CA2981979A1 - Egfr-directed car therapy for glioblastoma - Google Patents
Egfr-directed car therapy for glioblastoma Download PDFInfo
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- CA2981979A1 CA2981979A1 CA2981979A CA2981979A CA2981979A1 CA 2981979 A1 CA2981979 A1 CA 2981979A1 CA 2981979 A CA2981979 A CA 2981979A CA 2981979 A CA2981979 A CA 2981979A CA 2981979 A1 CA2981979 A1 CA 2981979A1
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| PCT/US2016/026057 WO2016164370A1 (en) | 2015-04-06 | 2016-04-05 | Egfr-directed car therapy for glioblastoma |
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| JP6694875B2 (ja) | 2014-05-15 | 2020-05-20 | ナショナル ユニヴァーシティ オブ シンガポール | 改変ナチュラルキラー細胞及びその使用 |
| CN108261426B (zh) * | 2017-01-04 | 2019-04-05 | 杭州康万达医药科技有限公司 | 药物组合物及其在治疗肿瘤和/或癌症的药物中的应用 |
| JP7270253B2 (ja) | 2017-03-27 | 2023-05-10 | ナショナル ユニヴァーシティ オブ シンガポール | ナチュラルキラー細胞のエクスビボ拡大及び活性化のための刺激細胞株 |
| CN107354199A (zh) * | 2017-07-04 | 2017-11-17 | 武汉波睿达生物科技有限公司 | 一种检测靶向cd30的cart细胞中car表达的荧光定量试剂盒 |
| CN107759701B (zh) * | 2017-10-27 | 2021-07-02 | 杭州优善生物科技有限公司 | 嵌合抗原受体、其修饰的NK细胞、编码DNA、mRNA、表达载体、制备方法和应用 |
| CN109836497A (zh) * | 2017-11-25 | 2019-06-04 | 深圳宾德生物技术有限公司 | 一种靶向egfr的单链抗体、嵌合抗原受体t细胞及其制备方法和应用 |
| CN109568351B (zh) * | 2018-11-30 | 2020-02-21 | 武汉波睿达生物科技有限公司 | 溶瘤病毒和car-t联合应用针对实体肿瘤的治疗 |
| CN111378046B (zh) * | 2018-12-27 | 2024-03-15 | 上海细胞治疗集团有限公司 | 一种免疫效应细胞转换受体 |
| CN110592024A (zh) * | 2019-09-12 | 2019-12-20 | 广东食品药品职业学院 | 以tEGFR与CD19为双靶点的CAR-NK细胞制备方法及其应用 |
| CN110845623B (zh) * | 2019-10-11 | 2021-07-09 | 厦门大学 | 一种egfr特异性嵌合抗原受体及其应用 |
| CN111925448B (zh) * | 2020-08-03 | 2022-06-21 | 山东大学 | 在体生成car-巨噬细胞的制备方法及肿瘤免疫治疗中的应用 |
| US20220072043A1 (en) * | 2020-09-10 | 2022-03-10 | Mustang Bio, Inc. | Combination therapy comprising cancer-targeted car-t cells and a method of using same for a treatment for cancer |
| WO2023034758A1 (en) * | 2021-08-30 | 2023-03-09 | Cytoimmune Therapeutics, Inc. | Methods and compositions for cell expansion |
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| JP2005521398A (ja) | 2002-03-27 | 2005-07-21 | ベイラー カレッジ オブ メディスン | 癌治療用の強力な腫瘍溶解性単純ヘルペスウイルス |
| JP3803790B2 (ja) * | 2003-02-17 | 2006-08-02 | 株式会社東北テクノアーチ | 新規なダイアボディ型二重特異性抗体 |
| JP2005333993A (ja) * | 2005-08-03 | 2005-12-08 | Tohoku Techno Arch Co Ltd | 新規なダイアボディ型二重特異性抗体 |
| US20110052570A1 (en) * | 2005-10-26 | 2011-03-03 | Children's Medical Center Corporation | Method to prognose response to anti-egfr therapeutics |
| SG172698A1 (en) | 2006-06-12 | 2011-07-28 | Trubion Pharmaceuticals Inc | Single-chain multivalent binding proteins with effector function |
| EP2626371A1 (en) | 2007-07-31 | 2013-08-14 | MedImmune, LLC | Multispecific epitope binding proteins and uses thereof |
| EP4032552B1 (en) | 2008-08-26 | 2023-10-04 | City of Hope | Method and compositions for enhanced anti-tumor effector functioning of t cells |
| ES2754394T3 (es) | 2010-09-08 | 2020-04-17 | Chemotherapeutisches Forschungsinstitut Georg Speyer Haus | Receptores de antígenos quiméricos con una región bisagra optimizada |
| CN107699585A (zh) | 2010-12-09 | 2018-02-16 | 宾夕法尼亚大学董事会 | 嵌合抗原受体‑修饰的t细胞治疗癌症的用途 |
| US9266960B2 (en) * | 2011-04-08 | 2016-02-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-epidermal growth factor receptor variant III chimeric antigen receptors and use of same for the treatment of cancer |
| AU2012300279A1 (en) | 2011-08-26 | 2014-04-03 | Merrimack Pharmaceuticals, Inc. | Tandem Fc bispecific antibodies |
| KR101956751B1 (ko) | 2011-10-07 | 2019-03-11 | 고쿠리츠다이가쿠호진 미에다이가쿠 | 키메라 항원 수용체 |
