CA3026436A1 - Method for obtaining a lipid-containing composition from microbial biomass - Google Patents
Method for obtaining a lipid-containing composition from microbial biomass Download PDFInfo
- Publication number
- CA3026436A1 CA3026436A1 CA3026436A CA3026436A CA3026436A1 CA 3026436 A1 CA3026436 A1 CA 3026436A1 CA 3026436 A CA3026436 A CA 3026436A CA 3026436 A CA3026436 A CA 3026436A CA 3026436 A1 CA3026436 A1 CA 3026436A1
- Authority
- CA
- Canada
- Prior art keywords
- oil
- lipid
- yeast
- biomass
- extraction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 150000008103 phosphatidic acids Chemical class 0.000 description 1
- 150000003905 phosphatidylinositols Chemical class 0.000 description 1
- 229940067626 phosphatidylinositols Drugs 0.000 description 1
- 229950004354 phosphorylcholine Drugs 0.000 description 1
- PYJNAPOPMIJKJZ-UHFFFAOYSA-N phosphorylcholine chloride Chemical compound [Cl-].C[N+](C)(C)CCOP(O)(O)=O PYJNAPOPMIJKJZ-UHFFFAOYSA-N 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000003495 polar organic solvent Substances 0.000 description 1
- 150000004291 polyenes Chemical class 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 239000008389 polyethoxylated castor oil Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 150000003096 polyprenols Chemical class 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 235000010408 potassium alginate Nutrition 0.000 description 1
- 239000000737 potassium alginate Substances 0.000 description 1
- MZYRDLHIWXQJCQ-YZOKENDUSA-L potassium alginate Chemical compound [K+].[K+].O1[C@@H](C([O-])=O)[C@@H](OC)[C@H](O)[C@H](O)[C@@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@@H](O)[C@H]1O MZYRDLHIWXQJCQ-YZOKENDUSA-L 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 235000019353 potassium silicate Nutrition 0.000 description 1
- 150000003135 prenol lipids Chemical class 0.000 description 1
- 239000000583 progesterone congener Substances 0.000 description 1
- 229940095055 progestogen systemic hormonal contraceptives Drugs 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 229940026235 propylene glycol monolaurate Drugs 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 150000004053 quinones Chemical class 0.000 description 1
- 238000003259 recombinant expression Methods 0.000 description 1
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- 238000007670 refining Methods 0.000 description 1
- 230000008844 regulatory mechanism Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 150000003313 saccharo lipids Chemical class 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 238000013341 scale-up Methods 0.000 description 1
- 235000014102 seafood Nutrition 0.000 description 1
- 150000003338 secosteroids Chemical class 0.000 description 1
- 238000011218 seed culture Methods 0.000 description 1
- 238000005204 segregation Methods 0.000 description 1
- 150000004666 short chain fatty acids Chemical class 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940080314 sodium bentonite Drugs 0.000 description 1
- 229910000280 sodium bentonite Inorganic materials 0.000 description 1
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 1
- 229910052911 sodium silicate Inorganic materials 0.000 description 1
- 235000019351 sodium silicates Nutrition 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- WWUZIQQURGPMPG-KRWOKUGFSA-N sphingosine Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO WWUZIQQURGPMPG-KRWOKUGFSA-N 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
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- JIWBIWFOSCKQMA-UHFFFAOYSA-N stearidonic acid Natural products CCC=CCC=CCC=CCC=CCCCCC(O)=O JIWBIWFOSCKQMA-UHFFFAOYSA-N 0.000 description 1
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- 229940116362 tragacanth Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 229910052905 tridymite Inorganic materials 0.000 description 1
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- 238000000825 ultraviolet detection Methods 0.000 description 1
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- 229940035893 uracil Drugs 0.000 description 1
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 description 1
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- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B1/00—Production of fats or fatty oils from raw materials
- C11B1/10—Production of fats or fatty oils from raw materials by extracting
- C11B1/104—Production of fats or fatty oils from raw materials by extracting using super critical gases or vapours
