CA3018180C - Pyrimidines and variants thereof, and uses therefor - Google Patents
Pyrimidines and variants thereof, and uses therefor Download PDFInfo
- Publication number
- CA3018180C CA3018180C CA3018180A CA3018180A CA3018180C CA 3018180 C CA3018180 C CA 3018180C CA 3018180 A CA3018180 A CA 3018180A CA 3018180 A CA3018180 A CA 3018180A CA 3018180 C CA3018180 C CA 3018180C
- Authority
- CA
- Canada
- Prior art keywords
- compound
- formula
- mmol
- mixture
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662313334P | 2016-03-25 | 2016-03-25 | |
| US62/313,334 | 2016-03-25 | ||
| PCT/US2017/023126 WO2017165255A1 (en) | 2016-03-25 | 2017-03-20 | Pyrimidines and variants thereof, and uses therefor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA3018180A1 CA3018180A1 (en) | 2017-09-28 |
| CA3018180C true CA3018180C (en) | 2024-02-20 |
Family
ID=59900805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3018180A Active CA3018180C (en) | 2016-03-25 | 2017-03-20 | Pyrimidines and variants thereof, and uses therefor |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10662162B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3433258B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6902045B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102377805B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN108779119B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2017237929B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3018180C (cg-RX-API-DMAC7.html) |
| MA (1) | MA44489A (cg-RX-API-DMAC7.html) |
| MX (1) | MX384368B (cg-RX-API-DMAC7.html) |
| RU (1) | RU2760733C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017165255A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10822311B2 (en) | 2016-03-14 | 2020-11-03 | Afferent Pharmaceuticals, Inc. | Pyrimidines and variants thereof, and uses therefor |
| KR102377805B1 (ko) | 2016-03-25 | 2022-03-22 | 애퍼런트 파마슈티컬스 인크. | 피리미딘 및 그의 변이체, 및 그의 용도 |
| AU2017381739B2 (en) | 2016-12-19 | 2020-06-11 | Novartis Ag | New picolinic acid derivatives and their use as intermediates |
| US10676444B2 (en) * | 2016-12-20 | 2020-06-09 | Afferent Pharmaceuticals, Inc. | Crystalline salts and polymorphs of a P2X3 antagonist |
| US11414444B2 (en) | 2017-11-01 | 2022-08-16 | Beijing Tide Pharmaceutical Co., Ltd. | P2X3 and/or P2X2/3 receptor antagonist, pharmaceutical composition comprising same, and use thereof |
| CN107778255B (zh) * | 2017-11-16 | 2019-10-25 | 山东大学 | 一种二芳基嘧啶类hiv-1逆转录酶抑制剂及其制备方法和应用 |
| KR20220008286A (ko) * | 2019-04-30 | 2022-01-20 | 베이징 타이드 파마슈티컬 코퍼레이션 리미티드 | 디아미노피리미딘 화합물을 사용하여 자궁내막증-관련 통증 치료 방법 |
| WO2020221275A1 (zh) * | 2019-04-30 | 2020-11-05 | 北京泰德制药股份有限公司 | 二氨基嘧啶类化合物或其水合物的固体形式及其制备方法和用途 |
| US20220211703A1 (en) * | 2019-04-30 | 2022-07-07 | Beijing Tide Pharmaceutical Co., Ltd. | Method for treating cough by using diaminopyrimidine compound |
| EP3981765A4 (en) * | 2019-06-06 | 2023-05-31 | Beijing Tide Pharmaceutical Co., Ltd. | P2X3 AND/OR P2X2/3 RECEPTOR ANTAGONIST, PHARMACEUTICAL COMPOSITION CONTAINING IT AND THEIR USE |
