CA2978457A1 - Etv2 and uses thereof - Google Patents
Etv2 and uses thereofInfo
- Publication number
- CA2978457A1 CA2978457A1 CA2978457A CA2978457A CA2978457A1 CA 2978457 A1 CA2978457 A1 CA 2978457A1 CA 2978457 A CA2978457 A CA 2978457A CA 2978457 A CA2978457 A CA 2978457A CA 2978457 A1 CA2978457 A1 CA 2978457A1
- Authority
- CA
- Canada
- Prior art keywords
- human
- etv2
- human animal
- blastocyst
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
- C12N15/877—Techniques for producing new mammalian cloned embryos
- C12N15/8778—Swine embryos
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0604—Whole embryos; Culture medium therefor
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/108—Swine
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
- A01K2267/025—Animal producing cells or organs for transplantation
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Applications Claiming Priority (3)
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| US201562127330P | 2015-03-03 | 2015-03-03 | |
| US62/127,330 | 2015-03-03 | ||
| PCT/US2016/020768 WO2016141234A1 (en) | 2015-03-03 | 2016-03-03 | Etv2 and uses thereof |
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| CA2978457A1 true CA2978457A1 (en) | 2016-09-09 |
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| CA2978457A Abandoned CA2978457A1 (en) | 2015-03-03 | 2016-03-03 | Etv2 and uses thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| MX2017011345A (es) | 2015-03-03 | 2018-04-24 | Univ Minnesota | Gen de variante ets2 etv2 y usos del mismo. |
| JP2018523999A (ja) | 2015-06-30 | 2018-08-30 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | ヒト化心筋 |
| JP2018522553A (ja) | 2015-06-30 | 2018-08-16 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | ヒト化骨格筋 |
| WO2018144860A1 (en) * | 2017-02-03 | 2018-08-09 | Cornell University | Stable three-dimensional blood vessels and methods for forming the same |
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| AU721375B2 (en) | 1996-01-09 | 2000-06-29 | Regents Of The University Of California, The | Porcine embryonic stem-like cells, methods of making and using the cells to produce transgenic pigs |
| US5994619A (en) | 1996-04-01 | 1999-11-30 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Production of chimeric bovine or porcine animals using cultured inner cell mass cells |
| CN1241210A (zh) | 1996-10-11 | 2000-01-12 | 得克萨斯农业及机械体系综合大学 | 产生原生殖细胞和转基因动物物种的方法 |
| JPWO2003034818A1 (ja) * | 2001-10-24 | 2005-02-10 | 中外製薬株式会社 | Ｓｇｒｆ遺伝子改変非ヒト動物 |
| US20040133931A1 (en) | 2003-01-08 | 2004-07-08 | Gavin William G. | Method and system for fusion and activation following nuclear transfer in reconstructed embryos |
| AU2003213813A1 (en) | 2002-03-22 | 2003-10-13 | St. Jude Children's Research Hospital | Improved method for generating genetically modified animals |
| US20050257279A1 (en) | 2002-07-03 | 2005-11-17 | Su Qian | Agouti-related protein deficient cells, non-human transgenic animals and methods of selecting compounds which regulate energy metabolism |
| GB2398784B (en) | 2003-02-26 | 2005-07-27 | Babraham Inst | Removal and modification of the immunoglobulin constant region gene cluster of a non-human mammal |
| WO2006014551A2 (en) | 2004-07-06 | 2006-02-09 | Michigan State University | In vivo methods for effecting tissue specific differentiation of embryonic stem cells |
| ES2678416T3 (es) | 2007-01-11 | 2018-08-10 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Células derivadas de músculo para el tratamiento de patologías de las vías urinarias y métodos de fabricación y uso de las mismas |
| WO2008089482A1 (en) * | 2007-01-20 | 2008-07-24 | Boehringer Ingelheim International Gmbh | C-reactive protein (crp) knockout mouse |
