CA3041540C - Magnetic lysis method and device - Google Patents
Magnetic lysis method and device Download PDFInfo
- Publication number
- CA3041540C CA3041540C CA3041540A CA3041540A CA3041540C CA 3041540 C CA3041540 C CA 3041540C CA 3041540 A CA3041540 A CA 3041540A CA 3041540 A CA3041540 A CA 3041540A CA 3041540 C CA3041540 C CA 3041540C
- Authority
- CA
- Canada
- Prior art keywords
- axis
- beads
- cells
- magnet
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/06—Lysis of microorganisms
- C12N1/066—Lysis of microorganisms by physical processes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M1/00—Apparatus for enzymology or microbiology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Sustainable Development (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27239609P | 2009-09-21 | 2009-09-21 | |
| US61/272,396 | 2009-09-21 | ||
| CA2811872A CA2811872C (en) | 2009-09-21 | 2010-09-20 | Magnetic lysis method and device |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2811872A Division CA2811872C (en) | 2009-09-21 | 2010-09-20 | Magnetic lysis method and device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA3041540A1 CA3041540A1 (en) | 2011-03-24 |
| CA3041540C true CA3041540C (en) | 2021-08-24 |
Family
ID=43756937
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3041540A Active CA3041540C (en) | 2009-09-21 | 2010-09-20 | Magnetic lysis method and device |
| CA2811872A Active CA2811872C (en) | 2009-09-21 | 2010-09-20 | Magnetic lysis method and device |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2811872A Active CA2811872C (en) | 2009-09-21 | 2010-09-20 | Magnetic lysis method and device |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US8399190B2 (enExample) |
| EP (2) | EP3067112B1 (enExample) |
| JP (1) | JP2013505018A (enExample) |
| CN (2) | CN105969761B (enExample) |
| CA (2) | CA3041540C (enExample) |
| ES (1) | ES2709123T3 (enExample) |
| IN (1) | IN2012DN03431A (enExample) |
| WO (1) | WO2011034621A2 (enExample) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006032044A2 (en) | 2004-09-15 | 2006-03-23 | Microchip Biotechnologies, Inc. | Microfluidic devices |
| JP5063616B2 (ja) | 2006-02-03 | 2012-10-31 | インテジェニックス インコーポレイテッド | マイクロ流体デバイス |
| KR20100028526A (ko) | 2007-02-05 | 2010-03-12 | 마이크로칩 바이오테크놀로지스, 인크. | 마이크로유체 및 나노유체 장치, 시스템 및 응용 |
| US10125388B2 (en) | 2007-10-31 | 2018-11-13 | Akonni Biosystems, Inc. | Integrated sample processing system |
| EP2234916A4 (en) | 2008-01-22 | 2016-08-10 | Integenx Inc | UNIVERSAL SPECIMEN PREPARATION SYSTEM AND ITS USE IN AN INTEGRATED ANALYSIS SYSTEM |
| US9492797B2 (en) | 2008-09-23 | 2016-11-15 | Bio-Rad Laboratories, Inc. | System for detection of spaced droplets |
| US8709762B2 (en) | 2010-03-02 | 2014-04-29 | Bio-Rad Laboratories, Inc. | System for hot-start amplification via a multiple emulsion |
| US8633015B2 (en) * | 2008-09-23 | 2014-01-21 | Bio-Rad Laboratories, Inc. | Flow-based thermocycling system with thermoelectric cooler |
| US12090480B2 (en) | 2008-09-23 | 2024-09-17 | Bio-Rad Laboratories, Inc. | Partition-based method of analysis |
