CA2986739C - Plx-8394 or plx-7904 for use in the treatment of braf-v600-related diseases - Google Patents
Plx-8394 or plx-7904 for use in the treatment of braf-v600-related diseases Download PDFInfo
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- CA2986739C CA2986739C CA2986739A CA2986739A CA2986739C CA 2986739 C CA2986739 C CA 2986739C CA 2986739 A CA2986739 A CA 2986739A CA 2986739 A CA2986739 A CA 2986739A CA 2986739 C CA2986739 C CA 2986739C
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Biomedical Technology (AREA)
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- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US201562165813P | 2015-05-22 | 2015-05-22 | |
| US62/165,813 | 2015-05-22 | ||
| PCT/US2016/033587 WO2016191296A1 (en) | 2015-05-22 | 2016-05-20 | Plx-8394 or plx-7904 for use in the treatment of braf-v600-related diseases |
Publications (2)
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| CA2986739A1 CA2986739A1 (en) | 2016-12-01 |
| CA2986739C true CA2986739C (en) | 2023-03-14 |
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| CA2986739A Active CA2986739C (en) | 2015-05-22 | 2016-05-20 | Plx-8394 or plx-7904 for use in the treatment of braf-v600-related diseases |
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| EP (1) | EP3297630A1 (OSRAM) |
| JP (2) | JP2018515570A (OSRAM) |
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| CN (2) | CN113893253A (OSRAM) |
| BR (1) | BR112017025045A2 (OSRAM) |
| CA (1) | CA2986739C (OSRAM) |
| TW (1) | TWI812581B (OSRAM) |
| WO (1) | WO2016191296A1 (OSRAM) |
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| BRPI0814423B1 (pt) | 2007-07-17 | 2022-04-19 | Plexxikon, Inc | Compostos que modulam quinase e composição farmacêutica compreendendo os mesmos |
| AU2012214762B2 (en) | 2011-02-07 | 2015-08-13 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| US9358235B2 (en) | 2012-03-19 | 2016-06-07 | Plexxikon Inc. | Kinase modulation, and indications therefor |
| WO2014039714A2 (en) | 2012-09-06 | 2014-03-13 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| BR112015014752B1 (pt) | 2012-12-21 | 2022-07-05 | Plexxikon, Inc | Compostos e seus uso para modulação de cinase |
| RU2680100C9 (ru) | 2013-03-15 | 2019-04-18 | Плексксикон Инк. | Гетероциклические соединения и их применения |
| US20140303121A1 (en) | 2013-03-15 | 2014-10-09 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
| CA2912568A1 (en) | 2013-05-30 | 2014-12-04 | Plexxikon Inc. | Compounds for kinase modulation, and indications therefor |
| US10160755B2 (en) | 2015-04-08 | 2018-12-25 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| US9745298B2 (en) | 2015-05-06 | 2017-08-29 | Plexxikon Inc. | Synthesis of a compound that modulates kinases |
| DK3292123T3 (da) | 2015-05-06 | 2020-08-17 | Plexxikon Inc | Faste former af en forbindelse, der modulerer kinaser |
| TWI658042B (zh) | 2015-05-22 | 2019-05-01 | 美商普雷辛肯公司 | 雜環化合物的合成 |
| US10829484B2 (en) | 2015-07-28 | 2020-11-10 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| CA3129180A1 (en) | 2015-09-21 | 2017-03-30 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
| MX2018006856A (es) | 2015-12-07 | 2018-08-01 | Plexxikon Inc | Compuestos y metodos para modulacion de la quinasa, e indicaciones de los mismos. |
| JP6921846B6 (ja) | 2016-03-16 | 2021-09-15 | プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． | キナーゼ調節およびその適応症のための化合物および方法 |
