CA3007311A1 - Composition de conjugues d'agonistes-constructions d'anticorps et leurs procedes d'utilisation - Google Patents
Composition de conjugues d'agonistes-constructions d'anticorps et leurs procedes d'utilisation Download PDFInfo
- Publication number
- CA3007311A1 CA3007311A1 CA3007311A CA3007311A CA3007311A1 CA 3007311 A1 CA3007311 A1 CA 3007311A1 CA 3007311 A CA3007311 A CA 3007311A CA 3007311 A CA3007311 A CA 3007311A CA 3007311 A1 CA3007311 A1 CA 3007311A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- antibody
- conjugate
- salt
- domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
Abstract
L'invention concerne diverses compositions de constructions d'anticorps. L'invention concerne aussi des compositions de conjugués de composés immunostimulateurs-constructions d'anticorps. L'invention concerne également des procédés de préparation et d'utilisation des conjugués de composés immunostimulateurs-constructions d'anticorps. Les procédés incluent des procédés de traitement d'affections comme le cancer. L'invention concerne par ailleurs un genre de composés agonistes du stimulateur STING et un procédé de synthèse.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562264260P | 2015-12-07 | 2015-12-07 | |
US62/264,260 | 2015-12-07 | ||
US15/173,075 | 2016-06-03 | ||
US15/173,075 US20170158772A1 (en) | 2015-12-07 | 2016-06-03 | Compositions of antibody construct - agonist conjugates and methods of use thereof |
US201662371141P | 2016-08-04 | 2016-08-04 | |
US62/371,141 | 2016-08-04 | ||
PCT/US2016/065353 WO2017100305A2 (fr) | 2015-12-07 | 2016-12-07 | Composition de conjugués d'agonistes-constructions d'anticorps et leurs procédés d'utilisation |
Publications (1)
Publication Number | Publication Date |
---|---|
CA3007311A1 true CA3007311A1 (fr) | 2017-06-15 |
Family
ID=59013332
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA3007311A Abandoned CA3007311A1 (fr) | 2015-12-07 | 2016-12-07 | Composition de conjugues d'agonistes-constructions d'anticorps et leurs procedes d'utilisation |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP3386536A4 (fr) |
CA (1) | CA3007311A1 (fr) |
DE (1) | DE212016000029U1 (fr) |
WO (1) | WO2017100305A2 (fr) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11453697B1 (en) | 2015-08-13 | 2022-09-27 | Merck Sharp & Dohme Llc | Cyclic di-nucleotide compounds as sting agonists |
GEP20207182B (en) | 2015-08-13 | 2020-11-25 | Merck Sharp & Dohme | Cyclic di-nucleotide compounds as sting agonists |
IL280430B2 (en) | 2016-03-18 | 2023-11-01 | Univ Texas | Cyclic dinucleotide compounds and methods of use |
WO2018009916A1 (fr) | 2016-07-07 | 2018-01-11 | The Board Of Trustees Of The Leland Stanford Junior University | Conjugués d'adjuvant d'anticorps |
RS62410B1 (sr) | 2016-10-04 | 2021-10-29 | Merck Sharp & Dohme | Benzo[b]tiofenska jedinjenja kao agonisti sting |
JOP20170192A1 (ar) * | 2016-12-01 | 2019-01-30 | Takeda Pharmaceuticals Co | داي نوكليوتيد حلقي |
CA3049842A1 (fr) * | 2017-02-02 | 2018-08-09 | Silverback Therapeutics, Inc. | Compositions de produit de recombinaison-peptide et leurs methodes d'utilisation |
AR113224A1 (es) * | 2017-04-28 | 2020-02-19 | Novartis Ag | Conjugados de anticuerpo que comprenden un agonista de sting |
US11466047B2 (en) | 2017-05-12 | 2022-10-11 | Merck Sharp & Dohme Llc | Cyclic di-nucleotide compounds as sting agonists |
