GB2583469B - Rapid evaporative ionisation mass spectrometry ("REIMS") and desorption electrospray ionisation mass spectrometry ("DESI-MS") analysis of biopsy samples - Google Patents

Rapid evaporative ionisation mass spectrometry ("REIMS") and desorption electrospray ionisation mass spectrometry ("DESI-MS") analysis of biopsy samples Download PDF

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Publication number
GB2583469B
GB2583469B GB1905763.7A GB201905763A GB2583469B GB 2583469 B GB2583469 B GB 2583469B GB 201905763 A GB201905763 A GB 201905763A GB 2583469 B GB2583469 B GB 2583469B
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United Kingdom
Prior art keywords
mass spectrometry
ionisation mass
reims
desi
analysis
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GB201905763D0 (en
GB2583469A (en
Inventor
Takáts Zoltán
Jones Emrys
Ian Langridge James
Raymond Morris Michael
Karancsi Tamás
Derek Pringle Steven
Balog Júlia
Simon Dániel
Gödörházy Lajos
Szalay Dániel
George Richardson Keith
Robert Bennett Phillip
Alan Macintyre David
Pruski Pamela
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Micromass UK Ltd
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Micromass UK Ltd
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Priority claimed from GB201503879A external-priority patent/GB201503879D0/en
Priority claimed from GB201503867A external-priority patent/GB201503867D0/en
Priority claimed from GBGB1503878.9A external-priority patent/GB201503878D0/en
Priority claimed from GB201503863A external-priority patent/GB201503863D0/en
Priority claimed from GB201503877A external-priority patent/GB201503877D0/en
Priority claimed from GB201503876A external-priority patent/GB201503876D0/en
Priority claimed from GB201503864A external-priority patent/GB201503864D0/en
Priority claimed from GBGB1516003.9A external-priority patent/GB201516003D0/en
Priority claimed from GBGB1518369.2A external-priority patent/GB201518369D0/en
Application filed by Micromass UK Ltd filed Critical Micromass UK Ltd
Priority claimed from GB1714120.1A external-priority patent/GB2552602B/en
Publication of GB201905763D0 publication Critical patent/GB201905763D0/en
Publication of GB2583469A publication Critical patent/GB2583469A/en
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GB1905763.7A 2015-03-06 2016-03-07 Rapid evaporative ionisation mass spectrometry ("REIMS") and desorption electrospray ionisation mass spectrometry ("DESI-MS") analysis of biopsy samples Active GB2583469B (en)

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GB201503876A GB201503876D0 (en) 2015-03-06 2015-03-06 Rapid evaporative ionization mass spectrometry (REIMS) imaging platform for direct mapping from bulk tissue
GB201503864A GB201503864D0 (en) 2015-03-06 2015-03-06 Heated rapid evaporative ionisation mass spectrometry ("REIMS") collision surface
GB201503879A GB201503879D0 (en) 2015-03-06 2015-03-06 Rapid evaporative ionisation mass spectrometry (REIMS) applications
GB201503877A GB201503877D0 (en) 2015-03-06 2015-03-06 In-vivo endoscopic tissue identification tool utilising rapid evaporative ionization mass spectrometry (REIMS)
GB201503863A GB201503863D0 (en) 2015-03-06 2015-03-06 Rapid evaporation ionization mass spectrometry (REIMS) imaging platform for direct mapping from bacteria growth media
GBGB1503878.9A GB201503878D0 (en) 2015-03-06 2015-03-06 Liquid separator for endoscopic electrosurgical applications
GB201503867A GB201503867D0 (en) 2015-03-06 2015-03-06 Ionisation of gaseous samles in rapid evaporative ionisation mass spectrometry (REIMS)
GBGB1516003.9A GB201516003D0 (en) 2015-09-09 2015-09-09 Rapid evaporative ionisation mass spectrometry (REIMS) applications
GBGB1518369.2A GB201518369D0 (en) 2015-10-16 2015-10-16 Heated rapid evaporative ionisation mass spectrometry ("REIMS") collision surface
GB1714120.1A GB2552602B (en) 2015-03-06 2016-03-07 Desorption electrospray ionisation mass spectrometry ("DESI-MS") analysis of swabs

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GB201905763D0 GB201905763D0 (en) 2019-06-05
GB2583469A GB2583469A (en) 2020-11-04
GB2583469B true GB2583469B (en) 2021-02-17