| TW201815766A (zh) | 2016-09-22 | 2018-05-01 | 美商普雷辛肯公司 | 用於ｉｄｏ及ｔｄｏ調節之化合物及方法以及其適應症 |
| CA3047580A1 (en) | 2016-12-23 | 2018-07-26 | Plexxikon Inc. | Compounds and methods for cdk8 modulation and indications therefor |
| WO2018134254A1 (en) | 2017-01-17 | 2018-07-26 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| AU2018237047A1 (en) | 2017-03-20 | 2019-10-17 | Plexxikon Inc. | Crystalline forms of 4-(1-(1,1-di(pyridin-2-yl)ethyl)-6-(3,5-dimethylisoxazol-4-yl)-1H- pyrrolo[3,2-b]pyridin-3-yl)benzoic acid that inhibits bromodomain |
| WO2018218633A1 (en) | 2017-06-02 | 2018-12-06 | Beijing Percans Oncology Co. Ltd. | Combination therapies for treating cancers |
| US10428067B2 (en) | 2017-06-07 | 2019-10-01 | Plexxikon Inc. | Compounds and methods for kinase modulation |
| BR112019028235B1 (pt) | 2017-07-25 | 2024-04-30 | Plexxikon, Inc. | Composições e seus métodos de preparação |
| US10717735B2 (en) | 2017-10-13 | 2020-07-21 | Plexxikon Inc. | Solid forms of a compound for modulating kinases |
| TWI803530B (zh) * | 2017-10-27 | 2023-06-01 | 美商普雷辛肯公司 | 調節激酶之化合物之調配物 |
| WO2019183145A1 (en) | 2018-03-20 | 2019-09-26 | Plexxikon Inc. | Compounds and methods for ido and tdo modulation, and indications therefor |
| WO2019195959A1 (en) | 2018-04-08 | 2019-10-17 | Cothera Biosciences, Inc. | Combination therapy for cancers with braf mutation |
| CN108610336A (zh) * | 2018-06-03 | 2018-10-02 | 刘思良 | 一种重氮类衍生物及其在癌症治疗中的应用 |
| CN108864060A (zh) * | 2018-06-03 | 2018-11-23 | 刘思良 | 一种重氮类衍生物及其在癌症治疗中的应用 |
| CN108586439A (zh) * | 2018-06-03 | 2018-09-28 | 刘思良 | 一种Raf激酶抑制剂及其在癌症治疗中的应用 |
| WO2020036852A1 (en) | 2018-08-13 | 2020-02-20 | Beijing Percans Oncology Co. Ltd. | Biomarkers for cancer therapy |
| US20210379047A1 (en) * | 2018-10-30 | 2021-12-09 | Institute For Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center | Combination Therapies For Treating Cancer |
| BR112021019957A2 (pt) | 2019-04-09 | 2021-12-07 | Plexxikon Inc | Azinas condensadas para modulação de ep300 ou cbp e indicações da mesma |
| CN110585433A (zh) * | 2019-09-27 | 2019-12-20 | 青岛大学 | Braf-v600e的抑制剂的应用及用于治疗甲状腺癌的药物 |
| EP4483882A3 (en) | 2019-12-10 | 2025-03-05 | F. Hoffmann-La Roche AG | New methylquinazolinone derivatives |
| EP4073102A4 (en) | 2019-12-12 | 2024-05-08 | Ting Therapeutics LLC | Compositions and methods for the prevention and treatment of hearing loss |
| CN111057690A (zh) * | 2019-12-23 | 2020-04-24 | 维塔恩(广州)医药有限公司 | 肿瘤相关基因braf突变相关抗原短肽及其应用 |
| TW202206422A (zh) | 2020-04-23 | 2022-02-16 | 美商普雷辛肯公司 | 用於ｃｄ７３調節之化合物及方法及其適應症 |
| AU2021263383A1 (en) | 2020-04-29 | 2022-11-24 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
| WO2022040512A1 (en) | 2020-08-21 | 2022-02-24 | Plexxikon Inc. | Combinational drug anticancer therapies |
| WO2023049798A1 (en) * | 2021-09-22 | 2023-03-30 | Henry Ford Health System | Hdac3 inhibitors for the treatment of langerhans cell histiocytosis and langerhans cell sarcoma |
| CN118845777B (zh) * | 2024-06-28 | 2025-02-25 | 遵义医科大学附属医院 | 一种克诺拉尼用作淋巴水肿治疗剂的用途 |
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| WO2007002433A1 (en) | 2005-06-22 | 2007-01-04 | Plexxikon, Inc. | Pyrrolo [2, 3-b] pyridine derivatives as protein kinase inhibitors |
| WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
| BRPI0814423B1 (pt) | 2007-07-17 | 2022-04-19 | Plexxikon, Inc | Compostos que modulam quinase e composição farmacêutica compreendendo os mesmos |
