CA3001316A1 - Neural precursor cell populations and uses thereof - Google Patents

Neural precursor cell populations and uses thereof Download PDF

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Publication number
CA3001316A1
CA3001316A1 CA3001316A CA3001316A CA3001316A1 CA 3001316 A1 CA3001316 A1 CA 3001316A1 CA 3001316 A CA3001316 A CA 3001316A CA 3001316 A CA3001316 A CA 3001316A CA 3001316 A1 CA3001316 A1 CA 3001316A1
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CA
Canada
Prior art keywords
cells
cell
neural precursor
population
enriched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3001316A
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English (en)
French (fr)
Inventor
Cory NICHOLAS
Luis FUENTEALBA
Cheuk Ka TONG
Marina BERSHTEYN
Sonja KRIKS
Stuart Chambers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neurona Therapeutics Inc
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Neurona Therapeutics Inc
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Publication date
Application filed by Neurona Therapeutics Inc filed Critical Neurona Therapeutics Inc
Publication of CA3001316A1 publication Critical patent/CA3001316A1/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0618Cells of the nervous system
    • C12N5/0619Neurons
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0618Cells of the nervous system
    • C12N5/0623Stem cells

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
CA3001316A 2015-10-08 2016-10-10 Neural precursor cell populations and uses thereof Pending CA3001316A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562239042P 2015-10-08 2015-10-08
US62/239,042 2015-10-08
PCT/US2016/056316 WO2017062971A1 (en) 2015-10-08 2016-10-10 Neural precursor cell populations and uses thereof

Publications (1)

Publication Number Publication Date
CA3001316A1 true CA3001316A1 (en) 2017-04-13

Family

ID=57200130

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3001316A Pending CA3001316A1 (en) 2015-10-08 2016-10-10 Neural precursor cell populations and uses thereof

Country Status (8)

Country Link
US (1) US20180369287A1 (https=)
EP (1) EP3359647A1 (https=)
JP (4) JP2018529389A (https=)
CN (1) CN108291207A (https=)
AU (3) AU2016335563B2 (https=)
CA (1) CA3001316A1 (https=)
HK (1) HK1258172A1 (https=)
WO (1) WO2017062971A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015069736A1 (en) 2013-11-08 2015-05-14 The Mclean Hospital Corporation METHODS FOR EFFICIENT GENERATION OF GABAergic INTERNEURONS FROM PLURIPOTENT STEM CELLS
JP2022043373A (ja) * 2018-12-28 2022-03-16 国立大学法人京都大学 大脳皮質細胞からのl1cam陽性細胞の取得およびその細胞製剤としての使用
US12343359B2 (en) 2019-05-23 2025-07-01 Dignity Health Inhibitory interneuron treatment methods, uses and compositions for diabetes
WO2023004345A1 (en) * 2021-07-21 2023-01-26 University Of Washington Compositions and methods for enhancing cardiomyocyte transplant engraftment
KR102684884B1 (ko) * 2021-08-05 2024-07-15 성균관대학교산학협력단 신경줄기세포의 줄기세포능 증진을 위한 gng2의 용도
CN113826564A (zh) * 2021-08-31 2021-12-24 南通大学 一种检测小鼠运动能力的方法
CN114736957B (zh) * 2022-04-15 2024-03-12 中国人民解放军空军军医大学 外泌体介导rna casc15干预阿尔茨海默症突触损失的应用
CN118064356A (zh) * 2022-11-22 2024-05-24 浙江霍德生物工程有限公司 前脑神经前体细胞在治疗与前脑神经细胞的死亡和/或功能不全相关的疾病中的应用
WO2025075929A1 (en) * 2023-10-02 2025-04-10 Neurona Therapeutics Inc. Methods of treating seizure activity
CN117092354B (zh) * 2023-10-18 2023-12-29 亿航(苏州)生物医药有限公司 一种用于识别脑源性细胞的细胞外囊泡的蛋白标志物

