CA3019012A1 - Methods of using (2r, 6r)-hydroxynorketamine and (2s, 6s)-hydroxynorketamine in the treatment of depression, anxiety, anhedonia, fatigue, suicidal ideation, and post traumatic stress disorders - Google Patents
Methods of using (2r, 6r)-hydroxynorketamine and (2s, 6s)-hydroxynorketamine in the treatment of depression, anxiety, anhedonia, fatigue, suicidal ideation, and post traumatic stress disorders Download PDFInfo
- Publication number
- CA3019012A1 CA3019012A1 CA3019012A CA3019012A CA3019012A1 CA 3019012 A1 CA3019012 A1 CA 3019012A1 CA 3019012 A CA3019012 A CA 3019012A CA 3019012 A CA3019012 A CA 3019012A CA 3019012 A1 CA3019012 A1 CA 3019012A1
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- CA
- Canada
- Prior art keywords
- disorder
- hnk
- ketamine
- anxiety
- hydroxynorketamine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
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| US201662313317P | 2016-03-25 | 2016-03-25 | |
| US62/313,317 | 2016-03-25 | ||
| PCT/US2017/024238 WO2017165877A1 (en) | 2016-03-25 | 2017-03-27 | Methods of using (2r, 6r)-hydroxynorketamine and (2s, 6s)-hydroxynorketamine in the treatment of depression, anxiety, anhedonia, suicidal ideation, and post traumatic stress disorders |
Publications (1)
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| CA3019012A1 true CA3019012A1 (en) | 2017-09-28 |
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| CA3019012A Abandoned CA3019012A1 (en) | 2016-03-25 | 2017-03-27 | Methods of using (2r, 6r)-hydroxynorketamine and (2s, 6s)-hydroxynorketamine in the treatment of depression, anxiety, anhedonia, fatigue, suicidal ideation, and post traumatic stress disorders |
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| US (1) | US20190083420A1 (https=) |
| EP (1) | EP3432869A1 (https=) |
| JP (1) | JP2019512528A (https=) |
| CN (1) | CN109475514A (https=) |
| AU (1) | AU2017238858A1 (https=) |
| CA (1) | CA3019012A1 (https=) |
| WO (1) | WO2017165877A1 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| SI3043785T1 (sl) | 2013-09-13 | 2022-02-28 | National University Corporation Chiba University | Uporaba R-ketamina in njegove soli kot farmacevtska sredstva |
| US11191734B2 (en) | 2015-06-27 | 2021-12-07 | Shenox Pharmaceuticals, Llc | Ketamine transdermal delivery system |
| JP7603368B2 (ja) | 2016-03-25 | 2024-12-20 | ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ | （２ｒ，６ｒ）－ヒドロキシノルケタミン塩酸塩の結晶形態 |
| WO2017180589A1 (en) * | 2016-04-11 | 2017-10-19 | Auspex Pharmaceuticals, Inc. | Deuterated ketamine derivatives |
| ES2991544T3 (es) * | 2016-11-30 | 2024-12-04 | Wolfson Philip E | Ketamina para el tratamiento de síntomas relacionados con la menstruación |
| PL3505157T3 (pl) | 2017-12-29 | 2022-04-11 | Celon Pharma S.A. | Kompozycja ketaminy w postaci suchego proszku do podawania dopłucnego w leczeniu depresji opornej na leczenie |
| JP7548669B2 (ja) | 2018-02-15 | 2024-09-10 | 国立大学法人千葉大学 | 炎症性疾患若しくは骨疾患の予防又は治療剤及び医薬組成物 |
| CN110343050B (zh) * | 2018-04-04 | 2021-09-24 | 上海键合医药科技有限公司 | 芳香类化合物及其制备方法和用途 |
| AU2019262197B2 (en) | 2018-05-04 | 2024-12-19 | Perception Neuroscience, Inc. | Methods of treating substance abuse |
| WO2020237748A1 (zh) * | 2019-05-24 | 2020-12-03 | 北京大学深圳研究生院 | 一种长效化合物的制备方法 |
| BR112022005579A2 (pt) * | 2019-11-05 | 2022-06-21 | Claes Thulin | 4-[5-[(rac)-1-[5-(3-clorofenil)-3-isoxazolil]etoxi]-4-metil-4h-1,2,4-triazol-3-il]piridina para uso na prevenção e/ou no tratamento de surmenage em um mamífero |
| CN113125586B (zh) * | 2019-12-31 | 2022-05-24 | 成都百裕制药股份有限公司 | 一种1-[2-(2，4-二甲基-苯硫基)-苯基]哌嗪及其异构体的检测方法 |
| CN112521357B (zh) * | 2020-08-31 | 2021-10-08 | 深圳瑞健生物科技有限公司 | 一种长效低成瘾性hnk衍生物及其制备方法 |
| US12466785B2 (en) | 2020-08-31 | 2025-11-11 | Shenzhen Ruijian Biotechnology Co., Ltd | Long-acting low-addiction HNK derivative and preparation method therefor |
| WO2022041174A1 (zh) | 2020-08-31 | 2022-03-03 | 深圳瑞健生物科技有限公司 | 一种长效低成瘾性hnk衍生物及其制备方法 |
| CN112516130B (zh) * | 2020-08-31 | 2022-01-04 | 深圳瑞健生物科技有限公司 | 一种长效低成瘾性化合物在制备药物中的应用 |
| CN114524737B (zh) * | 2020-11-23 | 2024-10-22 | 江苏恒瑞医药股份有限公司 | 一种取代的环己酮类化合物 |
| CN114947839B (zh) * | 2022-05-27 | 2025-12-02 | 华东师范大学 | 大脑调控的训练方法、装置及电子设备 |
| CN120736994B (zh) * | 2025-01-26 | 2025-11-18 | 上海东西智荟生物医药有限公司 | 氯胺酮衍生物及其在精神疾病的治疗中的用途 |
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| EP3904332B1 (en) * | 2011-10-14 | 2024-12-04 | The United States of America, as represented by The Secretary, Department of Health and Human Services | The use of (2r, 6r)-hydroxynorketamine, (s)-dehydronorketamine and other stereoisomeric dehydro and hydroxylated metabolites of (r,s)- ketamine in the treatment of depression and neuropathic pain |
| WO2014020155A1 (en) * | 2012-08-02 | 2014-02-06 | Clinpharm Reform Gmbh | Oral transmucosal adminstration forms of s-ketamine |
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- 2017-03-27 JP JP2018550327A patent/JP2019512528A/ja active Pending
- 2017-03-27 AU AU2017238858A patent/AU2017238858A1/en not_active Abandoned
- 2017-03-27 EP EP17716697.2A patent/EP3432869A1/en not_active Withdrawn
- 2017-03-27 US US16/088,294 patent/US20190083420A1/en not_active Abandoned
- 2017-03-27 WO PCT/US2017/024238 patent/WO2017165877A1/en not_active Ceased
- 2017-03-27 CN CN201780029039.8A patent/CN109475514A/zh active Pending
Also Published As
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| CN109475514A (zh) | 2019-03-15 |
| WO2017165877A1 (en) | 2017-09-28 |
| EP3432869A1 (en) | 2019-01-30 |
| JP2019512528A (ja) | 2019-05-16 |
| US20190083420A1 (en) | 2019-03-21 |
| AU2017238858A1 (en) | 2018-10-18 |
| WO2017165877A8 (en) | 2018-10-18 |
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