CA2978166A1 - Instrumentation d'admission pour analyseur d'ions couple a un dispositif de spectrometrie de masse d'ionisation par evaporation rapide ("reims") - Google Patents

Instrumentation d'admission pour analyseur d'ions couple a un dispositif de spectrometrie de masse d'ionisation par evaporation rapide ("reims") Download PDF

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Publication number
CA2978166A1
CA2978166A1 CA2978166A CA2978166A CA2978166A1 CA 2978166 A1 CA2978166 A1 CA 2978166A1 CA 2978166 A CA2978166 A CA 2978166A CA 2978166 A CA2978166 A CA 2978166A CA 2978166 A1 CA2978166 A1 CA 2978166A1
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Canada
Prior art keywords
aerosol
smoke
vapour
tissue
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2978166A
Other languages
English (en)
Inventor
Zoltan Takats
Julia BALOG
Steven Derek Pringle
Tamas Karancsi
Michael Raymond MORRIS
Lajos Godorhazy
Daniel Szalay
Daniel Simon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Micromass UK Ltd
Original Assignee
Micromass UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB201503876A external-priority patent/GB201503876D0/en
Priority claimed from GB201503879A external-priority patent/GB201503879D0/en
Priority claimed from GBGB1503878.9A external-priority patent/GB201503878D0/en
Priority claimed from GB201503864A external-priority patent/GB201503864D0/en
Priority claimed from GB201503863A external-priority patent/GB201503863D0/en
Priority claimed from GB201503867A external-priority patent/GB201503867D0/en
Priority claimed from GB201503877A external-priority patent/GB201503877D0/en
Priority claimed from GBGB1516003.9A external-priority patent/GB201516003D0/en
Priority claimed from GBGB1518369.2A external-priority patent/GB201518369D0/en
Application filed by Micromass UK Ltd filed Critical Micromass UK Ltd
Priority claimed from PCT/GB2016/050620 external-priority patent/WO2016142690A1/fr
Publication of CA2978166A1 publication Critical patent/CA2978166A1/fr
Abandoned legal-status Critical Current

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    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0468—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample
    • H01J49/049—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample with means for applying heat to desorb the sample; Evaporation
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Abstract

L'invention concerne un appareil comprenant un premier dispositif (1) de génération d'aérosols, de fumée ou de vapeur (5) à partir d'une ou plusieurs régions d'une cible, un conduit d'admission vers un analyseur d'ions ou un spectromètre de masse, le conduit d'admission ayant une entrée à travers laquelle l'aérosol, la fumée ou la vapeur (5) passe, et un agencement de pompe Venturi agencé et adapté pour diriger l'aérosol, la fumée ou la vapeur vers l'entrée.
CA2978166A 2015-03-06 2016-03-07 Instrumentation d'admission pour analyseur d'ions couple a un dispositif de spectrometrie de masse d'ionisation par evaporation rapide ("reims") Abandoned CA2978166A1 (fr)

Applications Claiming Priority (19)