| CN120058573B (zh) * | 2025-04-29 | 2025-12-23 | 潍坊学院 | 一种1-三溴甲基磺酰基萘及其衍生物的合成方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2953567A (en) * | 1956-11-23 | 1960-09-20 | Burroughs Wellcome Co | 5-phenylmercaptopyrimidines and method |
| WO2000059893A1 (en) * | 1999-04-06 | 2000-10-12 | Krenitsky Pharmaceuticals Inc. | Neurotrophic thio substituted pyrimidines |
| EP1345926B1 (en) | 2000-12-21 | 2006-05-17 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| AU2005229331B2 (en) * | 2004-03-05 | 2011-10-13 | F. Hoffmann-La Roche Ag | Diaminopyrimidines as P2X3 and P2X2/3 antagonists |
| WO2007025899A1 (en) * | 2005-09-01 | 2007-03-08 | F. Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 modulators |
| EP1924566B1 (en) * | 2005-09-01 | 2016-01-13 | F.Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 modulators |
| BRPI0615040A2 (pt) * | 2005-09-01 | 2011-04-26 | Hoffmann La Roche | diaminopirimidinas como moduladores de p2x3 e p2x2/3 |
| EP1924565B1 (en) * | 2005-09-01 | 2016-09-14 | F.Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p3x2/3 modulators |
| EP2079713B1 (en) * | 2006-10-04 | 2014-04-16 | F. Hoffmann-La Roche AG | Process for synthesis of phenoxy diaminopyrimidine derivatives |
| WO2008104474A1 (en) * | 2007-02-28 | 2008-09-04 | F. Hoffmann-La Roche Ag | Diaminopyrimidines |
| WO2008104472A1 (en) | 2007-02-28 | 2008-09-04 | F. Hoffmann-La Roche Ag | 2, 4 -diaminopyrimidine derivatives and their use as p2x antagonists or as prodrugs thereof |
| AU2008319735A1 (en) * | 2007-10-31 | 2009-05-07 | Nissan Chemical Industries, Ltd. | Pyridazinone derivatives and use thereof as P2X7 receptor inhibitors |
| GB2471713A (en) | 2009-07-08 | 2011-01-12 | Univ Greenwich | 1,2,4-triazine derivatives and their use as sodium channel blockers |
| TWI637949B (zh) * | 2013-06-14 | 2018-10-11 | 塩野義製藥股份有限公司 | 胺基三衍生物及含有其等之醫藥組合物 |
| NZ716977A (en) * | 2013-08-23 | 2017-09-29 | Afferent Pharmaceuticals Inc | Methods of using diaminopyrimidine p2x3 and p2x2/3 receptor modulators for treatment of acute and sub-acute cough, urge to cough and chronic cough, in respiratory diseases |
| EP3981406A1 (en) * | 2014-07-03 | 2022-04-13 | Afferent Pharmaceuticals Inc. | Methods and compositions for treating diseases and conditions |
| US10822311B2 (en) * | 2016-03-14 | 2020-11-03 | Afferent Pharmaceuticals, Inc. | Pyrimidines and variants thereof, and uses therefor |
| KR102377805B1 (ko) * | 2016-03-25 | 2022-03-22 | 애퍼런트 파마슈티컬스 인크. | 피리미딘 및 그의 변이체, 및 그의 용도 |
-
2017
- 2017-03-20 KR KR1020187029805A patent/KR102377805B1/ko active Active
- 2017-03-20 RU RU2018137032A patent/RU2760733C2/ru active
- 2017-03-20 CN CN201780019534.0A patent/CN108779119B/zh active Active
- 2017-03-20 AU AU2017237929A patent/AU2017237929B2/en active Active
- 2017-03-20 EP EP17770880.7A patent/EP3433258B1/en active Active
- 2017-03-20 US US16/080,840 patent/US10662162B2/en active Active
- 2017-03-20 MA MA044489A patent/MA44489A/fr unknown
