인대구경북과학기술원 약물 전달 디바이스
CN112731954B (zh) * 2020-12-25 2024-06-21 深圳市优必选科技股份有限公司 机器人的运动控制方法、装置、机器人及存储介质
KR20230132869A (ko) * 2021-01-29 2023-09-18 바이오그레일 에이피에스 단일 부착부 약물 전달 장치
DK180991B1 (en) * 2021-01-29 2022-09-06 Biograil ApS Drug delivery device with carrier and insert
EP4284483A1 (en) * 2021-01-29 2023-12-06 Biograil APS Drug delivery device with releasable attachment part
CN118176034A (zh) * 2021-10-28 2024-06-11 柏欧格瑞有限责任公司 高剂量药物输送装置
WO2024086013A1 (en) * 2022-10-17 2024-04-25 Rani Therapeutics, Llc Ustekinumab dosage forms and methods
CN116027048A (zh) * 2023-02-06 2023-04-28 山东中鸿特检生物科技有限公司 一种细胞因子风暴综合征诊断试剂盒及其应用

Family Cites Families (119)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
IL47062A (en) 1975-04-10 1979-07-25 Yeda Res & Dev Process for diminishing antigenicity of tissues to be usedas transplants by treatment with glutaraldehyde
US4281645A (en) 1977-06-28 1981-08-04 Duke University, Inc. Method and apparatus for monitoring metabolism in body organs
US4190328A (en) 1978-12-01 1980-02-26 Levine Robert A Process for detection of blood-borne parasites
JPS5588732A (en) 1978-12-26 1980-07-04 Olympus Optical Co Endoscope
US4665077A (en) 1979-03-19 1987-05-12 The Upjohn Company Method for treating rejection of organ or skin grafts with 6-aryl pyrimidine compounds
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US4987071A (en) 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
US5116742A (en) 1986-12-03 1992-05-26 University Patents, Inc. RNA ribozyme restriction endoribonucleases and methods
US4904582A (en) 1987-06-11 1990-02-27 Synthetic Genetics Novel amphiphilic nucleic acid conjugates
IL85746A (en) 1988-03-15 1994-05-30 Yeda Res & Dev Preparations comprising t-lymphocyte cells treated with 8-methoxypsoralen or cell membranes separated therefrom for preventing or treating autoimmune diseases
FI891226A (fi) 1988-04-28 1989-10-29 Univ Leland Stanford Junior Reseptordeterminanter i anti-t-celler foer behandling av autoimmunsjukdom.
JP2681061B2 (ja) 1988-06-08 1997-11-19 ロンドン・ダイアグノスティック・インコーポレーテッド 検出可能なシグナルのセンシタイザー誘導発生を利用したアッセイ
WO1990008187A1 (en) 1989-01-19 1990-07-26 Dana Farber Cancer Institute Soluble two domain cd2 protein
JP3472297B2 (ja) 1989-03-21 2003-12-02 ザ イミューン レスポンス コーポレイション 特定のt細胞集団の病原性応答により生じる疾患に対するワクチン接種および方法
DE69031919T3 (de) 1989-07-19 2005-01-27 Connetics Corp., Palo Alto T-zell-rezeptor-peptide als heilmittel für autoimmune und bösartige krankheiten
US6251581B1 (en) 1991-05-22 2001-06-26 Dade Behring Marburg Gmbh Assay method utilizing induced luminescence
US5279607A (en) 1991-05-30 1994-01-18 The State University Of New York Telemetry capsule and process
US5314805A (en) 1991-10-28 1994-05-24 Molecular Probes, Inc. Dual-fluorescence cell viability assay using ethidium homodimer and calcein AM
US5318557A (en) 1992-07-13 1994-06-07 Elan Medical Technologies Limited Medication administering device
WO1994004678A1 (en) 1992-08-21 1994-03-03 Casterman Cecile Immunoglobulins devoid of light chains
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
US5853697A (en) 1995-10-25 1998-12-29 The United States Of America, As Represented By The Department Of Health & Human Services Methods of treating established colitis using antibodies against IL-12
US5763602A (en) 1996-10-01 1998-06-09 Li; Ying-Syi Methods of syntheses of phthalocyanine compounds
US6171586B1 (en) 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