Application Number Priority Date Filing Date Title
GB201503879A GB201503879D0 (en) 2015-03-06 2015-03-06 Rapid evaporative ionisation mass spectrometry (REIMS) applications
GB1503863.1 2015-03-06
GBGB1503878.9A GB201503878D0 (en) 2015-03-06 2015-03-06 Liquid separator for endoscopic electrosurgical applications
GB1503864.9 2015-03-06
GB201503864A GB201503864D0 (en) 2015-03-06 2015-03-06 Heated rapid evaporative ionisation mass spectrometry ("REIMS") collision surface
GB201503863A GB201503863D0 (en) 2015-03-06 2015-03-06 Rapid evaporation ionization mass spectrometry (REIMS) imaging platform for direct mapping from bacteria growth media
GB1503878.9 2015-03-06
GB1503876.3 2015-03-06
GB1503879.7 2015-03-06
GB201503876A GB201503876D0 (en) 2015-03-06 2015-03-06 Rapid evaporative ionization mass spectrometry (REIMS) imaging platform for direct mapping from bulk tissue
GB1503877.1 2015-03-06
GB1503867.2 2015-03-06
GB201503867A GB201503867D0 (en) 2015-03-06 2015-03-06 Ionisation of gaseous samles in rapid evaporative ionisation mass spectrometry (REIMS)
GB201503877A GB201503877D0 (en) 2015-03-06 2015-03-06 In-vivo endoscopic tissue identification tool utilising rapid evaporative ionization mass spectrometry (REIMS)
GB1516003.9 2015-09-09
GBGB1516003.9A GB201516003D0 (en) 2015-09-09 2015-09-09 Rapid evaporative ionisation mass spectrometry (REIMS) applications
GBGB1518369.2A GB201518369D0 (en) 2015-10-16 2015-10-16 Heated rapid evaporative ionisation mass spectrometry ("REIMS") collision surface
GB1518369.2 2015-10-16
PCT/GB2016/050620 WO2016142690A1 (fr) 2015-03-06 2016-03-07 Instrumentation d'admission pour analyseur d'ions couplé à un dispositif de spectrométrie de masse d'ionisation par évaporation rapide ("reims")

Publications (1)

Publication Number Publication Date
CA2978166A1 true CA2978166A1 (fr) 2016-09-15

Family

ID=55524388

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3234867A Pending CA3234867A1 (fr) 2015-03-06 2016-03-07 Ionisation amelioree d'echantillons gazeux
CA2978166A Abandoned CA2978166A1 (fr) 2015-03-06 2016-03-07 Instrumentation d'admission pour analyseur d'ions couple a un dispositif de spectrometrie de masse d'ionisation par evaporation rapide ("reims")

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA3234867A Pending CA3234867A1 (fr) 2015-03-06 2016-03-07 Ionisation amelioree d'echantillons gazeux

Country Status (4)

Country Link
JP (1) JP2021053404A (fr)
CN (4) CN107635477B (fr)
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Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11969764B2 (en) * 2016-07-18 2024-04-30 Sortera Technologies, Inc. Sorting of plastics
GB201808949D0 (en) * 2018-05-31 2018-07-18 Micromass Ltd Bench-top time of flight mass spectrometer
GB201808932D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Bench-top time of flight mass spectrometer
GB201808912D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Bench-top time of flight mass spectrometer
GB201808893D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Bench-top time of flight mass spectrometer
CN108828051B (zh) * 2018-07-04 2021-03-23 浙江工商大学 快速蒸发离子化质谱的南极磷虾油的脂质实时检测方法
CN109088303B (zh) * 2018-08-23 2020-03-31 深圳市创鑫激光股份有限公司 调节脉冲激光器输出功率的方法、装置以及脉冲激光器
US20200392577A1 (en) * 2019-06-13 2020-12-17 Nantworks, LLC Biological Deposit Labeling And Tracking
CN110596401B (zh) * 2019-09-11 2024-05-14 宁波盘福生物科技有限公司 用于蛋白质检测的高场不对称波形离子淌度装置及方法
CN110623725A (zh) * 2019-09-16 2019-12-31 南京桑迪医疗科技有限公司 一种射频等离子体针刀用电极针头更换装置及其使用方法
CN111254091B (zh) * 2020-01-20 2022-04-19 浙江工业大学 一种嗜麦芽窄食单胞菌gyh及其在降解氯代烃类污染物中的应用
CN111351831A (zh) * 2020-02-26 2020-06-30 西安交通大学医学院第二附属医院 基于质谱分析组织术中检测、标记设备及其检测方法
CN113552348B (zh) * 2021-07-28 2022-05-27 四川省医学科学院·四川省人民医院 用于检测SARS-CoV-2冠状病毒S蛋白的纳米颗粒溶液、制备方法、试剂盒及应用
JPWO2023037536A1 (fr) * 2021-09-13 2023-03-16
CN114100716B (zh) * 2021-12-01 2023-04-21 上海天马微电子有限公司 微流控装置及其驱动方法
CN114441621B (zh) * 2021-12-27 2023-08-22 江苏省食品药品监督检验研究院 一种基于电喷雾-离子迁移谱检测化妆品中禁用抗菌药的方法和试剂盒及应用
CN115184447A (zh) * 2022-07-25 2022-10-14 司法鉴定科学研究院 一种墨水溯源方法
CN115337054B (zh) * 2022-10-19 2023-01-10 成都美创医疗科技股份有限公司 等离子辅助乳腺肿瘤旋切活检针

