CA2981070A1 - Piezoelectric dispenser with replaceable ampoule - Google Patents
Piezoelectric dispenser with replaceable ampoule Download PDFInfo
- Publication number
- CA2981070A1 CA2981070A1 CA2981070A CA2981070A CA2981070A1 CA 2981070 A1 CA2981070 A1 CA 2981070A1 CA 2981070 A CA2981070 A CA 2981070A CA 2981070 A CA2981070 A CA 2981070A CA 2981070 A1 CA2981070 A1 CA 2981070A1
- Authority
- CA
- Canada
- Prior art keywords
- fluid
- platform
- aperture
- package
- conduit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000003708 ampul Substances 0.000 title claims description 59
- 239000012530 fluid Substances 0.000 claims abstract description 128
- 239000003814 drug Substances 0.000 claims abstract description 76
- 229940079593 drug Drugs 0.000 claims abstract description 73
- 238000000034 method Methods 0.000 claims abstract description 20
- 230000007246 mechanism Effects 0.000 claims abstract description 19
- 230000008878 coupling Effects 0.000 claims abstract description 3
- 238000010168 coupling process Methods 0.000 claims abstract description 3
- 238000005859 coupling reaction Methods 0.000 claims abstract description 3
- 239000000758 substrate Substances 0.000 claims description 26
- 230000003287 optical effect Effects 0.000 claims description 21
- 229910052782 aluminium Inorganic materials 0.000 claims description 10
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 10
- 230000010363 phase shift Effects 0.000 claims description 6
- 230000008602 contraction Effects 0.000 claims description 2
- 229910000975 Carbon steel Inorganic materials 0.000 claims 1
- 239000010962 carbon steel Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000006073 displacement reaction Methods 0.000 description 12
- 230000010355 oscillation Effects 0.000 description 12
- 210000001747 pupil Anatomy 0.000 description 9
- 238000007789 sealing Methods 0.000 description 8
- 230000001580 bacterial effect Effects 0.000 description 7
- 238000011109 contamination Methods 0.000 description 7
- 230000033001 locomotion Effects 0.000 description 7
- 229910000831 Steel Inorganic materials 0.000 description 5
- 238000005452 bending Methods 0.000 description 5
- 239000011248 coating agent Substances 0.000 description 5
- 238000000576 coating method Methods 0.000 description 5
- 210000000795 conjunctiva Anatomy 0.000 description 5
- 230000005291 magnetic effect Effects 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 239000010959 steel Substances 0.000 description 5
- 238000013459 approach Methods 0.000 description 4
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 description 4
- -1 polyethylene Polymers 0.000 description 4
- 239000004952 Polyamide Substances 0.000 description 3
- 239000004698 Polyethylene Substances 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 239000000443 aerosol Substances 0.000 description 3
- 230000004397 blinking Effects 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 238000012377 drug delivery Methods 0.000 description 3
- 210000003811 finger Anatomy 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000003595 mist Substances 0.000 description 3
- 229920002647 polyamide Polymers 0.000 description 3
- 229920000573 polyethylene Polymers 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000011514 reflex Effects 0.000 description 3
- 229920001169 thermoplastic Polymers 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000003302 ferromagnetic material Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 230000000116 mitigating effect Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 238000003825 pressing Methods 0.000 description 2
- 229910052761 rare earth metal Inorganic materials 0.000 description 2
- 150000002910 rare earth metals Chemical class 0.000 description 2
- 238000000518 rheometry Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 239000004416 thermosoftening plastic Substances 0.000 description 2
- 238000011200 topical administration Methods 0.000 description 2
- 238000013022 venting Methods 0.000 description 2