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GB2202422.8A Active GB2601669B (en) 2015-03-06 2016-03-07 Collision surface for improved ionisation
GB2015580.0A Active GB2585167B (en) 2015-03-06 2016-03-07 Physically Guided Rapid Evaporative Ionisation Mass Spectrometry
GB2208854.6A Withdrawn GB2607198A (en) 2015-03-06 2016-03-07 Spectrometric analysis
GB2110454.2A Withdrawn GB2594421A (en) 2015-03-06 2016-03-07 Inlet instrumentation for ion analyser coupled to rapid evaporative ionisation mass spectrometry ("REIMS") device
GB2117492.5A Active GB2598259B (en) 2015-03-06 2016-03-07 Cell Population Analysis
GB2202418.6A Active GB2601439B8 (en) 2015-03-06 2016-03-07 Collision surface for improved ionisation
GB2014274.1A Active GB2584972B (en) 2015-03-06 2016-03-07 Liquid trap or separator for electrosurgical applications
GB1905763.7A Active GB2583469B (en) 2015-03-06 2016-03-07 Rapid evaporative ionisation mass spectrometry ("REIMS") and desorption electrospray ionisation mass spectrometry ("DESI-MS") analysis of biopsy samples
GB2202822.9A Active GB2602212B (en) 2015-03-06 2016-03-07 Spectrometric analysis
GB2019168.0A Active GB2587288B (en) 2015-03-06 2016-03-07 Detection of bacteria in swab samples using desorption ionisation and mass spectrometry
GB2202832.8A Withdrawn GB2601954A (en) 2015-03-06 2016-03-07 Spectrometric analysis

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GB2202422.8A Active GB2601669B (en) 2015-03-06 2016-03-07 Collision surface for improved ionisation
GB2015580.0A Active GB2585167B (en) 2015-03-06 2016-03-07 Physically Guided Rapid Evaporative Ionisation Mass Spectrometry
GB2208854.6A Withdrawn GB2607198A (en) 2015-03-06 2016-03-07 Spectrometric analysis
GB2110454.2A Withdrawn GB2594421A (en) 2015-03-06 2016-03-07 Inlet instrumentation for ion analyser coupled to rapid evaporative ionisation mass spectrometry ("REIMS") device
GB2117492.5A Active GB2598259B (en) 2015-03-06 2016-03-07 Cell Population Analysis
GB2202418.6A Active GB2601439B8 (en) 2015-03-06 2016-03-07 Collision surface for improved ionisation
GB2014274.1A Active GB2584972B (en) 2015-03-06 2016-03-07 Liquid trap or separator for electrosurgical applications

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GB2202822.9A Active GB2602212B (en) 2015-03-06 2016-03-07 Spectrometric analysis
GB2019168.0A Active GB2587288B (en) 2015-03-06 2016-03-07 Detection of bacteria in swab samples using desorption ionisation and mass spectrometry
GB2202832.8A Withdrawn GB2601954A (en) 2015-03-06 2016-03-07 Spectrometric analysis

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Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220161298A1 (en) * 2016-07-18 2022-05-26 Sortera Alloys, Inc. Sorting of plastics
GB201808949D0 (en) * 2018-05-31 2018-07-18 Micromass Ltd Bench-top time of flight mass spectrometer
GB201808912D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Bench-top time of flight mass spectrometer
CN108828051B (en) * 2018-07-04 2021-03-23 浙江工商大学 Method for detecting lipid of antarctic krill oil in real time by rapid evaporation ionization mass spectrometry
CN109088303B (en) * 2018-08-23 2020-03-31 深圳市创鑫激光股份有限公司 Method and device for adjusting output power of pulse laser and pulse laser
US20200392577A1 (en) * 2019-06-13 2020-12-17 Nantworks, LLC Biological Deposit Labeling And Tracking
CN110596401A (en) * 2019-09-11 2019-12-20 宁波盘福生物科技有限公司 High-field asymmetric waveform ion mobility device and method for protein detection
CN110623725A (en) * 2019-09-16 2019-12-31 南京桑迪医疗科技有限公司 Electrode needle head replacing device for radio frequency plasma needle knife and using method thereof
CN111254091B (en) * 2020-01-20 2022-04-19 浙江工业大学 Stenotrophomonas maltophilia GYH and application thereof in degradation of chlorinated hydrocarbon pollutants
CN111351831A (en) * 2020-02-26 2020-06-30 西安交通大学医学院第二附属医院 Detection and marking device and detection method based on mass spectrometry in histology
CN113252579A (en) * 2021-04-27 2021-08-13 浙江省现代农业装备设计研究院 Facility-based agricultural comprehensive sensor device and air parameter detection method thereof
CN113552348B (en) * 2021-07-28 2022-05-27 四川省医学科学院·四川省人民医院 Nanoparticle solution for detecting SARS-CoV-2 coronavirus S protein, preparation method, kit and application
CN113610007B (en) * 2021-08-09 2024-04-16 重庆医科大学 Nasal cavity sampling object detection device
JPWO2023037536A1 (en) * 2021-09-13 2023-03-16
CN114100716B (en) * 2021-12-01 2023-04-21 上海天马微电子有限公司 Microfluidic device and driving method thereof
CN114441621B (en) * 2021-12-27 2023-08-22 江苏省食品药品监督检验研究院 Method and kit for detecting forbidden antibacterial drugs in cosmetics based on electrospray-ion mobility spectrometry and application of kit
CN115337054B (en) * 2022-10-19 2023-01-10 成都美创医疗科技股份有限公司 Plasma-assisted rotary-cut biopsy needle for breast tumors