| GB2502409B8 (en) | 2008-09-23 | 2014-10-15 | Bio Rad Laboratories | Droplet-based assay system |
| US9598725B2 (en) | 2010-03-02 | 2017-03-21 | Bio-Rad Laboratories, Inc. | Emulsion chemistry for encapsulated droplets |
| US11130128B2 (en) | 2008-09-23 | 2021-09-28 | Bio-Rad Laboratories, Inc. | Detection method for a target nucleic acid |
| US9764322B2 (en) | 2008-09-23 | 2017-09-19 | Bio-Rad Laboratories, Inc. | System for generating droplets with pressure monitoring |
| US9156010B2 (en) | 2008-09-23 | 2015-10-13 | Bio-Rad Laboratories, Inc. | Droplet-based assay system |
| WO2011120020A1 (en) | 2010-03-25 | 2011-09-29 | Quantalife, Inc. | Droplet transport system for detection |
| US9417190B2 (en) | 2008-09-23 | 2016-08-16 | Bio-Rad Laboratories, Inc. | Calibrations and controls for droplet-based assays |
| US9089844B2 (en) | 2010-11-01 | 2015-07-28 | Bio-Rad Laboratories, Inc. | System for forming emulsions |
| US12162008B2 (en) | 2008-09-23 | 2024-12-10 | Bio-Rad Laboratories, Inc. | Partition-based method of analysis |
| US10512910B2 (en) | 2008-09-23 | 2019-12-24 | Bio-Rad Laboratories, Inc. | Droplet-based analysis method |
| US8951939B2 (en) | 2011-07-12 | 2015-02-10 | Bio-Rad Laboratories, Inc. | Digital assays with multiplexed detection of two or more targets in the same optical channel |
| US8663920B2 (en) | 2011-07-29 | 2014-03-04 | Bio-Rad Laboratories, Inc. | Library characterization by digital assay |
| US9132394B2 (en) | 2008-09-23 | 2015-09-15 | Bio-Rad Laboratories, Inc. | System for detection of spaced droplets |
| US9399215B2 (en) | 2012-04-13 | 2016-07-26 | Bio-Rad Laboratories, Inc. | Sample holder with a well having a wicking promoter |
| KR20110111449A (ko) | 2008-12-31 | 2011-10-11 | 인터젠엑스 인크. | 미세유체 칩을 갖는 기구 |
| US8388908B2 (en) | 2009-06-02 | 2013-03-05 | Integenx Inc. | Fluidic devices with diaphragm valves |
| RU2559541C2 (ru) | 2009-06-05 | 2015-08-10 | Интедженкс Инк. | Универсальная система подготовки образцов и применение в интегрированной системе анализа |
| CA2767056C (en) | 2009-09-02 | 2018-12-04 | Bio-Rad Laboratories, Inc. | System for mixing fluids by coalescence of multiple emulsions |
| CA3041540C (en) * | 2009-09-21 | 2021-08-24 | Bio-Rad Laboratories, Inc. | Magnetic lysis method and device |
| US8584703B2 (en) | 2009-12-01 | 2013-11-19 | Integenx Inc. | Device with diaphragm valve |
| JP2013524171A (ja) | 2010-03-25 | 2013-06-17 | クァンタライフ・インコーポレーテッド | 液滴ベースのアッセイのための液滴の発生 |
| JP2013524169A (ja) | 2010-03-25 | 2013-06-17 | クァンタライフ・インコーポレーテッド | 液滴によるアッセイ用の検出システム |
| US8512538B2 (en) | 2010-05-28 | 2013-08-20 | Integenx Inc. | Capillary electrophoresis device |
| US8763642B2 (en) | 2010-08-20 | 2014-07-01 | Integenx Inc. | Microfluidic devices with mechanically-sealed diaphragm valves |
| WO2012024658A2 (en) | 2010-08-20 | 2012-02-23 | IntegenX, Inc. | Integrated analysis system |
| US12097495B2 (en) | 2011-02-18 | 2024-09-24 | Bio-Rad Laboratories, Inc. | Methods and compositions for detecting genetic material |
| US9150826B2 (en) * | 2011-03-14 | 2015-10-06 | Zymo Research Corporation | Portable sample disruptor apparatus, kits, and methods |
