CA2997960A1 - Anti-trem2 antibodies and methods of use thereof - Google Patents
Anti-trem2 antibodies and methods of use thereof Download PDFInfo
- Publication number
- CA2997960A1 CA2997960A1 CA2997960A CA2997960A CA2997960A1 CA 2997960 A1 CA2997960 A1 CA 2997960A1 CA 2997960 A CA2997960 A CA 2997960A CA 2997960 A CA2997960 A CA 2997960A CA 2997960 A1 CA2997960 A1 CA 2997960A1
- Authority
- CA
- Canada
- Prior art keywords
- amino acid
- seq
- acid sequence
- hvr
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562238044P | 2015-10-06 | 2015-10-06 | |
| US62/238,044 | 2015-10-06 | ||
| US201662369666P | 2016-08-01 | 2016-08-01 | |
| US62/369,666 | 2016-08-01 | ||
| PCT/US2016/055828 WO2017062672A2 (en) | 2015-10-06 | 2016-10-06 | Anti-trem2 antibodies and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2997960A1 true CA2997960A1 (en) | 2017-04-13 |
Family
ID=57178515
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2997960A Pending CA2997960A1 (en) | 2015-10-06 | 2016-10-06 | Anti-trem2 antibodies and methods of use thereof |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20190330335A1 (https=) |
| EP (1) | EP3359569A2 (https=) |
| JP (2) | JP7725185B2 (https=) |
| KR (1) | KR20180068999A (https=) |
| CN (2) | CN117069841A (https=) |
| AU (2) | AU2016334051B2 (https=) |
| CA (1) | CA2997960A1 (https=) |
| SG (1) | SG10201912150TA (https=) |
| WO (1) | WO2017062672A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110998329A (zh) * | 2017-07-20 | 2020-04-10 | 西托姆克斯治疗公司 | 定性和/或定量分析可活化抗体的特性的方法及其用途 |
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| EP3177322A4 (en) | 2014-08-08 | 2018-07-18 | Alector LLC | Anti-trem2 antibodies and methods of use thereof |
| CA2961950A1 (en) | 2014-09-28 | 2016-03-31 | The Regents Of The University Of California | Modulation of stimulatory and non-stimulatory myeloid cells |
| KR102799807B1 (ko) | 2015-12-30 | 2025-04-24 | 코디악 사이언시스 인코포레이티드 | 항체 및 이의 접합체 |
| PE20190208A1 (es) | 2016-05-02 | 2019-02-07 | Prothena Biosciences Ltd | Anticuerpos que reconocen tau |
| CA3022515A1 (en) | 2016-05-02 | 2017-11-09 | Prothena Biosciences Limited | Antibodies recognizing tau |
| EP3452507B1 (en) | 2016-05-02 | 2022-10-19 | Prothena Biosciences Limited | Tau immunotherapy |
| EP3487886A2 (en) | 2016-07-22 | 2019-05-29 | Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE) | Trem2 cleavage modulators and uses thereof |
| JP7159188B2 (ja) * | 2016-12-13 | 2022-10-24 | アキリ・インタラクティヴ・ラブズ・インコーポレイテッド | ナビゲーション課題を使用するバイオマーカーの識別およびナビゲーション課題を使用する治療のためのプラットフォーム |
| BR112019017021A2 (pt) | 2017-02-17 | 2020-04-14 | Denali Therapeutics Inc | anticorpos anti-tau e métodos de uso dos mesmos |
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| JOP20190248A1 (ar) * | 2017-04-21 | 2019-10-20 | Amgen Inc | بروتينات ربط مولد ضد trem2 واستخداماته |
| CN110881274B (zh) | 2017-05-02 | 2024-11-15 | 普罗塞纳生物科学有限公司 | 识别tau的抗体 |
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| WO2019118513A1 (en) | 2017-12-12 | 2019-06-20 | Pionyr Immunotherapeutics, Inc. | Anti-trem2 antibodies and related methods |
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| CN121253826A (zh) * | 2018-10-05 | 2026-01-02 | 西雅图儿童医院以西雅图儿童研究机构名义经营 | 针对原发性免疫缺陷、胱氨酸病和威尔逊病的新生儿筛查 |
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-
2016
- 2016-10-06 AU AU2016334051A patent/AU2016334051B2/en active Active
- 2016-10-06 EP EP16784666.6A patent/EP3359569A2/en active Pending
- 2016-10-06 CN CN202310465565.6A patent/CN117069841A/zh active Pending
- 2016-10-06 WO PCT/US2016/055828 patent/WO2017062672A2/en not_active Ceased
- 2016-10-06 KR KR1020187012495A patent/KR20180068999A/ko not_active Ceased
- 2016-10-06 CA CA2997960A patent/CA2997960A1/en active Pending
- 2016-10-06 CN CN201680070761.1A patent/CN108738323B/zh active Active
- 2016-10-06 US US15/766,363 patent/US20190330335A1/en not_active Abandoned
- 2016-10-06 SG SG10201912150TA patent/SG10201912150TA/en unknown
- 2016-10-06 JP JP2018517785A patent/JP7725185B2/ja active Active
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110998329A (zh) * | 2017-07-20 | 2020-04-10 | 西托姆克斯治疗公司 | 定性和/或定量分析可活化抗体的特性的方法及其用途 |
| US12498367B2 (en) | 2017-07-20 | 2025-12-16 | Cytomx Therapeutics, Inc. | Methods of qualitatively and/or quantitatively analyzing properties of activatable antibodies and uses thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3359569A2 (en) | 2018-08-15 |
| SG10201912150TA (en) | 2020-02-27 |
| JP7725185B2 (ja) | 2025-08-19 |
| US20190330335A1 (en) | 2019-10-31 |
| KR20180068999A (ko) | 2018-06-22 |
| AU2016334051A1 (en) | 2018-04-12 |
| CN108738323B (zh) | 2023-05-26 |
| WO2017062672A3 (en) | 2017-05-26 |
| CN108738323A (zh) | 2018-11-02 |
| JP2018537956A (ja) | 2018-12-27 |
| WO2017062672A2 (en) | 2017-04-13 |
| JP2023093528A (ja) | 2023-07-04 |
| AU2024200443A1 (en) | 2024-04-04 |
| CN117069841A (zh) | 2023-11-17 |
| AU2016334051B2 (en) | 2023-10-26 |
| US20230295297A1 (en) | 2023-09-21 |
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