CA3033964A1 - Gaba(a) receptor modulators and methods to control airway hyperresponsiveness and inflammation in asthma - Google Patents
Gaba(a) receptor modulators and methods to control airway hyperresponsiveness and inflammation in asthma Download PDFInfo
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- CA3033964A1 CA3033964A1 CA3033964A CA3033964A CA3033964A1 CA 3033964 A1 CA3033964 A1 CA 3033964A1 CA 3033964 A CA3033964 A CA 3033964A CA 3033964 A CA3033964 A CA 3033964A CA 3033964 A1 CA3033964 A1 CA 3033964A1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
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| US201662375694P | 2016-08-16 | 2016-08-16 | |
| US62/375,694 | 2016-08-16 | ||
| US201662427771P | 2016-11-29 | 2016-11-29 | |
| US62/427,771 | 2016-11-29 | ||
| PCT/US2017/047185 WO2018035246A1 (en) | 2016-08-16 | 2017-08-16 | Gaba(a) receptor modulators and methods to control airway hyperresponsiveness and inflammation in asthma |
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| CA3033964A1 true CA3033964A1 (en) | 2018-02-22 |
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| ES (1) | ES2895965T3 (OSRAM) |
| WO (1) | WO2018035246A1 (OSRAM) |
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| WO2021198124A1 (en) | 2020-03-31 | 2021-10-07 | F. Hoffmann-La Roche Ag | Benzodiazepine derivatives as gaba a gamma1 pams |
| EP3901155A1 (en) * | 2020-04-20 | 2021-10-27 | F. Hoffmann-La Roche AG | New benzodiazepine derivatives as gaba a gamma1 pam |
| CN118019742A (zh) | 2021-09-29 | 2024-05-10 | 豪夫迈·罗氏有限公司 | 作为GABA A γ1 PAM的新颖苯并二氮杂䓬衍生物 |
| JP2024536393A (ja) | 2021-10-06 | 2024-10-04 | エフ. ホフマン-ラ ロシュ アーゲー | GABA A γ1受容体のポジティブアロステリックモジュレーターとしてのベンゾジアゼピン誘導体 |
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| ZA755418B (en) | 1974-09-11 | 1977-06-29 | Hoffmann La Roche | Diazepine derivatives |
| US4125726A (en) | 1977-03-11 | 1978-11-14 | Hoffmann-La Roche Inc. | Imidazo[1,5-a][1,4]benzodiazepines |
| US4401597A (en) | 1978-05-15 | 1983-08-30 | Hoffmann-La Roche Inc. | Imidazodiazepines and processes therefor |
| US4226768A (en) * | 1979-05-29 | 1980-10-07 | Hoffmann-La Roche Inc. | Process for the preparation of imidazobenzodiazepines |
| US4238610A (en) | 1979-12-20 | 1980-12-09 | Hoffmann-La Roche Inc. | Intermediates for the production of imidazobenzodiazepines |
| ZA845757B (en) | 1983-08-25 | 1985-04-24 | Hoffmann La Roche | Benzodiazepine derivatives |
| US5317018A (en) | 1992-06-09 | 1994-05-31 | Armin Walser | Benzodiazepines and compositions for treating anxiety and panic disorders, and idiopathic and psychomotor epilepsy |
| TW349100B (en) | 1994-11-11 | 1999-01-01 | Hoffmann La Roche | Oxazolyl- and thiazolylimidazo-benzo- and thienodiazepines |
| CA2184802C (en) | 1995-10-10 | 2007-07-31 | Karl-Heinz Bender | Process for manufacture of imidazo benzodiazepine derivatives |
| GB9911152D0 (en) | 1999-05-14 | 1999-07-14 | Glaxo Group Ltd | Short-acting benzodiazepines |
| US6512114B1 (en) | 1999-06-30 | 2003-01-28 | Abbott Laboratories | Process for the preparation of Midazolam |
| US20010014738A1 (en) | 1999-06-30 | 2001-08-16 | Madhup K. Dhaon | Process for the preparation of imidazodiazepine intermediates |
| US6262260B1 (en) | 2000-03-23 | 2001-07-17 | Abbott Laboratories | Process for the preparation of midazolam |