| WO2009143018A2 (en) | 2008-05-19 | 2009-11-26 | Plexxikon, Inc. | Compounds and methods for kinase modulation, and indications therefor |
| MX2011008303A (es) | 2009-04-03 | 2011-11-29 | Plexxikon Inc | Composiciones del acido propano-1-sulfonico {3-[5-(4-cloro-fenil)- 1h-pirrolo [2,3-b]-piridina-3-carbonil]-2,4-difluoro-fenil}-amida y el uso de las mismas. |
| EP2501236B1 (en) | 2009-11-18 | 2017-03-29 | Plexxikon Inc. | N-[2-fluoro-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-phenyl]-4-benzenesulfonamide derivatives as Raf protein kinase modulators for the treatment of cancer |
| MX2012007429A (es) | 2009-12-23 | 2012-07-23 | Plexxikon Inc | Compuestos y metodos para la modulacion de quinasa e indicaciones de la misma. |
| AU2012214762B2 (en) | 2011-02-07 | 2015-08-13 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| CA2836474A1 (en) | 2011-05-17 | 2012-11-22 | Plexxikon Inc. | Kinase modulation and indications therefor |
| US9358235B2 (en) | 2012-03-19 | 2016-06-07 | Plexxikon Inc. | Kinase modulation, and indications therefor |
| KR20240146112A (ko) * | 2012-08-17 | 2024-10-07 | 에프. 호프만-라 로슈 아게 | 코비메티닙 및 베무라피닙을 투여함을 포함하는 흑색종의 조합 치료법 |
| US20140303121A1 (en) | 2013-03-15 | 2014-10-09 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
| PT2976106T (pt) * | 2013-03-21 | 2021-05-26 | Array Biopharma Inc | Terapia de combinação que compreende um inibidor de b-raf e um segundo inibidor |
| CA2912568A1 (en) * | 2013-05-30 | 2014-12-04 | Plexxikon Inc. | Compounds for kinase modulation, and indications therefor |
| US9856259B2 (en) | 2014-09-15 | 2018-01-02 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
| US10160755B2 (en) | 2015-04-08 | 2018-12-25 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| DK3292123T3 (da) | 2015-05-06 | 2020-08-17 | Plexxikon Inc | Faste former af en forbindelse, der modulerer kinaser |
| TWI658042B (zh) | 2015-05-22 | 2019-05-01 | 美商普雷辛肯公司 | 雜環化合物的合成 |
| US10829484B2 (en) | 2015-07-28 | 2020-11-10 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| CA3129180A1 (en) | 2015-09-21 | 2017-03-30 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
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2016
- 2016-05-20 BR BR112017025045A patent/BR112017025045A2/pt not_active Application Discontinuation
- 2016-05-20 KR KR1020177036179A patent/KR20180006447A/ko not_active Withdrawn
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- 2016-05-20 JP JP2017560716A patent/JP2018515570A/ja active Pending
- 2016-05-20 EP EP16727904.1A patent/EP3297630A1/en not_active Withdrawn
- 2016-05-20 CN CN201680033004.7A patent/CN107801378A/zh active Pending
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- 2016-05-20 WO PCT/US2016/033587 patent/WO2016191296A1/en not_active Ceased
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2021
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| TW201707704A (zh) | 2017-03-01 |
| CN107801378A (zh) | 2018-03-13 |
| EP3297630A1 (en) | 2018-03-28 |
| US9814714B2 (en) | 2017-11-14 |
| CA2986739A1 (en) | 2016-12-01 |
| WO2016191296A1 (en) | 2016-12-01 |
| US20160339025A1 (en) | 2016-11-24 |
| BR112017025045A2 (pt) | 2018-08-07 |
| KR20180006447A (ko) | 2018-01-17 |
| TWI812581B (zh) | 2023-08-21 |
| JP2018515570A (ja) | 2018-06-14 |
| JP2022058398A (ja) | 2022-04-12 |
| CN113893253A (zh) | 2022-01-07 |
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