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3770954A (en) * 1971-12-29 1973-11-06 Gen Electric Method and apparatus for analysis of impurities in air and other gases
US5033541A (en) * 1989-11-17 1991-07-23 Cetac Technologies, Inc. Double pass tandem cooling aerosol condenser
US6667474B1 (en) * 2000-10-27 2003-12-23 Thermo Finnigan Llc Capillary tube assembly with replaceable capillary tube
US6713757B2 (en) * 2001-03-02 2004-03-30 Mds Inc. Controlling the temporal response of mass spectrometers for mass spectrometry
US20030119193A1 (en) * 2001-04-25 2003-06-26 Robert Hess System and method for high throughput screening of droplets
CA2495378C (fr) * 2002-08-22 2011-03-01 Applera Corporation Procede de caracterisation de biomolecules au moyen d'une strategie dependant de resultats
US7425700B2 (en) * 2003-05-22 2008-09-16 Stults John T Systems and methods for discovery and analysis of markers
JP2005108578A (ja) * 2003-09-30 2005-04-21 Hitachi Ltd 質量分析装置
GB0514964D0 (en) * 2005-07-21 2005-08-24 Ms Horizons Ltd Mass spectrometer devices & methods of performing mass spectrometry
US7335897B2 (en) * 2004-03-30 2008-02-26 Purdue Research Foundation Method and system for desorption electrospray ionization
CN101073137A (zh) * 2004-03-30 2007-11-14 普渡研究基金会 用于解吸电喷雾离子化的方法和系统
DE102004053064B4 (de) * 2004-11-03 2007-11-08 Bruker Daltonik Gmbh Ionisierung durch Tröpfchenaufprall
GB2425178A (en) * 2005-04-13 2006-10-18 Univ Sheffield Analysis of biological samples by mass spectrometry
JP2007051934A (ja) * 2005-08-18 2007-03-01 Toppan Printing Co Ltd 飛行時間型二次イオン質量分析法における質量軸校正方法
JP2007165116A (ja) * 2005-12-14 2007-06-28 Shimadzu Corp 質量分析装置
US8637325B2 (en) * 2009-02-16 2014-01-28 University Of Wyoming Method and apparatus for pyrolysis-induced cleavage in peptides and proteins
CN101201335B (zh) * 2006-12-29 2011-06-15 东华理工学院 质谱仪表面解吸常压化学电离源
CN101113970B (zh) * 2007-08-28 2010-06-09 清华大学 一种无外部高压的质谱离子源及其离子化分析方法
US20090088772A1 (en) * 2007-09-27 2009-04-02 Blumenkranz Stephen J Fiber optic in-situ chemical analysis in a robotic surgical system
US9905409B2 (en) * 2007-11-30 2018-02-27 Waters Technologies Corporation Devices and methods for performing mass analysis
WO2009146396A1 (fr) * 2008-05-30 2009-12-03 Craig Whitehouse Sources d’ions à modes de fonctionnement simple et multiple pour ionisation chimique à pression atmosphérique
GB0813777D0 (en) * 2008-07-28 2008-09-03 Micromass Ltd Mass spectrometer
US8203117B2 (en) * 2008-09-30 2012-06-19 Prosolia, Inc. Method and apparatus for embedded heater for desorption and ionization of analytes
US8448493B2 (en) * 2008-10-23 2013-05-28 Woods Hole Oceanographic Institution Gas chromatograph-combustion system and method for mass spectrometry
CA2704093A1 (fr) * 2009-05-18 2010-11-18 Jeol Usa, Inc. Methode d'analyse inorganique par spectrometrie de masse
RU2558884C2 (ru) * 2009-05-27 2015-08-10 Майкромасс Юк Лимитед Система и способ для идентификации биологических тканей