- 229920002943 EPDM rubber Polymers 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- 208000001860 Eye Infections Diseases 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004820 Pressure-sensitive adhesive Substances 0.000 description 1
- 229910000639 Spring steel Inorganic materials 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 229910052790 beryllium Inorganic materials 0.000 description 1
- ATBAMAFKBVZNFJ-UHFFFAOYSA-N beryllium atom Chemical compound [Be] ATBAMAFKBVZNFJ-UHFFFAOYSA-N 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000005388 borosilicate glass Substances 0.000 description 1
- 239000003990 capacitor Substances 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- KPLQYGBQNPPQGA-UHFFFAOYSA-N cobalt samarium Chemical compound [Co].[Sm] KPLQYGBQNPPQGA-UHFFFAOYSA-N 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 239000013536 elastomeric material Substances 0.000 description 1
- 229920006332 epoxy adhesive Polymers 0.000 description 1
- 210000000744 eyelid Anatomy 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 238000000608 laser ablation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000004377 microelectronic Methods 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 229910052758 niobium Inorganic materials 0.000 description 1
- 239000010955 niobium Substances 0.000 description 1
- GUCVJGMIXFAOAE-UHFFFAOYSA-N niobium atom Chemical compound [Nb] GUCVJGMIXFAOAE-UHFFFAOYSA-N 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 238000012858 packaging process Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000009512 pharmaceutical packaging Methods 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 230000036316 preload Effects 0.000 description 1
- 229910000938 samarium–cobalt magnet Inorganic materials 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 229910000679 solder Inorganic materials 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- KKEYFWRCBNTPAC-UHFFFAOYSA-L terephthalate(2-) Chemical compound [O-]C(=O)C1=CC=C(C([O-])=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-L 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000003813 thumb Anatomy 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0026—Ophthalmic product dispenser attachments to facilitate positioning near the eye
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0043—Non-destructive separation of the package, e.g. peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/005—Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0211—Ceramics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0612—Eyes
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562178464P | 2015-04-10 | 2015-04-10 | |
| US62/178,464 | 2015-04-10 | ||
| PCT/US2016/026795 WO2016164830A1 (en) | 2015-04-10 | 2016-04-08 | Piezoelectric dispenser with replaceable ampoule |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2981070A1 true CA2981070A1 (en) | 2016-10-13 |
Family
ID=57073392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2981070A Abandoned CA2981070A1 (en) | 2015-04-10 | 2016-04-08 | Piezoelectric dispenser with replaceable ampoule |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10583038B2 (https=) |
| EP (1) | EP3253433A4 (https=) |
| JP (1) | JP2018515153A (https=) |
| KR (1) | KR20170135862A (https=) |
| CN (1) | CN107530509A (https=) |
| AU (1) | AU2016246060B2 (https=) |
| CA (1) | CA2981070A1 (https=) |
| WO (1) | WO2016164830A1 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6329130B2 (ja) | 2012-04-10 | 2018-05-30 | アイノビア，インコーポレイティド | 噴霧エジェクタ機構、電荷分離及び制御可能な液滴電荷を提供する装置、並びに低投与量の点眼 |
| EA201492094A1 (ru) | 2012-05-15 | 2015-04-30 | Айновиа, Инк. | Эжекторные устройства, способы, возбудители и схемы для них |
| CN113230021A (zh) | 2015-01-12 | 2021-08-10 | 科达莱昂治疗公司 | 微滴递送设备和方法 |
| JP2018515153A (ja) | 2015-04-10 | 2018-06-14 | ケダリオン セラピューティックス，インコーポレイテッド | 交換式アンプルを備えた圧電式ディスペンサ |
| KR102412086B1 (ko) * | 2017-01-20 | 2022-06-22 | 켄달리온 테라퓨틱스 인코포레이티드 | 압전 유체 분배기 |
| JP7227163B2 (ja) | 2017-06-10 | 2023-02-21 | アイノビア，インコーポレイティド | 流体を取扱い、目に流体を送出するための方法および装置 |
| WO2019113483A1 (en) * | 2017-12-08 | 2019-06-13 | Kedalion Therapeutics, Inc. | Fluid delivery alignment system |
| CN111712308A (zh) | 2017-12-13 | 2020-09-25 | 奥弗技术有限责任公司 | 用于产生嗅觉刺激的系统和方法 |
