CA3034332A1 - Kinase inhibitor compounds, compositions, and methods of treating cancer - Google Patents

Kinase inhibitor compounds, compositions, and methods of treating cancer Download PDF

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Publication number
CA3034332A1
CA3034332A1 CA3034332A CA3034332A CA3034332A1 CA 3034332 A1 CA3034332 A1 CA 3034332A1 CA 3034332 A CA3034332 A CA 3034332A CA 3034332 A CA3034332 A CA 3034332A CA 3034332 A1 CA3034332 A1 CA 3034332A1
Authority
CA
Canada
Prior art keywords
alkyl
mmol
compound
dmso
mhz
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3034332A
Other languages
English (en)
French (fr)
Inventor
Arvin C. Dar
Ross L. Cagan
Alex P. SCOPTON
Masahiro Sonoshita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Icahn School of Medicine at Mount Sinai
Original Assignee
Icahn School of Medicine at Mount Sinai
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icahn School of Medicine at Mount Sinai filed Critical Icahn School of Medicine at Mount Sinai
Publication of CA3034332A1 publication Critical patent/CA3034332A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA3034332A 2016-08-17 2017-08-17 Kinase inhibitor compounds, compositions, and methods of treating cancer Pending CA3034332A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662376138P 2016-08-17 2016-08-17
US62/376,138 2016-08-17
PCT/US2017/047383 WO2018035346A1 (en) 2016-08-17 2017-08-17 Kinase inhibitor compounds, compositions, and methods of treating cancer

Publications (1)

Publication Number Publication Date
CA3034332A1 true CA3034332A1 (en) 2018-02-22

Family

ID=61197083

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3034332A Pending CA3034332A1 (en) 2016-08-17 2017-08-17 Kinase inhibitor compounds, compositions, and methods of treating cancer

Country Status (6)

Country Link
US (2) US10519113B2 (https=)
EP (1) EP3500257B1 (https=)
JP (1) JP2019528279A (https=)
CN (1) CN110072526A (https=)
CA (1) CA3034332A1 (https=)
WO (1) WO2018035346A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108440404A (zh) * 2018-05-08 2018-08-24 西安凯伦生物科技有限公司 具有多重激酶抑制作用的抗肿瘤药物及其制备方法和应用
CN111362871B (zh) * 2018-12-25 2022-05-17 北京福元医药股份有限公司 取代的吡啶-2-甲酰胺类化合物及其用途
KR20220032607A (ko) 2020-02-27 2022-03-15 국립대학법인 홋가이도 다이가쿠 항암제를 스크리닝하는 방법 및 췌장암 치료를 위한 키나아제 억제제의 조합 의약
CN113402456B (zh) * 2020-03-16 2023-03-03 深圳大学 一种抗肿瘤药物以及一种化合物或其药学上可接受的盐在抗肿瘤药物中的应用
JP2023525757A (ja) * 2020-05-08 2023-06-19 ジョージアミューン・インコーポレイテッド Ａｋｔ３モジュレーター
WO2022094477A1 (en) * 2020-11-02 2022-05-05 Icahn School Of Medicine At Mount Sinai Methods of treating tumors and cancers having dysregulated wnt signaling pathways
KR102710925B1 (ko) * 2021-06-01 2024-09-27 부산대학교 산학협력단 신규 스퀘어아마이드 유도체 및 이의 용도
WO2025083280A1 (en) * 2023-10-19 2025-04-24 Universitat De Barcelona Sorafenib analogs for use in the treatment of cancer