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/12—Animal feeding-stuffs obtained by microbiological or biochemical processes by fermentation of natural products, e.g. of vegetable material, animal waste material or biomass
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/20—Shaping or working-up of animal feeding-stuffs by moulding, e.g. making cakes or briquettes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/25—Shaping or working-up of animal feeding-stuffs by extrusion
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B1/00—Production of fats or fatty oils from raw materials
- C11B1/10—Production of fats or fatty oils from raw materials by extracting
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Fats And Perfumes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Edible Oils And Fats (AREA)
Applications Claiming Priority (11)
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|---|---|---|---|
| US201161441842P | 2011-02-11 | 2011-02-11 | |
| US201161441836P | 2011-02-11 | 2011-02-11 | |
| US201161441849P | 2011-02-11 | 2011-02-11 | |
| US201161441854P | 2011-02-11 | 2011-02-11 | |
| US61/441,836 | 2011-02-11 | ||
| US61/441,842 | 2011-02-11 | ||
| US61/441,854 | 2011-02-11 | ||
| US61/441,849 | 2011-02-11 | ||
| US201161487019P | 2011-05-17 | 2011-05-17 | |
| US61/487,019 | 2011-05-17 | ||
| CA2825039A CA2825039C (en) | 2011-02-11 | 2012-02-10 | Method for obtaining a lipid-containing composition from microbial biomass |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2825039A Division CA2825039C (en) | 2011-02-11 | 2012-02-10 | Method for obtaining a lipid-containing composition from microbial biomass |
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| CA3026436A1 true CA3026436A1 (en) | 2012-08-16 |
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| CA2825039A Expired - Fee Related CA2825039C (en) | 2011-02-11 | 2012-02-10 | Method for obtaining a lipid-containing composition from microbial biomass |
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| EP (1) | EP2672833A4 (cg-RX-API-DMAC7.html) |
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| CN (1) | CN103841825B (cg-RX-API-DMAC7.html) |
| CA (2) | CA3026436A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012109545A2 (cg-RX-API-DMAC7.html) |
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| CA2795460A1 (en) * | 2010-04-22 | 2011-10-27 | E. I. Du Pont De Nemours And Company | Method for obtaining polyunsaturated fatty acid-containing compositions from microbial biomass |
| WO2013013210A1 (en) * | 2011-07-21 | 2013-01-24 | Dsm Ip Assets B.V. | Microbial oils enriched in polyunsaturated fatty acids |
| MX372724B (es) | 2012-12-24 | 2020-06-19 | Qualitas Health Inc | Formulaciones de acido eicosapentaenoico (epa). |
| ES2875965T3 (es) | 2013-12-04 | 2021-11-11 | Nippon Suisan Kaisha Ltd | Aceite microbiano que contiene ácido dihomo-gamma-linolénico y biomasa microbiana que contiene ácido dihomo-gamma-linolénico |
| CL2013003813A1 (es) * | 2013-12-31 | 2014-06-06 | Univ Pontificia Catolica Chile | Procedimiento para la obtención de carotenoides (en particular astaxantina) a partir de un sustrato de microalgas en polvo, el que se comprime para formar pellets, los cuales son sometidos a extracción por dioxido de carbono (co2) supercrítico. |
| WO2016043251A1 (ja) * | 2014-09-17 | 2016-03-24 | 日本水産株式会社 | エイコサペンタエン酸アルキルエステルを含有する組成物及びその製造方法 |
| CN106793798A (zh) | 2014-10-02 | 2017-05-31 | 赢创德固赛有限公司 | 具有高抗磨损性和高水稳定性的含pufa的饲料 |
| EP3200606B1 (de) * | 2014-10-02 | 2021-03-31 | Evonik Operations GmbH | Verfahren zur herstellung eines pufas enthaltenden futtermittels durch extrusion einer pufas enthaltenden biomasse des typs labyrinthulomycetes |
| CN106793799B (zh) | 2014-10-02 | 2021-05-14 | 赢创运营有限公司 | 用于养殖动物的方法 |
| CN107075540A (zh) | 2014-10-02 | 2017-08-18 | 赢创德固赛有限公司 | 用于制备具有高细胞稳定性的含pufa生物质的方法 |
| US20180303129A1 (en) * | 2014-10-24 | 2018-10-25 | Trustees Of Dartmouth College | Aquaculture feed formulation and aquaculture product produced with same |
| BR112017015709A8 (pt) * | 2015-01-26 | 2018-07-31 | Roquette Freres | Método para preparar uma farinha de microalgas trituradas ricas em lipídio |
| US20180187121A1 (en) * | 2015-06-15 | 2018-07-05 | White Dog Labs, Inc. | Method for producing one or more oil-soluble bioproducts |
| CN104962589B (zh) * | 2015-08-05 | 2019-02-26 | 嘉必优生物技术（武汉）股份有限公司 | 一种富含磷脂型多不饱和脂肪酸的微生物油脂及制备方法 |
| CN104962590B (zh) * | 2015-08-05 | 2018-08-17 | 嘉必优生物技术（武汉）股份有限公司 | 一种微生物来源的磷脂型多不饱和脂肪酸油脂及制备方法 |