- 2017-03-20 WO PCT/US2017/023126 patent/WO2017165255A1/en not_active Ceased
- 2017-03-20 MX MX2018011622A patent/MX384368B/es unknown
- 2017-03-20 CA CA3018180A patent/CA3018180C/en active Active
- 2017-03-20 JP JP2018549444A patent/JP6902045B2/ja active Active
-
2020
- 2020-04-13 US US16/846,452 patent/US11230532B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| RU2760733C2 (ru) | 2021-11-30 |
| MA44489A (fr) | 2019-01-30 |
| CN108779119B (zh) | 2022-02-08 |
| US20200239421A1 (en) | 2020-07-30 |
| MX2018011622A (es) | 2019-03-28 |
| US10662162B2 (en) | 2020-05-26 |
| US20190055202A1 (en) | 2019-02-21 |
| MX384368B (es) | 2025-03-14 |
| EP3433258B1 (en) | 2023-07-19 |
| AU2017237929B2 (en) | 2021-04-15 |
| JP6902045B2 (ja) | 2021-07-14 |
| AU2017237929A1 (en) | 2018-09-13 |
| KR102377805B1 (ko) | 2022-03-22 |
| JP2019510025A (ja) | 2019-04-11 |
| EP3433258A4 (en) | 2019-10-30 |
| RU2018137032A3 (cg-RX-API-DMAC7.html) | 2020-05-22 |
| EP3433258A1 (en) | 2019-01-30 |
| WO2017165255A1 (en) | 2017-09-28 |
| RU2018137032A (ru) | 2020-04-27 |
| CA3018180A1 (en) | 2017-09-28 |
| KR20180128015A (ko) | 2018-11-30 |
| BR112018069105A2 (pt) | 2019-01-29 |
| US11230532B2 (en) | 2022-01-25 |
| CN108779119A (zh) | 2018-11-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA3018180C (en) | Pyrimidines and variants thereof, and uses therefor | |
| AU2017233841B2 (en) | Pyrimidines and variants thereof, and uses therefor | |
| AU2013334236B2 (en) | Heteroaryl inhibitors of PDE4 | |
| AU2010332969B2 (en) | New CCR2 receptor antagonists and uses thereof | |
| EP2183224B1 (en) | 6-amino-pyrimidine-4-carboxamide derivatives and related compounds which bind to the sphingosine 1-phosphate (s1p) receptor for the treatment of multiple sclerosis | |
| US9725445B2 (en) | Cycloalkyl nitrile pyrazolo pyridones as Janus kinase inhibitors | |
| KR20150128722A (ko) | 카텝신 c의 억제제로서 치환된 2-아자-바이사이클로[2.2.1]헵탄-3-카복실산(벤질-시아노-메틸)-아미드 | |
| CN115340555A (zh) | 一种作为cdk抑制剂的吡啶乙酰胺类衍生物、其制备方法及用途 | |
| WO2016169421A1 (zh) | 咪唑并异吲哚类衍生物、其制备方法及其在医药上的应用 | |
| CN109563033B (zh) | 脂族脯氨酰胺衍生物 | |
| TW202519211A (zh) | 經取代之胺基吡啶化合物及用其治療疾病之方法 | |
| TW201726651A (zh) | ２，３，４，５－四氫吡啶－６－胺衍生物 | |
| BR112018069105B1 (pt) | Composto de pirimidina, composição e uso do mesmo | |
| JP2017533929A (ja) | プロキネチシン介在消化器疾患を治療するためのスルホニルピペリジン誘導体及びその使用 | |
| HK40061670A (en) | Compounds and compositions for treating conditions associated with apj receptor activity |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20220318 |
|
| EEER | Examination request |
Effective date: 20220318 |
|
| EEER | Examination request |
Effective date: 20220318 |
|
| EEER | Examination request |
Effective date: 20220318 |
|
| EEER | Examination request |
Effective date: 20220318 |
|
| EEER | Examination request |
Effective date: 20220318 |
|
| EEER | Examination request |
Effective date: 20220318 |
|
| EEER | Examination request |
Effective date: 20220318 |
|
| EEER | Examination request |
Effective date: 20220318 |
|
| EEER | Examination request |
Effective date: 20220318 |