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK286213B6 (sk) * 1997-12-22 2008-05-06 Bayer Corporation Substituované heterocyklické močoviny, farmaceutický prípravok ich obsahujúci a ich použitie
US7235576B1 (en) * 2001-01-12 2007-06-26 Bayer Pharmaceuticals Corporation Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
MXPA04007830A (es) * 2002-02-11 2005-07-01 Bayer Pharmaceuticals Corp Arilureas como inhibidores de cinasa.
CA2494824A1 (en) 2002-08-08 2004-02-19 Boehringer Ingelheim Pharmaceuticals, Inc. Fluorinated phenyl-naphthalenyl-urea compounds as inhibitors of cytokines involved in inflammatory processes
DE602004030222D1 (de) * 2003-02-28 2011-01-05 Bayer Healthcare Llc 2-oxo-1,3,5-perhydrotriazapinderivate, die sich zur behandlung von hyperproliferativen, angiogenen und entzündlichen erkrankungen eignen
EP1608639A2 (en) * 2003-02-28 2005-12-28 Bayer Pharmaceuticals Corporation Novel bicyclic urea derivatives useful in the treatment of cancer and other disorders
WO2004113274A2 (en) 2003-05-20 2004-12-29 Bayer Pharmaceuticals Corporation Diaryl ureas with kinase inhibiting activity
CA2531485C (en) * 2003-07-07 2013-03-26 Merck Patent Gmbh Malonamide derivatives
EA010485B1 (ru) * 2003-07-23 2008-10-30 Байер Фамэсьютиклс Копэрейшн Производное n,n'-дифенилмочевины, фармацевтическая композиция (варианты) и способ лечения и предупреждения заболеваний и состояний с его использованием (варианты)
WO2006026501A1 (en) * 2004-08-27 2006-03-09 Bayer Pharmaceuticals Corporation New pharmaceutical compositions for the treatment of cancer
US8580798B2 (en) * 2005-12-21 2013-11-12 Bayer Intellectual Property Gmbh Substituted pyrimidine derivatives useful in the treatment of cancer and other disorders
KR20090071603A (ko) * 2006-09-19 2009-07-01 노파르티스 아게 Ｒａｆ 억제제에 대한 표적 조절, 효능, 진단 및/또는 예후의 바이오마커
CN101260106A (zh) * 2007-03-06 2008-09-10 中国药科大学 Raf激酶抑制剂及其制备方法和用途
US20090012091A1 (en) * 2007-07-02 2009-01-08 Kinagen, Inc. Oximide derivatives and their therapeutical application
CN101723890B (zh) * 2008-10-10 2011-11-23 中国科学院成都生物研究所 芳基硫脲及其制备方法和用途
JP2011063516A (ja) * 2009-09-15 2011-03-31 Daiichi Sankyo Co Ltd アミド誘導体
WO2011046991A2 (en) * 2009-10-15 2011-04-21 Gilead Connecticut, Inc. Certain substituted ureas as modulators of kinase activity
US9029401B2 (en) * 2011-02-14 2015-05-12 The Regents Of The University Of California Sorafenib derivatives as sEH inhibitors
CA2843330C (en) * 2011-08-03 2016-09-20 National Taiwan University Substituted phenyl- and heteroaryl-phenyl ether agonists of src homology-2 containing protein tyrosine phosphatase-1 and treatment methods using the same
US9090617B1 (en) * 2011-08-03 2015-07-28 National Taiwan University Agonists of Src homology-2 containing protein tyrosine phosphatase-1 and treatment methods using the same
CN103508961B (zh) * 2012-06-26 2015-07-22 中美冠科生物技术（太仓）有限公司 抗肿瘤药物
US10449182B2 (en) * 2012-07-06 2019-10-22 The Regents Of The University Of California Sorafenib derivatives as p21 inhibitors
WO2015051149A1 (en) 2013-10-04 2015-04-09 The Trustees Of Columbia University In The City Of New York Sorafenib analogs and uses thereof

Also Published As

Publication number Publication date
EP3500257A1 (en) 2019-06-26
US20200325103A1 (en) 2020-10-15
WO2018035346A8 (en) 2019-03-07
US20190202789A1 (en) 2019-07-04
US10519113B2 (en) 2019-12-31
EP3500257B1 (en) 2025-07-02
US11066370B2 (en) 2021-07-20
JP2019528279A (ja) 2019-10-10
CN110072526A (zh) 2019-07-30
WO2018035346A1 (en) 2018-02-22
EP3500257A4 (en) 2020-01-22

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Effective date: 20220809