CA3024631C - Control of bioreactor processes - Google Patents

Control of bioreactor processes Download PDF

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Publication number
CA3024631C
CA3024631C CA3024631A CA3024631A CA3024631C CA 3024631 C CA3024631 C CA 3024631C CA 3024631 A CA3024631 A CA 3024631A CA 3024631 A CA3024631 A CA 3024631A CA 3024631 C CA3024631 C CA 3024631C
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CA
Canada
Prior art keywords
flow rate
bioreactor
measured
containing substrate
control
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3024631A
Other languages
English (en)
French (fr)
Other versions
CA3024631A1 (en
Inventor
Guy William WATERS
Jason Carl Bromley
Justin Yi YANG
Jarod Nathan WILSON
Christophe Collet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lanzatech NZ Inc
Original Assignee
Lanzatech NZ Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lanzatech NZ Inc filed Critical Lanzatech NZ Inc
Publication of CA3024631A1 publication Critical patent/CA3024631A1/en
Application granted granted Critical
Publication of CA3024631C publication Critical patent/CA3024631C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/12—Bioreactors or fermenters specially adapted for specific uses for producing fuels or solvents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/06—Ethanol, i.e. non-beverage
    • C12P7/065—Ethanol, i.e. non-beverage with microorganisms other than yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B99/00—Subject matter not provided for in other groups of this subclass
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Computer Hardware Design (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Physics & Mathematics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA3024631A 2014-07-11 2015-05-06 Control of bioreactor processes Active CA3024631C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14/329,881 US9617566B2 (en) 2014-07-11 2014-07-11 Control of bioreactor processes
US14/329,881 2014-07-11
CA2954496A CA2954496C (en) 2014-07-11 2015-05-06 Control of bioreactor processes

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2954496A Division CA2954496C (en) 2014-07-11 2015-05-06 Control of bioreactor processes

Publications (2)

Publication Number Publication Date
CA3024631A1 CA3024631A1 (en) 2016-01-14
CA3024631C true CA3024631C (en) 2022-03-15

Family

ID=55064652

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3024631A Active CA3024631C (en) 2014-07-11 2015-05-06 Control of bioreactor processes
CA2954496A Active CA2954496C (en) 2014-07-11 2015-05-06 Control of bioreactor processes

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2954496A Active CA2954496C (en) 2014-07-11 2015-05-06 Control of bioreactor processes

Country Status (13)

Country Link
US (2) US9617566B2 (https=)
EP (2) EP3766983A1 (https=)
JP (2) JP6599427B2 (https=)
KR (1) KR102531892B1 (https=)
CN (1) CN106574276B (https=)
BR (1) BR112017000449B1 (https=)
CA (2) CA3024631C (https=)
EA (1) EA033036B1 (https=)
ES (1) ES2841337T3 (https=)
PL (1) PL3167068T3 (https=)
PT (1) PT3167068T (https=)
TW (2) TWI649426B (https=)
WO (1) WO2016007216A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10017789B2 (en) 2015-03-25 2018-07-10 The Board Of Regents For Oklahoma State University System and method for feedback control of gas supply for ethanol production via syngas fermentation using pH as a key control indicator
US10167445B2 (en) * 2016-04-04 2019-01-01 Hong Peng Cell culture monitoring system with low power consumption
CN111051517B (zh) * 2017-09-08 2023-10-27 朗泽科技有限公司 用于使用富氢气的含有c1的底物生产代谢物的方法和系统
US10889792B2 (en) 2018-02-09 2021-01-12 Global Life Sciences Solutions Usa Llc Cell expansion vessel systems and methods
JP7520322B2 (ja) 2018-02-09 2024-07-23 グローバル・ライフ・サイエンシズ・ソリューションズ・ユーエスエー・エルエルシー 細胞療法のためのバイオプロセッシング方法
KR102276219B1 (ko) * 2019-02-15 2021-07-12 씨제이제일제당 (주) 생물반응기의 운전 조건을 결정하는 장치 및 방법
KR102494796B1 (ko) * 2020-04-20 2023-02-01 현대제철 주식회사 바이오 연료 제조방법
JP2024513395A (ja) 2021-04-09 2024-03-25 ランザテク，インコーポレイテッド 供給原料を提供するためのプロセス及び装置