| US8835424B2 (en) | 2002-03-28 | 2014-09-16 | Wisconsin Alumni Research Foundation | Selective agents for pain suppression |
| US7119196B2 (en) | 2002-03-28 | 2006-10-10 | Wisys Technology Foundation, Inc. | Anxiolytic agents with reduced sedative and ataxic effects |
| AU2005255011A1 (en) | 2004-06-09 | 2005-12-29 | Avanir Pharmaceuticals | Heterocyclic derivatives for treatment of hyperlipidemia and related diseases |
| CA2570185A1 (en) | 2004-06-30 | 2006-01-12 | Wisys Technology Foundation Inc. | Stereospecific anxiolytic and anticonvulsant agents with reduced muscle-relaxant, sedative-hypnotic and ataxic effects |
| EP1888594A2 (en) | 2005-05-16 | 2008-02-20 | Wisys Technology Foundation, Inc. | Gabaergic agents to treat memory deficits |
| US8119629B2 (en) | 2007-10-03 | 2012-02-21 | Bristol-Meyers Squibb Company | Carboxamide GABAA α2 modulators |
| US20100261711A1 (en) | 2009-03-20 | 2010-10-14 | Wisys Technology Foundation | Selective anticonvulsant agents and their uses |
| IT1399764B1 (it) | 2010-05-04 | 2013-05-03 | F S I Fabbrica Italiana Sint | Procedimento per la sintesi di 4h-imidazo [1,5-a][1,4]benzodiazepine, in particolare di midazolam. |
| US9006233B2 (en) * | 2011-04-28 | 2015-04-14 | Uwm Research Foundation, Inc. | Gabaergic receptor subtype selective ligands and their uses |
| WO2012162254A1 (en) | 2011-05-23 | 2012-11-29 | Elan Pharmaceuticals, Inc. | Inhibitors of lrrk2 kinase activity |
| EP2592077A1 (en) | 2011-11-11 | 2013-05-15 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities |
| CN103204838B (zh) | 2012-01-13 | 2017-06-09 | 北京盛诺基医药科技有限公司 | 多羟基苯并吡喃酮类化合物的合成及其抗肿瘤作用 |
| CN103319486B (zh) | 2012-03-22 | 2017-10-10 | 徐州市心血管病研究所 | 合成4H‑咪唑并[1,5‑a][1,4]苯二氮卓,特别是咪达唑仑的方法 |
| WO2014047413A1 (en) * | 2012-09-21 | 2014-03-27 | Uwm Research Foundation, Inc. | Novel gabaa agonists and methods of using to control airway hyperresponsiveness and inflammation in asthma |
| JP7023876B2 (ja) | 2016-03-18 | 2022-02-22 | ユーダブリューエム・リサーチ・ファウンデーション,インコーポレーテッド | α5含有GABAA受容体アゴニストによる神経変性および神経精神障害における認知症状および気分症状の処置 |
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2017
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- 2017-08-16 CN CN201780063337.9A patent/CN109790170B/zh active Active
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- 2017-08-16 EP EP17758373.9A patent/EP3500573B1/en active Active
- 2017-08-16 CA CA3033964A patent/CA3033964A1/en active Pending
- 2017-08-16 WO PCT/US2017/047185 patent/WO2018035246A1/en not_active Ceased
- 2017-08-16 ES ES17758373T patent/ES2895965T3/es active Active
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| Publication number | Publication date |
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| JP2019528267A (ja) | 2019-10-10 |
| CN109790170B (zh) | 2022-08-02 |
| EP3500573B1 (en) | 2021-10-06 |
| US20230103216A1 (en) | 2023-03-30 |
| BR112019003065A2 (pt) | 2019-05-21 |
| JP7013446B2 (ja) | 2022-02-15 |
| WO2018035246A1 (en) | 2018-02-22 |
| US20210284649A1 (en) | 2021-09-16 |
| US11447495B2 (en) | 2022-09-20 |
| ES2895965T3 (es) | 2022-02-23 |
| AU2017313753A1 (en) | 2019-03-07 |
| AU2017313753B2 (en) | 2022-01-27 |
| CN109790170A (zh) | 2019-05-21 |
| US12054491B2 (en) | 2024-08-06 |
| EP3500573A1 (en) | 2019-06-26 |
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| EEER | Examination request |
Effective date: 20220809 |
|
| EEER | Examination request |
Effective date: 20220809 |