| CA2855746A1 (en) | 2011-11-16 | 2013-05-23 | John Stephen HILL | Methods of treating epidermal growth factor deletion mutant viii related disorders |
| US9447194B2 (en) | 2012-02-13 | 2016-09-20 | Seattle Children's Hospital | Bispecific chimeric antigen receptors and encoding polynucleotides thereof |
| EP2817330B1 (en) | 2012-02-22 | 2020-07-08 | The Trustees of the University of Pennsylvania | Use of icos-based cars to enhance antitumor activity and car persistence |
| CN103483452B (zh) * | 2012-06-12 | 2021-08-13 | 上海细胞治疗集团有限公司 | 双信号独立的嵌合抗原受体及其用途 |
| CN103113470B (zh) | 2013-02-27 | 2015-04-22 | 四川大学 | 靶向人egfr的基因工程化淋巴细胞及其制备方法和用途 |
| CA2904369A1 (en) * | 2013-03-07 | 2014-09-12 | Baylor College Of Medicine | Targeting cd138 in cancer |
| US20140302037A1 (en) | 2013-03-15 | 2014-10-09 | Amgen Inc. | BISPECIFIC-Fc MOLECULES |
| CA2910666A1 (en) * | 2013-05-03 | 2014-11-06 | Ohio State Innovation Foundation | Cs1-specific chimeric antigen receptor engineered immune effector cells |
| AU2014274982B2 (en) * | 2013-06-04 | 2019-12-05 | Cytomx Therapeutics, Inc | Compositions and methods for conjugating activatable antibodies |
| ES2845924T3 (es) | 2013-10-15 | 2021-07-28 | Scripps Research Inst | Interruptores de células T con receptores de antígenos quiméricos peptídicos y usos de los mismos |
| CN114457044A (zh) | 2013-10-25 | 2022-05-10 | 普西奥克瑟斯医疗有限公司 | 武装有异源基因的溶瘤腺病毒 |
| EP3593812A3 (en) | 2014-03-15 | 2020-05-27 | Novartis AG | Treatment of cancer using chimeric antigen receptor |
| TWI750110B (zh) | 2014-07-21 | 2021-12-21 | 瑞士商諾華公司 | 使用人類化抗-ｂｃｍａ嵌合抗原受體治療癌症 |
| CA2977350C (en) | 2015-02-20 | 2022-08-23 | Ohio State Innovation Foundation | Bivalent antibody directed against nkg2d and tumor associated antigens |
| US10744157B2 (en) | 2015-03-26 | 2020-08-18 | The Trustees Of Dartmouth College | Anti-MICA antigen binding fragments, fusion molecules, cells which express and methods of using |
| MA44314A (fr) | 2015-11-05 | 2018-09-12 | Juno Therapeutics Inc | Récepteurs chimériques contenant des domaines induisant traf, et compositions et méthodes associées |
| SG11201901528RA (en) | 2016-08-23 | 2019-03-28 | Univ California | Proteolytically cleavable chimeric polypeptides and methods of use thereof |
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- 2016-04-05 CN CN201680025143.5A patent/CN108367057B/zh not_active Expired - Fee Related
- 2016-04-05 AU AU2016246457A patent/AU2016246457B2/en not_active Ceased
- 2016-04-05 US US15/564,166 patent/US11045543B2/en active Active
- 2016-04-05 EP EP16777143.5A patent/EP3280437A4/en not_active Withdrawn
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2018
- 2018-08-13 HK HK18110330.8A patent/HK1250918A1/zh unknown
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2020
- 2020-07-03 JP JP2020115454A patent/JP2020156522A/ja active Pending
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2021
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| Publication number | Publication date |
|---|---|
| AU2016246457B2 (en) | 2020-10-15 |
| US20210308261A1 (en) | 2021-10-07 |
| JP2018513687A (ja) | 2018-05-31 |
| US11045543B2 (en) | 2021-06-29 |
| EP3280437A1 (en) | 2018-02-14 |
| AU2016246457A1 (en) | 2017-10-26 |
| KR20180012749A (ko) | 2018-02-06 |
| JP6879932B2 (ja) | 2021-06-02 |
| US20180117146A1 (en) | 2018-05-03 |
| WO2016164370A1 (en) | 2016-10-13 |
| JP2020156522A (ja) | 2020-10-01 |
| CN108367057A (zh) | 2018-08-03 |
| CN108367057B (zh) | 2022-11-22 |
| EP3280437A4 (en) | 2018-09-12 |
| HK1250918A1 (zh) | 2019-01-18 |
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