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2425178A (en) * 2005-04-13 2006-10-18 Univ Sheffield Analysis of biological samples by mass spectrometry
US20120149009A1 (en) * 2009-08-17 2012-06-14 Levis Robert J Vaporization device and method for imaging mass spectrometry
US20120295276A1 (en) * 2011-05-18 2012-11-22 Purdue Research Foundation (Prf) Mass spectral analysis
WO2014106165A1 (en) * 2012-12-30 2014-07-03 Brigham And Women's Hospital, Inc. System and method for analysis of bio-metabolites for-use in image-guided surgery

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3770954A (en) * 1971-12-29 1973-11-06 Gen Electric Method and apparatus for analysis of impurities in air and other gases
US5033541A (en) * 1989-11-17 1991-07-23 Cetac Technologies, Inc. Double pass tandem cooling aerosol condenser
CA2167099A1 (en) * 1995-01-17 1996-07-18 William David Reents Jr. Particulate analysis of fluid samples
WO1997034534A1 (en) * 1996-03-18 1997-09-25 Femrx, Inc. Method and device for tissue vaporization and extraction
US6667474B1 (en) * 2000-10-27 2003-12-23 Thermo Finnigan Llc Capillary tube assembly with replaceable capillary tube
US6713757B2 (en) * 2001-03-02 2004-03-30 Mds Inc. Controlling the temporal response of mass spectrometers for mass spectrometry
US20030119193A1 (en) * 2001-04-25 2003-06-26 Robert Hess System and method for high throughput screening of droplets
US6940065B2 (en) * 2002-08-22 2005-09-06 Applera Corporation Method for characterizing biomolecules utilizing a result driven strategy
US7425700B2 (en) * 2003-05-22 2008-09-16 Stults John T Systems and methods for discovery and analysis of markers
JP2005108578A (en) * 2003-09-30 2005-04-21 Hitachi Ltd Mass spectroscope
GB0514964D0 (en) * 2005-07-21 2005-08-24 Ms Horizons Ltd Mass spectrometer devices & methods of performing mass spectrometry
US7335897B2 (en) * 2004-03-30 2008-02-26 Purdue Research Foundation Method and system for desorption electrospray ionization
CN101073137A (en) * 2004-03-30 2007-11-14 普渡研究基金会 Method and system for desorption electrospray ionization
DE102004053064B4 (en) * 2004-11-03 2007-11-08 Bruker Daltonik Gmbh Ionization by droplet impact
JP2007051934A (en) * 2005-08-18 2007-03-01 Toppan Printing Co Ltd Mass axis calibration method in time-of-flight secondary ion mass analysis method
JP2007165116A (en) * 2005-12-14 2007-06-28 Shimadzu Corp Mass spectrometer
US8637325B2 (en) * 2009-02-16 2014-01-28 University Of Wyoming Method and apparatus for pyrolysis-induced cleavage in peptides and proteins
CN101173914A (en) * 2006-10-30 2008-05-07 国立中山大学 Atmospheric pressure liquid phase mass spectrometric analysis method and atmospheric pressure liquid phase mass spectrograph
CN101201335B (en) * 2006-12-29 2011-06-15 东华理工学院 Surface desorption atmospheric chemical ionization source of mass spectrometer
CN101113970B (en) * 2007-08-28 2010-06-09 清华大学 Mass spectra ion source without external high pressure and ionization analytical method thereof
US20090088772A1 (en) * 2007-09-27 2009-04-02 Blumenkranz Stephen J Fiber optic in-situ chemical analysis in a robotic surgical system
WO2009070555A1 (en) * 2007-11-30 2009-06-04 Waters Technologies Corporation Devices and methods for performing mass analysis
KR20220008944A (en) * 2008-01-18 2022-01-21 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 Methods of detecting signatures of disease or conditions in bodily fluids
WO2009146396A1 (en) * 2008-05-30 2009-12-03 Craig Whitehouse Single and multiple operating mode ion sources with atmospheric pressure chemical ionization
GB0813777D0 (en) * 2008-07-28 2008-09-03 Micromass Ltd Mass spectrometer
WO2010039675A1 (en) * 2008-09-30 2010-04-08 Prosolia, Inc. Method and apparatus for embedded heater for desorption and ionization of analytes
WO2010048548A2 (en) * 2008-10-23 2010-04-29 Woods Hole Oceanographic Institution Gas chromatograph-combustion system and method for mass spectrometry
CA2704093A1 (en) * 2009-05-18 2010-11-18 Jeol Usa, Inc. Method of inorganic analysis by mass spectrometry
KR101938742B1 (en) * 2009-05-27 2019-01-15 마이크로매스 유케이 리미티드 System and method for identification of biological tissues