| CA2830443C (en) | 2011-03-18 | 2021-11-16 | Bio-Rad Laboratories, Inc. | Multiplexed digital assays with combinatorial use of signals |
| EP2697648B1 (en) | 2011-04-13 | 2018-08-22 | Akonni Biosystems, Inc. | Microarray based sample detection system |
| JP2014512826A (ja) | 2011-04-25 | 2014-05-29 | バイオ−ラド ラボラトリーズ インコーポレイテッド | 核酸分析のための方法および組成物 |
| EP2760578B1 (en) | 2011-09-28 | 2020-08-26 | President and Fellows of Harvard College | Systems and methods for droplet production and/or fluidic manipulation |
| KR101548124B1 (ko) * | 2011-10-04 | 2015-08-31 | (주) 메디컬그룹베스티안 | 피부결함의 완화 또는 치료를 위한 세포처리 및 적용 시스템 |
| US10865440B2 (en) | 2011-10-21 | 2020-12-15 | IntegenX, Inc. | Sample preparation, processing and analysis systems |
| US20150136604A1 (en) | 2011-10-21 | 2015-05-21 | Integenx Inc. | Sample preparation, processing and analysis systems |
| US9707528B2 (en) | 2012-02-22 | 2017-07-18 | T2 Biosystems, Inc. | Containers for agitation of liquid samples and methods of use thereof |
| US9333471B2 (en) | 2012-04-11 | 2016-05-10 | STAT—Diagnostica & Innovation, S.L. | Fluidically integrated magnetic bead beater |
| US9304066B2 (en) | 2012-04-11 | 2016-04-05 | Stat-Diagnostica & Innovation S.L. | Fluidically integrated rotary bead beader |
| WO2014047523A2 (en) | 2012-09-21 | 2014-03-27 | California Institute Of Technology | Methods and devices for sample lysis |
| CN105050720A (zh) | 2013-01-22 | 2015-11-11 | 华盛顿大学商业化中心 | 顺序递送流体体积和相关的设备、系统和方法 |
| CN105873681B (zh) | 2013-11-18 | 2019-10-11 | 尹特根埃克斯有限公司 | 用于样本分析的卡盒和仪器 |
| US20150203806A1 (en) * | 2014-01-21 | 2015-07-23 | Uw Center For Commercialization | Systems for disrupting biological samples and associated devices and methods |
| WO2015128725A1 (en) * | 2014-02-28 | 2015-09-03 | Dh Technologies Development Pte. Ltd. | Magnetic elements for processing fluids |
| US10208332B2 (en) | 2014-05-21 | 2019-02-19 | Integenx Inc. | Fluidic cartridge with valve mechanism |
| EP3549675A1 (en) | 2014-06-19 | 2019-10-09 | Akonni Biosystems, Inc. | Molecular analysis system and use thereof |
| EP3209410B1 (en) | 2014-10-22 | 2024-12-25 | IntegenX Inc. | Electrophoresis cartridge and corresponding method for sample preparation, processing and analysis |
| JP6642448B2 (ja) * | 2014-11-18 | 2020-02-05 | 富士フイルム和光純薬株式会社 | 検体の破砕装置およびその方法 |
| CA3007019A1 (en) * | 2015-12-01 | 2017-06-08 | Akonni Biosystems, Inc. | Integrated sample processing system |
| EP3199629A1 (en) | 2016-01-30 | 2017-08-02 | Safeguard Biosystems Holdings Ltd. | Bead beating tube and method for extracting deoxyribonucleic acid and/or ribonucleic acid from microorganisms |
| CN109154542A (zh) * | 2016-03-17 | 2019-01-04 | Sk电信有限公社 | 生物样品预处理设备 |
| BR112019015034A2 (pt) * | 2017-01-30 | 2020-03-10 | Safeguard Biosystems Holdings Ltd. | Tubo de batimento de microesfera e método para extração de ácido desoxirribonucleico e/ou ácido ribonucleico a partir de micro-organismos |
| EP3573756A1 (en) * | 2017-01-30 | 2019-12-04 | Safeguard Biosystems Holdings Ltd. | Bead beating tube and method for extracting deoxyribonucleic acid and/or ribonucleic acid from microorganisms |
| US20190017013A1 (en) * | 2017-07-14 | 2019-01-17 | Mbio Diagnostics, Inc. | Mechanical lysis apparatus and method |
