CA2982169A1 - Protein biomarker panels for detecting colorectal cancer and advanced adenoma - Google Patents
Protein biomarker panels for detecting colorectal cancer and advanced adenoma Download PDFInfo
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- CA2982169A1 CA2982169A1 CA2982169A CA2982169A CA2982169A1 CA 2982169 A1 CA2982169 A1 CA 2982169A1 CA 2982169 A CA2982169 A CA 2982169A CA 2982169 A CA2982169 A CA 2982169A CA 2982169 A1 CA2982169 A1 CA 2982169A1
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Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9141756B1 (en) | 2010-07-20 | 2015-09-22 | University Of Southern California | Multi-scale complex systems transdisciplinary analysis of response to therapy |
| KR101937531B1 (ko) * | 2016-09-28 | 2019-01-10 | 국립암센터 | 대장암 진단 장치와 대장암 진단 정보 제공 방법 |
| US20180100858A1 (en) | 2016-10-07 | 2018-04-12 | Applied Proteomics, Inc. | Protein biomarker panels for detecting colorectal cancer and advanced adenoma |
| WO2018111989A1 (en) | 2016-12-14 | 2018-06-21 | Purdue Research Foundation | Fibroblast activation protein (fap)-targeted imaging and therapy |
| US11062792B2 (en) | 2017-07-18 | 2021-07-13 | Analytics For Life Inc. | Discovering genomes to use in machine learning techniques |
| US11139048B2 (en) | 2017-07-18 | 2021-10-05 | Analytics For Life Inc. | Discovering novel features to use in machine learning techniques, such as machine learning techniques for diagnosing medical conditions |
| CN111684282A (zh) * | 2017-12-05 | 2020-09-18 | 迪森德克斯公司 | 结直肠癌生物标志物的稳健小组 |
| JP7102509B2 (ja) * | 2018-04-04 | 2022-07-19 | 富士フイルム株式会社 | 医療文書作成支援装置、医療文書作成支援方法、及び医療文書作成支援プログラム |
| CN112970067A (zh) * | 2018-06-30 | 2021-06-15 | 20/20基因系统股份有限公司 | 癌症分类器模型、机器学习系统和使用方法 |
| AU2019297457A1 (en) * | 2018-07-05 | 2021-02-25 | Edp Biotech Corporation | Kits and methods for detecting markers |
| US11011276B2 (en) * | 2018-07-09 | 2021-05-18 | Chang Gung Memorial Hospital, Linkou | Method for establishing computer-aided data interpretation model for immune diseases by immunomarkers and visualization |
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| US20210349017A1 (en) * | 2020-05-08 | 2021-11-11 | Caci, Inc. - Federal | Systems and methods for detection of biological agents using infrared spectroscopy |
| CN116868229A (zh) * | 2021-02-16 | 2023-10-10 | 威里利生命科学有限责任公司 | 用于数字化病理学样本中的生物标志物检测的系统和方法 |
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| WO2024208824A1 (en) * | 2023-04-03 | 2024-10-10 | Oncodiag | Methods for the diagnosis and surveillance of cancer |
| CN118983105A (zh) * | 2024-06-24 | 2024-11-19 | 浙江省肿瘤医院 | 一种用于高级别浆液性卵巢癌晚期患者无复发生存的预测模型 |
Family Cites Families (99)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4444879A (en) | 1981-01-29 | 1984-04-24 | Science Research Center, Inc. | Immunoassay with article having support film and immunological counterpart of analyte |
| US4517289A (en) | 1982-08-18 | 1985-05-14 | Brigham And Women's Hospital | Monoclonal antibodies for human tissue cross-matching |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4921789A (en) | 1988-04-20 | 1990-05-01 | New England Deaconess Hospital Corporation | Marker for colorectal carcinoma and methods of detecting the same |
| US5344760A (en) | 1991-06-03 | 1994-09-06 | Ciba Corning Diagnostics Corp. | Method of cancer detection |
| US5786158A (en) | 1992-04-30 | 1998-07-28 | Yale University | Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids |
| US5790761A (en) | 1992-12-11 | 1998-08-04 | Heseltine; Gary L. | Method and apparatus for the diagnosis of colorectal cancer |
| AU6350894A (en) | 1993-03-05 | 1994-09-26 | Clifford W. Schweinfest | Colon mucosa gene having down-regulated expression in colon adenomas and adenocarcinomas |
| US7229770B1 (en) | 1998-10-01 | 2007-06-12 | The Regents Of The University Of California | YKL-40 as a marker and prognostic indicator for cancers |
| DK85193D0 (da) | 1993-07-16 | 1993-07-16 | Cancerforskningsfondet Af 1989 | Suppression of inhibitors |
| US6316208B1 (en) | 1994-01-07 | 2001-11-13 | Memorial Sloan-Kettering Cancer Center | Methods for determining isolated p27 protein levels and uses thereof |
| EP0854934A4 (en) | 1995-08-18 | 2000-09-06 | Donald W Landry | DETECTION OF ORGANIC COMPOUNDS BY REGULATION OF ANTIBODY CATALYZED REACTIONS |
| US5800347A (en) | 1995-11-03 | 1998-09-01 | The General Hospital Corporation | ROC method for early detection of disease |
| NO954667D0 (no) | 1995-11-17 | 1995-11-17 | Dagfinn Oegreid | Fremgangsmåte til deteksjon av Ki-ras mutasjoner |
| US5983211A (en) | 1996-01-24 | 1999-11-09 | Heseltine; Gary L. | Method and apparatus for the diagnosis of colorectal cancer |
| US6242212B1 (en) | 1996-02-09 | 2001-06-05 | Thomas Jefferson University | Fragile histidine triad (FHIT) nucleic acids and methods of producing FHIT proteins |
| GB9810040D0 (en) | 1998-05-11 | 1998-07-08 | Univ Nottingham | Blood borne tumour markers |
| US6303372B1 (en) | 1998-06-12 | 2001-10-16 | Chiron Corporation | cDNA molecule encoding human CIF130 |
| GB9827228D0 (en) | 1998-12-10 | 1999-02-03 | Univ Nottingham | Cancer detection method and reagents |
| CA2372667A1 (en) | 1999-01-10 | 2000-11-23 | Steven Laken | Methods of detecting colorectal disease by conduction an assay to detect a mutation in a bat-26 locus |
| US7153700B1 (en) | 1999-03-26 | 2006-12-26 | Dana-Farber Cancer Institute, Inc. | Methods and compositions for diagnosing and predicting the behavior of cancer |
| DE60021068T2 (de) | 1999-04-09 | 2006-05-18 | Rigshospitalet | Gewebeinhibitor der matrix-metalproteinase typ 1 (timp-1) als krebsmarker |
| US20010041365A1 (en) | 2000-01-10 | 2001-11-15 | Michael Laposata | Methods for monitoring alcohol consumption |
| US6322986B1 (en) | 2000-01-18 | 2001-11-27 | Albany Medical College | Method for colorectal cancer prognosis and treatment selection |
| US7301016B2 (en) | 2000-03-07 | 2007-11-27 | Millennium Pharmaceuticals, Inc. | Human transferase family members and uses thereof |
| US7577683B2 (en) | 2000-06-08 | 2009-08-18 | Ingenuity Systems, Inc. | Methods for the construction and maintenance of a knowledge representation system |
| US6531283B1 (en) | 2000-06-20 | 2003-03-11 | Molecular Staging, Inc. | Protein expression profiling |
| AU2001280639A1 (en) | 2000-07-18 | 2002-01-30 | Millennium Pharmaceuticals, Inc. | 13237,18480,2245 or 16228 human protein kinase molecules and uses therefor |
| US6706506B2 (en) | 2000-07-24 | 2004-03-16 | Cornell Research Foundation, Inc. | Detection of epithelial cell cancers and precancerous conditions |
| AU2001297575A1 (en) | 2000-11-08 | 2002-10-08 | Millennium Pharmaceuticals, Inc. | 38650, 28472, 5495, 65507, 81588 and 14354 methods and compositions of human proteins and uses thereof |
| US7312086B2 (en) | 2000-12-07 | 2007-12-25 | Bristol-Myers Squibb Company | Methods of diagnosing colon adenocarcinoma using the human g-protein coupled receptor hgprbmy23 |