US9194384B2 (en) * 2009-12-17 2015-11-24 The Charles Stark Draper Laboratory, Inc. MEMS electrostatic fluidic pumps and valves
US20130284915A1 (en) * 2010-12-27 2013-10-31 Bio Chromato, Inc. Mass spectrometry method, mass spectrometer, and mass spectrometry system
WO2012143737A1 (en) * 2011-04-20 2012-10-26 Micromass Uk Limited Atmospheric pressure ion source by interacting high velocity spray with a target
CN103650100A (en) * 2011-04-28 2014-03-19 菲利普莫里斯生产公司 Computer-assisted structure identification
WO2012155090A2 (en) * 2011-05-12 2012-11-15 Illinois State University High sensitivity mass spectrometry systems
GB201109383D0 (en) * 2011-06-03 2011-07-20 Micromass Ltd Aperture gas flow restriction
TWI449081B (en) * 2011-08-31 2014-08-11 Univ Nat Sun Yat Sen Thermal desorption ionization device, mass spectrometer, and method for mass spectrometry
EP3299822B1 (en) * 2011-11-10 2018-12-05 InfanDx AG Method and use of metabolic compounds for diagnosing stroke
US9117642B2 (en) * 2011-12-23 2015-08-25 Micromass Uk Limited Interfacing capillary electrophoresis to a mass spectrometer via an impactor spray ionization source
EP2798657B1 (en) * 2011-12-28 2020-05-06 Micromass UK Limited Collision ion generator and separator
US9105458B2 (en) * 2012-05-21 2015-08-11 Sarah Trimpin System and methods for ionizing compounds using matrix-assistance for mass spectrometry and ion mobility spectrometry
CN102800553B (en) * 2012-09-02 2015-07-29 王利兵 A kind of gas phase liquid chromatogram-electronics bombardment electron spray dual ion source flight time mass spectrum system
WO2014064400A1 (en) * 2012-10-25 2014-05-01 Micromass Uk Limited Improved reproducibility of impact-based ionization source for low and high organic mobile phase compositions using a mesh target
US20140350534A1 (en) * 2013-02-20 2014-11-27 Sloan-Kettering Institute For Cancer Research Raman based ablation/resection systems and methods
JP6079319B2 (en) * 2013-03-06 2017-02-15 株式会社デンソー Light control device
US20140264004A1 (en) * 2013-03-15 2014-09-18 Purdue Research Foundation Systems and methods for analyzing a sample using a mass spectrometry probe configured to contact the sample
US9788906B2 (en) * 2013-03-15 2017-10-17 Synaptive Medical (Barbados) Inc. Context aware surgical systems for intraoperatively configuring imaging devices
CN103293141B (en) * 2013-03-25 2015-03-11 江苏省质量安全工程研究院 A liquor vintage recognition method based on a fusion technology of ion mobility spectrometry/ mass spectrometry/ Raman spectroscopy
WO2015004457A1 (en) * 2013-07-09 2015-01-15 Micromass Uk Limited Intelligent dynamic range enhancement
US9305761B2 (en) * 2013-08-14 2016-04-05 Waters Technologies Corporation Ion source for mass spectrometer and method of producing analyte ion stream
GB201317831D0 (en) * 2013-10-09 2013-11-20 Micromass Ltd MS/MS analysis using ECD or ETD fragmentation
GB2523873B (en) * 2013-11-26 2016-04-20 Waters Technologies Corp Systems, devices and methods for connecting a chromatography system to a mass spectrometer

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2425178A (en) * 2005-04-13 2006-10-18 Univ Sheffield Analysis of biological samples by mass spectrometry
US20120149009A1 (en) * 2009-08-17 2012-06-14 Levis Robert J Vaporization device and method for imaging mass spectrometry
US20120295276A1 (en) * 2011-05-18 2012-11-22 Purdue Research Foundation (Prf) Mass spectral analysis
WO2014106165A1 (en) * 2012-12-30 2014-07-03 Brigham And Women's Hospital, Inc. System and method for analysis of bio-metabolites for-use in image-guided surgery

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Analytical Chemistry (epub Feb 2015); Vol 87, pp 2527-2534, "Rapid evaporative ionization mass spectrometry imaging...", "Golf et al *
Cancer Research (epub Feb 2015); Vol 75, pp 1828-1837, "Spatially resolved metabolic phenotyping...", Guenther et al *
Journal of Trace Elements in Medicine and Biology (epub Feb 2016); Vol 35, pp 97-102, "Element bioimaging of liver needle biopsy...", Hachmoeller et al *

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