| US10610843B2 (en) | 2017-11-28 | 2020-04-07 | Talis Biomedical Corporation | Magnetic mixing apparatus |
| GB2574046B (en) * | 2018-05-24 | 2022-12-07 | Oxford Nanopore Tech Plc | Improved Container |
| US10820847B1 (en) | 2019-08-15 | 2020-11-03 | Talis Biomedical Corporation | Diagnostic system |
| EP3910052A1 (en) * | 2020-05-13 | 2021-11-17 | PreOmics GmbH | Magnetic cleavage of compounds |
| EP3910341A1 (en) * | 2020-05-13 | 2021-11-17 | PreOmics GmbH | Sample preparation for mass spectrometry |
| CN111394223A (zh) * | 2020-05-18 | 2020-07-10 | 中国人民解放军军事科学院军事医学研究院 | 便携式全自动液氮研磨装置 |
| DE102020209001B4 (de) * | 2020-07-17 | 2024-04-18 | Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. | Lyse einer Probe mittels Magnetelementen und rotatorischer Relativbewegung |
| US11788450B2 (en) * | 2020-10-30 | 2023-10-17 | Johnson Matthey Public Limited Company | TWC catalysts for gasoline engine exhaust gas treatments |
| JP2024508432A (ja) * | 2021-02-22 | 2024-02-27 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 磁気剪断バイオリアクタ装置および方法 |
| CN115717104A (zh) * | 2021-08-27 | 2023-02-28 | 基蛋生物科技股份有限公司 | 一种试剂盒检测装置 |
| USD1140078S1 (en) | 2022-09-02 | 2026-08-04 | Becton, Dickinson And Company | Test device |
| USD1069156S1 (en) | 2023-04-10 | 2025-04-01 | Becton, Dickinson And Company | Dispensing device |
| WO2024243614A1 (en) * | 2023-05-26 | 2024-12-05 | NGB Innovation Pty Ltd | Diagnostic system and method |
| WO2026043913A1 (en) * | 2024-08-20 | 2026-02-26 | Gen-Probe Incorporated | On-board lysis, internal control, and volumetric expansion in a fluidic cartridge |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2350534A (en) | 1942-10-05 | 1944-06-06 | Rosinger Arthur | Magnetic stirrer |
| US2774803A (en) | 1952-09-20 | 1956-12-18 | Asea Ab | Inductive stirring device for metallurgical furnace |
| US3384353A (en) | 1967-05-31 | 1968-05-21 | Cole Parmer Instr & Equipment | Magnetic stirrer |
| SE397637B (sv) * | 1976-03-09 | 1977-11-14 | Wik G | Magnetomrorare |
| US4227815A (en) * | 1979-07-06 | 1980-10-14 | Beckman Instruments, Inc. | Magnetic stirrer for sample container of photometric analyzer |
| US5536475A (en) | 1988-10-11 | 1996-07-16 | Baxter International Inc. | Apparatus for magnetic cell separation |
| US4911555A (en) * | 1989-05-04 | 1990-03-27 | The Jackson Laboratory | Magnetic stirrer for multiple samples |
| ES2177093T3 (es) * | 1997-12-06 | 2002-12-01 | Dna Res Innovations Ltd | Aislamiento de acidos nucleicos. |
| FR2781500B1 (fr) * | 1998-07-23 | 2000-09-08 | Bio Merieux | Dispositif perfectionne et procede de lyse de micro-organismes |
| US6176609B1 (en) * | 1998-10-13 | 2001-01-23 | V & P Scientific, Inc. | Magnetic tumble stirring method, devices and machines for mixing in vessels |
| US6357907B1 (en) * | 1999-06-15 | 2002-03-19 | V & P Scientific, Inc. | Magnetic levitation stirring devices and machines for mixing in vessels |
| US7375125B2 (en) * | 1999-08-04 | 2008-05-20 | Ore Pharmaceuticals, Inc. | Melanocortin-4 receptor binding compounds and methods of use thereof |