| US11883739B2 (en) | 2017-12-13 | 2024-01-30 | OVR Tech, LLC | Replaceable liquid scent cartridge |
| US11351450B2 (en) | 2017-12-13 | 2022-06-07 | OVR Tech, LLC | Systems and techniques for generating scent |
| WO2019143777A1 (en) * | 2018-01-17 | 2019-07-25 | Eyenovia, Inc. | Methods and devices for delivering atropine to the eye as a micro-dose stream of droplets |
| US20190314197A1 (en) | 2018-04-12 | 2019-10-17 | Kedalion Therapeutics, Inc. | Topical Ocular Delivery Methods and Devices for Use in the Same |
| US12350194B1 (en) | 2018-04-12 | 2025-07-08 | Bausch + Lomb Ireland Limited | Topical ocular delivery of fluids with controlled mass dosing and wireless communication |
| WO2020010116A1 (en) * | 2018-07-03 | 2020-01-09 | Kedalion Therapeutics, Inc. | Topical ocular delivery devices and methods for using the same |
| US11577268B2 (en) | 2018-10-18 | 2023-02-14 | OVR Tech, LLC | Device for atomizing fluid |
| CN111184602B (zh) * | 2018-11-14 | 2022-12-02 | 财团法人工业技术研究院 | 眼用配戴装置 |
| US11679028B2 (en) | 2019-03-06 | 2023-06-20 | Novartis Ag | Multi-dose ocular fluid delivery system |
| CN113543752B (zh) * | 2019-03-06 | 2024-10-15 | 博士伦爱尔兰有限公司 | 多剂量眼流体输送系统 |
| US12097145B2 (en) | 2019-03-06 | 2024-09-24 | Bausch + Lomb Ireland Limited | Vented multi-dose ocular fluid delivery system |
| JP7240575B2 (ja) * | 2019-07-16 | 2023-03-16 | 草桶 大輝 | 液体吐出装置及び投薬装置 |
| US12496218B1 (en) | 2019-11-12 | 2025-12-16 | Bausch + Lomb Ireland Limited | Fractionated topical ocular drug delivery methods and devices for use in the same |
| WO2021119513A1 (en) | 2019-12-11 | 2021-06-17 | Eyenovia, Inc. | Systems and devices for delivering fluids to the eye and methods of use |
| CN115768384A (zh) | 2020-04-17 | 2023-03-07 | 科达隆治疗公司 | 流体动力致动的不含防腐剂分配系统 |
| US12090087B2 (en) | 2020-04-17 | 2024-09-17 | Bausch + Lomb Ireland Limited | Hydrodynamically actuated preservative free dispensing system having a collapsible liquid reservoir |
| US11938057B2 (en) | 2020-04-17 | 2024-03-26 | Bausch + Lomb Ireland Limited | Hydrodynamically actuated preservative free dispensing system |
| US12290472B2 (en) | 2020-04-17 | 2025-05-06 | Bausch + Lomb Ireland Limited | Hydrodynamically actuated preservative free dispensing system |
| CA3117362A1 (en) * | 2020-04-24 | 2021-10-24 | SOSD Health & Medical Innovations Inc. | Ultrasonic nebulizer |
| JP7651799B2 (ja) * | 2020-05-13 | 2025-03-27 | トゥウェンティ トゥウェンティ セラピューティクス エルエルシー | 光を利用した位置合わせおよび照準合わせを備えた眼用薬剤アプリケータ |
| CN114209494B (zh) * | 2021-12-02 | 2023-11-10 | 江西省儿童医院 | 一种眼科使用的红眼病治疗用雾化治疗器 |
| AU2023240412A1 (en) * | 2022-03-25 | 2024-10-03 | Bausch + Lomb Ireland Limited | Membrane actuated hydrodynamic dispensing system |
| KR20250036724A (ko) * | 2022-05-02 | 2025-03-14 | 보슈 롬 아일랜드 리미티드 | 환기형 다중 용량 안구 유체 전달 시스템 |
| WO2025049906A1 (en) * | 2023-08-31 | 2025-03-06 | Nanodropper, Inc. | Cartridge based spray applicator for ophthalmic medicine |
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| US3779245A (en) | 1972-06-13 | 1973-12-18 | R Windsor | Device for applying materials to the area of the eye |
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-
2016
- 2016-04-08 JP JP2017546889A patent/JP2018515153A/ja active Pending
- 2016-04-08 US US15/094,849 patent/US10583038B2/en active Active
- 2016-04-08 CN CN201680020848.8A patent/CN107530509A/zh active Pending
- 2016-04-08 AU AU2016246060A patent/AU2016246060B2/en active Active
- 2016-04-08 CA CA2981070A patent/CA2981070A1/en not_active Abandoned
- 2016-04-08 EP EP16777429.8A patent/EP3253433A4/en not_active Withdrawn
- 2016-04-08 WO PCT/US2016/026795 patent/WO2016164830A1/en not_active Ceased
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|---|---|
| US10583038B2 (en) | 2020-03-10 |
| EP3253433A4 (en) | 2018-08-22 |
| AU2016246060B2 (en) | 2020-10-22 |
| CN107530509A (zh) | 2018-01-02 |
| KR20170135862A (ko) | 2017-12-08 |
| US20160296367A1 (en) | 2016-10-13 |
| US20200197220A1 (en) | 2020-06-25 |
| EP3253433A1 (en) | 2017-12-13 |
| JP2018515153A (ja) | 2018-06-14 |
| AU2016246060A1 (en) | 2017-11-16 |
| WO2016164830A1 (en) | 2016-10-13 |
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