UA67760C2 (uk) 1997-12-11 2004-07-15 Міннесота Майнінг Енд Мануфакчурінг Компані Імідазонафтиридин та тетрагідроімідазонафтиридин, фармацевтична композиція, спосіб індукування біосинтезу цитокінів та спосіб лікування вірусної інфекції, проміжні сполуки
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
JP2002504689A (ja) 1998-02-18 2002-02-12 デイド・ベーリング・インコーポレイテッド 複数の検体の検出において使用するための化学ルミネセンス組成物
EP1108435B1 (en) 1998-08-24 2007-01-03 Chugai Seiyaku Kabushiki Kaisha Preventives or remedies for pancreatitis containing anti-il-6 receptor antibodies as the active ingredient
US6331530B1 (en) 1999-07-13 2001-12-18 The Trustees Of Columbia University In The City Of New York Hydrophilic carrier for photosensitizers that cleaves when they catalyze the formation of singlet oxygen
US6703248B1 (en) 1999-12-15 2004-03-09 Dade Behring Marburg Gmbh Particles for diagnostic and therapeutic use
GB9930000D0 (en) 1999-12-21 2000-02-09 Phaeton Research Ltd An ingestible device
US6902734B2 (en) 2000-08-07 2005-06-07 Centocor, Inc. Anti-IL-12 antibodies and compositions thereof
US20030117491A1 (en) 2001-07-26 2003-06-26 Dov Avni Apparatus and method for controlling illumination in an in-vivo imaging device
CA2475516A1 (en) 2002-03-05 2003-09-18 Aclara Biosciences, Inc. Multiplex analysis using membrane-bound sensitizers
US7797033B2 (en) 2002-04-08 2010-09-14 Smart Pill Corporation Method of using, and determining location of, an ingestible capsule
US9211259B2 (en) 2002-11-29 2015-12-15 Foamix Pharmaceuticals Ltd. Antibiotic kit and composition and uses thereof
KR20050098277A (ko) * 2003-01-29 2005-10-11 이-필 파마 리미티드 위장관 내 약물의 능동 송달
US7871607B2 (en) 2003-03-05 2011-01-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
US20060104968A1 (en) 2003-03-05 2006-05-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
US7247711B2 (en) 2003-05-09 2007-07-24 Centocor, Inc. IL-23p40 specific antibody
WO2005000101A2 (en) 2003-06-12 2005-01-06 University Of Utah Research Foundation Apparatus, systems and methods for diagnosing carpal tunnel syndrome
US7402398B2 (en) 2003-07-17 2008-07-22 Monogram Biosciences, Inc. Measuring receptor homodimerization
US20050065441A1 (en) 2003-08-29 2005-03-24 Arkady Glukhovsky System, apparatus and method for measurement of motion parameters of an in-vivo device
JP4445732B2 (ja) 2003-08-29 2010-04-07 オリンパス株式会社 被検体内導入装置および無線型被検体内情報取得システム
JP2005074031A (ja) 2003-09-01 2005-03-24 Pentax Corp カプセル内視鏡
AU2004275804A1 (en) 2003-09-23 2005-04-07 Light Sciences Oncology, Inc. Conjugates for photodynamic therapy
US8206285B2 (en) 2003-12-31 2012-06-26 Given Imaging Ltd. Apparatus, system and method to indicate in-vivo device location
EP3269738A1 (en) 2004-03-24 2018-01-17 Chugai Seiyaku Kabushiki Kaisha Subtypes of humanized antibody against interleukin-6 receptor
EP1750676B1 (en) 2004-05-20 2014-07-23 Biosensors International Group, Ltd. Ingestible device platform for the colon
JP4709836B2 (ja) 2004-05-21 2011-06-29 ギブン イメージング リミテッド 自律型体内デバイス
AR051444A1 (es) 2004-09-24 2007-01-17 Centocor Inc Proteinas derivadas de inmunoglobulina especifica de il-23p40, composiciones, epitopos, metodos y usos
JO3000B1 (ar) 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
CN101107038A (zh) * 2005-01-18 2008-01-16 皇家飞利浦电子股份有限公司 电控胶囊
US20080121825A1 (en) * 2005-01-18 2008-05-29 Koninklijke Philips Electronics, N.V. Electronically Controlled Capsule For Releasing Radiation
PL2390267T3 (pl) 2005-06-07 2013-09-30 Esbatech A Novartis Co Llc Stabilne i rozpuszczalne przeciwciała hamujące TNF(alfa)
TR201902033T4 (tr) 2005-06-30 2019-03-21 Janssen Biotech Inc Anti-IL-23 antikorları, bileşimleri, yöntemleri ve kullanımları.
