CA3026991A1 - Lysine conjugated immunoglobulins - Google Patents
Lysine conjugated immunoglobulins Download PDFInfo
- Publication number
- CA3026991A1 CA3026991A1 CA3026991A CA3026991A CA3026991A1 CA 3026991 A1 CA3026991 A1 CA 3026991A1 CA 3026991 A CA3026991 A CA 3026991A CA 3026991 A CA3026991 A CA 3026991A CA 3026991 A1 CA3026991 A1 CA 3026991A1
- Authority
- CA
- Canada
- Prior art keywords
- immunoglobulin
- amino acid
- antigen
- residue
- binding portion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/68031—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being an auristatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y203/00—Acyltransferases (2.3)
- C12Y203/02—Aminoacyltransferases (2.3.2)
- C12Y203/02013—Protein-glutamine gamma-glutamyltransferase (2.3.2.13), i.e. transglutaminase or factor XIII
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662348410P | 2016-06-10 | 2016-06-10 | |
| US62/348,410 | 2016-06-10 | ||
| PCT/JP2017/021672 WO2017213267A1 (en) | 2016-06-10 | 2017-06-12 | Lysine conjugated immunoglobulins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3026991A1 true CA3026991A1 (en) | 2017-12-14 |
Family
ID=59315675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3026991A Pending CA3026991A1 (en) | 2016-06-10 | 2017-06-12 | Lysine conjugated immunoglobulins |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US10941431B2 (enExample) |
| EP (1) | EP3468614A1 (enExample) |
| JP (1) | JP7041077B2 (enExample) |
| KR (1) | KR102538866B1 (enExample) |
| CN (1) | CN109475642B (enExample) |
| AU (1) | AU2017279352B2 (enExample) |
| BR (1) | BR112018075253A2 (enExample) |
| CA (1) | CA3026991A1 (enExample) |
| CL (1) | CL2021003383A1 (enExample) |
| CO (1) | CO2018013314A2 (enExample) |
| IL (1) | IL263329B (enExample) |
| JO (1) | JOP20180118A1 (enExample) |
| MX (1) | MX419566B (enExample) |
| MY (1) | MY202858A (enExample) |
| NZ (1) | NZ748605A (enExample) |
| PE (1) | PE20190340A1 (enExample) |
| PH (1) | PH12018502594A1 (enExample) |
| RU (2) | RU2762939C2 (enExample) |
| SG (1) | SG11201810470XA (enExample) |
| UA (1) | UA126799C2 (enExample) |
| WO (1) | WO2017213267A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4032902A1 (en) | 2015-12-18 | 2022-07-27 | Eisai R&D Management Co., Ltd. | C-terminal lysine conjugated immunoglobulins |
| SG11201810470XA (en) | 2016-06-10 | 2018-12-28 | Eisai R&D Man Co Ltd | Lysine conjugated immunoglobulins |
| EP3966238A2 (en) * | 2019-05-09 | 2022-03-16 | Merus N.V. | Variant domains for multimerizing proteins and separation thereof |
| GB201907093D0 (en) * | 2019-05-20 | 2019-07-03 | Ucl Business Plc | Antibody functionalisation |
| CA3167317C (en) * | 2020-02-12 | 2025-05-27 | Eli Lilly And Company | CRYSTALLIZATION OF ANTIBODIES OR ANTIGEN-BINDING FRAGMENTS |
