CA3027469C - Treatment of vascular calcification - Google Patents
Treatment of vascular calcification Download PDFInfo
- Publication number
- CA3027469C CA3027469C CA3027469A CA3027469A CA3027469C CA 3027469 C CA3027469 C CA 3027469C CA 3027469 A CA3027469 A CA 3027469A CA 3027469 A CA3027469 A CA 3027469A CA 3027469 C CA3027469 C CA 3027469C
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- Prior art keywords
- parp inhibitor
- calcification
- use according
- parp
- inhibitor
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
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- Pharmacology & Pharmacy (AREA)
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| GBGB1610400.2A GB201610400D0 (en) | 2016-06-15 | 2016-06-15 | Vascular calcification |
| GB1610400.2 | 2016-06-15 | ||
| PCT/GB2017/051744 WO2017216563A1 (en) | 2016-06-15 | 2017-06-15 | Treatment of vascular calcification |
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| GB201610400D0 (en) | 2016-06-15 | 2016-07-27 | Cambridge Entpr Ltd And Kings College London | Vascular calcification |
| WO2020150147A1 (en) * | 2019-01-14 | 2020-07-23 | The Regents Of The University Of California | Compositions and methods for treating ocular conditions |
| CN113940935A (zh) * | 2021-10-09 | 2022-01-18 | 华中科技大学同济医学院附属协和医院 | 奥拉帕尼的新用途 |
| CN114010635A (zh) * | 2021-11-21 | 2022-02-08 | 华中科技大学同济医学院附属协和医院 | 尼拉帕尼及其衍生物的新用途 |
| CN120392751A (zh) * | 2025-07-04 | 2025-08-01 | 吉林大学 | Parp1抑制剂在制备防治放射性肺损伤药物中的应用 |
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| US6514983B1 (en) | 1997-09-03 | 2003-02-04 | Guilford Pharmaceuticals Inc. | Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage |
| US6706290B1 (en) | 1998-07-06 | 2004-03-16 | Olvai E. Kajander | Methods for eradication of nanobacteria |
| ES2247817T3 (es) | 1998-07-06 | 2006-03-01 | Nanobac Oy | Metodo para la erradicacion de nanobacterias. |
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| KR20060130205A (ko) | 2004-03-12 | 2006-12-18 | 콜라제넥스 파마슈티칼스, 인크 | 비-항균성 테트라사이클린 제제로 대동맥 협착증을치료하는 방법 |
| US20060069068A1 (en) | 2004-07-15 | 2006-03-30 | Nanobac Pharmaceuticals, Inc. | Methods and compositions for the treatment of diseases characterized by pathological calcification |
| US20060083727A1 (en) | 2004-07-15 | 2006-04-20 | Nanobac Pharmaceuticals, Inc. | Methods and compositions for the treatment of diseases characterized by calcification and/or plaque formation |
| US20100292183A1 (en) | 2009-05-15 | 2010-11-18 | Shanmugavel Madasamy | Tetracycline and uses thereof |
| GB201020811D0 (en) | 2010-12-08 | 2011-01-19 | Solvotrin Innovations Ltd | Compounds |
| US9314473B2 (en) | 2011-02-03 | 2016-04-19 | Pop Test Oncology Limited Liability Company | System and method for diagnosis and treatment |
| WO2012151701A1 (en) | 2011-05-10 | 2012-11-15 | Université Laval / Vice-Rectorat À La Recherche Et À La Création | Methods for the treatment and diagnostic of pulmonary arterial hypertension |
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| GB201610400D0 (en) | 2016-06-15 | 2016-07-27 | Cambridge Entpr Ltd And Kings College London | Vascular calcification |
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| US10159685B2 (en) | 2018-12-25 |
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| ES2894844T8 (es) | 2022-02-25 |
| EP3471721A1 (en) | 2019-04-24 |
| JP6992952B2 (ja) | 2022-02-03 |
| CN109475533A (zh) | 2019-03-15 |
| CN109475533B (zh) | 2022-04-01 |
| WO2017216563A1 (en) | 2017-12-21 |
| CA3027469A1 (en) | 2017-12-21 |
| JP2019518030A (ja) | 2019-06-27 |
| EP3471721B1 (en) | 2021-09-29 |
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