US20070027362A1 (en) 2005-07-27 2007-02-01 Olympus Medical Systems Corp. Infrared observation system
US7612181B2 (en) 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
KR20130108481A (ko) 2005-08-19 2013-10-02 아보트 러보러터리즈 이원 가변 도메인 면역글로불린 및 이의 용도
JP2009541298A (ja) * 2006-06-20 2009-11-26 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 胃腸障害を処置するための電子カプセル
RU2009106062A (ru) * 2006-06-23 2010-08-27 Конинклейке Филипс Электроникс, Н.В. (Nl) Система доставки медикамента
US8615284B2 (en) 2006-09-06 2013-12-24 Innurvation, Inc. Method for acoustic information exchange involving an ingestible low power capsule
CN101534711B (zh) 2006-10-31 2012-11-14 皇家飞利浦电子股份有限公司 用于在胃肠道中释放药物的可吞吃的多喷嘴给药设备的设计
WO2008104968A1 (en) * 2007-02-26 2008-09-04 Duocure, Inc. Spray administration of compositions including active agents such as peptides to the gastrointestinal tract
NZ579297A (en) * 2007-02-28 2012-03-30 Schering Corp Combination therapy comprising an il-23 antagonist and a cytokine antagonist for treatment of immune disorders
ES2524345T3 (es) * 2007-04-04 2014-12-05 Sigmoid Pharma Limited Composición farmacéutica oral
JP4932588B2 (ja) 2007-05-08 2012-05-16 オリンパス株式会社 画像処理装置および画像処理プログラム
US7842144B1 (en) 2007-06-01 2010-11-30 The United States Of America As Represented By The Secretary Of The Navy Methods of making double base casting powder
AU2008304756B8 (en) 2007-09-26 2015-02-12 Chugai Seiyaku Kabushiki Kaisha Anti-IL-6 receptor antibody
RU2490025C2 (ru) 2007-10-02 2013-08-20 Чугаи Сейяку Кабусики Кайся Терапевтические средства, используемые против реакции трансплантат против хозяина, содержащие в качестве активного ингредиента ингибитор рецептора интерлейкина-6
WO2009046168A1 (en) 2007-10-02 2009-04-09 Avaxia Biologics, Inc. Antibody therapy for use in the digestive tract
EP2254464B1 (en) 2008-02-18 2017-01-04 Medimetrics Personalized Drug Delivery B.V. Administration of drugs to a patient
US8034344B2 (en) 2008-05-13 2011-10-11 Novimmune S.A. Anti-IL-6/IL-6R antibodies and methods of use thereof
CN102124344B (zh) * 2008-05-16 2015-04-01 霍夫曼-拉罗奇有限公司 生物标记用于评估β7整联蛋白拮抗剂治疗胃肠道炎性病症的用途
TWI440469B (zh) 2008-09-26 2014-06-11 Chugai Pharmaceutical Co Ltd Improved antibody molecules
KR100931946B1 (ko) 2009-06-10 2009-12-15 주식회사 인트로메딕 캡슐 내시경에 의해 촬영된 이미지 데이터를 저장하고 있는 서버로부터 관심있는 데이터를 우선하여 단말기에 수신하여 확인할 수 있도록 하는 서버-클라이언트 시스템의 이미지 데이터 전송 프로세싱 방법
WO2011004395A1 (en) 2009-07-06 2011-01-13 Intas Biopharmaceuticals Limited Microemulsion formulation for biologicals
EP2461746A1 (en) 2009-08-05 2012-06-13 Tel HaShomer Medical Research Infrastructure and Services Ltd. Methods and devices for providing information useful in the diagnosis of abnormalities of the gastrointestinal tract
US9026192B2 (en) 2009-11-24 2015-05-05 Given Imaging Ltd Device and method for in vivo imaging
EP2571573A4 (en) * 2010-03-17 2013-12-04 Photopill Medical Ltd PHOTOTHERAPY BY CAPSULE
DE112012000404T5 (de) 2011-01-04 2014-04-17 Charitè Universitätsmedizin Berlin Modulatoren von IL-12 und/oder IL-23 zur Prävention oder Behandlung des Morbus Alzheimer
CA2821926A1 (en) 2011-01-07 2012-07-12 Abbvie Inc. Anti-il-12/il-23 antibodies and uses thereof
BR112013021863A2 (pt) 2011-03-03 2016-11-22 Apexigen Inc anticorpos anti-receptor il-6 e métodos de uso
EP2623017B1 (en) 2011-04-01 2017-11-08 Olympus Corporation Receiving device and capsule endoscope system