| JP2005518779A (ja) | 2001-03-23 | 2005-06-30 | イェダ リサーチ アンド デベロップメント カンパニー リミテッド | ガンを発症する危険性を明らかにするための方法およびキット、ガン治療の有効性および投与量を評価するための方法およびキット、ならびにdna修復酵素の活性とガンとを相関させるための方法およびキット |
| US20030064385A1 (en) | 2001-05-16 | 2003-04-03 | Dressman Marlene Michelle | Genes expressed in breast cancer as prognostic and therapeutic targets |
| US7031846B2 (en) | 2001-08-16 | 2006-04-18 | Affymetrix, Inc. | Method, system, and computer software for the presentation and storage of analysis results |
| EP1430071B1 (en) | 2001-09-07 | 2011-04-06 | The Johns Hopkins University School Of Medicine | Secreted and cell surface genes expressed in benign and malignant colorectal tumors |
| US20040018973A1 (en) | 2002-01-25 | 2004-01-29 | University Of Pittsburgh | Nuclear matrix protein alterations associated with colon cancer and colon metastasis to the liver, and uses thereof |
| US20030186248A1 (en) | 2002-03-29 | 2003-10-02 | Erlander Mark G. | Interpreting cytological specimens via molecular histological signatures |
| EP1367395A1 (de) | 2002-05-02 | 2003-12-03 | B.R.A.H.M.S Aktiengesellschaft | Diagnose von Neoplasmen mit Hilfe von anti-Gangliosid-Antikörpern |
| WO2003097872A2 (en) | 2002-05-21 | 2003-11-27 | Mtm Laboratories Ag | G - protein coupled receptor marker molecules associated with colorectal lesions |
| US20050153382A1 (en) | 2002-06-06 | 2005-07-14 | Chengdu Kuachang Science And Technology Co., Ltd. | Biochip kit comprising biochip based on antigen-antibody reactions, and its usage |
| US7425700B2 (en) | 2003-05-22 | 2008-09-16 | Stults John T | Systems and methods for discovery and analysis of markers |
| EP1644858B1 (en) | 2003-07-10 | 2017-12-06 | Genomic Health, Inc. | Expression profile algorithm and test for cancer prognosis |
| DE102004037860A1 (de) | 2004-08-04 | 2006-03-16 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Turmormarker zur Diagnose von Karzinomen und/oder davon abstammender Metastasen |
| DE602004009716T2 (de) | 2004-08-13 | 2008-08-28 | Indivumed Gmbh | Verwendung von transthyretin als biomarker zum nachweis von kolorektalen adenomen; verfahren und nachweis-system |
| US20060105419A1 (en) | 2004-08-16 | 2006-05-18 | Biosite, Inc. | Use of a glutathione peroxidase 1 as a marker in cardiovascular conditions |
| WO2006047481A2 (en) | 2004-10-22 | 2006-05-04 | Redpath Integrated Pathology, Inc. | Enhanced amplifiability of minute fixative-treated tissue samples, minute stained cytology samples, and other minute sources of dna |
| US9109256B2 (en) | 2004-10-27 | 2015-08-18 | Esoterix Genetic Laboratories, Llc | Method for monitoring disease progression or recurrence |
| WO2006094149A2 (en) | 2005-03-01 | 2006-09-08 | Exact Sciences Corporation | Methods and compositions for detecting adenoma |
| US9075062B2 (en) | 2005-03-22 | 2015-07-07 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Identification of biomarkers by serum protein profiling |
| EP1920071B1 (en) | 2005-07-29 | 2018-12-26 | Siemens Healthcare Diagnostics Inc. | Neoplastic disease-related methods, kits, systems and databases |
| CA2772688A1 (en) | 2005-09-12 | 2007-03-22 | Phenomenome Discoveries Inc. | Methods for the diagnosis of colorectal cancer and ovarian cancer health states |
| CN101263391A (zh) | 2005-09-12 | 2008-09-10 | 菲诺梅诺米发现公司 | 通过测量维生素e-相关的代谢物诊断结肠直肠癌和卵巢癌的方法 |
| US7892758B2 (en) | 2005-09-27 | 2011-02-22 | University Of Saskatchewan | Use of N-myristoyltransferase on non-tumor tissue for cancer diagnosis |
