CA3039177A1 - Antibodies with improved stability to intestinal digestion - Google Patents
Antibodies with improved stability to intestinal digestion Download PDFInfo
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- CA3039177A1 CA3039177A1 CA3039177A CA3039177A CA3039177A1 CA 3039177 A1 CA3039177 A1 CA 3039177A1 CA 3039177 A CA3039177 A CA 3039177A CA 3039177 A CA3039177 A CA 3039177A CA 3039177 A1 CA3039177 A1 CA 3039177A1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Endocrinology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562237270P | 2015-10-05 | 2015-10-05 | |
| US62/237,270 | 2015-10-05 | ||
| PCT/US2016/054304 WO2017062253A2 (en) | 2015-10-05 | 2016-09-29 | Antibodies with improved stability to intestinal digestion |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3039177A1 true CA3039177A1 (en) | 2017-04-13 |
Family
ID=58488349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3039177A Pending CA3039177A1 (en) | 2015-10-05 | 2016-09-29 | Antibodies with improved stability to intestinal digestion |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11891440B2 (OSRAM) |
| EP (1) | EP3359190A4 (OSRAM) |
| JP (2) | JP7235287B2 (OSRAM) |
| AU (2) | AU2016335912B2 (OSRAM) |
| BR (1) | BR112018006953A2 (OSRAM) |
| CA (1) | CA3039177A1 (OSRAM) |
| IL (1) | IL258496A (OSRAM) |
| WO (1) | WO2017062253A2 (OSRAM) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109790533B (zh) * | 2016-08-15 | 2023-04-04 | 国立大学法人北海道大学 | 抗pd-l1抗体 |
| WO2020123798A1 (en) * | 2018-12-12 | 2020-06-18 | President And Fellows Of Harvard College | Bovine versions of fcmbl for the detection and treatment of bovine microbial infections |
| WO2022109313A1 (en) * | 2020-11-20 | 2022-05-27 | Zoetis Services Llc | Bovine antibody variants |
| WO2025057225A1 (en) * | 2023-09-14 | 2025-03-20 | Invitrogen Bioservices India Private Limited | Engineered antibodies and uses thereof |
| CN120209146A (zh) * | 2025-03-31 | 2025-06-27 | 上海百英生物科技股份有限公司 | 一种包含非天然氨基酸修饰的Claudin 6抗体及其制备方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6194551B1 (en) * | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| US7670595B2 (en) * | 2004-06-28 | 2010-03-02 | Merck Patent Gmbh | Fc-interferon-beta fusion proteins |
| EP2244735A4 (en) * | 2007-10-02 | 2011-02-23 | Avaxia Biologics Inc | ANTIBODY THERAPY FOR USE IN THE DIGESTIVE TUBE |
| US8647626B2 (en) * | 2007-10-02 | 2014-02-11 | Avaxia Biologics, Incorporated | Compositions comprising TNF-specific antibodies for oral delivery |
| EA201290241A1 (ru) * | 2009-10-29 | 2013-02-28 | Янссен Байотек Инк. | Изменение гликозилирования антител |
| AR084210A1 (es) * | 2010-12-08 | 2013-05-02 | Abbott Lab | PROTEINAS DE UNION AL TNF-a |
| RU2013129203A (ru) * | 2010-12-27 | 2015-02-10 | Джапан Хелт Сайенсес Фаундейшн | Моноклональное антитело, распознающее белок l2 папилломавируса человека (впч), и способ определения титра впч-нейтрализующего антитела, использующий такое антитело |
| EP2739650A4 (en) * | 2011-08-01 | 2015-04-01 | Avaxia Biologics Inc | SPECIFIC BOVINE POLYCLONAL ANTIBODY OF HUMAN TNF |
| CN115850489A (zh) * | 2016-08-15 | 2023-03-28 | 国立大学法人北海道大学 | 抗pd-1抗体 |
-
2016
- 2016-09-29 BR BR112018006953A patent/BR112018006953A2/pt not_active Application Discontinuation
- 2016-09-29 WO PCT/US2016/054304 patent/WO2017062253A2/en not_active Ceased
- 2016-09-29 US US15/765,958 patent/US11891440B2/en active Active
- 2016-09-29 AU AU2016335912A patent/AU2016335912B2/en active Active
- 2016-09-29 JP JP2018536696A patent/JP7235287B2/ja active Active
- 2016-09-29 CA CA3039177A patent/CA3039177A1/en active Pending
- 2016-09-29 EP EP16854106.8A patent/EP3359190A4/en not_active Withdrawn
-
2018
- 2018-04-04 IL IL258496A patent/IL258496A/en unknown
-
2022
- 2022-09-29 JP JP2022156598A patent/JP2022185053A/ja active Pending
-
2023
- 2023-06-29 US US18/344,311 patent/US20240067715A1/en not_active Abandoned
- 2023-08-16 AU AU2023216791A patent/AU2023216791A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017062253A3 (en) | 2017-05-11 |
| WO2017062253A2 (en) | 2017-04-13 |
| BR112018006953A2 (pt) | 2018-10-23 |
| AU2023216791A1 (en) | 2023-09-07 |
| JP2018537117A (ja) | 2018-12-20 |
| US20220073602A1 (en) | 2022-03-10 |
| EP3359190A4 (en) | 2020-05-06 |
| IL258496A (en) | 2018-05-31 |
| JP7235287B2 (ja) | 2023-03-08 |
| US11891440B2 (en) | 2024-02-06 |
| AU2016335912B2 (en) | 2023-08-31 |
| JP2022185053A (ja) | 2022-12-13 |
| US20240067715A1 (en) | 2024-02-29 |
| AU2016335912A1 (en) | 2018-05-24 |
| EP3359190A2 (en) | 2018-08-15 |
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