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5173429A (en) 1990-11-09 1992-12-22 The Board Of Trustees Of The University Of Arkansas Clostridiumm ljungdahlii, an anaerobic ethanol and acetate producing microorganism
US5593886A (en) 1992-10-30 1997-01-14 Gaddy; James L. Clostridium stain which produces acetic acid from waste gases
US5807722A (en) 1992-10-30 1998-09-15 Bioengineering Resources, Inc. Biological production of acetic acid from waste gases with Clostridium ljungdahlii
UA72220C2 (uk) 1998-09-08 2005-02-15 Байоенджініерінг Рісорсиз, Інк. Незмішувана з водою суміш розчинник/співрозчинник для екстрагування оцтової кислоти, спосіб одержання оцтової кислоти (варіанти), спосіб анаеробного мікробного бродіння для одержання оцтової кислоти (варіанти), модифікований розчинник та спосіб його одержання
JP2002526750A (ja) 1998-10-02 2002-08-20 ワトキンス，ウィリアム，ブルース，キャンベル 圧迫ガーメントを寸法設定するための測定器具及び測定方法
WO2000068407A1 (en) 1999-05-07 2000-11-16 Bioengineering Resources, Inc. Clostridium strains which produce ethanol from substrate-containing gases
WO2002008438A2 (en) * 2000-07-25 2002-01-31 Bioengineering Resources, Inc. Methods for increasing the production of ethanol from microbial fermentation
US20090104594A1 (en) * 2004-12-29 2009-04-23 Biogen Idec Bioreactor Process Control System and Method
NZ546496A (en) 2006-04-07 2008-09-26 Lanzatech New Zealand Ltd Gas treatment process
NZ553984A (en) 2007-03-19 2009-07-31 Lanzatech New Zealand Ltd Alcohol production process
CN102016052B (zh) * 2007-08-15 2015-04-29 朗泽科技新西兰有限公司 生产醇的工艺
NZ560757A (en) 2007-10-28 2010-07-30 Lanzatech New Zealand Ltd Improved carbon capture in microbial fermentation of industrial gases to ethanol
EA019266B1 (ru) 2008-03-12 2014-02-28 Ланзатек Нью Зиленд Лимитед Микробиологический способ производства спирта
CN102361989B (zh) 2009-01-29 2014-03-12 兰扎泰克新西兰有限公司 醇的生产方法
EP2449121B1 (en) * 2009-07-02 2020-09-02 Lanzatech New Zealand Limited Alcohol production process
US20120258441A1 (en) * 2009-12-22 2012-10-11 Ge Healthcare Bio-Sciences Ab Method for controlling culture parameters in a bioreactor
AU2011249140B2 (en) 2010-05-04 2013-10-03 Lanzatech Nz, Inc. Improved fermentation of waste gases
CA2786903C (en) * 2010-07-28 2015-01-20 Lanzatech New Zealand Limited Novel bacteria and methods of use thereof for producing ethanol and acetate
CA2807102C (en) 2010-07-31 2018-08-21 Myriant Corporation Improved fermentation process for the production of organic acids
CA2836686C (en) 2010-10-22 2015-11-17 Lanzatech New Zealand Limited Methods and systems for the production of alcohols and/or acids
AU2011316891B2 (en) 2010-10-22 2013-09-19 Lanzatech Nz, Inc. Methods and systems for the production of hydrocarbon products
EA024474B1 (ru) 2010-10-29 2016-09-30 Ланцатек Нью Зилэнд Лимитед Способ производства углеводородных продуктов
KR101950042B1 (ko) * 2010-12-03 2019-02-19 이네오스 바이오 에스에이 비 co-흡수 조절을 포함하는 발효 방법
US10100338B2 (en) * 2012-05-22 2018-10-16 Ineos Bio S.A. Method of operation of a syngas fermentation process
US10233478B2 (en) 2012-09-19 2019-03-19 Ineos Bio Sa Process for reducing CO2 emissions and increasing alcohol productivity in syngas fermentation
WO2014081848A1 (en) 2012-11-20 2014-05-30 Butamax Advanced Biofuels Llc Butanol purification

Also Published As

Publication number Publication date
US20160010116A1 (en) 2016-01-14
CA2954496A1 (en) 2016-01-14
BR112017000449B1 (pt) 2022-10-25
KR102531892B1 (ko) 2023-05-11
TWI673366B (zh) 2019-10-01
TW201920688A (zh) 2019-06-01
WO2016007216A1 (en) 2016-01-14
CN106574276B (zh) 2020-11-06
EP3167068B1 (en) 2020-10-28
CA2954496C (en) 2019-01-08
CA3024631A1 (en) 2016-01-14
KR20170028389A (ko) 2017-03-13
EP3167068A4 (en) 2018-03-21
EA033036B1 (ru) 2019-08-30
PT3167068T (pt) 2020-12-21
EP3167068A1 (en) 2017-05-17
US20170175064A1 (en) 2017-06-22
TWI649426B (zh) 2019-02-01
JP2019193636A (ja) 2019-11-07
US9617566B2 (en) 2017-04-11
TW201625801A (zh) 2016-07-16
JP6955531B2 (ja) 2021-10-27
US11753612B2 (en) 2023-09-12
PL3167068T3 (pl) 2021-04-19
BR112017000449A2 (pt) 2017-11-07
EA201790136A1 (ru) 2017-05-31
JP2017521077A (ja) 2017-08-03
JP6599427B2 (ja) 2019-10-30
EP3766983A1 (en) 2021-01-20
ES2841337T3 (es) 2021-07-08
CN106574276A (zh) 2017-04-19

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