| EP2177910A1 (en) | 2005-11-10 | 2010-04-21 | Aurelium Biopharma Inc. | Tissue diagnostics for breast cancer |
| GB0524190D0 (en) | 2005-11-28 | 2006-01-04 | Helse Stavanger Hf | Method |
| ES2277785B1 (es) | 2005-12-21 | 2008-06-16 | Oryzon Genomics, S.A. | Metodo de analisis de expresion diferencial en cancer colorectal. |
| US20090035801A1 (en) | 2005-12-27 | 2009-02-05 | Power3 Medical Products, Inc. | Twelve (12) protein biomarkers for diagnosis and early detection of breast cancer |
| KR20090003178A (ko) | 2006-01-11 | 2009-01-09 | 게노믹 헬쓰, 인코포레이티드 | 직장결장암 예후에 대한 유전자 발현 마커 |
| US20070231304A1 (en) | 2006-01-30 | 2007-10-04 | Introgen Therapeutics, Inc. | Prognostic factors for anti-hyperproliferative disease gene therapy |
| WO2007127002A2 (en) | 2006-03-31 | 2007-11-08 | Cell Signaling Technology, Inc. | Protein markers of responsiveness to type iii receptor tyrosine kinase inhibitors |
| CA2657691A1 (en) | 2006-06-19 | 2007-12-27 | Vanderbilt University | Methods and compositions for diagnostic and therapeutic targeting of cox-2 |
| US7811778B2 (en) | 2006-09-06 | 2010-10-12 | Vanderbilt University | Methods of screening for gastrointestinal cancer |
| WO2008073858A2 (en) | 2006-12-08 | 2008-06-19 | The Johns Hopkins University | Cancer chemoprevention strategy based on loss of imprinting of igf2 |
| ATE535805T1 (de) | 2007-01-26 | 2011-12-15 | Univ Louisville Res Found | Verfahren zur erkennung von autoantikörpern zur diagnostizierung und charakterisierung von erkrankungen |
| WO2008116178A2 (en) | 2007-03-21 | 2008-09-25 | Vanderbilt University | Systems and methods for diagnosis and prognosis of colorectal cancer |
| CN101971033A (zh) | 2007-06-04 | 2011-02-09 | 戴诺普雷克斯公司 | 用于结直肠癌的生物标志物组合 |
| WO2009015299A1 (en) | 2007-07-26 | 2009-01-29 | California Pacific Medical Center | Method to predict or diagnose a gastrointestinal disorder or disease |
| DE102007034993A1 (de) | 2007-07-26 | 2009-01-29 | Hanna Diehl | Lösliches Cadherin 17 für die Diagnose und Risikostratifizierung von Darmtumor oder Darmkrebs |
| US8426140B2 (en) | 2007-09-28 | 2013-04-23 | Royal College Of Surgeons In Ireland | Method of assessing colorectal cancer status in an individual |
| ATE521894T1 (de) | 2007-11-20 | 2011-09-15 | Hoffmann La Roche | Verfahren zur beurteilung von kolorektalem krebs anhand einer stuhlprobe durch verwendung einer marker-kombination aus calprotectin und einem hämoglobin/haptoglobin-komplex |
| KR101058753B1 (ko) | 2007-11-22 | 2011-08-24 | 한국생명공학연구원 | 대장암 마커로서의 esm-1 유전자 및 이를 이용한대장암의 진단 및 치료에의 용도 |
| BRPI0820793A2 (pt) | 2007-12-10 | 2015-06-16 | Hoffmann La Roche | Seprase como marcador de câncer |
| WO2009074276A2 (en) * | 2007-12-10 | 2009-06-18 | Roche Diagnostics Gmbh | Marker panel for colorectal cancer |
| US20110053879A1 (en) | 2008-02-08 | 2011-03-03 | Poniard Pharmaceuticals, Inc. | Picoplatin and amrubicin to treat lung cancer |
| CN102027128A (zh) | 2008-02-11 | 2011-04-20 | 哈达斯特医学服务与开发有限公司 | 作为癌症标志物的结肠癌相关的转录物1(ccat-1) |
| US20110076700A1 (en) | 2008-02-29 | 2011-03-31 | Nihon University | Anti-crp antibody and utilization of the same |
| US20110245087A1 (en) | 2008-03-18 | 2011-10-06 | Gunter Weiss | Method for optimizing and validating an assay for determining the presence or absence of a medical condition |
| US20110104256A1 (en) | 2008-03-25 | 2011-05-05 | Yaolin Wang | Methods for treating or preventing colorectal cancer |
| SG189774A1 (en) | 2008-04-10 | 2013-05-31 | Genenews Corp | Method and apparatus for determining a probability of colorectal cancer in a subject |