| US20030203491A1 (en) * | 2002-04-26 | 2003-10-30 | Andrevski Zygmunt M. | Gravitational flow purification system |
| MY146476A (en) * | 2004-06-24 | 2012-08-15 | Boehringer Ingelheim Vetmed | Method of diagnosing lawsonia intracellularis |
| EP1650297B1 (en) * | 2004-10-19 | 2011-04-13 | Samsung Electronics Co., Ltd. | Method and apparatus for the rapid disruption of cells or viruses using micro magnetic beads and laser |
| US20070125942A1 (en) | 2005-07-06 | 2007-06-07 | The Regents Of The University Of California | Apparatuses, systems and methods for isolating and separating biological materials |
| US20070247968A1 (en) * | 2006-04-21 | 2007-10-25 | V & P Scientific, Inc. | Sandwich magnetic stir elements for stirring the contents of vessels |
| CN101466460A (zh) | 2006-07-14 | 2009-06-24 | 西格玛-奥尔德利希公司 | 磁力搅拌器 |
| US20080063628A1 (en) * | 2006-09-11 | 2008-03-13 | Davis Janet E | Methods to promote cell differentiation |
| EP2083069A1 (de) | 2008-01-24 | 2009-07-29 | Qiagen GmbH | Verfahren und Vorrichtung für das Aufschließen von biologischen Zellen |
| CA3041540C (en) * | 2009-09-21 | 2021-08-24 | Bio-Rad Laboratories, Inc. | Magnetic lysis method and device |
-
2010
- 2010-09-20 CA CA3041540A patent/CA3041540C/en active Active
- 2010-09-20 EP EP16166269.7A patent/EP3067112B1/en not_active Not-in-force
- 2010-09-20 ES ES16166269T patent/ES2709123T3/es active Active
- 2010-09-20 CN CN201510589994.XA patent/CN105969761B/zh not_active Expired - Fee Related
- 2010-09-20 WO PCT/US2010/002569 patent/WO2011034621A2/en not_active Ceased
- 2010-09-20 EP EP10817590.2A patent/EP2480324A4/en not_active Ceased
- 2010-09-20 CN CN201080042060.XA patent/CN102686306B/zh not_active Expired - Fee Related
- 2010-09-20 CA CA2811872A patent/CA2811872C/en active Active
- 2010-09-20 US US12/886,144 patent/US8399190B2/en not_active Expired - Fee Related
- 2010-09-20 JP JP2012529754A patent/JP2013505018A/ja active Pending
- 2010-09-20 IN IN3431DEN2012 patent/IN2012DN03431A/en unknown
-
2013
- 2013-02-12 US US13/765,399 patent/US9217174B2/en active Active
-
2015
- 2015-12-22 US US14/978,562 patent/US10138458B2/en active Active
-
2018
- 2018-09-24 US US16/140,171 patent/US11118156B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN102686306B (zh) | 2015-11-25 |
| CA2811872C (en) | 2019-06-18 |
| US8399190B2 (en) | 2013-03-19 |
| US20190024039A1 (en) | 2019-01-24 |
| EP2480324A2 (en) | 2012-08-01 |
| CN102686306A (zh) | 2012-09-19 |
| US20160215255A1 (en) | 2016-07-28 |
| CN105969761A (zh) | 2016-09-28 |
| US10138458B2 (en) | 2018-11-27 |
| CN105969761B (zh) | 2020-04-07 |
| JP2013505018A (ja) | 2013-02-14 |
| US20120003654A2 (en) | 2012-01-05 |
| US20110070589A1 (en) | 2011-03-24 |
| CA2811872A1 (en) | 2011-03-24 |
| WO2011034621A3 (en) | 2011-11-24 |
| US20130157274A1 (en) | 2013-06-20 |
| WO2011034621A2 (en) | 2011-03-24 |
| US9217174B2 (en) | 2015-12-22 |
| US11118156B2 (en) | 2021-09-14 |
| IN2012DN03431A (enExample) | 2015-10-23 |
| ES2709123T3 (es) | 2019-04-15 |
| EP3067112A1 (en) | 2016-09-14 |
| EP2480324A4 (en) | 2013-10-02 |
| EP3067112B1 (en) | 2018-12-26 |
| CA3041540A1 (en) | 2011-03-24 |
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