CA3022877A1 - Treatment of angiogenesis-associated diseases using rna complexes that target angpt2 and pdgfb - Google Patents

Treatment of angiogenesis-associated diseases using rna complexes that target angpt2 and pdgfb Download PDF

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Publication number
CA3022877A1
CA3022877A1 CA3022877A CA3022877A CA3022877A1 CA 3022877 A1 CA3022877 A1 CA 3022877A1 CA 3022877 A CA3022877 A CA 3022877A CA 3022877 A CA3022877 A CA 3022877A CA 3022877 A1 CA3022877 A1 CA 3022877A1
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Prior art keywords
rna complex
angpt2
asipdgfb
rna
cell
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CA3022877A
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English (en)
French (fr)
Inventor
Dong-Ki Lee
Sun Woo Hong
Tae Yeon Lee
Sae-Lo-Oom LEE
Hanna LEE
Dayeon Yu
Ji Eom
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Olix Pharmaceuticals Inc
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Olix Pharmaceuticals Inc
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Publication of CA3022877A1 publication Critical patent/CA3022877A1/en
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/31—Combination therapy

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  • Medicinal Chemistry (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA3022877A 2016-02-02 2017-02-01 Treatment of angiogenesis-associated diseases using rna complexes that target angpt2 and pdgfb Pending CA3022877A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662290330P 2016-02-02 2016-02-02
US62/290,330 2016-02-02
PCT/IB2017/000167 WO2017134526A1 (en) 2016-02-02 2017-02-01 Treatment of angiogenesis-associated diseases using rna complexes that target angpt2 and pdgfb

Publications (1)

Publication Number Publication Date
CA3022877A1 true CA3022877A1 (en) 2017-08-10

Family

ID=59386437

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3022877A Pending CA3022877A1 (en) 2016-02-02 2017-02-01 Treatment of angiogenesis-associated diseases using rna complexes that target angpt2 and pdgfb

Country Status (7)

Country Link
US (2) US10519449B2 (enExample)
EP (1) EP3411481A4 (enExample)
JP (1) JP7003044B2 (enExample)
KR (1) KR102825945B1 (enExample)
CN (1) CN108779464B (enExample)
CA (1) CA3022877A1 (enExample)
WO (1) WO2017134526A1 (enExample)

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