| CN102027373B (zh) | 2008-05-14 | 2017-10-10 | 埃斯苏黎世公司 | 发现用于前列腺癌诊断和治疗之生物标志物和药物靶标的方法及其确立的生物标志物测定 |
| ES2506116T3 (es) | 2008-05-23 | 2014-10-13 | Biocartis Nv | Nuevo biomarcador para diagnóstico, predicción y/o pronóstico de septicemia y usos del mismo |
| MX2011000655A (es) | 2008-07-18 | 2011-03-21 | Oragenics Inc | Composiciones para la deteccion y tratamiento de cancer colorrectal. |
| EP2169077A1 (en) | 2008-09-19 | 2010-03-31 | Vereniging voor christelijk hoger onderwijs, wetenschappelijk onderzoek en patiëntenzorg | Methods and compositions for diagnosing an adenocarcinoma |
| US20100204299A1 (en) | 2009-02-11 | 2010-08-12 | Daniel Regnier | C-cbl and antagonists thereof for the treatment and diagnosis of cancer |
| EP2398918B1 (en) | 2009-02-20 | 2018-06-20 | Onconome, Inc. | Methods for diagnosis and prognosis of colorectal cancer |
| CN102326081B (zh) | 2009-02-24 | 2014-11-19 | 霍夫曼-拉罗奇有限公司 | s-ErbB-3作为癌症标志物的应用 |
| CA2777800C (en) | 2009-10-15 | 2019-11-12 | Crescendo Bioscience | Biomarkers and methods for measuring and monitoring inflammatory disease activity |
| US7736861B1 (en) | 2009-10-19 | 2010-06-15 | Aveo Pharmaceuticals, Inc. | Tivozanib response prediction |
| CA2781408A1 (en) * | 2009-11-20 | 2011-05-26 | University Of Louisville Research Foundation Inc. | Biomarkers of cancer |
| WO2011119934A2 (en) | 2010-03-26 | 2011-09-29 | Mayo Foundation For Medical Education And Research | Methods and materials for detecting colorectal neoplasm |
| US10119959B2 (en) | 2010-06-25 | 2018-11-06 | The Board Of Trustees Of The Leland Stanford Junior University | Method of assaying an individual for immune impairment |
| GB201012590D0 (en) | 2010-07-27 | 2010-09-08 | Queen Mary & Westfield College | Methods for diagnosing cancer |
| US8389684B2 (en) | 2010-09-13 | 2013-03-05 | Tsinghua University | Tumor biomarker |
| WO2012101283A1 (en) | 2011-01-28 | 2012-08-02 | Biosystems International Sas | Combinatorial biomarkers for clinical applications in lung cancer patient management |
| CA2827894A1 (en) | 2011-02-22 | 2012-08-30 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Circulating biomarkers |
| CA2845568A1 (en) | 2011-08-19 | 2013-02-28 | Myriad Genetics, Inc. | Gene signatures for lung cancer prognosis and therapy selection |
| WO2013152989A2 (en) | 2012-04-10 | 2013-10-17 | Eth Zurich | Biomarker assay and uses thereof for diagnosis, therapy selection, and prognosis of cancer |
| ES2762403T3 (es) | 2012-04-26 | 2020-05-25 | Stichting Vumc | Biomarcadores |
| KR20150090240A (ko) | 2012-11-30 | 2015-08-05 | 어플라이드 프로테오믹스, 인크. | 결장 종양의 존재 또는 위험의 평가 방법 |
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2016
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- 2016-04-08 HK HK18110284.4A patent/HK1255533A1/zh unknown
- 2016-04-08 WO PCT/US2016/026773 patent/WO2016164815A1/en not_active Ceased
- 2016-04-08 EP EP16717530.6A patent/EP3281016A1/en not_active Withdrawn
- 2016-04-08 JP JP2017552968A patent/JP2018517892A/ja active Pending
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| US20160299144A1 (en) | 2016-10-13 |
| WO2016164815A1 (en) | 2016-10-13 |
| GB2545361A (en) | 2017-06-14 |
| GB2545361B (en) | 2018-01-24 |
| US20190257835A1 (en) | 2019-08-22 |
| EP3281016A1 (en) | 2018-02-14 |
| US20170370937A1 (en) | 2017-12-28 |
| JP2018517892A (ja) | 2018-07-05 |
| HK1255533A1 (zh) | 2019-08-16 |
| US9689874B2 (en) | 2017-06-27 |
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