| CN107778337B (zh) * | 2016-08-26 | 2020-12-08 | 国投生物科技投资有限公司 | 超临界二氧化碳萃取螺旋藻中糖脂的方法 |
| US11547953B2 (en) * | 2018-03-16 | 2023-01-10 | Ricoh Company, Ltd. | Method of producing extract and extraction residue of biological material, extract, and extraction residue |
| WO2020186128A1 (en) * | 2019-03-14 | 2020-09-17 | Dsm Ip Assets B.V. | Methods of obtaining lipids from a microbial cell composition |
| FI131688B1 (en) * | 2019-06-12 | 2025-09-17 | Aurotec Gmbh | Thin-film treatment apparatus |
| KR20220143872A (ko) * | 2020-02-10 | 2022-10-25 | 씨16 바이오사이언시스 인코포레이티드 | 미생물로 생산된 팜 오일 대체품 |
| CN111822716A (zh) * | 2020-07-21 | 2020-10-27 | 泉州华大超硬工具科技有限公司 | 一种新型工艺串珠的制备方法 |
| WO2022071562A1 (ja) * | 2020-10-02 | 2022-04-07 | 日本たばこ産業株式会社 | たばこシート |
| US20240000697A1 (en) * | 2020-11-12 | 2024-01-04 | C16 Biosciences, Inc. | Personal care compositions comprising microbially produced oil |
| WO2022104046A1 (en) * | 2020-11-12 | 2022-05-19 | C16 Biosciences, Inc. | Edible microbial oil |
| KR20240093686A (ko) * | 2021-10-17 | 2024-06-24 | 라이코드 리미티드 | 피토엔-함유 올레오레진 및 조성물 |
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| GB2218984B (en) * | 1988-05-27 | 1992-09-23 | Renafield Limited | Process for preparing high-concentration mixtures of polyunsaturated fatty acids & their esters and their prophylactic or therapeutic uses |
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| MX2009012596A (es) | 2007-05-24 | 2009-12-08 | Du Pont | Genes de diacilglicerol aciltransferasa de yarrowia lipolytica para la produccion mejorada de lipidos de almacenamiento de semillas y para los perfiles alterados de acidos grasos en el frijol de soya. |
| EP2172558B1 (en) * | 2007-07-30 | 2017-07-19 | Nippon Suisan Kaisha, Ltd. | Method for production of epa-enriched oil and dha-enriched oil |
| CN101970638B (zh) | 2007-10-03 | 2015-02-11 | 纳幕尔杜邦公司 | 用于高水平生产二十碳五烯酸的优化解脂耶氏酵母菌株 |
| US20090155447A1 (en) | 2007-12-12 | 2009-06-18 | Solae, Llc | Protein extrudates comprising omega-3 fatty acids |
| US20100170144A1 (en) * | 2008-04-09 | 2010-07-08 | Solazyme, Inc. | Hydroprocessing Microalgal Oils |
| GB0813598D0 (en) * | 2008-07-24 | 2008-09-03 | Pharma Marine As | Process |
| US8268598B2 (en) | 2008-09-19 | 2012-09-18 | E I Du Pont De Nemours And Company | Mutant Δ5 desaturases mutated in the heme-binding motif (HPGG) and their use in making polyunsaturated fatty acids |
| CN104770424A (zh) | 2008-10-14 | 2015-07-15 | 索拉兹米公司 | 微藻生物质的食品组合物 |
| US9175318B2 (en) | 2008-12-18 | 2015-11-03 | E. I. Dupont De Nemours And Company | Reducing byproduction of malonates by yeast in a fermentation process |
| US8399226B2 (en) * | 2009-06-16 | 2013-03-19 | E I Du Pont De Nemours And Company | High eicosapentaenoic acid oils from improved optimized strains of Yarrowia lipolytica |
| CA2785742C (en) | 2009-12-30 | 2015-02-17 | Basf Pharma (Callanish) Limited | Simulated moving bed chromatographic separation process |
| CA2795460A1 (en) | 2010-04-22 | 2011-10-27 | E. I. Du Pont De Nemours And Company | Method for obtaining polyunsaturated fatty acid-containing compositions from microbial biomass |
| AU2012214285A1 (en) * | 2011-02-11 | 2013-07-18 | E. I. Du Pont De Nemours And Company | Purification of triglyceride oil from microbial sources using short path distillation |
-
2012
- 2012-02-10 CA CA3026436A patent/CA3026436A1/en not_active Abandoned
- 2012-02-10 EP EP12744464.4A patent/EP2672833A4/en not_active Withdrawn
- 2012-02-10 CN CN201280007938.5A patent/CN103841825B/zh not_active Expired - Fee Related
- 2012-02-10 WO PCT/US2012/024662 patent/WO2012109545A2/en not_active Ceased
- 2012-02-10 CA CA2825039A patent/CA2825039C/en not_active Expired - Fee Related
- 2012-02-10 JP JP2013553593A patent/JP6061866B2/ja not_active Expired - Fee Related
- 2012-02-10 US US13/370,971 patent/US8999663B2/en not_active Expired - Fee Related
-
2015
- 2015-03-10 US US14/643,219 patent/US20150218484A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2012214266A1 (en) | 2013-07-25 |
| CN103841825A (zh) | 2014-06-04 |
| US20130046105A1 (en) | 2013-02-21 |
| EP2672833A2 (en) | 2013-12-18 |
| CN103841825B (zh) | 2017-03-22 |
| US8999663B2 (en) | 2015-04-07 |
| JP6061866B2 (ja) | 2017-01-18 |
| CA2825039A1 (en) | 2012-08-16 |
| JP2014510165A (ja) | 2014-04-24 |
| EP2672833A4 (en) | 2015-06-10 |
| WO2012109545A3 (en) | 2014-02-20 |
| US20150218484A1 (en) | 2015-08-06 |
| CA2825039C (en) | 2020-04-28 |
| WO2012109545A2 (en) | 2012-08-16 |
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