| JP7664943B2 (ja) * | 2020-03-25 | 2025-04-18 | イーライ リリー アンド カンパニー | 多重特異性結合タンパク質およびそれを開発する方法 |
| MX2022014530A (es) | 2020-05-20 | 2023-02-27 | Janssen Biotech Inc | Métodos para la conjugación específica del sitio de proteínas que contienen dominios fc glicosilados. |
| US20240173377A1 (en) * | 2020-09-25 | 2024-05-30 | Epivax, Inc. | Retro - inverso regulatory t cell epitopes |
| WO2023026235A1 (en) * | 2021-08-27 | 2023-03-02 | Janssen Biotech, Inc. | Anti-psma antibodies and uses thereof |
| CN117164701A (zh) * | 2022-12-27 | 2023-12-05 | 优洛生物(上海)有限公司 | 一种经改造的抗体、其制备方法及其用途 |
| IL322523A (en) | 2023-02-28 | 2025-10-01 | Eisai R&D Man Co Ltd | Anti-PSMA antibodies, conjugates and methods of use |
| US20240337664A1 (en) * | 2023-04-07 | 2024-10-10 | Regeneron Pharmaceuticals, Inc. | Characterization of crosslinking sites in antibody-drug conjugates |
| CN119375471A (zh) * | 2023-07-26 | 2025-01-28 | 菲鹏生物股份有限公司 | 抗体和抗体缀合物及其用途 |
| WO2025199464A1 (en) | 2024-03-22 | 2025-09-25 | Eisai R&D Management Co., Ltd. | Anti-trop2 antibody-drug conjugates and methods of use |
| CN120779021A (zh) * | 2024-04-08 | 2025-10-14 | 菲鹏生物股份有限公司 | 抗体缀合物及其用途 |
| WO2026044149A2 (en) | 2024-08-21 | 2026-02-26 | Eisai R&D Management Co., Ltd. | Synthesis of drug-linker combinations for antibody-drug conjugates |
| US20260139068A1 (en) | 2024-08-21 | 2026-05-21 | Eisai R&D Management Co., Ltd. | Anti-cd73 antibodies, conjugates, and methods of use |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI903489A7 (fi) | 1988-11-11 | 1990-07-10 | Medical Res Council | Yhden osan sisältävät ligandit, näitä ligandeja sisältävät reseptorit, menetelmiä niiden valmistamiseksi sekä ligandien ja reseptorien käytt ö |
| EP2033662B1 (en) | 2004-01-21 | 2012-10-17 | Novo Nordisk Health Care AG | Transglutaminase mediated conjugation of peptides |
| CA2813411C (en) * | 2010-11-05 | 2016-08-02 | Rinat Neuroscience Corporation | Engineered polypeptide conjugates and methods for making thereof using transglutaminase |
| WO2013176516A1 (ko) | 2012-05-24 | 2013-11-28 | 한화케미칼 주식회사 | 트랜스글루타미나아제를 이용하여 제조한 항체-약물 결합체 및 이의 용도 |
| EP2916872B1 (en) | 2012-11-09 | 2019-02-27 | Innate Pharma | Recognition tags for tgase-mediated conjugation |
| WO2014159579A1 (en) | 2013-03-14 | 2014-10-02 | Abbvie Inc. | MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE |
| KR20160042871A (ko) * | 2013-06-21 | 2016-04-20 | 이나뜨 파르마, 에스.아. | 폴리펩티드의 효소적 콘쥬게이션 |
| KR20160040556A (ko) * | 2013-07-11 | 2016-04-14 | 노파르티스 아게 | 미생물 트랜스글루타미나제를 사용한 리신-특이적 화학효소적 단백질 변형 |
| US10195289B2 (en) * | 2013-07-31 | 2019-02-05 | Rinat Neuroscience Corp. | Engineered polypeptide conjugates using transglutaminase |
| KR20190072663A (ko) | 2014-04-25 | 2019-06-25 | 리나트 뉴로사이언스 코프. | 약물이 고도로 로딩된 항체-약물 접합체 |
| EP4032902A1 (en) | 2015-12-18 | 2022-07-27 | Eisai R&D Management Co., Ltd. | C-terminal lysine conjugated immunoglobulins |
