CA3029361A1 - New processes for the preparation of vemurafenib - Google Patents
New processes for the preparation of vemurafenib Download PDFInfo
- Publication number
- CA3029361A1 CA3029361A1 CA3029361A CA3029361A CA3029361A1 CA 3029361 A1 CA3029361 A1 CA 3029361A1 CA 3029361 A CA3029361 A CA 3029361A CA 3029361 A CA3029361 A CA 3029361A CA 3029361 A1 CA3029361 A1 CA 3029361A1
- Authority
- CA
- Canada
- Prior art keywords
- formula
- compound
- process according
- mixture
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20165557 | 2016-07-01 | ||
| FI20165557 | 2016-07-01 | ||
| FI20165778 | 2016-10-12 | ||
| FI20165778 | 2016-10-12 | ||
| PCT/FI2017/000012 WO2018002415A1 (en) | 2016-07-01 | 2017-06-30 | New processes for the preparation of vemurafenib |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3029361A1 true CA3029361A1 (en) | 2018-01-04 |
Family
ID=59416718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3029361A Pending CA3029361A1 (en) | 2016-07-01 | 2017-06-30 | New processes for the preparation of vemurafenib |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10407427B2 (OSRAM) |
| EP (1) | EP3478684B1 (OSRAM) |
| JP (1) | JP6911062B2 (OSRAM) |
| CA (1) | CA3029361A1 (OSRAM) |
| ES (1) | ES2802476T3 (OSRAM) |
| HR (1) | HRP20200821T1 (OSRAM) |
| HU (1) | HUE049682T2 (OSRAM) |
| PL (1) | PL3478684T3 (OSRAM) |
| RS (1) | RS60451B1 (OSRAM) |
| WO (1) | WO2018002415A1 (OSRAM) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110291089B (zh) | 2017-01-17 | 2022-05-27 | 海帕瑞吉尼克斯股份有限公司 | 用于促进肝再生或者减少或预防肝细胞死亡的蛋白激酶抑制剂 |
| EP3860598B1 (en) | 2018-10-03 | 2023-09-06 | Jyväskylän Yliopisto | Vemurafenib and salts thereof for use in the treatment of enteroviral infections |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1303759B1 (it) * | 1998-11-17 | 2001-02-23 | Dompe Spa | Procedimento migliorato per la preparazione di acido 7-azaindolil-3-carbossilico. |
| DK2395004T3 (en) | 2005-06-22 | 2016-03-21 | Plexxikon Inc | Pyrrolo [2,3-b] pyridine derivatives as protein kinase inhibitors |
| US8329724B2 (en) | 2009-08-03 | 2012-12-11 | Hoffmann-La Roche Inc. | Process for the manufacture of pharmaceutically active compounds |
| US8779150B2 (en) | 2010-07-21 | 2014-07-15 | Hoffmann-La Roche Inc. | Processes for the manufacture of propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1 H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide |
| CN105008356A (zh) | 2013-03-14 | 2015-10-28 | 拉蒂奥法姆有限责任公司 | 固态形式的盐酸威罗菲尼 |
| WO2015075749A1 (en) | 2013-11-22 | 2015-05-28 | Laurus Labs Private Limited | Novel processes for the preparation of vemurafenib |
| CZ2013943A3 (cs) | 2013-11-27 | 2015-06-03 | Zentiva, K.S. | Krystalické formy vemurafenibu |
| WO2016083956A1 (en) | 2014-11-29 | 2016-06-02 | Shilpa Medicare Limited | Substantially pure vemurafenib and its salts |
-
2017
- 2017-06-30 HU HUE17745368A patent/HUE049682T2/hu unknown
- 2017-06-30 PL PL17745368T patent/PL3478684T3/pl unknown
- 2017-06-30 CA CA3029361A patent/CA3029361A1/en active Pending
- 2017-06-30 ES ES17745368T patent/ES2802476T3/es active Active
- 2017-06-30 RS RS20200741A patent/RS60451B1/sr unknown
- 2017-06-30 EP EP17745368.5A patent/EP3478684B1/en active Active
- 2017-06-30 JP JP2018568670A patent/JP6911062B2/ja not_active Expired - Fee Related
- 2017-06-30 WO PCT/FI2017/000012 patent/WO2018002415A1/en not_active Ceased
- 2017-06-30 US US16/313,597 patent/US10407427B2/en not_active Expired - Fee Related
- 2017-06-30 HR HRP20200821TT patent/HRP20200821T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3478684B1 (en) | 2020-04-15 |
| ES2802476T3 (es) | 2021-01-19 |
| JP2019522662A (ja) | 2019-08-15 |
| HRP20200821T1 (hr) | 2020-08-07 |
| WO2018002415A1 (en) | 2018-01-04 |
| EP3478684A1 (en) | 2019-05-08 |
| US10407427B2 (en) | 2019-09-10 |
| US20190194197A1 (en) | 2019-06-27 |
| HUE049682T2 (hu) | 2020-10-28 |
| RS60451B1 (sr) | 2020-07-31 |
| JP6911062B2 (ja) | 2021-07-28 |
| PL3478684T3 (pl) | 2020-08-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20220525 |