CA3002192C - Anticorps anti-muc16 et leurs procedes d'utilisation - Google Patents
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- CA3002192C CA3002192C CA3002192A CA3002192A CA3002192C CA 3002192 C CA3002192 C CA 3002192C CA 3002192 A CA3002192 A CA 3002192A CA 3002192 A CA3002192 A CA 3002192A CA 3002192 C CA3002192 C CA 3002192C
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Classifications
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/70503—Immunoglobulin superfamily
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C07K2317/622—Single chain antibody (scFv)
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
Abstract
Il est décrit des anticorps et des fragments de liaison à lantigène de ceux-ci qui se lient spécifiquement à un polypeptide, ou une partie antigénique de celui-ci, le polypeptide étant choisi parmi a) un polypeptide de lectodomaine de MUC16, b) un polypeptide du domaine cytoplasmique de MUC16, et c) un polypeptide du domaine extracellulaire de MUC16 qui contient un polypeptide à boucle cystéine. Les anticorps de linvention et les compositions les contenant sont utiles dans des applications diagnostiques et thérapeutiques pour des maladies dans lesquelles MUC16 est surexprimé, telles quun cancer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA3188287A CA3188287A1 (fr) | 2010-03-26 | 2011-03-25 | Anticorps anti-muc16 et leurs procedes d'utilisation |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31796410P | 2010-03-26 | 2010-03-26 | |
| US61/317,964 | 2010-03-26 | ||
| CA2793753A CA2793753C (fr) | 2010-03-26 | 2011-03-25 | Anticorps anti-muc16 et leurs procedes d'utilisation |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2793753A Division CA2793753C (fr) | 2010-03-26 | 2011-03-25 | Anticorps anti-muc16 et leurs procedes d'utilisation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3188287A Division CA3188287A1 (fr) | 2010-03-26 | 2011-03-25 | Anticorps anti-muc16 et leurs procedes d'utilisation |
Publications (2)
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|---|---|
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