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
WO2001088104A2 (en) 2000-05-17 2001-11-22 Geron Corporation Neural progenitor cell populations
EP2298867A3 (en) 2000-06-20 2013-01-16 ES Cell International Pte Ltd. Method of controlling differentiation of embryonic stem (ES) cells by culturing ES cells in the presence of bmp-2 pathway antagonists
JPWO2004005496A1 (ja) 2002-07-05 2005-11-04 麒麟麦酒株式会社 臍帯血、骨髄、末梢血等に含まれる新規な未分化幹細胞集団
US20060211111A1 (en) 2002-12-18 2006-09-21 Maisam Mitalipova Compositions and methods for neural cell production and stabilization
ZA200401646B (en) * 2003-03-12 2004-06-07 Reliance Life Sciences Pvt Ltd Derivation of terminally differentiated dopaminergic neurons from human embryonic stem cells.
US20070020608A1 (en) 2003-05-08 2007-01-25 Peter Eriksson Method for the generation of neural progenitor cells
US7820439B2 (en) 2003-09-03 2010-10-26 Reliance Life Sciences Pvt Ltd. In vitro generation of GABAergic neurons from pluripotent stem cells
US7682828B2 (en) 2003-11-26 2010-03-23 Whitehead Institute For Biomedical Research Methods for reprogramming somatic cells
JP2008501320A (ja) 2004-06-02 2008-01-24 イーエス・セル・インターナショナル・プライヴェート・リミテッド 細胞保存方法
US20060008451A1 (en) 2004-07-06 2006-01-12 Michigan State University In vivo methods for effecting tissue specific differentiation of embryonic stem cells
EP1814979B1 (en) * 2004-11-17 2015-04-08 Neuralstem, Inc. Transplantation of human neural cells for treatment of neurodegenerative conditions
EP1856248A4 (en) 2005-02-09 2010-01-20 Burnham Inst Medical Research HOMOGENEOUS NEURALE CURRENT CELLS
WO2006091766A2 (en) 2005-02-24 2006-08-31 Jau-Nan Lee Human trophoblast stem cells and use thereof
US7803364B2 (en) 2005-11-17 2010-09-28 The Cleveland Clinic Foundation Multipotent neural stem cells
WO2007067280A2 (en) 2005-12-08 2007-06-14 University Of Louisville Research Foundation, Inc. Very small embryonic-like (vsel) stem cells and methods of isolating and using the same
CA2645186A1 (en) * 2006-01-20 2007-07-26 The Regents Of The University Of California Transplantation of neural cells
ES2663875T3 (es) 2006-11-03 2018-04-17 Multiple Sclerosis Research Center Of New York Células madre mesenquimáticas derivadas de la médula ósea como fuente de progenitores neurales
EP2607477B1 (en) 2007-05-03 2020-09-23 The Brigham and Women's Hospital, Inc. Multipotent stem cells and uses thereof
US8574567B2 (en) 2007-05-03 2013-11-05 The Brigham And Women's Hospital, Inc. Multipotent stem cells and uses thereof
US20100287638A1 (en) 2007-10-01 2010-11-11 The Hospital For Sick Children Neural tumor stem cells and methods of use thereof
US20110165129A1 (en) 2008-05-06 2011-07-07 Arnold Kriegstein Ameliorating Nervous Systems Disorders
WO2010144696A1 (en) 2009-06-11 2010-12-16 Burnham Institute For Medical Research Directed differentiation of stem cells
KR20110015739A (ko) 2009-08-10 2011-02-17 삼성전자주식회사 Emi방사 저감을 위한 플라즈마 디스플레이 장치
WO2011079307A2 (en) 2009-12-23 2011-06-30 The Salk Institute For Biological Studies Methods and compositions for treating neurological disorders
WO2011091048A1 (en) 2010-01-19 2011-07-28 The Board Of Trustees Of The Leland Stanford Junior University Direct conversion of cells to cells of other lineages
CA2835215C (en) * 2011-05-18 2023-10-10 The Regents Of The University Of California Non-immortal human retinal cell compositions, method for preparing them, and their use for treating retinal diseases
WO2013076726A1 (en) 2011-11-21 2013-05-30 Ramot At Tel-Aviv University Ltd. Stem cell-derived neural cells for cell therapy in neurological disorders
KR101429217B1 (ko) 2012-02-06 2014-08-12 동국대학교 산학협력단 줄기세포를 신경세포로 분화시키는 방법
WO2013139429A1 (en) 2012-03-21 2013-09-26 Merck Patent Gmbh Induced neural stem cells
WO2013155222A2 (en) 2012-04-10 2013-10-17 The Regents Of The University Of California Brain-specific enhancers for cell-based therapy
JP2014082956A (ja) 2012-10-19 2014-05-12 Somar Corp 細胞培養基材、およびそれを用いた細胞培養方法並びに多能性幹細胞の分化誘導方法
CA2899507A1 (en) * 2013-03-14 2014-09-25 The Regents Of The University Of California In vitro production of medial ganglionic eminence precursor cells
EP3498824A1 (en) 2013-04-26 2019-06-19 Memorial Sloan-Kettering Cancer Center Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells
CN106164255B (zh) 2013-09-20 2020-02-14 隆萨有限公司 细胞的核重编程的方法
WO2015069736A1 (en) 2013-11-08 2015-05-14 The Mclean Hospital Corporation METHODS FOR EFFICIENT GENERATION OF GABAergic INTERNEURONS FROM PLURIPOTENT STEM CELLS

Also Published As

Publication number Publication date
JP2025022948A (ja) 2025-02-14
JP2018529389A (ja) 2018-10-11
AU2025283558A1 (en) 2026-01-15
HK1258172A1 (zh) 2019-11-08
US20180369287A1 (en) 2018-12-27
EP3359647A1 (en) 2018-08-15
JP2022169768A (ja) 2022-11-09
JP7138959B2 (ja) 2022-09-20
JP7598655B2 (ja) 2024-12-12
AU2023200389A1 (en) 2023-02-23
AU2016335563A1 (en) 2018-05-24
AU2023200389B2 (en) 2025-09-25
AU2016335563B2 (en) 2022-10-27
CN108291207A (zh) 2018-07-17
WO2017062971A1 (en) 2017-04-13
JP2020202865A (ja) 2020-12-24

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