| WO2008102602A1 (ja) | 2007-02-22 | 2008-08-28 | The University Of Tokyo | Ｂｌａｓｔｏｃｙｓｔ ｃｏｍｐｌｅｍｅｎｔａｔｉｏｎを利用した臓器再生法 |
| US20110067125A1 (en) * | 2008-02-22 | 2011-03-17 | The University Of Tokyo | Method for producing founder animal for reproducing animal having lethal phenotype caused by gene modification |
| GB2490443B8 (en) | 2008-08-22 | 2014-08-13 | Univ Tokyo | Organ regeneration method utilizing iPS cell and blastocyst complementation |
| US20120207744A1 (en) | 2009-03-19 | 2012-08-16 | Mendlein John D | Reprogramming compositions and methods of using the same |
| WO2010133686A1 (en) | 2009-05-20 | 2010-11-25 | Cardio3 Biosciences S.A. | Parmaceutical composition for the treatment of heart diseases. |
| PT2702160T (pt) | 2011-04-27 | 2020-07-30 | Amyris Inc | Métodos para modificação genómica |
| SG195252A1 (en) | 2011-06-02 | 2013-12-30 | Harvard College | Methods and uses for ex vivo tissue culture systems |
| US9862929B2 (en) | 2011-11-18 | 2018-01-09 | Kyoto University | Method of inducing differentiation from pluripotent stem cells to skeletal muscle cells |
| IL221187A (en) | 2012-07-30 | 2017-01-31 | Adom Advanced Optical Tech Ltd | A system to perform optical tomography in two 2D beams |
| US20140115728A1 (en) | 2012-10-24 | 2014-04-24 | A. Joseph Tector | Double knockout (gt/cmah-ko) pigs, organs and tissues |
| US11377639B2 (en) | 2013-11-15 | 2022-07-05 | Wisconsin Alumni Research Foundation | Lineage reprogramming to induced cardiac progenitor cells (iCPC) by defined factors |
| MX2016014066A (es) * | 2014-04-28 | 2017-05-03 | Recombinetics Inc | Edicion de genes multiples en cerdos. |
| MX2017011345A (es) | 2015-03-03 | 2018-04-24 | Univ Minnesota | Gen de variante ets2 etv2 y usos del mismo. |
| JP2018523999A (ja) | 2015-06-30 | 2018-08-30 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | ヒト化心筋 |
| JP2018522553A (ja) | 2015-06-30 | 2018-08-16 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | ヒト化骨格筋 |
| JP2019502400A (ja) | 2015-10-27 | 2019-01-31 | リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミネソタＲｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｍｉｎｎｅｓｏｔａ | キメラ胚補助臓器作製用の組成物及び方法 |
| CN108125943A (zh) | 2018-01-17 | 2018-06-08 | 云南省第二人民医院 | 前胡醇当归脂作为制备抗动脉粥样硬化药物的应用 |
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2016
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- 2016-03-03 AU AU2016226087A patent/AU2016226087A1/en not_active Abandoned
- 2016-03-03 SG SG11201707151YA patent/SG11201707151YA/en unknown
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- 2016-03-03 RU RU2017132331A patent/RU2017132331A/ru not_active Application Discontinuation
- 2016-03-03 CA CA2978457A patent/CA2978457A1/en not_active Abandoned
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- 2016-03-03 BR BR112017018932A patent/BR112017018932A2/pt not_active Application Discontinuation
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- 2017-09-04 PH PH12017501589A patent/PH12017501589A1/en unknown
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2023
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| MX2017011345A (es) | 2018-04-24 |
| CL2017002226A1 (es) | 2018-07-27 |
| PH12017501589A1 (en) | 2018-02-05 |
| WO2016141234A1 (en) | 2016-09-09 |
| JP2018506984A (ja) | 2018-03-15 |
| KR20170121262A (ko) | 2017-11-01 |
| BR112017018932A2 (pt) | 2018-07-31 |
| RU2017132331A (ru) | 2019-04-03 |
| SG11201707151YA (en) | 2017-09-28 |
| AU2016226087A1 (en) | 2017-10-26 |
| IL254241A0 (en) | 2017-10-31 |
| US20230365638A1 (en) | 2023-11-16 |
| US11673928B2 (en) | 2023-06-13 |
| US20180037620A1 (en) | 2018-02-08 |
| KR102684690B1 (ko) | 2024-07-15 |
| EP3264891A1 (en) | 2018-01-10 |
| EP3264891A4 (en) | 2018-09-05 |
| CN108024522A (zh) | 2018-05-11 |
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