MA49772A (fr) | 2017-08-04 | 2021-04-21 | Merck Sharp & Dohme | Agonistes benzo[b]thiophène de sting pour le traitement du cancer |
AU2018311965A1 (en) | 2017-08-04 | 2020-02-13 | Merck Sharp & Dohme Llc | Combinations of PD-1 antagonists and benzo[b]thiophene sting antagonists for cancer treatment |
CN107365361B (zh) * | 2017-08-21 | 2020-05-19 | 中国药科大学 | 与pd-l1结合的重复域锚定蛋白及其用途 |
US10953032B2 (en) * | 2017-08-31 | 2021-03-23 | Bristol-Myers Squibb Company | Cyclic dinucleotides as anticancer agents |
EP3676278B1 (fr) * | 2017-08-31 | 2023-04-12 | Bristol-Myers Squibb Company | Dinucléotides cycliques utilisés en tant qu'agents anticancéreux |
US11707531B2 (en) * | 2017-09-11 | 2023-07-25 | F-star Therapeutics, Inc. | Compounds, compositions, and methods for the treatment of disease |
US11584774B2 (en) | 2017-09-11 | 2023-02-21 | F-star Therapeutics, Inc. | Compounds, compositions, and methods for the treatment of disease |
US11542293B2 (en) | 2017-11-10 | 2023-01-03 | Takeda Pharmaceutical Company Limited | Sting modulator compounds, and methods of making and using |
EP3727401A4 (fr) | 2017-12-20 | 2022-04-06 | Merck Sharp & Dohme Corp. | Composés dinucléotidiques cycliques utilisés comme agonistes sting |
EP3505188A1 (fr) | 2017-12-29 | 2019-07-03 | Invivogen | Conjugués de dinucléotide pro-cycliques pour l'induction de la cytokine |
CA3095646A1 (fr) | 2018-04-03 | 2019-10-10 | Merck Sharp & Dohme Corp. | Benzothiophenes et composes associes utilises en tant qu'agonistes de sting |
WO2019195063A1 (fr) | 2018-04-03 | 2019-10-10 | Merck Sharp & Dohme Corp. | Composés aza-benzothiophènes utilisés en tant qu'agonistes de sting |
WO2019227007A1 (fr) | 2018-05-25 | 2019-11-28 | Incyte Corporation | Composés hétérocycliques tricycliques en tant qu'activateurs de sting |
US10875872B2 (en) | 2018-07-31 | 2020-12-29 | Incyte Corporation | Heteroaryl amide compounds as sting activators |
US11008344B2 (en) | 2018-07-31 | 2021-05-18 | Incyte Corporation | Tricyclic heteroaryl compounds as STING activators |
AU2019337051B2 (en) | 2018-09-06 | 2023-11-23 | Daiichi Sankyo Company, Limited | Novel cyclic dinucleotide derivative and antibody-drug conjugate thereof |
US11596692B1 (en) | 2018-11-21 | 2023-03-07 | Incyte Corporation | PD-L1/STING conjugates and methods of use |
WO2020190725A1 (fr) | 2019-03-15 | 2020-09-24 | Bolt Biotherapeutics, Inc. | Immunoconjugués ciblant le her2 |
EP3962493A2 (fr) | 2019-05-03 | 2022-03-09 | Flagship Pioneering Innovations V, Inc. | Métodes de modulation de l'activité immunitaire |
US11787833B2 (en) | 2019-05-09 | 2023-10-17 | Aligos Therapeutics, Inc. | Modified cyclic dinucleoside compounds as sting modulators |
CN114206355A (zh) * | 2019-06-03 | 2022-03-18 | 芝加哥大学 | 用靶向癌症的佐剂治疗癌症的方法和组合物 |
WO2020245321A1 (fr) | 2019-06-04 | 2020-12-10 | Institut Curie | Méthodes de production de monomères et d'oligomères de la sous-unité b de la toxine de shiga (stxb), et leurs utilisations |
EP3999118A1 (fr) | 2019-07-19 | 2022-05-25 | Immunesensor Therapeutics, Inc. | Conjugués anticorps-agonistes de sting et leur utilisation en immunothérapie |
JP2022543086A (ja) | 2019-08-02 | 2022-10-07 | メルサナ セラピューティクス インコーポレイテッド | がんの処置用のSTING(インターフェロン遺伝子刺激因子)アゴニストとしてのビス-[N-((5-カルバモイル)-1H-ベンゾ[d]イミダゾール-2-イル)-ピラゾール-5-カルボキサミド]誘導体および関連化合物 |
WO2021046112A1 (fr) * | 2019-09-03 | 2021-03-11 | Bolt Biotherapeutics, Inc. | Composés aminoquinoline, immunoconjugués et leurs utilisations |
