CA3043888A1 - Tgf.beta. signal convertor - Google Patents

Tgf.beta. signal convertor Download PDF

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Publication number
CA3043888A1
CA3043888A1 CA3043888A CA3043888A CA3043888A1 CA 3043888 A1 CA3043888 A1 CA 3043888A1 CA 3043888 A CA3043888 A CA 3043888A CA 3043888 A CA3043888 A CA 3043888A CA 3043888 A1 CA3043888 A1 CA 3043888A1
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CA
Canada
Prior art keywords
polypeptide
domain
beta
intracellular signaling
tgf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3043888A
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English (en)
French (fr)
Inventor
Benjamin BOYERINAS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
2Seventy Bio Inc
Original Assignee
Bluebird Bio Inc
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Filing date
Publication date
Application filed by Bluebird Bio Inc filed Critical Bluebird Bio Inc
Publication of CA3043888A1 publication Critical patent/CA3043888A1/en
Pending legal-status Critical Current

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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
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    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
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    • C07—ORGANIC CHEMISTRY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • A—HUMAN NECESSITIES
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    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
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    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
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  • Hematology (AREA)
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  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
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CA3043888A 2016-11-17 2017-11-17 Tgf.beta. signal convertor Pending CA3043888A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662423565P 2016-11-17 2016-11-17
US62/423,565 2016-11-17
US201762467496P 2017-03-06 2017-03-06
US62/467,496 2017-03-06
PCT/US2017/062358 WO2018094244A1 (en) 2016-11-17 2017-11-17 TGFβ SIGNAL CONVERTOR

Publications (1)

Publication Number Publication Date
CA3043888A1 true CA3043888A1 (en) 2018-05-24

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ID=62145775

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3043888A Pending CA3043888A1 (en) 2016-11-17 2017-11-17 Tgf.beta. signal convertor

Country Status (14)

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US (3) US11654158B2 (enExample)
EP (2) EP4353822A3 (enExample)
JP (3) JP7263235B2 (enExample)
KR (2) KR102653324B1 (enExample)
CN (2) CN110072885B (enExample)
AU (3) AU2017362484B2 (enExample)
BR (1) BR112019009904A2 (enExample)
CA (1) CA3043888A1 (enExample)
DK (1) DK3541833T5 (enExample)
ES (1) ES2977435T3 (enExample)
IL (2) IL266628B2 (enExample)
MA (1) MA46862A (enExample)
MX (2) MX2019005724A (enExample)
WO (1) WO2018094244A1 (enExample)

Cited By (1)

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CN112194728A (zh) * 2020-09-22 2021-01-08 沣潮医药科技（上海）有限公司 用于内毒素清除的嵌合抗原受体及其应用

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US9725710B2 (en) 2014-01-08 2017-08-08 Flodesign Sonics, Inc. Acoustophoresis device with dual acoustophoretic chamber
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
CN108137669B (zh) * 2015-05-18 2023-02-17 优瑞科生物技术公司 抗ror1嵌合抗原受体
US11474085B2 (en) 2015-07-28 2022-10-18 Flodesign Sonics, Inc. Expanded bed affinity selection
US11459540B2 (en) 2015-07-28 2022-10-04 Flodesign Sonics, Inc. Expanded bed affinity selection
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
US11085035B2 (en) 2016-05-03 2021-08-10 Flodesign Sonics, Inc. Therapeutic cell washing, concentration, and separation utilizing acoustophoresis
BR112019009904A2 (pt) 2016-11-17 2019-08-13 Bluebird Bio, Inc. conversor de sinal de tgfss
WO2018191490A1 (en) * 2017-04-13 2018-10-18 The Trustees Of The University Of Pennsylvania Use of gene editing to generate universal tcr re-directed t cells for adoptive immunotherapy
KR20200110326A (ko) * 2017-12-14 2020-09-23 블루버드 바이오, 인코포레이티드. Daric 인터류킨 수용체
KR20220066413A (ko) 2017-12-14 2022-05-24 프로디자인 소닉스, 인크. 음향 트랜스듀서 구동기 및 제어기
AR114273A1 (es) 2018-03-02 2020-08-12 Allogene Therapeutics Inc Receptores inducibles de citoquina quimérica
CN110615843B (zh) * 2018-06-20 2023-05-09 上海隆耀生物科技有限公司 一种包含第三信号受体的嵌合抗原受体及其应用
CN113272318A (zh) * 2018-09-05 2021-08-17 孔锡卿 用于实体癌的嵌合抗原受体和表达嵌合抗原受体的t细胞
PH12021551861A1 (en) 2019-03-01 2022-05-30 Allogene Therapeutics Inc Constitutively active chimeric cytokine receptors
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