US8598521B2 (en) * 2009-08-17 2013-12-03 Temple University Of The Commonwealth System Of Higher Education Vaporization device and method for imaging mass spectrometry
US9194384B2 (en) * 2009-12-17 2015-11-24 The Charles Stark Draper Laboratory, Inc. MEMS electrostatic fluidic pumps and valves
WO2012090914A1 (fr) * 2010-12-27 2012-07-05 株式会社資生堂 Procédé de spectrométrie de masse, spectromètre de masse et système de spectrométrie de masse
US8809777B2 (en) * 2011-04-20 2014-08-19 Micromass Uk Limited Atmospheric pressure ion source by interacting high velocity spray with a target
WO2012146787A1 (fr) * 2011-04-28 2012-11-01 Philip Morris Products S.A. Identification de structure assistée par ordinateur
US8592754B2 (en) * 2011-05-12 2013-11-26 Illinois State University High sensitivity mass spectrometry systems
US9157921B2 (en) * 2011-05-18 2015-10-13 Purdue Research Foundation Method for diagnosing abnormality in tissue samples by combination of mass spectral and optical imaging
GB201109383D0 (en) * 2011-06-03 2011-07-20 Micromass Ltd Aperture gas flow restriction
TWI449081B (zh) * 2011-08-31 2014-08-11 Univ Nat Sun Yat Sen 熱脫附游離裝置、質譜系統，及質譜分析方法
EP3299822B1 (fr) * 2011-11-10 2018-12-05 InfanDx AG Procédé et utilisation de composés métaboliques pour diagnostiquer un accident vasculaire cérébral
JP6263776B2 (ja) * 2011-12-23 2018-01-24 マイクロマス ユーケー リミテッド インパクタスプレーイオン化源を介した、キャピラリー電気泳動から質量分析計のへのインターフェース化
IN2014MN01506A (fr) * 2011-12-28 2015-05-01 Medimass Kft
US9105458B2 (en) * 2012-05-21 2015-08-11 Sarah Trimpin System and methods for ionizing compounds using matrix-assistance for mass spectrometry and ion mobility spectrometry
CN102800553B (zh) * 2012-09-02 2015-07-29 王利兵 一种气相液相色谱-电子轰击电喷雾双重离子源飞行时间质谱系统
CA2886655A1 (fr) * 2012-10-25 2014-05-01 Micromass Uk Limited Reproductibilite amelioree de source d'ionisation basee sur l'impact pour des compositions a phase mobile organique faible et elevee au moyen d'une cible de treillis
US9568477B2 (en) * 2012-12-30 2017-02-14 Brigham And Women's Hospital, Inc. System and method for analysis of bio-metabolites for-use in image-guided surgery
US20140350534A1 (en) * 2013-02-20 2014-11-27 Sloan-Kettering Institute For Cancer Research Raman based ablation/resection systems and methods
JP6079319B2 (ja) * 2013-03-06 2017-02-15 株式会社デンソー ライト制御装置
CA2902771C (fr) * 2013-03-15 2018-08-14 Synaptive Medical (Barbados) Inc. Systemes chirurgicaux sensibles au contexte
US20140264004A1 (en) * 2013-03-15 2014-09-18 Purdue Research Foundation Systems and methods for analyzing a sample using a mass spectrometry probe configured to contact the sample
WO2015004457A1 (fr) * 2013-07-09 2015-01-15 Micromass Uk Limited Amélioration de plage dynamique intelligente
GB2523873B (en) * 2013-11-26 2016-04-20 Waters Technologies Corp Systems, devices and methods for connecting a chromatography system to a mass spectrometer

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