| SG11201810470XA (en) | 2016-06-10 | 2018-12-28 | Eisai R&D Man Co Ltd | Lysine conjugated immunoglobulins |
-
2017
- 2017-06-12 SG SG11201810470XA patent/SG11201810470XA/en unknown
- 2017-06-12 RU RU2018145507A patent/RU2762939C2/ru active
- 2017-06-12 JP JP2018563925A patent/JP7041077B2/ja active Active
- 2017-06-12 RU RU2021136863A patent/RU2021136863A/ru unknown
- 2017-06-12 AU AU2017279352A patent/AU2017279352B2/en active Active
- 2017-06-12 WO PCT/JP2017/021672 patent/WO2017213267A1/en not_active Ceased
- 2017-06-12 UA UAA201900242A patent/UA126799C2/uk unknown
- 2017-06-12 EP EP17737890.8A patent/EP3468614A1/en active Pending
- 2017-06-12 MY MYPI2018002415A patent/MY202858A/en unknown
- 2017-06-12 NZ NZ748605A patent/NZ748605A/en unknown
- 2017-06-12 CA CA3026991A patent/CA3026991A1/en active Pending
- 2017-06-12 BR BR112018075253-3A patent/BR112018075253A2/pt unknown
- 2017-06-12 KR KR1020197000701A patent/KR102538866B1/ko active Active
- 2017-06-12 CN CN201780043485.4A patent/CN109475642B/zh active Active
- 2017-06-12 PE PE2018003193A patent/PE20190340A1/es unknown
- 2017-06-12 MX MX2018015331A patent/MX419566B/es unknown
- 2017-07-28 US US15/662,981 patent/US10941431B2/en active Active
-
2018
- 2018-11-27 IL IL263329A patent/IL263329B/en unknown
- 2018-12-07 CO CONC2018/0013314A patent/CO2018013314A2/es unknown
- 2018-12-09 JO JOP/2018/0118A patent/JOP20180118A1/ar unknown
- 2018-12-10 PH PH12018502594A patent/PH12018502594A1/en unknown
-
2021
- 2021-01-27 US US17/159,655 patent/US11753669B2/en active Active
- 2021-12-16 CL CL2021003383A patent/CL2021003383A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20210171998A1 (en) | 2021-06-10 |
| AU2017279352B2 (en) | 2024-07-25 |
| JP2019525897A (ja) | 2019-09-12 |
| PE20190340A1 (es) | 2019-03-07 |
| US10941431B2 (en) | 2021-03-09 |
| IL263329B (en) | 2022-05-01 |
| US20180044711A1 (en) | 2018-02-15 |
| RU2018145507A (ru) | 2020-07-10 |
| CL2021003383A1 (es) | 2022-08-19 |
| RU2762939C2 (ru) | 2021-12-24 |
| RU2021136863A (ru) | 2022-02-01 |
| BR112018075253A2 (pt) | 2019-04-30 |
| JOP20180118A1 (ar) | 2019-01-30 |
| KR102538866B1 (ko) | 2023-06-02 |
| PH12018502594A1 (en) | 2019-10-14 |
| AU2017279352A1 (en) | 2018-12-13 |
| MX419566B (es) | 2025-01-14 |
| NZ748605A (en) | 2023-05-26 |
| SG11201810470XA (en) | 2018-12-28 |
| RU2018145507A3 (enExample) | 2020-10-15 |
| CN109475642B (zh) | 2023-05-02 |
| MY202858A (en) | 2024-05-25 |
| US11753669B2 (en) | 2023-09-12 |
| CO2018013314A2 (es) | 2019-02-19 |
| MX2018015331A (es) | 2019-08-16 |
| KR20190018159A (ko) | 2019-02-21 |
| JP7041077B2 (ja) | 2022-03-23 |
| CN109475642A (zh) | 2019-03-15 |
| IL263329A (en) | 2018-12-31 |
| WO2017213267A1 (en) | 2017-12-14 |
| EP3468614A1 (en) | 2019-04-17 |
| UA126799C2 (uk) | 2023-02-08 |
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