WO2012158648A1 (en) 2011-05-13 2012-11-22 Massachusetts Institute Of Technology Method and apparatus for delivering a substance
US8907081B2 (en) 2011-05-27 2014-12-09 Sharp Laboratories Of America, Inc. Long wavelength absorbing porphyrin photosensitizers for dye-sensitized solar cells
AU2012346861A1 (en) 2011-11-30 2014-06-19 AbbVie Deutschland GmbH & Co. KG Methods and compositions for determining responsiveness to treatment with a tnf-alpha inhibitor
US9795330B2 (en) 2011-12-15 2017-10-24 Given Imaging Ltd. Device, system and method for in-vivo detection of bleeding in the gastrointestinal tract
CN104271028B (zh) 2011-12-15 2017-11-17 基文影像公司 确定患者的胃肠道随时间的出血曲线的类型的系统
WO2013087912A1 (en) 2011-12-16 2013-06-20 Synthon Biopharmaceuticals B.V. Compounds and methods for treating inflammatory diseases
WO2013113326A1 (en) 2012-01-31 2013-08-08 Curevac Gmbh Pharmaceutical composition comprising a polymeric carrier cargo complex and at least one protein or peptide antigen
FR2986432B1 (fr) 2012-02-06 2014-03-14 Univ Lille Ii Droit & Sante Proteines 28kda gst provenant de schistosomes pour leur utilisation dans le traitement des maladies inflammatoires auto-immunes engendrant une reponse de type th1 et/ou th17
WO2013120184A1 (en) 2012-02-17 2013-08-22 Micropharma Limited Ingestible medical device
US9487590B2 (en) 2012-09-25 2016-11-08 Cytomx Therapeutics, Inc. Activatable antibodies that bind interleukin-6 receptor and methods of use thereof
RU2015155590A (ru) 2013-05-24 2017-06-29 Нестек С.А. Путеспецифичные маркеры для диагностики синдрома раздраженного кишечника
US9324145B1 (en) 2013-08-08 2016-04-26 Given Imaging Ltd. System and method for detection of transitions in an image stream of the gastrointestinal tract
EP3049145B1 (en) * 2013-09-26 2020-06-17 Progenity, Inc. Delivery capsule with threshold release
WO2015099749A1 (en) 2013-12-27 2015-07-02 Capso Vision Inc. Capsule camera device with multi-spectral light sources
EP3089994B1 (en) 2013-12-30 2022-05-04 Epimab Biotherapeutics, Inc. Fabs-in-tandem immunoglobulin and uses thereof
WO2015112575A1 (en) 2014-01-22 2015-07-30 The Board Of Regents Of The University Of Nebraska Gastrointestinal sensor implantation system
WO2015183886A1 (en) 2014-05-30 2015-12-03 Schaeffler Technologies Gmbh & Co. Kg Torque converter including spherical clutch
JP6648120B2 (ja) * 2014-09-25 2020-02-14 プロジェニティ, インコーポレイテッド 局所化能力を有する電気機械丸薬デバイス
US9714288B2 (en) 2014-09-30 2017-07-25 The Regents Of The University Of California Antisense compounds and uses thereof
CN104473611B (zh) 2015-01-19 2018-01-30 吉林大学 具有超声波定位功能的胶囊内窥镜系统
US10064544B2 (en) 2015-01-26 2018-09-04 The Chinese University Of Hong Kong Endoscopic capsule and endoscopic system
KR102622281B1 (ko) 2015-03-31 2024-01-08 소리소 파마슈티컬스 인크. 폴리펩티드
US10773063B2 (en) 2015-05-31 2020-09-15 Check-Cap Ltd Drug delivery capsule
JP2017012395A (ja) 2015-06-30 2017-01-19 富士フイルム株式会社 内視鏡システム及び内視鏡システムの作動方法
CA3034267A1 (en) 2016-08-18 2018-02-22 Mitchell Lawrence Jones Systems for obtaining samples using ingestible devices
EP3509469A1 (en) 2016-09-09 2019-07-17 Progenity, Inc. Electromechanical ingestible device for delivery of a dispensable substance
CA3036334A1 (en) 2016-09-09 2018-03-15 Mitchell Lawrence Jones Systems and methods for extracting a sample from an ingestible device
US10610104B2 (en) 2016-12-07 2020-04-07 Progenity, Inc. Gastrointestinal tract detection methods, devices and systems