WO2021110987A1 (fr) | 2019-12-06 | 2021-06-10 | Life & Soft | Procédés et appareils permettant de diagnostiquer un cancer à partir d'acides nucléiques acellulaires |
CN111233850B (zh) * | 2020-01-21 | 2022-09-23 | 南开大学 | 含苯并噻唑氨基和杂芳基的萘酚衍生物与制备方法和用途 |
WO2021168274A1 (fr) | 2020-02-21 | 2021-08-26 | Silverback Therapeutics, Inc. | Conjugués d'anticorps de nectine-4 et leurs utilisations |
IL296124A (en) | 2020-03-06 | 2022-11-01 | Daiichi Sankyo Co Ltd | Conjugation of an antibody with a drug including a novel cyclic dinucleotide derivative |
JP2023541497A (ja) | 2020-03-13 | 2023-10-03 | ヘファイストス-ファーマ | 脱酸素化リポ多糖(lps)、天然非毒性lpsおよびそれらの使用 |
WO2021232019A1 (fr) | 2020-05-15 | 2021-11-18 | Immunesensor Therapeutics, Inc. | Polythérapies à agoniste de sting assorties d'inhibiteurs de points de contrôle immunitaires |
AU2021300362A1 (en) | 2020-07-01 | 2023-02-23 | ARS Pharmaceuticals, Inc. | Anti-ASGR1 antibody conjugates and uses thereof |
EP3943505A1 (fr) | 2020-07-22 | 2022-01-26 | Encefa | Peptides cd31 de liaison à cd38 et leurs utilisations |
JPWO2022050300A1 (fr) | 2020-09-02 | 2022-03-10 | ||
MX2023005381A (es) | 2020-11-09 | 2023-05-23 | Takeda Pharmaceuticals Co | Conjugados de anticuerpo y farmaco. |
US20240033366A1 (en) | 2020-12-02 | 2024-02-01 | Institut Curie | FUNCTIONALIZED SHIGA TOXIN B-SUBUNIT (STxB) PROTEINS AND CONJUGATES THEREOF |
KR20230152073A (ko) | 2021-02-26 | 2023-11-02 | 브레누스 파마 | 비자가 다중 스트레스성 암 세포 및 암의 백신접종 및 치료를 위한 이의 용도 |
CA3226976A1 (fr) | 2021-07-23 | 2023-01-26 | Immunesensor Therapeutics, Inc. | Polytherapies a base d'agonistes de sting comprenant des cytokines |
WO2023041717A1 (fr) | 2021-09-16 | 2023-03-23 | Aboleris Pharma | Domaines de liaison anti-cd45rc humaine et leurs utilisations |
TW202342105A (zh) * | 2021-12-17 | 2023-11-01 | 大陸商北京加科思新藥研發有限公司 | 包含可用作sting激動劑的化合物的化合物-連接基構建體及其用途 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE920561A1 (en) * | 1991-02-21 | 1992-08-26 | Gilead Sciences | Aptamer specific for thrombin and methods of use |
DE69535592T2 (de) | 1994-03-25 | 2008-06-12 | Isotechnika, Inc., Edmonton | Verbesserung der effektivität von arzneimitteln duren deuterierung |
US6334997B1 (en) | 1994-03-25 | 2002-01-01 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
AR039067A1 (es) * | 2001-11-09 | 2005-02-09 | Pfizer Prod Inc | Anticuerpos para cd40 |
US8946387B2 (en) * | 2002-08-14 | 2015-02-03 | Macrogenics, Inc. | FcγRIIB specific antibodies and methods of use thereof |
PE20142406A1 (es) * | 2012-05-04 | 2015-01-23 | Pfizer | Antigenos asociados a prostata y regimenes de inmunoterapia basados en vacuna |
CA2936377A1 (fr) * | 2014-01-10 | 2015-07-16 | Shanghai Birdie Biotech, Inc. | Composes et compositions pour le traitement de tumeurs exprimant egfr |
-
2016
- 2016-12-07 CA CA3007311A patent/CA3007311A1/fr not_active Abandoned
- 2016-12-07 WO PCT/US2016/065353 patent/WO2017100305A2/fr active Application Filing
- 2016-12-07 DE DE212016000029.2U patent/DE212016000029U1/de not_active Expired - Lifetime
- 2016-12-07 EP EP16873755.9A patent/EP3386536A4/fr not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
WO2017100305A3 (fr) | 2017-07-20 |
EP3386536A4 (fr) | 2019-07-31 |
WO2017100305A2 (fr) | 2017-06-15 |
WO2017100305A8 (fr) | 2017-09-08 |
EP3386536A2 (fr) | 2018-10-17 |
DE212016000029U1 (de) | 2017-07-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |
Effective date: 20220607 |
|
FZDE | Discontinued |
Effective date: 20220607 |