CA3009445C - Combined biomarker measurement of fibrosis - Google Patents

Combined biomarker measurement of fibrosis Download PDF

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Publication number
CA3009445C
CA3009445C CA3009445A CA3009445A CA3009445C CA 3009445 C CA3009445 C CA 3009445C CA 3009445 A CA3009445 A CA 3009445A CA 3009445 A CA3009445 A CA 3009445A CA 3009445 C CA3009445 C CA 3009445C
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Canada
Prior art keywords
piiinp
monoclonal antibody
sandwich immunoassay
linked
cross
Prior art date
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Active
Application number
CA3009445A
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English (en)
French (fr)
Other versions
CA3009445A1 (en
Inventor
Federica GENOVESE
Mette Juul NIELSEN
Lisa LARSEN
Diane Julie Oersnes-Leeming
Morten Karsdal
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Nordic Bioscience AS
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Nordic Bioscience AS
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Publication date
Priority claimed from US15/014,241 external-priority patent/US9835631B2/en
Application filed by Nordic Bioscience AS filed Critical Nordic Bioscience AS
Publication of CA3009445A1 publication Critical patent/CA3009445A1/en
Application granted granted Critical
Publication of CA3009445C publication Critical patent/CA3009445C/en
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/581Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/08Hepato-biliairy disorders other than hepatitis
    • G01N2800/085Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/70Mechanisms involved in disease identification
    • G01N2800/7052Fibrosis
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
CA3009445A 2016-02-03 2017-02-02 Combined biomarker measurement of fibrosis Active CA3009445C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15/014,241 US9835631B2 (en) 2013-04-15 2016-02-03 Combined biomarker measurement of fibrosis
US15/014,241 2016-02-03
PCT/EP2017/052271 WO2017134172A1 (en) 2016-02-03 2017-02-02 Combined biomarker measurement of fibrosis

Publications (2)

Publication Number Publication Date
CA3009445A1 CA3009445A1 (en) 2017-08-10
CA3009445C true CA3009445C (en) 2024-03-19

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA3009445A Active CA3009445C (en) 2016-02-03 2017-02-02 Combined biomarker measurement of fibrosis

Country Status (6)

Country Link
EP (1) EP3411716A1 (ja)
JP (1) JP7094219B2 (ja)
KR (1) KR102668479B1 (ja)
CN (1) CN108431606B (ja)
CA (1) CA3009445C (ja)
WO (1) WO2017134172A1 (ja)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201717301D0 (en) * 2017-10-20 2017-12-06 Nordic Bioscience As Type xvi collagen assay
GB201802070D0 (en) * 2018-02-08 2018-03-28 Nordic Bioscience As Elastin assay
US20240003906A1 (en) 2020-04-16 2024-01-04 Nordic Bioscience A/S Biomarker of Fibrosis
CN113881625A (zh) * 2021-09-14 2022-01-04 广东省科学院健康医学研究所 一种细胞薄片培养添加剂及其应用
WO2023139154A1 (en) 2022-01-19 2023-07-27 Nordic Bioscience A/S A method for detecting covid-19 in a patient

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69915059T2 (de) 1998-05-28 2004-08-26 Bayer Healthcare Ag Monoklonaler antikörper und assay zur bestimmung von n-terminalem prokollagen-propeptid typ iii (piiinp)
US7668661B2 (en) * 2000-04-28 2010-02-23 Siemens Healthcare Diagnostics Inc. Liver disease-related methods and systems
DE60029302T2 (de) * 2000-04-28 2007-08-09 Bayer Ag Diagnose von Leberfibrose mit Hilfe von Serummarkeralgorithmen
US20070225242A1 (en) * 2005-06-21 2007-09-27 The Board Of Trustees Of The Leland Stanford Junior University Method and composition for treating and preventing tumor metastasis in vivo
CN101835490A (zh) * 2007-08-02 2010-09-15 阿雷斯托生物科学股份有限公司 Lox和loxl2抑制剂及其应用
CN101377509A (zh) * 2008-03-14 2009-03-04 北京科美东雅生物技术有限公司 Iii型前胶原n端肽化学发光免疫分析定量测定试剂盒及其制备方法
MX2011008296A (es) * 2009-02-06 2012-03-14 Gilead Biologics Inc Metodos y composiciones para el tratamiento de neovascularizacion.
EP2414844B1 (en) * 2009-03-30 2014-12-10 Nordic Bioscience A/S Fibrosis biomarker assay
KR20120064072A (ko) * 2009-09-16 2012-06-18 시오노기세야쿠 가부시키가이샤 콜라겐 네오에피토프 항체
CN102093465A (zh) * 2009-12-10 2011-06-15 北京北方生物技术研究所 分离ⅲ型前胶原氨基末端肽的方法
KR101753447B1 (ko) * 2010-09-24 2017-07-03 그리폴스 테라퓨틱스 인코포레이티드 면역크로마토그래피 장치, 방법 및 키트
CN102020715B (zh) * 2010-10-22 2012-09-05 上海贝西生物科技有限公司 一种抗ⅲ型前胶原氨基末端肽单克隆抗体及其用途
US20140170312A1 (en) * 2012-12-14 2014-06-19 Smith International, Inc. Method of making rhenium coating
GB201306792D0 (en) * 2013-04-15 2013-05-29 Nordic Bioscience As PIIINP Neo-epitope assay
GB201505654D0 (en) * 2015-04-01 2015-05-13 Nordic Bioscience As Immunoassay for collagen type VI sequence
CN106053826A (zh) * 2016-05-12 2016-10-26 威海威高生物科技有限公司 Ⅲ型前胶原n端肽定量测定试剂盒及其制备方法

Also Published As

Publication number Publication date
JP2019510210A (ja) 2019-04-11
KR20180104648A (ko) 2018-09-21
KR102668479B1 (ko) 2024-05-22
CN108431606B (zh) 2022-04-05
EP3411716A1 (en) 2018-12-12
CA3009445A1 (en) 2017-08-10
JP7094219B2 (ja) 2022-07-01
WO2017134172A1 (en) 2017-08-10
CN108431606A (zh) 2018-08-21

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