CA3047241A1 (en) 2016-12-14 2018-06-21 Progenity, Inc. Ingestible device recovery system
US20180168489A1 (en) 2016-12-15 2018-06-21 Progenity Inc. Ingestible Device and Associated Methods
DK3600009T3 (da) 2017-03-31 2021-01-18 Progenity Inc Indretning, der kan indtages, med lokaliseringsegenskaber

Also Published As

Publication number Publication date
CN110072551B (zh) 2023-05-23
US20200262908A1 (en) 2020-08-20
AU2017376807A1 (en) 2019-06-13
EP3554540C0 (en) 2023-08-02
CA3045475A1 (en) 2018-06-21
CN117045784A (zh) 2023-11-14
EP3554540B1 (en) 2023-08-02
WO2018112232A1 (en) 2018-06-21
JP2023071838A (ja) 2023-05-23
US11597762B2 (en) 2023-03-07
BR112019011702A2 (pt) 2019-10-22
JP7237834B2 (ja) 2023-03-13
JP2020501699A (ja) 2020-01-23
KR20190095931A (ko) 2019-08-16
CN110072551A (zh) 2019-07-30
EP3554540A1 (en) 2019-10-23

Similar Documents

Publication Publication Date Title
MX2019006823A (es) Tratamiento de una enfermedad del tracto gastrointestinal con inhibidor de interleucina-12/interleucina-23 (il-12/il-23) liberado usando un dispositivo ingerible.
MX2019006867A (es) Tratamiento de una enfermedad del tracto gastrointestinal con un inhibidor de integrina.
MX2019006864A (es) Tratamiento de una enfermedad del tracto gastrointestinal con un inhibidor de factor de necrosis tumoral (tnf).
CY1122143T1 (el) Φαρμακευτικοι συνδυασμοι που περιλαμβανουν εναν αναστολεα της b-raf, εναν αναστολεα του egfr και προαιρετικα εναν αναστολεα της ρι3κ-αλφα
MX2019006821A (es) Tratamiento de una enfermedad del tracto gastrointestinal con un inhibidor de cinasa de janus (jak) y dispositivos.
MX2017015574A (es) Inhibidores de tirosina quinasa de bruton.
WO2017091749A8 (en) Shape changing drug delivery devices and methods
TW201613919A (en) Inhibitors of Bruton's tyrosine kinase
PH12019500061A1 (en) Oral gastroretentive formulations and uses thereof
PH12018502738A1 (en) Compositions, devices, and methods for the treatment of alcohol use disorder
CY1119532T1 (el) (s)-πιρλινδολη και τα φαρμακευτικως αποδεκτα αλατα αυτης για χρηση στην ιατρικη
PH12018500254A1 (en) Combinations of an ox40 antibody and a tlr4 modulator and uses thereof
CY1119522T1 (el) (r)- πιρλινδολη και τα φαρμακευτικως αποδεκτα αλατα αυτης για χρηση στην ιατρικη
MX2019005309A (es) Anticuerpos anti-bag3 en combinacion con inhibidores del punto de control inmunitario para uso terapeutico.
EP3844168A4 (en) COMBINATION DRUG PREPARATIONS FOR THE TREATMENT OF PATIENTS WITH CARDIOVASCULAR DISEASE AND ASSOCIATED CONDITIONS
CL2016003271A1 (es) Métodos para tratar infecciones
TW201613926A (en) Inhibitors of bruton's tyrosine kinase
IL271592A (en) The compounds that combine an anti-inflammatory drug and the action of Dicer for the treatment of neurological diseases.
UA104615U (uk) Спосіб лікування токсокарозу
UA111998U (uk) Застосування декаметоксину як фармацевтично активної речовини для лікування захворювань шлунково-кишкового тракту та кишкових інфекцій перорально
EA201692163A1 (ru) Лекарственное средство для лечения пациентов с тиннитусом
TH168817A (th) อนุพันธ์อินโดลิซีนซึ่งเป็นสารยับยั้งฟอสโฟอิโนซิไทด์ 3-ไคเนส
UA91788U (uk) Спосіб інтра- та післяопераційного введення гепатопротекторів при вогнищевих ураженнях печінки
UA101950U (uk) Фармацевтична композиція для лікування і профілактики застуди
CN302310390S (zh) 高电位治疗仪